{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:22:10Z","timestamp":1792290130132,"version":"4.4.0"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["144625\\u20131"],"award-info":[{"award-number":["144625\\u20131"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902183"],"award-info":[{"award-number":["31902183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272892"],"award-info":[{"award-number":["32272892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.coph.2022.102314","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T19:27:28Z","timestamp":1667417248000},"page":"102314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-1607","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2022.102314_bib1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jada.2009.08.007","article-title":"Using the energy gap to address obesity: a commentary","volume":"109","author":"Hill","year":"2009","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.coph.2022.102314_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.orcp.2015.08.007","article-title":"Secular differences in the association between caloric intake, macronutrient intake, and physical activity with obesity","volume":"10","author":"Brown","year":"2016","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.coph.2022.102314_bib3","first-page":"1626","article-title":"Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics","volume":"278","author":"Klimentidis","year":"2011","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.coph.2022.102314_bib4","first-page":"161","article-title":"Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals","author":"Egusquiza","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.coph.2022.102314_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.scitotenv.2018.06.084","article-title":"Chronic exposure to fungicide propamocarb induces bile acid metabolic disorder and increases trimethylamine in C57BL\/6J mice","volume":"642","author":"Wu","year":"2018","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.coph.2022.102314_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.fct.2017.11.001","article-title":"Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats","volume":"111","author":"Fang","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib7","first-page":"257","article-title":"Environmental contaminants and pancreatic beta-cells","volume":"8","author":"Fabricio","year":"2016","journal-title":"J\u00a0Clin Res Pediatr Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0013-9351(83)90225-6","article-title":"Malathion induced hematological and biochemical changes in the Indian catfish Heteropneustes fossilis","volume":"30","author":"Mishra","year":"1983","journal-title":"Environ Res"},{"key":"10.1016\/j.coph.2022.102314_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.fct.2017.07.053","article-title":"Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL\/6J mice","volume":"108","author":"Xiao","year":"2017","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib10","doi-asserted-by":"crossref","first-page":"112216","DOI":"10.1016\/j.fct.2021.112216","article-title":"Bisphenol F and bisphenol S promote lipid accumulation and adipogenesis in human adipose-derived stem cells","volume":"152","author":"Reina-P\u00e9rez","year":"2021","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.taap.2006.08.011","article-title":"In\u00a0vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in\u00a0vivo induction pathway","volume":"217","author":"Takeuchi","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.coph.2022.102314_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.toxlet.2015.07.009","article-title":"Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation","volume":"238","author":"Mangum","year":"2015","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.coph.2022.102314_bib13","first-page":"1","article-title":"Interaction between \u03b2-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.coph.2022.102314_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chemosphere.2014.03.042","article-title":"Bisphenol A is related to circulating levels of adiponectin, leptin and ghrelin, but not to fat mass or fat distribution in humans","volume":"112","author":"R\u00f6nn","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.coph.2022.102314_bib15","first-page":"1","article-title":"ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity","author":"Brownstein","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.coph.2022.102314_bib16","doi-asserted-by":"crossref","first-page":"e49555","DOI":"10.7554\/eLife.49555","article-title":"Decreasing human body temperature in the United States since the industrial revolution","volume":"9","author":"Protsiv","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.coph.2022.102314_bib17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/j.2040-4603.2017.tb00778.x","article-title":"Adipose tissue as a site of toxin accumulation","volume":"7","author":"Jackson","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1139\/z92-025","article-title":"Evolution of brown fat: its absence in marsupials and monotremes","volume":"70","author":"Hayward","year":"1992","journal-title":"Can J Zool"},{"key":"10.1016\/j.coph.2022.102314_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.coph.2022.102314_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cmet.2015.04.008","article-title":"Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis","volume":"21","author":"McGlashon","year":"2015","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nm.2297","article-title":"Brown adipose tissue activity controls triglyceride clearance","volume":"17","author":"Bartelt","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.coph.2022.102314_bib22","doi-asserted-by":"crossref","first-page":"16616","DOI":"10.1074\/jbc.M117.790451","article-title":"Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice","volume":"292","author":"Bal","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.coph.2022.102314_bib23","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1113\/JP273395","article-title":"Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to brown adipose tissue","volume":"595","author":"Blondin","year":"2017","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cmet.2016.12.005","article-title":"Inhibition of intracellular triglyceride lipolysis suppresses cold-induced Brown adipose tissue metabolism and increases shivering in humans","volume":"25","author":"Blondin","year":"2017","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cmet.2010.03.008","article-title":"Human brown adipose tissue","volume":"11","author":"Enerback","year":"2010","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib26","doi-asserted-by":"crossref","first-page":"R479","DOI":"10.1152\/ajpregu.00443.2017","article-title":"Is activation of human brown adipose tissue a viable target for weight management?","volume":"315","author":"Marlatt","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib27","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.biocel.2004.04.003","article-title":"The brown adipocyte: update on its metabolic role","volume":"36","author":"Sell","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.coph.2022.102314_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","article-title":"UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality","volume":"9","author":"Feldmann","year":"2009","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib29","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/j.2040-4603.2014.tb00592.x","article-title":"Central nervous system regulation of brown adipose tissue","volume":"4","author":"Morrison","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib30","doi-asserted-by":"crossref","first-page":"27077","DOI":"10.1074\/jbc.M101049200","article-title":"beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase","volume":"276","author":"Cao","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.coph.2022.102314_bib31","first-page":"31","article-title":"Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective","author":"Shi","year":"2017","journal-title":"Horm Mol Biol Clin Invest"},{"key":"10.1016\/j.coph.2022.102314_bib32","doi-asserted-by":"crossref","first-page":"884S","DOI":"10.3945\/ajcn.110.001917","article-title":"Regulation of PGC-1\u03b1, a nodal regulator of mitochondrial biogenesis","volume":"93","author":"Fernandez-Marcos","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.coph.2022.102314_bib33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A\u00a0cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.coph.2022.102314_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2014.03.007","article-title":"Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice","volume":"19","author":"Harms","year":"2014","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib35","series-title":"Brown adipose tissue","first-page":"161","article-title":"Role of cAMP and cGMP signaling in brown fat","author":"Reverte-Salisa","year":"2018"},{"key":"10.1016\/j.coph.2022.102314_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.coph.2022.102314_bib37","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cmet.2016.08.010","article-title":"AMPK\/\u03b1-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis","volume":"24","author":"Yang","year":"2016","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/oby.20605","article-title":"Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue","volume":"22","author":"Wan","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.coph.2022.102314_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2016.06.006","article-title":"Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through brown and beige adipose tissue function","volume":"24","author":"Mottillo","year":"2016","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fendo.2020.00222","article-title":"Brown adipose tissue, diet-induced thermogenesis, and thermogenic food ingredients: from mice to men","volume":"11","author":"Saito","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-7075-1-5","article-title":"Diet induced thermogenesis","volume":"1","author":"Westerterp","year":"2004","journal-title":"Nutr Metab"},{"key":"10.1016\/j.coph.2022.102314_bib42","doi-asserted-by":"crossref","first-page":"R185","DOI":"10.1530\/JOE-18-0240","article-title":"Diet-induced thermogenesis: fake friend or foe?","volume":"238","author":"Ho","year":"2018","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib43","doi-asserted-by":"crossref","first-page":"E374","DOI":"10.1152\/ajpendo.1989.257.3.E374","article-title":"Metabolic and sympathetic nerve activities of brown adipose tissue in tube-fed rats","volume":"257","author":"Saito","year":"1989","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102314_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2018.05.020","article-title":"Postprandial oxidative metabolism of human brown fat indicates thermogenesis","volume":"28","author":"Din","year":"2018","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib45","doi-asserted-by":"crossref","first-page":"E515","DOI":"10.1152\/ajpendo.00097.2017","article-title":"Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice","volume":"313","author":"von Essen","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102314_bib46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.orcp.2007.02.001","article-title":"The\u2212 3826 A\u2192 G variant of the uncoupling protein-1 gene diminishes thermogenesis during acute cold exposure in healthy children","volume":"1","author":"Nagai","year":"2007","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.coph.2022.102314_bib47","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.coph.2022.102314_bib48","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.1152\/ajpendo.00237.2020","article-title":"Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men","volume":"320","author":"Loeliger","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102314_bib49","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2967\/jnumed.111.100701","article-title":"Fasting and postprandial activity of brown adipose tissue in healthy men","volume":"53","author":"Vrieze","year":"2012","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.coph.2022.102314_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2018.05.020","article-title":"Postprandial oxidative metabolism of human Brown fat indicates thermogenesis","volume":"28","author":"M","year":"2018","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib51","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1073160","article-title":"betaAR signaling required for diet-induced thermogenesis and obesity resistance","volume":"297","author":"Bachman","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.coph.2022.102314_bib52","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1530\/JOE-12-0155","article-title":"\u03b21 Adrenergic receptor is key to cold-and diet-induced thermogenesis in mice","volume":"214","author":"Ueta","year":"2012","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/db15-0889","article-title":"Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways","volume":"65","author":"Folgueira","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2022.102314_bib54","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00424-020-02347-8","article-title":"Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent","volume":"472","author":"Habek","year":"2020","journal-title":"Pflueg Arch Eur J Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib55","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1530\/JME-17-0263","article-title":"Uroguanylin: a new actor in the energy balance movie","volume":"60","author":"Folgueira","year":"2018","journal-title":"J\u00a0Mol Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib56","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nm.3766","article-title":"Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis","volume":"21","author":"Crane","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.coph.2022.102314_bib57","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41467-019-14080-7","article-title":"Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance","volume":"11","author":"Yabut","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2022.102314_bib58","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1038\/ncomms7794","article-title":"Regulation of systemic energy homeostasis by serotonin in adipose tissues","volume":"6","author":"Oh","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2022.102314_bib59","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1038\/s41467-021-25384-y","article-title":"The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.coph.2022.102314_bib60","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.celrep.2014.10.066","article-title":"ThermoMouse: an in\u00a0vivo model to identify modulators of UCP1 expression in brown adipose tissue","volume":"9","author":"Galmozzi","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.coph.2022.102314_bib61","first-page":"13","article-title":"Properties and uses of chlorpyrifos in the United States","volume":"231","author":"Solomon","year":"2014","journal-title":"Rev Environ Contam Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fendo.2019.00039","article-title":"Endocrine-mediated mechanisms of metabolic disruption and new approaches to examine the public health threat","volume":"10","author":"Kassotis","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.coph.2022.102314_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF03160916","article-title":"Weight gain associated with chronic exposure to chlorpyrifos in rats","volume":"3","author":"Meggs","year":"2007","journal-title":"J\u00a0Med Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib64","doi-asserted-by":"crossref","first-page":"E487","DOI":"10.1152\/ajpendo.00443.2018","article-title":"Intact innervation is essential for diet-induced recruitment of brown adipose tissue","volume":"316","author":"Fischer","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102314_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2337\/dbi17-0039","article-title":"Cellular energy sensing and metabolism-implications for treating diabetes: the 2017 outstanding scientific achievement award lecture","volume":"67","author":"Steinberg","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2022.102314_bib66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11892-018-1049-6","article-title":"Emerging role of AMPK in Brown and beige adipose tissue (BAT): implications for obesity, insulin resistance, and type 2 diabetes","volume":"18","author":"Desjardins","year":"2018","journal-title":"Curr Diabetes Rep"},{"key":"10.1016\/j.coph.2022.102314_bib67","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diabetes.54.4.1000","article-title":"Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion","volume":"54","author":"Fan","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2022.102314_bib68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2014.03.031","article-title":"Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK","volume":"20","author":"Martinez de Morentin","year":"2014","journal-title":"Cell Metabol"},{"key":"10.1016\/j.coph.2022.102314_bib69","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ijo.2015.63","article-title":"Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure","volume":"39","author":"Xu","year":"2015","journal-title":"Int J Obes"},{"key":"10.1016\/j.coph.2022.102314_bib70","doi-asserted-by":"crossref","first-page":"e38734","DOI":"10.1371\/journal.pone.0038734","article-title":"Activation of pregnane X receptor by pregnenolone 16 alpha-carbonitrile prevents high-fat diet-induced obesity in AKR\/J mice","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.coph.2022.102314_bib71","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF00570132","article-title":"Tissue-specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats","volume":"62","author":"Gorski","year":"1988","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib72","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3390\/ijerph8062265","article-title":"Effect of endocrine disruptor pesticides: a review","volume":"8","author":"Mnif","year":"2011","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.coph.2022.102314_bib73","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1210\/jc.2003-031517","article-title":"Acetylcholine regulates ghrelin secretion in humans","volume":"89","author":"Broglio","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102314_bib74","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1538\/expanim.16-0092","article-title":"The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance","volume":"66","author":"Kawajiri","year":"2017","journal-title":"Exp Anim"},{"key":"10.1016\/j.coph.2022.102314_bib75","first-page":"22","article-title":"The aryl hydrocarbon receptor in energy balance: the road from dioxin-induced wasting syndrome to combating obesity with ahr ligands","author":"Girer","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2022.102314_bib76","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3389\/fphys.2018.01891","article-title":"Environmental pollutants effect on Brown adipose tissue","volume":"9","author":"Di Gregorio","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib77","doi-asserted-by":"crossref","first-page":"e103337","DOI":"10.1371\/journal.pone.0103337","article-title":"Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring","volume":"9","author":"La Merrill","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.coph.2022.102314_bib78","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12940-021-00721-2","article-title":"Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice","volume":"20","author":"vonderEmbse","year":"2021","journal-title":"Environ Health"},{"key":"10.1016\/j.coph.2022.102314_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-8977-8-20","article-title":"Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues","volume":"8","author":"Xu","year":"2011","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib80","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fphys.2016.00029","article-title":"Influencing factors of thermogenic adipose tissue activity","volume":"7","author":"Zhang","year":"2016","journal-title":"Front Physiol"},{"key":"10.1016\/j.coph.2022.102314_bib81","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.2337\/db12-1039","article-title":"PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice","volume":"62","author":"He","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.coph.2022.102314_bib82","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.taap.2008.08.020","article-title":"Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: chlorpyrifos, diazinon, dieldrin and divalent nickel","volume":"233","author":"Slotkin","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.coph.2022.102314_bib83","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.brainresbull.2007.10.008","article-title":"Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood","volume":"75","author":"Slotkin","year":"2008","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.coph.2022.102314_bib84","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/taap.1999.8806","article-title":"The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles","volume":"161","author":"Mariussen","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.coph.2022.102314_bib85","first-page":"605","article-title":"Selective serotonin re-uptake inhibitors: an overview","volume":"30","author":"Joshi","year":"2018","journal-title":"Psychiatr Danub"},{"key":"10.1016\/j.coph.2022.102314_bib86","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0045-6535(00)00196-X","article-title":"Effects of bisphenol A on energy balance and accumulation in brown adipose tissue in rats","volume":"42","author":"Nunez","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.coph.2022.102314_bib87","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tox.2014.04.001","article-title":"Programming of metabolic effects in C57BL\/6JxFVB mice by exposure to bisphenol A during gestation and lactation","volume":"321","author":"van Esterik","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.coph.2022.102314_bib88","first-page":"12","article-title":"Estrogen receptor alpha controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling","author":"Zhou","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coph.2022.102314_bib89","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.3390\/ijerph17249403","article-title":"Adipose tissue and endocrine-disrupting chemicals: does sex matter?","volume":"17","author":"Magueresse-Battistoni","year":"2020","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.coph.2022.102314_bib90","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1096\/fj.201600787rr","article-title":"Pharmacologic activation of estrogen receptor beta increases mitochondrial function, energy expenditure, and brown adipose tissue","volume":"31","author":"Ponnusamy","year":"2017","journal-title":"Faseb J"},{"key":"10.1016\/j.coph.2022.102314_bib91","first-page":"113","article-title":"The E-screen assay as a tool to identify estrogens - an update on estrogenic environmental-pollutants","volume":"103","author":"Soto","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.coph.2022.102314_bib92","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1054\/mehy.1998.0811","article-title":"What are the implications of the interaction between DDT and estrogen receptors in the body?","volume":"54","author":"Jaga","year":"2000","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.coph.2022.102314_bib93","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1289\/ehp.8748","article-title":"PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract","volume":"114","author":"Ma","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.coph.2022.102314_bib94","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1055\/a-0919-3879","article-title":"Inhibition of type 1 iodothyronine deiodinase by bisphenol A","volume":"51","author":"da Silva","year":"2019","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.coph.2022.102314_bib95","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0300-483X(96)03488-9","article-title":"Decreased liver type I 5'-deiodinase and increased brown adipose tissue type II 5'-deiodinase activity in 2,3,7,8-tetrachlorobibenzo-p-dioxin (TCDD)-treated Long-Evans rats","volume":"114","author":"Raasmaja","year":"1996","journal-title":"Toxicology"},{"key":"10.1016\/j.coph.2022.102314_bib96","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/toxsci\/kfv098","article-title":"The environmental pollutants perfluorooctane sulfonate and perfluorooctanoic acid upregulate uncoupling protein 1 (UCP1) in Brown-fat mitochondria through a UCP1-dependent reduction in food intake","volume":"146","author":"Shabalina","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.coph.2022.102314_bib97","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00204-015-1535-4","article-title":"Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria","volume":"90","author":"Shabalina","year":"2016","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.coph.2022.102314_bib98","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature17399","article-title":"Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1","volume":"532","author":"Chouchani","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.coph.2022.102314_bib99","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.kint.2016.07.045","article-title":"Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target","volume":"90","author":"Tang","year":"2016","journal-title":"Kidney Int"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489222001412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489222001412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:55:07Z","timestamp":1778813707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489222001412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":99,"alternative-id":["S1471489222001412"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2022.102314","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2022.102314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102314"}}