{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:22:19Z","timestamp":1789762939954,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001381","name":"Singapore National Research Foundation","doi-asserted-by":"crossref","award":["NRF\/CREATE\/R-184-000-269-592"],"award-info":[{"award-number":["NRF\/CREATE\/R-184-000-269-592"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.coph.2017.12.002","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T11:11:52Z","timestamp":1514373112000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"special_numbering":"C","title":["Targeting the renin\u2013angiotensin system as novel therapeutic strategy for pulmonary diseases"],"prefix":"10.1016","volume":"40","author":[{"given":"Wan Shun Daniel","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wupeng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Shiu Fred","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2017.12.002_bib0265","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.trsl.2015.08.004","article-title":"Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease","volume":"167","author":"Durham","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.coph.2017.12.002_bib0270","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.drudis.2015.01.001","article-title":"Pharmacological treatment of idiopathic pulmonary fibrosis: an update","volume":"20","author":"Spagnolo","year":"2015","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.coph.2017.12.002_bib0275","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.coph.2017.12.002_bib0280","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/SHK.0000000000000633","article-title":"Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease","volume":"46","author":"Jia","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.coph.2017.12.002_bib0285","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ajh.2011.246","article-title":"Control of renin synthesis and secretion","volume":"25","author":"Kurtz","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.coph.2017.12.002_bib0290","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.cellsig.2014.06.011","article-title":"A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology","volume":"26","author":"Balakumar","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.coph.2017.12.002_bib0295","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.2174\/092986711796642562","article-title":"Local renin-angiotensin II systems, angiotensin-converting enzyme and its homologue ACE2: their potential role in the pathogenesis of chronic obstructive pulmonary diseases, pulmonary hypertension and acute respiratory distress syndrome","volume":"18","author":"Kaparianos","year":"2011","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.coph.2017.12.002_bib0300","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/CS20120081","article-title":"Renin\u2013angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease","volume":"123","author":"Shrikrishna","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.coph.2017.12.002_bib0305","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vph.2014.11.001","article-title":"Angiotensin type 1 and type 2 receptors during ontogeny: cardiovascular and renal effects","volume":"63","author":"Vinturache","year":"2014","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.coph.2017.12.002_bib0310","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1517\/14728222.2013.827664","article-title":"Targeting the \u2018Janus face\u2019 of the B2-bradykinin receptor","volume":"17","author":"Blaes","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.coph.2017.12.002_bib0315","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1165\/rcmb.2012-0451OC","article-title":"Angiotensin-converting enzyme 2\/angiotensin-(1\u20137)\/Mas axis protects against lung fibrosis by inhibiting the MAPK\/NF-kappaB pathway","volume":"50","author":"Meng","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.coph.2017.12.002_bib0320","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/pr.113.008425","article-title":"Pharmacology and signaling of MAS-related G protein-coupled receptors","volume":"66","author":"Solinski","year":"2014","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.coph.2017.12.002_bib0325","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.acvd.2012.02.010","article-title":"Three key proteases\u2014angiotensin-I-converting enzyme (ACE), ACE2 and renin\u2014within and beyond the renin\u2013angiotensin system","volume":"105","author":"Guang","year":"2012","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.coph.2017.12.002_bib0330","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00424-010-0844-y","article-title":"Angiotensin II induces hyperresponsiveness of bronchial smooth muscle via an activation of p42\/44 ERK in rats","volume":"460","author":"Sakai","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.coph.2017.12.002_bib0335","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1164\/ajrccm.162.1.9907128","article-title":"Type 1 angiotensin II receptor antagonism reduces antigen-induced airway reactions","volume":"162","author":"Myou","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coph.2017.12.002_bib0340","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.abb.2008.09.019","article-title":"Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat","volume":"481","author":"Liu","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.coph.2017.12.002_bib0345","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004180000235","article-title":"Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease","volume":"115","author":"Bullock","year":"2001","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.coph.2017.12.002_bib0350","first-page":"145","article-title":"Implications of the angiotensin converting enzyme gene insertion\/deletion polymorphism in health and disease: a snapshot review","volume":"1","author":"Gard","year":"2010","journal-title":"Int J Mol Epidemiol Genet"},{"key":"10.1016\/j.coph.2017.12.002_bib0355","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4614-8603-9_2","article-title":"Epidemiology of asthma: prevalence and burden of disease","volume":"795","author":"Croisant","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.coph.2017.12.002_bib0360","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1183\/13993003.00853-2015","article-title":"A summary of the new GINA strategy: a roadmap to asthma control","volume":"46","author":"Reddel","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.coph.2017.12.002_bib0365","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.5588\/ijtld.14.0170","article-title":"Global burden of asthma among children","volume":"18","author":"Asher","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.coph.2017.12.002_bib0370","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/bph.13057","article-title":"Angiotensin-(1\u20137) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation","volume":"172","author":"Magalhaes","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.coph.2017.12.002_sbref0375","doi-asserted-by":"crossref","first-page":"L1141","DOI":"10.1152\/ajplung.00029.2016","article-title":"Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1\u20137) Mas receptor knockout mice","volume":"311","author":"Magalhaes","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.coph.2017.12.002_sbref0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.taap.2016.06.026","article-title":"Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model","volume":"306","author":"Dhawale","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.coph.2017.12.002_bib0385","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/jamp.2009.0775","article-title":"Acute lung injury: epidemiology, pathogenesis, and treatment","volume":"23","author":"Johnson","year":"2010","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.coph.2017.12.002_bib0390","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.coph.2017.12.002_bib0395","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.burns.2015.04.010","article-title":"Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome","volume":"41","author":"Yilin","year":"2015","journal-title":"Burns"},{"key":"10.1016\/j.coph.2017.12.002_bib0400","doi-asserted-by":"crossref","first-page":"e1226","DOI":"10.1097\/CCM.0000000000002008","article-title":"Age-dependent changes in the pulmonary renin\u2013angiotensin system are associated with severity of lung injury in a model of acute lung injury in rats","volume":"44","author":"Schouten","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.coph.2017.12.002_bib0405","first-page":"15670","article-title":"Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1","volume":"8","author":"Deng","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.coph.2017.12.002_sbref0410","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s13054-017-1823-x","article-title":"A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome","volume":"21","author":"Khan","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.coph.2017.12.002_bib0415","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40635-015-0044-3","article-title":"Angiotensin-(1\u20137) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome","volume":"3","author":"Zambelli","year":"2015","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.coph.2017.12.002_bib0420","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1097\/CCM.0b013e31828a6688","article-title":"Angiotensin-(1\u20137) protects from experimental acute lung injury","volume":"41","author":"Klein","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.coph.2017.12.002_bib0425","doi-asserted-by":"crossref","first-page":"17021","DOI":"10.1038\/celldisc.2017.21","article-title":"miRNA-200c-3p is crucial in acute respiratory distress syndrome","volume":"3","author":"Liu","year":"2017","journal-title":"Cell Discov"},{"key":"10.1016\/j.coph.2017.12.002_bib0430","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.90200.2008","article-title":"Animal models of chronic obstructive pulmonary disease","volume":"295","author":"Wright","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.coph.2017.12.002_bib0435","doi-asserted-by":"crossref","first-page":"020415","DOI":"10.7189\/jogh.05.020415","article-title":"Global and regional estimates of COPD prevalence: systematic review and meta-analysis","volume":"5","author":"Adeloye","year":"2015","journal-title":"J Glob Health"},{"key":"10.1016\/j.coph.2017.12.002_bib0440","first-page":"4521","article-title":"Angiotensinogen gene M235T and angiotensin II-type 1 receptor gene A\/C1166 polymorphisms in chronic obstructive pulmonary disease","volume":"8","author":"Ayada","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.coph.2017.12.002_bib0445","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1164\/rccm.201601-0094OC","article-title":"Angiotensin-converting enzyme inhibition as an adjunct to pulmonary rehabilitation in chronic obstructive pulmonary disease","volume":"194","author":"Curtis","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coph.2017.12.002_bib0450","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pupt.2017.03.007","article-title":"Effect of angiotensin 2 receptor blockers on chronic obstructive lung disease mortality: a retrospective cohort study","volume":"44","author":"Paulin","year":"2017","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.coph.2017.12.002_bib0455","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/resp.12778","article-title":"Pharmacological management of IPF","volume":"21","author":"Borie","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.coph.2017.12.002_bib0460","doi-asserted-by":"crossref","first-page":"15561","DOI":"10.1038\/srep15561","article-title":"Chronic activation of the renin\u2013angiotensin system induces lung fibrosis","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.coph.2017.12.002_bib0465","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tice.2015.05.001","article-title":"Biochemical and histological impact of direct renin inhibition by aliskiren on myofibroblasts activation and differentiation in bleomycin induced pulmonary fibrosis in adult mice","volume":"47","author":"Asker","year":"2015","journal-title":"Tissue Cell"},{"key":"10.1016\/j.coph.2017.12.002_bib0470","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1159\/000430131","article-title":"Angiotensin-converting enzyme 2 attenuates bleomycin-induced lung fibrosis in mice","volume":"36","author":"Wang","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.coph.2017.12.002_bib0475","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1042\/CS20160193","article-title":"Angiotensin-(1\u20137) decreases the expression of collagen I via TGF-beta1\/Smad2\/3 and subsequently inhibits fibroblast-myofibroblast transition","volume":"130","author":"Zhou","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.coph.2017.12.002_bib0480","doi-asserted-by":"crossref","first-page":"25","DOI":"10.33549\/physiolres.932861","article-title":"Intrapulmonary activation of the angiotensin-converting enzyme type 2\/angiotensin 1\u20137\/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia","volume":"64","author":"Hampl","year":"2015","journal-title":"Physiol Res"},{"key":"10.1016\/j.coph.2017.12.002_bib0485","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1470320315576256","article-title":"Activation of renin\u2013angiotensin\u2013aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats","volume":"16","author":"Yuan","year":"2015","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.coph.2017.12.002_bib0490","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1086\/683696","article-title":"Dose-dependent, therapeutic potential of angiotensin-(1\u20137) for the treatment of pulmonary arterial hypertension","volume":"5","author":"Breitling","year":"2015","journal-title":"Pulm Circ"},{"key":"10.1016\/j.coph.2017.12.002_bib0495","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/bph.13044","article-title":"Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis","volume":"172","author":"Bruce","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.coph.2017.12.002_sbref0500","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/MNH.0000000000000254","article-title":"Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation","volume":"25","author":"Velkoska","year":"2016","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.coph.2017.12.002_bib0505","doi-asserted-by":"crossref","first-page":"e0142087","DOI":"10.1371\/journal.pone.0142087","article-title":"Effect of a selective Mas receptor agonist in cerebral ischemia in vitro and in vivo","volume":"10","author":"Lee","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coph.2017.12.002_sbref0510","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/1074248416686188","article-title":"ACE phenotyping as a guide toward personalized therapy with ACE inhibitors","volume":"22","author":"Danilov","year":"2017","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.coph.2017.12.002_bib0515","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2174\/156652309789753392","article-title":"Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?","volume":"9","author":"Lowenstein","year":"2009","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.coph.2017.12.002_bib0520","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ijrobp.2014.03.048","article-title":"Targeting the renin\u2013angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage","volume":"89","author":"Mahmood","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489217302102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489217302102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T23:18:51Z","timestamp":1603581531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489217302102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":52,"alternative-id":["S1471489217302102"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2017.12.002","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the renin\u2013angiotensin system as novel therapeutic strategy for pulmonary diseases","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2017.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}