{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:43Z","timestamp":1792798243620,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","award":["765441"],"award-info":[{"award-number":["765441"]}],"id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","award":["H2020- MSCA-765441"],"award-info":[{"award-number":["H2020- MSCA-765441"]}],"id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.coph.2021.07.002","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:50:45Z","timestamp":1628571045000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-4020","authenticated-orcid":false,"given":"Akanksha","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riet","family":"Hilhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Groten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-5742","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Paquet-Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2021.07.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04117-8","article-title":"Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration","volume":"9","author":"Lobanova","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2021.07.002_sref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/genes10060453","article-title":"The cGMP pathway and inherited photoreceptor degeneration: targets, compounds, and biomarkers","volume":"10","author":"Tolone","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.coph.2021.07.002_bib3","series-title":"EEL: retinitis Pigmentosa","author":"O'Neal","year":"2020"},{"key":"10.1016\/j.coph.2021.07.002_bib4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41436-020-0759-8","article-title":"Copy-number variation contributes 9 % of pathogenicity in the inherited retinal degenerations","volume":"22","author":"Zampaglione","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.coph.2021.07.002_sref5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial","volume":"390","author":"Russell","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.coph.2021.07.002_bib6","unstructured":"FDA approves novel gene therapy to treat patients with a rare form of inherited vision loss. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherited-vision-loss 2017."},{"key":"10.1016\/j.coph.2021.07.002_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s40259-020-00453-8","article-title":"Focused update on AAV-based gene therapy clinical trials for inherited retinal degeneration","volume":"34","author":"Fuller-Carter","year":"2020","journal-title":"BioDrugs"},{"key":"10.1016\/j.coph.2021.07.002_sref8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00439-016-1637-y","article-title":"Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial","volume":"135","author":"Ghazi","year":"2016","journal-title":"Hum Genet"},{"key":"10.1016\/j.coph.2021.07.002_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/14712598.2018.1389886","article-title":"Gene therapy for inherited retinal and optic nerve degenerations","volume":"18","author":"Moore","year":"2018","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.coph.2021.07.002_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258096","article-title":"The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.coph.2021.07.002_sref11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41587-020-0493-4","article-title":"First CRISPR therapy dosed","volume":"38","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.coph.2021.07.002_sref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0112142","article-title":"Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration","volume":"9","author":"Arango-Gonzalez","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.coph.2021.07.002_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2012.10.002","article-title":"The neuronal organization of the retina","volume":"76","author":"Masland","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.coph.2021.07.002_sref14","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1471-4159.2008.05822.x","article-title":"PKG activity causes photoreceptor cell death in two retinitis pigmentosa models","volume":"108","author":"Paquet-Durand","year":"2009","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.coph.2021.07.002_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1073\/pnas.10.7.329","article-title":"The inheritance of a retinal abnormality in white mice","volume":"10","author":"Keeler","year":"1924","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_bib16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/347677a0","article-title":"Retinal degeneration in the rd mouse is caused by a defect in the \u03b2 subunit of rod cGMP-phosphodiesterase","volume":"347","author":"Bowes","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.coph.2021.07.002_bib17","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4161\/cc.6.6.4029","article-title":"Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration","volume":"6","author":"Marigo","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.coph.2021.07.002_bib18","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1073\/pnas.91.3.974","article-title":"Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa","volume":"91","author":"Portera-Cailliau","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.07.005","article-title":"Cellular mechanisms of hereditary photoreceptor degeneration \u2013 focus on cGMP","volume":"74","author":"Power","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2021.07.002_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.512","article-title":"DNA methylation and differential gene regulation in photoreceptor cell death","volume":"5","author":"Farinelli","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.coph.2021.07.002_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079140","article-title":"Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death","volume":"8","author":"Wahlin","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.coph.2021.07.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddis.2010.4","article-title":"Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse","volume":"1","author":"Sancho-Pelluz","year":"2010","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.coph.2021.07.002_bib23","first-page":"1527","article-title":"Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice","volume":"20","author":"Mitton","year":"2014","journal-title":"Mol Vis"},{"key":"10.1016\/j.coph.2021.07.002_bib24","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1523\/JNEUROSCI.0774-17.2017","article-title":"Valproic acid for a treatment of retinitis pigmentosa: reasons for optimism and caution","volume":"37","author":"Todd","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.coph.2021.07.002_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/genes11101120","article-title":"Mechanisms of photoreceptor death in retinitis pigmentosa","volume":"11","author":"Newton","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.coph.2021.07.002_bib26","article-title":"FDA approves an inhibitor of a novel \u201cepigenetic writer","volume":"19","author":"Mullard","year":"2020","journal-title":"Nat Rev"},{"key":"10.1016\/j.coph.2021.07.002_bib27","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/annonc\/mdy174","article-title":"Latest clinical evidence and further development of PARP inhibitors in ovarian cancer","volume":"29","author":"Mirza","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.coph.2021.07.002_bib28","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2741\/1612","article-title":"cGMP signaling in vertebrate retinal photoreceptor cells","volume":"10","author":"Zhang","year":"2005","journal-title":"Front Biosci"},{"key":"10.1016\/j.coph.2021.07.002_bib29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng0693-130","article-title":"Recessive mutations in the gene encoding the B-subunit of rod phosphodiesterase in patients with retinitis pigmentosa","volume":"4","author":"Mclaughlin","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.coph.2021.07.002_bib30","first-page":"1912","article-title":"Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse","volume":"43","author":"Pawlyk","year":"2002","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/978-1-4419-1399-9_56","article-title":"Do calcium channel blockers rescue dying photoreceptors in the pde6b rd1 mouse?","volume":"664","author":"Barabas","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.coph.2021.07.002_bib32","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/hmg\/ddx121","article-title":"Two pathways of rod photoreceptor cell death induced by elevated cGMP","volume":"26","author":"Wang","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.coph.2021.07.002_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/EB.S9078","article-title":"Energy metabolism of the visual system","volume":"2","author":"Wong-Riley","year":"2010","journal-title":"Eye Brain"},{"key":"10.1016\/j.coph.2021.07.002_bib34","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.cub.2008.10.029","article-title":"ATP consumption by mammalian rod photoreceptors in darkness and in light","volume":"18","author":"Okawa","year":"2008","journal-title":"Curr Biol"},{"key":"10.1016\/j.coph.2021.07.002_bib35","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"L\u00e9veillard","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib36","first-page":"148","article-title":"The metabolism of carcinoma cells 1","volume":"9","author":"Warburg","year":"1925","journal-title":"J\u00a0Cancer Res"},{"key":"10.1016\/j.coph.2021.07.002_bib37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The science and translation of lactate shuttle theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.coph.2021.07.002_bib38","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1073\/pnas.91.22.10625","article-title":"Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization","volume":"91","author":"Pellerin","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_bib39","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/jnr.24015","article-title":"Lack of appropriate stoichiometry: strong evidence against an energetically important astrocyte\u2013neuron lactate shuttle in brain","volume":"95","author":"Dienel","year":"2017","journal-title":"J\u00a0Neurosci Res"},{"key":"10.1016\/j.coph.2021.07.002_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28899","article-title":"Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye","volume":"6","author":"Kanow","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.coph.2021.07.002_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01008","article-title":"Autophagy dysfunction and oxidative stress, two related mechanisms implicated in retinitis pigmentosa","volume":"9","author":"Moreno","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.coph.2021.07.002_bib42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","article-title":"Consequences of oxidative stress in age-related macular degeneration","volume":"33","author":"Jarrett","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.coph.2021.07.002_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/ars.2009.2788","article-title":"Potential therapeutic benefits of strategies directed to mitochondria","volume":"13","author":"Camara","year":"2010","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.coph.2021.07.002_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100935","article-title":"Dominant optic atrophy: culprit mitochondria in the optic nerve","author":"Lenaers","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2021.07.002_sref45","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2015.03.023","article-title":"Rod-derived cone viability factor promotes cone survival\u00a0by\u00a0stimulating aerobic glycolysis","volume":"161","author":"A\u00eft-Ali","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.coph.2021.07.002_bib46","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3389\/fnins.2019.01234","article-title":"Investigations into bioenergetic neuroprotection of cone photoreceptors: relevance to retinitis pigmentosa","volume":"13","author":"Narayan","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.coph.2021.07.002_bib47","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1167\/iovs.03-1184","article-title":"Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse","volume":"45","author":"Hackam","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib48","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.mcn.2006.01.001","article-title":"Up-regulation and increased phosphorylation of protein kinase C (PKC) \u03b4, \u03bc and \u03b8 in the degenerating rd1 mouse retina","volume":"31","author":"Azadi","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.coph.2021.07.002_bib49","doi-asserted-by":"crossref","first-page":"32068","DOI":"10.18632\/oncotarget.16643","article-title":"Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.coph.2021.07.002_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-41141-0","article-title":"Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing","volume":"9","author":"Ronning","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.coph.2021.07.002_bib51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/cells9020438","article-title":"Single-cell RNA sequencing in human retinal degeneration reveals distinct glial cell populations","volume":"9","author":"Voigt","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.coph.2021.07.002_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005535","article-title":"Post-transcriptional regulation across human tissues","volume":"13","author":"Franks","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.coph.2021.07.002_bib53","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1471-4159.2005.03628.x","article-title":"Calpain is activated in degenerating photoreceptors in the rd1 mouse","volume":"96","author":"Paquet-Durand","year":"2006","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.coph.2021.07.002_bib54","doi-asserted-by":"crossref","first-page":"10311","DOI":"10.1523\/JNEUROSCI.1514-07.2007","article-title":"Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse","volume":"27","author":"Paquet-Durand","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.coph.2021.07.002_bib55","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrc2901","article-title":"Activity-based protein profiling for biochemical pathway discovery in cancer","volume":"10","author":"Nomura","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.coph.2021.07.002_bib56","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exer.2019.03.007","article-title":"Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa","volume":"184","author":"Weiss","year":"2019","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.coph.2021.07.002_bib57","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cels.2016.08.009","article-title":"Highly multiplexed quantitative mass spectrometry analysis of ubiquitylomes","volume":"3","author":"Rose","year":"2016","journal-title":"Cell Syst"},{"key":"10.1016\/j.coph.2021.07.002_bib58","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/ijms22052345","article-title":"Metabolic analysis of vitreous\/lens and retina in wild type and retinal degeneration mice","volume":"22","author":"Murenu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2021.07.002_sref59","article-title":"The cGMP system in normal and degenerating mouse neuroretina: new proteins with cGMP interaction potential identified by a proteomics approach","author":"Rasmussen","year":"2020","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.coph.2021.07.002_bib60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41570-020-0162-7","article-title":"Single-cell analysis targeting the proteome","volume":"4","author":"Labib","year":"2020","journal-title":"Nat Rev Chem"},{"key":"10.1016\/j.coph.2021.07.002_sref61","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.2174\/0929867321666140601201337","article-title":"Novel in situ activity assays for the quantitative molecular analysis of neurodegenerative processes in the retina","volume":"21","author":"Ekstrom","year":"2014","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.coph.2021.07.002_sref62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22031180","article-title":"Identification of novel substrates for cGMP dependent protein kinase (PKG) through kinase activity profiling to understand its putative role in inherited retinal degeneration","volume":"22","author":"Roy","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/jappl.1953.6.3.189","article-title":"Continuous recording of blood oxygen tensions by polarography","volume":"6","author":"Clark","year":"1953","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.coph.2021.07.002_bib64","series-title":"Methods in molecular biology","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4939-3335-8_17","article-title":"Analysis of TLR-induced metabolic changes in dendritic cells using the seahorse XFe96 extracellular flux analyzer","author":"Pelgrom","year":"2016"},{"key":"10.1016\/j.coph.2021.07.002_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2019.04.001","article-title":"Retinal oximetry: metabolic imaging for diseases of the retina and brain","volume":"70","author":"Stef\u00e1nsson","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.coph.2021.07.002_bib66","series-title":"Methods in molecular biology","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4939-7720-8_11","article-title":"Determination of mitochondrial oxygen consumption in the retina ex\u00a0vivo: applications for retinal disease","author":"Adlakha","year":"2018"},{"key":"10.1016\/j.coph.2021.07.002_bib67","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/14756366.2016.1265522","article-title":"Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa","volume":"32","author":"Marchena","year":"2017","journal-title":"J\u00a0Enzyme Inhib Med Chem"},{"key":"10.1016\/j.coph.2021.07.002_bib68","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1167\/iovs.09-3903","article-title":"Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells","volume":"51","author":"Biermann","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib69","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/mds.25824","article-title":"A\u00a0phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy","volume":"29","author":"Tolosa","year":"2014","journal-title":"Mov Disord"},{"key":"10.1016\/j.coph.2021.07.002_sref70","doi-asserted-by":"crossref","first-page":"E2997","DOI":"10.1073\/pnas.1718792115","article-title":"Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration","volume":"115","author":"Vighi","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_bib71","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tips.2010.03.001","article-title":"Retinoids for treatment of retinal diseases","volume":"31","author":"Palczewski","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143846","article-title":"Safety and proof-of-concept study of oral QLT091001 in retinitis pigmentosa due to inherited deficiencies of retinal pigment epithelial 65 protein (RPE65) or lecithin: retinol acyltransferase (LRAT)","volume":"10","author":"Scholl","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.coph.2021.07.002_bib73","first-page":"1","article-title":"ATAC-Seq analysis\u00a0reveals a widespread decrease of chromatin accessibility in age-related macular degeneration","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2021.07.002_bib74","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-019-0608-2","article-title":"Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes","volume":"11","author":"Porter","year":"2019","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.coph.2021.07.002_bib75","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1172\/JCI86905","article-title":"Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration","volume":"126","author":"Zhang","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.coph.2021.07.002_bib76","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.coph.2021.07.002_sref77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102636","article-title":"Metabolite therapy guided by liquid biopsy proteomics\u00a0delays retinal neurodegeneration","volume":"52","author":"Wert","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.coph.2021.07.002_bib78","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1167\/iovs.15-16792","article-title":"Neuroprotective effects of voluntary exercise in an inherited retinal degeneration mouse model","volume":"56","author":"Hanif","year":"2015","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib79","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.ymthe.2017.05.015","article-title":"Using CRISPR-cas9 to generate gene-corrected autologous iPSCs for the treatment of inherited retinal degeneration","volume":"25","author":"Burnight","year":"2017","journal-title":"Mol Ther"},{"key":"10.1016\/j.coph.2021.07.002_bib80","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/humc.2013.037","article-title":"Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa","volume":"24","author":"Conlon","year":"2013","journal-title":"Hum Gene Ther Clin Dev"},{"key":"10.1016\/j.coph.2021.07.002_bib81","unstructured":"Fowzan Alkuraya (Principle investigator), Trial of Subretinal Injection of (rAAV2-VMD2-hMERTK); King Khaled Eye Specialist Hospital; ClinicalTrials.gov Identifier: NCT01482195."},{"key":"10.1016\/j.coph.2021.07.002_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0408-3","article-title":"Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration","volume":"12","author":"Kohno","year":"2015","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.coph.2021.07.002_bib83","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1167\/iovs.05-0371","article-title":"Gene replacement therapy rescues photoreceptor degeneration in a murine model of leber congenital amaurosis lacking RPGRIP","volume":"46","author":"Pawlyk","year":"2005","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.coph.2021.07.002_bib84","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ymthe.2020.11.029","article-title":"Clinical perspective: treating RPE65-associated retinal dystrophy","volume":"29","author":"Maguire","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.coph.2021.07.002_bib85","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1073\/pnas.96.7.3718","article-title":"Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase","volume":"96","author":"Chen","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_bib86","doi-asserted-by":"crossref","first-page":"14598","DOI":"10.1073\/pnas.1206937109","article-title":"Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coph.2021.07.002_sref87","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s00018-019-03283-2","article-title":"Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration","volume":"77","author":"Sahaboglu","year":"2020","journal-title":"Cell Mol Life Sci"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489221000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489221000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:56:15Z","timestamp":1761461775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489221000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":87,"alternative-id":["S1471489221000886"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2021.07.002","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2021.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}