{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:15:05Z","timestamp":1790644505290,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007527","name":"Universit\u00e9 de Rouen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008702","name":"Kagoshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.coph.2019.07.004","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:19:45Z","timestamp":1566040785000},"page":"82-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["On the origin of eating disorders: altered signaling between gut microbiota, adaptive immunity and the brain melanocortin system regulating feeding behavior"],"prefix":"10.1016","volume":"48","author":[{"given":"Sergue\u00ef O","family":"Fetissov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2019.07.004_bib0005","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1542\/peds.2014-0194","article-title":"Eating disorders in children and adolescents: state of the art review","volume":"134","author":"Campbell","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.coph.2019.07.004_sbref0010","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/erv.2553","article-title":"The science behind the Academy for Eating Disorders\u2019 nine truths about eating disorders","volume":"25","author":"Schaumberg","year":"2017","journal-title":"Eur Eat Disord Rev"},{"key":"10.1016\/j.coph.2019.07.004_sbref0015","doi-asserted-by":"crossref","DOI":"10.1177\/2045125318814734","article-title":"Genetic risk factors for eating disorders: an update and insights into pathophysiology","volume":"9","author":"Himmerich","year":"2019","journal-title":"Ther Adv Psychopharmacol"},{"key":"10.1016\/j.coph.2019.07.004_bib0020","doi-asserted-by":"crossref","first-page":"17155","DOI":"10.1073\/pnas.222658699","article-title":"Autoantibodies against \u03b1-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients","volume":"99","author":"Fetissov","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2019.07.004_bib0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight","volume":"443","author":"Morton","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.coph.2019.07.004_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/385165a0","article-title":"Role of melanocortinergic neurons in feeding and the agouti obesity syndrome","volume":"385","author":"Fan","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.coph.2019.07.004_bib0035","series-title":"Neuropsychiatric Disorders and Infection","first-page":"253","article-title":"Autoimmune component in anorexia and bulimia nervosa","author":"Fetissov","year":"2005"},{"key":"10.1016\/j.coph.2019.07.004_bib0040","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.nut.2008.06.021","article-title":"Emerging role of autoantibodies against appetite-regulating neuropeptides in eating disorders","volume":"24","author":"Fetissov","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.coph.2019.07.004_bib0045","first-page":"428","article-title":"The putative role of neuropeptide autoantibodies in anorexia nervosa","volume":"11","author":"Fetissov","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.coph.2019.07.004_bib0050","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.coph.2019.07.004_bib0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1176\/appi.ajp.2007.07060951","article-title":"Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V","volume":"165","author":"Eddy","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000450649","article-title":"The role of the melanocortin system in metabolic disease: new developments and advances","volume":"104","author":"Hill","year":"2017","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.coph.2019.07.004_bib0065","doi-asserted-by":"crossref","first-page":"T157","DOI":"10.1530\/JME-16-0014","article-title":"60 YEARS OF POMC: regulation of feeding and energy homeostasis by \u03b1-MSH","volume":"56","author":"Anderson","year":"2016","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.coph.2019.07.004_bib0070","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/ijo.2012.169","article-title":"Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review","volume":"37","author":"Valette","year":"2013","journal-title":"Int J Obes"},{"key":"10.1016\/j.coph.2019.07.004_bib0075","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1172\/JCI91578","article-title":"The long road to leptin","volume":"126","author":"Friedman","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coph.2019.07.004_sbref0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrendo.2016.150","article-title":"Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour","volume":"13","author":"Fetissov","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.coph.2019.07.004_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cmet.2015.10.017","article-title":"Gut commensal E. coli proteins activate host satiety pathways following nutrient-induced bacterial growth","volume":"23","author":"Breton","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.coph.2019.07.004_bib0090","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/0929867324666171005110620","article-title":"Bacterial protein mimetic of peptide hormone as a new class of protein-based drugs","volume":"26","author":"Fetissov","year":"2019","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.coph.2019.07.004_bib0095","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.cmet.2014.10.004","article-title":"The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo","volume":"20","author":"Panaro Brandon","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.coph.2019.07.004_bib0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.nupar.2019.01.258","article-title":"R\u00f4le de la prot\u00e9ine bact\u00e9rienne ClpB et d\u2019un de ses fragments peptidiques dans la r\u00e9gulation de la prise alimentaire","volume":"33","author":"Dominique","year":"2019","journal-title":"Nutr Clin M\u00e9tab"},{"key":"10.1016\/j.coph.2019.07.004_bib0105","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1016\/j.bmcl.2015.09.046","article-title":"A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist","volume":"25","author":"Ericson","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.coph.2019.07.004_bib0110","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.98","article-title":"Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide [alpha]-MSH, at the origin of eating disorders","volume":"4","author":"Tennoune","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nrendo.2016.175","article-title":"The endocrine manifestations of anorexia nervosa: mechanisms and management","volume":"13","author":"Schorr","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.coph.2019.07.004_bib0120","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/eat.22531","article-title":"Elevated plasma concentrations of bacterial ClpB protein in patients with eating disorders","volume":"49","author":"Breton","year":"2016","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.coph.2019.07.004_bib0125","doi-asserted-by":"crossref","unstructured":"Bruno B, Julien AR, Marion SB, Michel D, Jean-Denis T: An Update in the Management of Obesity: The Weight of CNS Targets. Recent Patents on CNS Drug Discovery (Discontinued) 2011, 6:164-180.","DOI":"10.2174\/157488911796958048"},{"key":"10.1016\/j.coph.2019.07.004_bib0130","first-page":"1","article-title":"Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept","volume":"296","author":"Oldstone","year":"2005","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.coph.2019.07.004_bib0135","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.nut.2007.12.006","article-title":"Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora","volume":"24","author":"Fetissov","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.coph.2019.07.004_bib0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41522-017-0039-9","article-title":"New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut","volume":"3","author":"Qiang","year":"2017","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.coph.2019.07.004_bib0145","doi-asserted-by":"crossref","first-page":"14865","DOI":"10.1073\/pnas.0507204102","article-title":"Autoantibodies against neuropeptides are associated with psychological traits in eating disorders","volume":"102","author":"Fetissov","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2019.07.004_sbref0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41398-019-0422-9","article-title":"Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders","volume":"9","author":"Lucas","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0155","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3685","article-title":"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans","volume":"4","author":"Takagi","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2019.07.004_bib0160","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(03)12378-1","article-title":"Eating disorders","volume":"361","author":"Fairburn","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.coph.2019.07.004_bib0165","article-title":"Stress hormones and eating disorders","author":"Chami","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.coph.2019.07.004_bib0170","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/archpsyc.55.7.603","article-title":"A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity","volume":"55","author":"Lilenfeld","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biopsych.2009.08.010","article-title":"Understanding the relation between anorexia nervosa and bulimia nervosa in a Swedish national twin sample","volume":"67","author":"Bulik","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0180","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1016\/S0261-5614(16)30629-X","article-title":"Effects of chronic food restriction and sex on the capacity of gut microbiota to produce CLPB protein: putative mechanisms underlying risk factors of eating disorders","volume":"35","author":"Breton","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.coph.2019.07.004_bib0185","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.nut.2014.11.003","article-title":"Sex-related effects of nutritional supplementation of Escherichia coli: relevance to eating disorders","volume":"31","author":"Tennoune","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.coph.2019.07.004_bib0190","first-page":"1219","article-title":"Recent advances in characterizing the gastrointestinal microbiome in Crohn\u2019s disease: a systematic review","volume":"21","author":"Wright","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.coph.2019.07.004_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104845","article-title":"The increased risk for autoimmune diseases in patients with eating disorders","volume":"9","author":"Raevuori","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.coph.2019.07.004_bib0200","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fmicb.2018.02013","article-title":"Effects of psychological, environmental and physical stressors on the gut microbiota","volume":"9","author":"Karl","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coph.2019.07.004_bib0205","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1093\/emboj\/18.24.6934","article-title":"Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB","volume":"18","author":"Mogk","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.coph.2019.07.004_bib0210","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.psyneuen.2008.08.021","article-title":"Regulation of feeding and anxiety by \u03b1-MSH reactive autoantibodies","volume":"34","author":"Hamze Sinno","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.coph.2019.07.004_bib0215","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.psyneuen.2011.05.008","article-title":"Intestinal inflammation influences \u03b1-MSH reactive autoantibodies: relevance to food intake and body weight","volume":"37","author":"Coquerel","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.coph.2019.07.004_sbref0220","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/jcpp.12958","article-title":"Bidirectional relationship between eating disorders and autoimmune diseases","volume":"60","author":"Hedman","year":"2019","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_sbref0225","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-2089","article-title":"Eating disorders, autoimmune, and autoinflammatory disease","volume":"140","author":"Zerwas","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.coph.2019.07.004_sbref0230","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1176\/appi.ajp.2017.16121402","article-title":"Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa","volume":"174","author":"Duncan","year":"2017","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_sbref0235","article-title":"A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.coph.2019.07.004_sbref0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nutres.2017.02.006","article-title":"Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients","volume":"39","author":"Elegido","year":"2017","journal-title":"Nutr Res"},{"key":"10.1016\/j.coph.2019.07.004_sbref0245","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.immuni.2019.02.014","article-title":"A weaning reaction to microbiota is required for resistance to immunopathologies in the adult","volume":"50","author":"Al Nabhani","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.coph.2019.07.004_bib0250","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.molmet.2016.03.004","article-title":"Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia","volume":"5","author":"Pomi\u00e9","year":"2016","journal-title":"Mol Metab"},{"key":"10.1016\/j.coph.2019.07.004_bib0255","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1503\/cmaj.121189","article-title":"Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months","volume":"185","author":"Azad","year":"2013","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.coph.2019.07.004_bib0260","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtbi.2017.05.028","article-title":"Fetal programming and eating disorder risk","volume":"428","author":"Jones","year":"2017","journal-title":"J Theor Biol"},{"key":"10.1016\/j.coph.2019.07.004_bib0265","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00787-016-0848-z","article-title":"Prenatal and early life stress and risk of eating disorders in adolescent girls and young women","volume":"25","author":"Su","year":"2016","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.coph.2019.07.004_bib0270","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/clin.1996.4310","article-title":"T lymphocyte subpopulations in anorexia nervosa and refeeding","volume":"82","author":"Mustafa","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.coph.2019.07.004_bib0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145274","article-title":"Gut dysbiosis in patients with anorexia nervosa","volume":"10","author":"Morita","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.coph.2019.07.004_bib0280","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/PSY.0000000000000247","article-title":"The intestinal microbiota in acute anorexia nervosa and during renourishment: relationship to depression, anxiety, and eating disorder psychopathology","volume":"77","author":"Kleiman","year":"2015","journal-title":"Psychosom Med"},{"key":"10.1016\/j.coph.2019.07.004_bib0285","doi-asserted-by":"crossref","DOI":"10.1038\/srep26752","article-title":"Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints","volume":"6","author":"Mack","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.coph.2019.07.004_bib0290","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/eat.22801","article-title":"Gut microbiota and body composition in anorexia nervosa inpatients in comparison to athletes, overweight, obese, and normal weight controls","volume":"50","author":"M\u00f6rkl","year":"2017","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.coph.2019.07.004_bib0295","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s40519-018-0499-9","article-title":"A systematic review of studies on the faecal microbiota in anorexia nervosa: future research may need to include microbiota from the small intestine","volume":"23","author":"Schwensen","year":"2018","journal-title":"Eat Weight Disord \u2013 Stud Anorex Bulimia Obes"},{"key":"10.1016\/j.coph.2019.07.004_bib0300","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.psc.2018.10.004","article-title":"The microbiome and eating disorders","volume":"42","author":"Seitz","year":"2019","journal-title":"Psychiatric Clin North Am"},{"key":"10.1016\/j.coph.2019.07.004_bib0305","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7020058","article-title":"Can gut microbiota and lifestyle help us in the handling of anorexia nervosa patients?","volume":"7","author":"Mendez-Figueroa","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.coph.2019.07.004_bib0310","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2174\/1570159X16666180118101354","article-title":"Is the impact of starvation on the gut microbiota specific or unspecific to anorexia nervosa? A narrative review based on a systematic literature search","volume":"16","author":"Mack","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.coph.2019.07.004_bib0315","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/ijo.2013.20","article-title":"Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli","volume":"37","author":"Million","year":"2013","journal-title":"Int J Obes"},{"key":"10.1016\/j.coph.2019.07.004_bib0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179739","article-title":"Microbiota in anorexia nervosa: the triangle between bacterial species, metabolites and psychological tests","volume":"12","author":"Borgo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.coph.2019.07.004_bib0325","article-title":"Altered host-gut microbes symbiosis in severely malnourished anorexia nervosa (AN) patients undergoing enteral nutrition: an explicative factor of functional intestinal disorders?","author":"Hanachi","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.coph.2019.07.004_bib0330","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn2682","article-title":"New insights into symptoms and neurocircuit function of anorexia nervosa","volume":"10","author":"Kaye","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.coph.2019.07.004_bib0335","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tips.2013.11.003","article-title":"Feelings about food: the ventral tegmental area in food reward and emotional eating","volume":"35","author":"Meye","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.coph.2019.07.004_bib0340","article-title":"Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin","author":"Berner","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.coph.2019.07.004_bib0345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.psyneuen.2015.02.020","article-title":"Dopamine release in the lateral hypothalamus is stimulated by \u03b1-MSH in both the anticipatory and consummatory phases of feeding","volume":"56","author":"Legrand","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.coph.2019.07.004_sbref0350","doi-asserted-by":"crossref","first-page":"E6576","DOI":"10.1073\/pnas.1720008115","article-title":"Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans","volume":"115","author":"V\u00e6r\u00f8y","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2019.07.004_sbref0355","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.it.2017.11.004","article-title":"Towards a general theory of immunity?","volume":"39","author":"Eberl","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.coph.2019.07.004_sbref0360","article-title":"Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomised, double-blind, placebo-controlled study","author":"Lew","year":"2018","journal-title":"Clin Nutr"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489219300128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489219300128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:50:07Z","timestamp":1761461407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489219300128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":72,"alternative-id":["S1471489219300128"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2019.07.004","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the origin of eating disorders: altered signaling between gut microbiota, adaptive immunity and the brain melanocortin system regulating feeding behavior","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2019.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}