{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:05:11Z","timestamp":1793840711542,"version":"4.6.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.coph.2021.08.001","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:34:09Z","timestamp":1630524849000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study"],"prefix":"10.1016","volume":"60","author":[{"given":"Satyajit","family":"Tripathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barsha","family":"Dassarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manojit","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motlalepula Gilbert","family":"Matsabisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2021.08.001_bib1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ni1519","article-title":"Immunopathology of highly virulent pathogens: insights from Ebola virus","volume":"8","author":"Zampieri","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coph.2021.08.001_sref2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41579-019-0233-2","article-title":"Therapeutic strategies to target the Ebola virus life cycle","volume":"17","author":"Hoenen","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.coph.2021.08.001_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(77)92001-3","article-title":"Viral haemorrhagic fever in southern Sudan and northern Zaire. Preliminary studies on the aetiological agent","author":"Bowen","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.coph.2021.08.001_bib4","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1093\/infdis\/jir296","article-title":"Reston ebolavirus in humans and animals in the Philippines: a review","volume":"204","author":"Miranda","year":"2011","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.coph.2021.08.001_bib5","doi-asserted-by":"crossref","first-page":"g7348","DOI":"10.1136\/bmj.g7348","article-title":"Ebola virus disease","volume":"349","author":"Beeching","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.coph.2021.08.001_bib6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.virusres.2015.09.002","article-title":"Viral bioterrorism: learning the lesson of Ebola virus in West Africa 2013\u20132015","volume":"210","author":"Cenciarelli","year":"2015","journal-title":"Virus Res"},{"key":"10.1016\/j.coph.2021.08.001_bib7","first-page":"97","article-title":"Pathologic features of filovirus infections in humans","volume":"235","author":"Zaki","year":"1999","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.coph.2021.08.001_bib8","first-page":"141","article-title":"Ebola virus disease: an overview on viral structure, mechanism of pathogenesis and prevention","volume":"76","author":"Samanta","year":"2017","journal-title":"Romanian Archives"},{"key":"10.1016\/j.coph.2021.08.001_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1086\/514308","article-title":"Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients","volume":"179","author":"Bwaka","year":"1999","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.coph.2021.08.001_bib10","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1086\/514321","article-title":"Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995","volume":"179","author":"Ksiazek","year":"1999","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.coph.2021.08.001_bib11","series-title":"Fields virology","first-page":"1409","article-title":"Filoviridae: Marburg and Ebola viruses","author":"Sanchez","year":"2007"},{"key":"10.1016\/j.coph.2021.08.001_bib12","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0002-9440(10)63591-2","article-title":"Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coph.2021.08.001_bib13","series-title":"Ebolaviruses","first-page":"15","article-title":"Forty years of Ebolavirus molecular biology: understanding a novel disease agent through the development and application of new technologies","author":"Groseth","year":"2017"},{"key":"10.1016\/j.coph.2021.08.001_bib14","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JVI.78.14.7344-7351.2004","article-title":"Contribution of Ebola virus glycoprotein, nucleoprotein, and VP24 to budding of VP40 virus-like particles","volume":"78","author":"Licata","year":"2004","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.coph.2021.08.001_sref15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bsheal.2019.12.009","article-title":"Single virus tracking of Ebola virus entry through lipid rafts in living host cells","volume":"2","author":"Jin","year":"2020","journal-title":"Biosaf Health"},{"key":"10.1016\/j.coph.2021.08.001_bib16","doi-asserted-by":"crossref","first-page":"S957","DOI":"10.1093\/infdis\/jir326","article-title":"Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis","volume":"204","author":"Aleksandrowicz","year":"2011","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.coph.2021.08.001_bib17","doi-asserted-by":"crossref","first-page":"13871","DOI":"10.1073\/pnas.250277297","article-title":"A\u00a0PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding","volume":"97","author":"Harty","year":"2000","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.coph.2021.08.001_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature07082","article-title":"Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor","volume":"454","author":"Lee","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.coph.2021.08.001_bib19","article-title":"Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea","volume":"13","author":"Sissoko","year":"2016","journal-title":"PLoS Med"},{"key":"10.1016\/j.coph.2021.08.001_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.coph.2021.08.001_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nri1329","article-title":"Immunotherapeutic uses of CpG oligodeoxynucleotides","volume":"4","author":"Klinman","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.coph.2021.08.001_bib22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nm.2202","article-title":"Advanced antisense therapies for postexposure protection against lethal filovirus infections","volume":"16","author":"Warren","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.coph.2021.08.001_sref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.coph.2021.08.001_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/35046108","article-title":"Development of a preventive vaccine for Ebola virus infection in primates","volume":"408","author":"Sullivan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.coph.2021.08.001_bib25","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/JVI.03361-12","article-title":"Venezuelan equine encephalitis virus replicon particle vaccine protects non-human primates from intramuscular and aerosol challenge with Ebolavirus","volume":"87","author":"Herbert","year":"2013","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.coph.2021.08.001_bib26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fimmu.2017.00252","article-title":"A\u00a0perspective on the development of plant-made vaccines in the fight against Ebola virus","volume":"8","author":"Rosales-Mendoza","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.coph.2021.08.001_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/glycob\/9.4.365","article-title":"N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants","volume":"9","author":"Cabanes-Macheteau","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.coph.2021.08.001_bib28","doi-asserted-by":"crossref","first-page":"28549","DOI":"10.3390\/ijms161226122","article-title":"Plants as factories for human pharmaceuticals: applications and challenges","volume":"16","author":"Yao","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2021.08.001_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-014-0205-0","article-title":"Plant-based vaccines against viruses","volume":"11","author":"Rybicki","year":"2014","journal-title":"Virol J"},{"key":"10.1016\/j.coph.2021.08.001_sref30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coviro.2017.07.019","article-title":"Using transgenic plants and modified plant viruses for the development of treatments for human diseases","volume":"26","author":"Loh","year":"2017","journal-title":"Current opinion in virology"},{"key":"10.1016\/j.coph.2021.08.001_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4928637","article-title":"Plant-based vaccines: production and challenges","author":"Laere","year":"2016","journal-title":"Journal of Botany"},{"key":"10.1016\/j.coph.2021.08.001_bib32","first-page":"485689","article-title":"Freeze-drying of plant tissue containing HBV surface antigen for the oral vaccine against hepatitis B","author":"Czyz","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.coph.2021.08.001_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jbiotec.2015.03.019","article-title":"Study of the immunogenicity of hepatitis B surface antigen synthesized in transgenic potato plants with increased biosafety","volume":"203","author":"Rukavtsova","year":"2015","journal-title":"J\u00a0Biotechnol"},{"key":"10.1016\/j.coph.2021.08.001_bib34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00425-013-1932-y","article-title":"Immunogenic properties of a lettuce-derived C4 (V3)6 multiepitopic HIV protein","volume":"238","author":"Govea-Alonso","year":"2013","journal-title":"Planta"},{"key":"10.1016\/j.coph.2021.08.001_bib35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s12033-015-9856-3","article-title":"A\u00a0plant-derived multi-HIV antigen induces broad immune responses in orally immunized mice","volume":"57","author":"Rubio-Infante","year":"2015","journal-title":"Mol Biotechnol"},{"key":"10.1016\/j.coph.2021.08.001_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151842","article-title":"Immunological characterization of plant-based HIV-1 Gag\/Dgp41 virus-like particles","volume":"11","author":"Kessans","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.coph.2021.08.001_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00705-013-1819-z","article-title":"Immunization with an HPV-16 L1- based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model","volume":"159","author":"Monroy-Garcia","year":"2014","journal-title":"Arch Virol"},{"key":"10.1016\/j.coph.2021.08.001_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4161\/hv.22292","article-title":"Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune responses in mice","volume":"9","author":"Liu","year":"2013","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.coph.2021.08.001_bib39","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4161\/hv.23234","article-title":"A\u00a0plant produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge","volume":"9","author":"Shoji","year":"2013","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.coph.2021.08.001_bib40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/21645515.2017.1264783","article-title":"Purification and immunogenicity of hemagglutinin from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana","volume":"13","author":"Pua","year":"2017","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.coph.2021.08.001_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4161\/hv.34365","article-title":"Immunogenicity of H1N1 influenza virus-like particles produced in Nicotiana benthamiana","volume":"11","author":"Shoji","year":"2015","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.coph.2021.08.001_bib42","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00299-015-1758-0","article-title":"Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice","volume":"34","author":"Nahampun","year":"2015","journal-title":"Plant Cell Rep"},{"key":"10.1016\/j.coph.2021.08.001_bib43","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1371\/journal.ppat.0030002","article-title":"Effective post-exposure treatment of Ebola infection","volume":"3","author":"Feldmann","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coph.2021.08.001_bib44","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/JVI.00456-08","article-title":"Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates","volume":"82","author":"Geisbert","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.coph.2021.08.001_bib45","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1021\/acssynbio.7b00234","article-title":"Production of functional anti-Ebola antibodies in Pichia pastoris","volume":"6","author":"Purcell","year":"2017","journal-title":"ACS Synth Biol"},{"key":"10.1016\/j.coph.2021.08.001_bib46","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1467-7652.2011.00593.x","article-title":"Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana","volume":"9","author":"Phoolcharoen","year":"2011","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.coph.2021.08.001_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/bit.22652","article-title":"High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system","volume":"106","author":"Huang","year":"2010","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.coph.2021.08.001_bib48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00299-016-2088-6","article-title":"Expression of an immunogenic LTB-based chimeric protein targeting Zaire ebolavirus epitopes from GP1 in plant cells","volume":"36","author":"R\u00edos-Huerta","year":"2017","journal-title":"Plant Cell Rep"},{"key":"10.1016\/j.coph.2021.08.001_sref49","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3389\/fimmu.2018.01803","article-title":"Advances in designing and developing vaccines, drugs, and therapies to counter Ebola virus","volume":"9","author":"Dhama","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.coph.2021.08.001_sref50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/0929867324666170718114724","article-title":"Transient production of recombinant pharmaceutical proteins in plants: evolution and perspectives","volume":"26","author":"Kopertekh","year":"2019","journal-title":"Curr Med Chem"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489221001120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489221001120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:54:07Z","timestamp":1761461647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489221001120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":50,"alternative-id":["S1471489221001120"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2021.08.001","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2021.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}