{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:47:14Z","timestamp":1781754434441,"version":"3.54.5"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.coph.2013.09.017","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T10:50:05Z","timestamp":1382525405000},"page":"11-17","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Multiple mechanisms have been tested in pain\u2014how can we improve the chances of success?"],"prefix":"10.1016","volume":"14","author":[{"given":"Ann G","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2013.09.017_bib0005","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tig.2012.02.004","article-title":"Pain genetics: past, present and future","volume":"28","author":"Mogil","year":"2012","journal-title":"Trends Genet"},{"key":"10.1016\/j.coph.2013.09.017_bib0010","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3305","article-title":"Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines","volume":"13","author":"Schaible","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.coph.2013.09.017_bib0015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.coph.2013.09.017_bib0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11916-010-0111-0","article-title":"Spinal cord mechanisms of chronic pain and clinical implications","volume":"14","author":"Cheng","year":"2010","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.coph.2013.09.017_bib0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.coph.2013.09.017_bib0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.expneurol.2011.12.021","article-title":"Immune responses of microglia in the spinal cord: contribution to pain states","volume":"234","author":"Schomberg","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.coph.2013.09.017_bib0035","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.pain.2012.04.014","article-title":"Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy","volume":"153","author":"Campbell","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0040","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1526-4637.2010.00981.x","article-title":"NMDA receptor antagonists for the treatment of neuropathic pain","volume":"11","author":"Collins","year":"2010","journal-title":"Pain Med"},{"key":"10.1016\/j.coph.2013.09.017_bib0045","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007115.pub2","article-title":"Duloxetine for treating painful neuropathy or chronic pain","volume":"7","author":"Lunn","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.coph.2013.09.017_bib0050","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ageing\/afs072","article-title":"Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial","volume":"41","author":"Abou-Raya","year":"2012","journal-title":"Age Ageing"},{"key":"10.1016\/j.coph.2013.09.017_bib0055","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1533-2500.2010.00401.x","article-title":"A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee","volume":"11","author":"Chappell","year":"2011","journal-title":"Pain Pract: Official J World Inst Pain"},{"key":"10.1016\/j.coph.2013.09.017_sbref0060","series-title":"Textbook of pain","first-page":"491","article-title":"Mechanism of action of anticonvulsant drugs as analgesic drugs","author":"Morisset","year":"2013"},{"key":"10.1016\/j.coph.2013.09.017_bib0065","series-title":"Textbook of pain","first-page":"455","article-title":"Cyclooxygenase inhibitors: clinical use","author":"Moore","year":"2013"},{"key":"10.1016\/j.coph.2013.09.017_bib0070","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2165\/11590470-000000000-00000","article-title":"Randomized Controlled Trials of COX-2 inhibitors: an analysis of doses used and trends over time to investigate implications for comparative safety","volume":"34","author":"Stefansdottir","year":"2011","journal-title":"Drug Saf"},{"key":"10.1016\/j.coph.2013.09.017_bib0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1212\/WNL.57.3.505","article-title":"Lamotrigine reduces painful diabetic neuropathy: a randomized, controlled study","volume":"57","author":"Eisenberg","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.coph.2013.09.017_bib0080","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/01.ajp.0000210957.39621.b2","article-title":"Lacosamide in painful diabetic peripheral neuropathy: a phase 2 double-blind placebo-controlled study","volume":"23","author":"Rauck","year":"2007","journal-title":"Clin J Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0085","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jpain.2009.01.322","article-title":"Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebo-controlled trial","volume":"10","author":"Shaibani","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pain.2006.09.040","article-title":"Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies","volume":"128","author":"Vinik","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0095","first-page":"CD009318","article-title":"Lacosamide for neuropathic pain and fibromyalgia in adults","volume":"2","author":"Hearn","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.coph.2013.09.017_bib0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2165\/00044011-200929040-00002","article-title":"Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analaysis from an open-label, two-stage adaptive, randomized, controlled trial","volume":"29","author":"Baron","year":"2009","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.coph.2013.09.017_bib0105","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1172\/JCI43158","article-title":"Pain as a channelopathy","volume":"120","author":"Raouf","year":"2010","journal-title":"J Clin Investig"},{"key":"10.1016\/j.coph.2013.09.017_sbref0110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ana.22485","article-title":"Gain of function Nav1.7 mutations in idiopathic small fiber neuropathy","volume":"71","author":"Faber","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.coph.2013.09.017_bib0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/jnnp.29.3.265","article-title":"Clinical trial of carbamazepine (Tegretol) in trigeminal neuralgia","volume":"29","author":"Campbell","year":"1966","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.coph.2013.09.017_sbref0120","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pain.2011.09.008","article-title":"Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker","volume":"153","author":"Goldberg","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0125","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/jnnp.52.4.472","article-title":"Oxcarbazepine: a new drug in the management of intractable trigeminal neuralgia","volume":"52","author":"Zakrzewska","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.coph.2013.09.017_bib0130","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1212\/WNL.48.6.1714","article-title":"Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia","volume":"48","author":"Lunardi","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.coph.2013.09.017_bib0135","series-title":"Proceedings of the 14th World Congress of Pain, PT 172","article-title":"CNV1014802, a novel, potent, nav1.7 selective, state-dependent sodium channel blocker with broad preclinical antihyperalgesic efficacy 3","author":"Rugiero","year":"2012"},{"key":"10.1016\/j.coph.2013.09.017_bib0140","first-page":"761","article-title":"The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognised drug target","volume":"11","author":"Thorpe","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.coph.2013.09.017_bib0145","series-title":"Textbook of pain","first-page":"500","article-title":"Anticonvulsants: clinical","author":"Ali","year":"2013"},{"key":"10.1016\/j.coph.2013.09.017_bib0150","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2377-9-6","article-title":"Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain","volume":"9","author":"Quilici","year":"2009","journal-title":"BMC Neurol"},{"key":"10.1016\/j.coph.2013.09.017_bib0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1464-5491.2010.03152.x","article-title":"Efficacy and safety of pregabalin for treating neuropathic pain associated with diabetic peripheral neuropathy: a 14 week, randomized, double-blind, placebo-controlled trial","volume":"28","author":"Satoh","year":"2011","journal-title":"Diabet Med"},{"key":"10.1016\/j.coph.2013.09.017_bib0160","first-page":"CD007076","article-title":"Pregabalin for acute and chronic pain in adults","volume":"3","author":"Moore","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.coph.2013.09.017_bib0165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1525-1403.2006.00055.x","article-title":"Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial","volume":"9","author":"Wallace","year":"2006","journal-title":"Neuromodulation J Int Neuromodulation Soc"},{"key":"10.1016\/j.coph.2013.09.017_sbref0170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/nedt.2007.3.1.69","article-title":"Ziconotide: a review of its pharmacology and use in the treatment of pain","volume":"3","author":"McGivern","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.coph.2013.09.017_bib0175","series-title":"Proceedings of the 14th World Congress of Pain, PT 155","article-title":"CNV2197944 a novel potent and selective cav2.2 state-dependent blocker for evaluation in chronic pain","author":"Morisset","year":"2012"},{"key":"10.1016\/j.coph.2013.09.017_bib0180","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ng0896-485","article-title":"Mutations in the TRKA\/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis","volume":"13","author":"Indo","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.coph.2013.09.017_sbref0185","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.pain.2013.03.006","article-title":"Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain","volume":"154","author":"Kivitz","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_sbref0190","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jpain.2012.05.006","article-title":"Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial","volume":"13","author":"Brown","year":"2012","journal-title":"J Pain"},{"key":"10.1016\/j.coph.2013.09.017_sbref0195","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/art.37950","article-title":"Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial","volume":"65","author":"Brown","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.coph.2013.09.017_bib0200","series-title":"Proceedings of the 14th World Congress of Pain, PT 452","article-title":"Analgesic efficacy of fulranumab in patients with neuropathic pain in a randomized, placebo-controlled, double-blind study","author":"Romano","year":"2012"},{"key":"10.1016\/j.coph.2013.09.017_bib0205","series-title":"Proceedings of the 14th World Congress of Pain, PT 453","article-title":"Analgesic efficacy of fulranumab in patients with painful diabetic peripheral neuropathy in a randomized, placebo-controlled,double-blind study","author":"Wang","year":"2012"},{"key":"10.1016\/j.coph.2013.09.017_sbref0210","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ejpain.2011.04.005","article-title":"Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury","volume":"15","author":"Anand","year":"2011","journal-title":"Eur J Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0215","series-title":"American College of Rheumatology Annual Meeting","article-title":"A randomized, placebo-controlled phase 2 study of ARRY-797 in patients with osteoarthritis pain refractory to NSAID treatment showed statistically significant improvements in WOMAC pain and in biomarkers of bone and cartilage degradation","author":"Daves","year":"2012"},{"key":"10.1016\/j.coph.2013.09.017_sbref0220","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.pain.2012.04.020","volume":"153","author":"Huggins","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_sbref0225","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.pain.2013.02.003","article-title":"A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia","volume":"154","author":"Kalliomaki","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0230","series-title":"Proceedings of the 13th World Congress of Pain, PM 379","article-title":"Phase II randomised controlled trial evaluating the efficacy and safety of the TRPV-1 antagonist AZD1386 in osteoarthritis of the knee","author":"Svensson","year":"2010"},{"key":"10.1016\/j.coph.2013.09.017_bib0235","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.pain.2013.02.004","article-title":"TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction","volume":"154","author":"Quiding","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0240","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1136\/annrheumdis-2011-143578","article-title":"Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine","volume":"71","author":"Keystone","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.coph.2013.09.017_bib0245","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3899\/jrheum.110874","article-title":"Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate","volume":"39","author":"Stock","year":"2012","journal-title":"J Rheumatol"},{"key":"10.1016\/j.coph.2013.09.017_sbref0250","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.expneurol.2011.11.006","article-title":"Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages","volume":"234","author":"Landry","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.coph.2013.09.017_bib0255","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pain.2009.06.013","article-title":"A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain","volume":"146","author":"Rowbotham","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0260","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.pain.2012.01.009","article-title":"Efficacy and safety of the \u03b14\u03b22 neuronal nicotinic receptor agonist ABT-894 in patients with diabetic peripheral neuropathic pain","volume":"153","author":"Rowbotham","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0265","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1212\/01.WNL.0000036273.98213.34","article-title":"A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain","volume":"59","author":"Wallace","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.coph.2013.09.017_bib0270","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/bja\/aem075","article-title":"Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction","volume":"98","author":"Sneyd","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.coph.2013.09.017_bib0275","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/AJP.0b013e318219799a","article-title":"A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar extraction","volume":"27","author":"Ostenfeld","year":"2011","journal-title":"Clin J Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0280","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/978-3-642-18891-6_13","article-title":"Substance P (NK1) receptor antagonists\u2014analgesics or not?","volume":"164","author":"Boyce","year":"2004","journal-title":"Tachykinins Handb Exp Pharmacol"},{"key":"10.1016\/j.coph.2013.09.017_bib0285","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/j.1476-5381.2011.01300.x","article-title":"Predictive validity of behavioural animal models for chronic pain","volume":"164","author":"Berge","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.coph.2013.09.017_bib0290","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2010.07.015","article-title":"The necessity of animal models in pain research","volume":"151","author":"Mogil","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0295","first-page":"41","article-title":"Human experimental pain models in drug development: translational pain research","volume":"8","author":"Arendt-Nielsen","year":"2007","journal-title":"Curr Opin Invest Drug"},{"key":"10.1016\/j.coph.2013.09.017_sbref0300","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1586\/ern.11.147","article-title":"Optimizing the early phase development of new analgesics by human pain biomarkers","volume":"11","author":"Arendt-Nielsen","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.coph.2013.09.017_bib0305","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jpain.2009.02.002","article-title":"Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera","volume":"10","author":"Arendt-Nielsen","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0310","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.nurt.2009.08.005","article-title":"Use of sensory methods for detecting target engagement in clinical trials of new analgesics","volume":"6","author":"Chizh","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.coph.2013.09.017_bib0315","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.drudis.2011.12.020","article-title":"Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival","volume":"17","author":"Morgan","year":"2012","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.coph.2013.09.017_bib0320","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pain.2006.02.006","article-title":"A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model","volume":"123","author":"Stahl","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0325","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/ALN.0b013e3181af6356","article-title":"Analgesic efficacy of peripheral Kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model","volume":"111","author":"Arendt-Nielsen","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.coph.2013.09.017_bib0330","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2006.04.014","article-title":"The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization","volume":"122","author":"Gazerani","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.coph.2013.09.017_bib0335","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00131402-200112000-00002","article-title":"Gabapentin and venlafaxine for the treatment of painful diabetic neuropathy","volume":"3","author":"Simpson","year":"2001","journal-title":"J Clin Neuromuscular Dis"},{"key":"10.1016\/j.coph.2013.09.017_bib0340","series-title":"Textbook of pain","first-page":"429","article-title":"Opioids: clinical use","author":"Schug","year":"2013"},{"key":"10.1016\/j.coph.2013.09.017_bib0345","first-page":"CD005451","article-title":"Carbamazepine for acute and chronic pain in adults","volume":"1","author":"Wiffen","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.coph.2013.09.017_bib0350","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007393.pub3","article-title":"Topical capsaicin (high concentration) for chronic neuropathic pain in adults","volume":"2","author":"Derry","year":"2013","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489213001902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489213001902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T08:26:12Z","timestamp":1539246372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489213001902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":70,"alternative-id":["S1471489213001902"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2013.09.017","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}