{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:24:21Z","timestamp":1786987461876,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Pharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.coph.2022.102323","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:56:37Z","timestamp":1670997397000},"page":"102323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pharmacotherapy of male hypogonadism"],"prefix":"10.1016","volume":"68","author":[{"given":"Giulia","family":"Rastrelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Vignozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coph.2022.102323_bib1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/andr.12770","article-title":"European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: endorsing organization: European Society of Endocrinology","volume":"8","author":"Corona","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_sref2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.eururo.2021.06.007","article-title":"European association of urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction","volume":"80","author":"Salonia","year":"2021","journal-title":"Eur Urol"},{"key":"10.1016\/j.coph.2022.102323_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/13685538.2021.1962840","article-title":"Recommendations on the diagnosis, treatment and monitoring of testosterone deficiency in men","volume":"24","author":"Lunenfeld","year":"2021","journal-title":"Aging Male"},{"key":"10.1016\/j.coph.2022.102323_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0911101","article-title":"Identification of late-onset hypogonadism in middle-aged and elderly men","volume":"363","author":"Wu","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.coph.2022.102323_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101615","article-title":"Androgens and male sexual function","author":"Corona","year":"2022","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"key":"10.1016\/j.coph.2022.102323_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40618-015-0425-1","article-title":"How to define hypogonadism? Results from a population of men consulting for sexual dysfunction","volume":"39","author":"Rastrelli","year":"2016","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.coph.2022.102323_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1159\/000520135","article-title":"Testosterone therapy for late-onset hypogonadism improves erectile function: a systematic review and meta-analysis","volume":"106","author":"Taniguchi","year":"2022","journal-title":"Urol Int"},{"key":"10.1016\/j.coph.2022.102323_bib8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5534\/wjmh.190061","article-title":"Treatment of functional hypogonadism besides pharmacological substitution","volume":"38","author":"Corona","year":"2020","journal-title":"World J Mens Health"},{"key":"10.1016\/j.coph.2022.102323_bib9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s40618-021-01702-5","article-title":"Testosterone supplementation and bone parameters: a systematic review and meta-analysis study","volume":"45","author":"Corona","year":"2022","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.coph.2022.102323_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101622","article-title":"Ageing male (part I): pathophysiology and diagnosis of functional hypogonadism","author":"Huhtaniemi","year":"2022","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"key":"10.1016\/j.coph.2022.102323_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-022-09738-5","article-title":"Bone health in ageing men","author":"David","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.coph.2022.102323_bib12","doi-asserted-by":"crossref","first-page":"8194","DOI":"10.3390\/ijms23158194","article-title":"Adipose tissue dysfunction and obesity-related male hypogonadism","volume":"23","author":"Genchi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2022.102323_bib13","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline","volume":"103","author":"Bhasin","year":"2018","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102323_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-022-09712-1","article-title":"Testosterone treatment of late-onset hypogonadism - benefits and risks","author":"Snyder","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.coph.2022.102323_bib15","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/17512433.2021.1938548","article-title":"The Role of testosterone treatment in patients with metabolic disorders","volume":"14","author":"Corona","year":"2021","journal-title":"Expet Rev Clin Pharmacol"},{"key":"10.1016\/j.coph.2022.102323_bib16","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/andr.12705","article-title":"Late-onset hypogonadism: metabolic impact","volume":"8","author":"Grossmann","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_bib17","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/andr.13185","article-title":"Efficacy and safety of letrozole or anastrozole in the treatment of male infertility with low testosterone-estradiol ratio: a meta-analysis and systematic review","volume":"10","author":"Guo","year":"2022","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_bib18","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/nutrit\/nuab072","article-title":"Examining the effects of calorie restriction on testosterone concentrations in men: a systematic review and meta-analysis","volume":"80","author":"Smith","year":"2022","journal-title":"Nutr Rev"},{"key":"10.1016\/j.coph.2022.102323_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/17446651.2019.1657827","article-title":"Metabolically healthy and unhealthy obesity in erectile dysfunction and male infertility","volume":"14","author":"Rastrelli","year":"2019","journal-title":"Expet Rev Endocrinol Metabol"},{"key":"10.1016\/j.coph.2022.102323_bib20","doi-asserted-by":"crossref","first-page":"E519","DOI":"10.1152\/ajpendo.00377.2018","article-title":"Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit","volume":"316","author":"Morelli","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102323_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/JOE-19-0532","article-title":"Testosterone improves muscle fiber asset and exercise performance in a metabolic syndrome model","volume":"245","author":"Sarchielli","year":"2020","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.coph.2022.102323_bib22","first-page":"22","article-title":"Neuroprotective effects of testosterone in the hypothalamus of an animal model of metabolic syndrome","author":"Sarchielli","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2022.102323_sref23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S2213-8587(20)30367-3","article-title":"Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial","volume":"9","author":"Wittert","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.coph.2022.102323_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/and.14453","article-title":"Direct conversion from long-acting testosterone replacement therapy to Natesto allows for spermatogenesis resumption: proof of concept","volume":"54","author":"Kavoussi","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.coph.2022.102323_bib25","series-title":"Consequences of anabolic-androgenic steroid abuse in males; sexual and reproductive perspective","author":"Corona","year":"2021"},{"key":"10.1016\/j.coph.2022.102323_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/EJE-21-0608","article-title":"Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections","volume":"186","author":"Handelsman","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.coph.2022.102323_bib27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/andr.12951","article-title":"The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: scrotal ultrasound reference ranges and associations with clinical, seminal, and biochemical characteristics","volume":"9","author":"Lotti","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_sref28","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmac016","article-title":"Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis","author":"Tharakan","year":"2022","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.coph.2022.102323_bib29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/humupd\/dmz028","article-title":"Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis","volume":"25","author":"Corona","year":"2019","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.coph.2022.102323_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12958-022-00953-y","article-title":"Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction","volume":"20","author":"Hu","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.coph.2022.102323_sref31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010021","article-title":"Treatment of men with central hypogonadism: alternatives for testosterone replacement therapy","volume":"22","author":"Ide","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.coph.2022.102323_bib32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/14656566.2022.2084690","article-title":"What are the pharmacological considerations for male congenital hypogonadotropic hypogonadism?","volume":"23","author":"Rastrelli","year":"2022","journal-title":"Expet Opin Pharmacother"},{"key":"10.1016\/j.coph.2022.102323_bib33","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/andr.262","article-title":"Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study","volume":"2","author":"Rastrelli","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_bib34","doi-asserted-by":"crossref","first-page":"654","DOI":"10.5534\/wjmh.200043","article-title":"Spermatogenesis of male patients with congenital hypogonadotropic hypogonadism receiving pulsatile gonadotropin-releasing hormone therapy versus gonadotropin therapy: a systematic review and meta-analysis","volume":"39","author":"Wei","year":"2021","journal-title":"World J Mens Health"},{"key":"10.1016\/j.coph.2022.102323_bib35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s40618-022-01741-6","article-title":"Management of male factor infertility: position statement from the Italian society of andrology and sexual medicine (SIAMS) : endorsing organization: Italian society of embryology, reproduction, and research (SIERR)","volume":"45","author":"Ferlin","year":"2022","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.coph.2022.102323_bib36","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/andr.12725","article-title":"Aromatase inhibitors and selective estrogen receptor modulators: unconventional therapies for functional hypogonadism?","volume":"8","author":"Awouters","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.coph.2022.102323_bib37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/17512433.2018.1445969","article-title":"Pharmacological management of late-onset hypogonadism","volume":"11","author":"Rastrelli","year":"2018","journal-title":"Expet Rev Clin Pharmacol"},{"key":"10.1016\/j.coph.2022.102323_bib38","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1080\/14656566.2019.1615057","article-title":"Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis","volume":"20","author":"Cannarella","year":"2019","journal-title":"Expet Opin Pharmacother"},{"key":"10.1016\/j.coph.2022.102323_bib39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/aja.aja_101_19","article-title":"A\u00a0systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility","volume":"22","author":"Del Giudice","year":"2020","journal-title":"Asian J Androl"},{"key":"10.1016\/j.coph.2022.102323_bib40","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1210\/clinem\/dgac028","article-title":"Relation of testosterone, dihydrotestosterone, and estradiol with changes in outcomes measures in the testosterone trials","volume":"107","author":"Stephens-Shields","year":"2022","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.coph.2022.102323_bib41","first-page":"447","article-title":"Testosterone therapy: what we have learned from trials","volume":"17","author":"Corona","year":"2020","journal-title":"J\u00a0Sex Med"},{"key":"10.1016\/j.coph.2022.102323_bib42","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.eururo.2017.03.032","article-title":"Meta-analysis of results of testosterone therapy on sexual function based on international index of erectile function scores","volume":"72","author":"Corona","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.coph.2022.102323_bib43","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-022-09746-5","article-title":"Obesity, type 2 diabetes, and testosterone in ageing men","author":"Wittert","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.coph.2022.102323_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.915309","article-title":"Baseline testosterone predicts body composition and metabolic response to testosterone therapy","volume":"13","author":"Deepika","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.coph.2022.102323_bib45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.euf.2018.07.006","article-title":"Systematic review of the impact of testosterone replacement therapy on depression in patients with late-onset testosterone deficiency","volume":"6","author":"Vartolomei","year":"2020","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.coph.2022.102323_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5534\/wjmh.200017","article-title":"Testosterone deficiency and risk of cognitive disorders in aging males","volume":"39","author":"Corona","year":"2021","journal-title":"World J Mens Health"},{"key":"10.1016\/j.coph.2022.102323_bib47","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-022-09728-7","article-title":"Testosterone, cognitive decline and dementia in ageing men","author":"Yeap","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.coph.2022.102323_bib48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/14740338.2018.1424831","article-title":"The safety of available treatments of male hypogonadism in organic and functional hypogonadism","volume":"17","author":"Corona","year":"2018","journal-title":"Expet Opin Drug Saf"},{"key":"10.1016\/j.coph.2022.102323_sref49","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1016\/S2666-7568(22)00096-4","article-title":"Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis","volume":"3","author":"Hudson","year":"2022","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.coph.2022.102323_bib50","first-page":"820","article-title":"Testosterone and cardiovascular risk: meta-analysis of interventional studies","volume":"15","author":"Corona","year":"2018","journal-title":"J\u00a0Sex Med"}],"container-title":["Current Opinion in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489222001503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471489222001503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T06:58:30Z","timestamp":1761461910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471489222001503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":50,"alternative-id":["S1471489222001503"],"URL":"https:\/\/doi.org\/10.1016\/j.coph.2022.102323","relation":{},"ISSN":["1471-4892"],"issn-type":[{"value":"1471-4892","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacotherapy of male hypogonadism","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coph.2022.102323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102323"}}