{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:29:34Z","timestamp":1792042174490,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Physiology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.cophys.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:08:55Z","timestamp":1575288535000},"page":"141-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sodium channels and transporters in the myometrium"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-3658","authenticated-orcid":false,"given":"Chinwendu","family":"Amazu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia M","family":"Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K","family":"England","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cophys.2019.11.011_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0146-0005(95)80045-X","article-title":"Ion channels and the control of myometrial electrical activity","volume":"19","author":"Sanborn","year":"1995","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0010","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1993.264.1.C1","article-title":"Uterine contraction and physiological mechanisms of modulation","volume":"264","author":"Wray","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1976.sp011517","article-title":"Changes in electrical properties of rat myometrium during gestation and following hormonal treatments","volume":"260","author":"Kuriyama","year":"1976","journal-title":"J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.1965.sp007591","article-title":"Membrane potential and ionic content in pregnant and non-pregnant rat myometrium","volume":"177","author":"Casteels","year":"1965","journal-title":"J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000061026","article-title":"Excitability in uterine smooth muscle","volume":"27","author":"Parkington","year":"2001","journal-title":"Front Horm Res"},{"key":"10.1016\/j.cophys.2019.11.011_sbref0030","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0002-9378(99)70390-X","article-title":"Contractile activity, membrane potential, and cytoplasmic calcium in human uterine smooth muscle in the third trimester of pregnancy and during labor","volume":"181","author":"Parkington","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0035","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1071-5576(03)00089-3","article-title":"Calcium signaling and uterine contractility","volume":"10","author":"Wray","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.cophys.2019.11.011_bib0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-3565(25)28297-0","article-title":"A comparison of the effects of various smooth muscle relaxants on the electrical and mechanical activity of rat uterus","volume":"168","author":"Diamond","year":"1969","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cophys.2019.11.011_bib0045","doi-asserted-by":"crossref","first-page":"C658","DOI":"10.1152\/ajpcell.1991.260.3.C658","article-title":"Gestational change in Na+ and Ca2+ channel current densities in rat myometrial smooth muscle cells","volume":"260","author":"Inoue","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0304-4157(89)90019-1","article-title":"Isozymes of the Na+\/K+-ATPase","volume":"988","author":"Sweadner","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cophys.2019.11.011_bib0055","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev.biochem.71.102201.141218","article-title":"Biochemistry of Na,K-ATPase","volume":"71","author":"Kaplan","year":"2002","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.cophys.2019.11.011_bib0060","doi-asserted-by":"crossref","first-page":"16925","DOI":"10.1016\/S0021-9258(18)55391-6","article-title":"Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells","volume":"266","author":"Jewell","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cophys.2019.11.011_bib0065","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/MNH.0b013e3283036cbf","article-title":"Functional roles of Na,K-ATPase subunits","volume":"17","author":"Geering","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.cophys.2019.11.011_bib0070","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1067\/mob.2003.166","article-title":"Changes in the isoforms of the sodium pump in the placenta and myometrium of women in labor","volume":"188","author":"Esplin","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0075","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13527","article-title":"Gestation changes sodium pump isoform expression, leading to changes in ouabain sensitivity, contractility, and intracellular calcium in rat uterus","volume":"5","author":"Floyd","year":"2017","journal-title":"Physiol Rep"},{"key":"10.1016\/j.cophys.2019.11.011_bib0080","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/1933719109355196","article-title":"Expression and distribution of Na, K-ATPase isoforms in the human uterus","volume":"17","author":"Floyd","year":"2010","journal-title":"Reprod Sci"},{"key":"10.1016\/j.cophys.2019.11.011_bib0085","doi-asserted-by":"crossref","first-page":"F633","DOI":"10.1152\/ajprenal.1998.275.5.F633","article-title":"Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function","volume":"275","author":"Blanco","year":"1998","journal-title":"Am J Physiol\u2013Renal Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jeb.198.1.1","article-title":"Functional-significance of the beta-subunit for heterodimeric P-Type Atpases","volume":"198","author":"Chow","year":"1995","journal-title":"J Exp Biol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1749-6632.1992.tb43789.x","article-title":"The beta subunit modulates potassium activation of the Na-K Pump","volume":"671","author":"Jaisser","year":"1992","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cophys.2019.11.011_bib0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1085\/jgp.56.3.360","article-title":"Characteristics of electrogenic sodium pumping in rat myometrium","volume":"56","author":"Taylor","year":"1970","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1472-8206.1996.tb00148.x","article-title":"Effect of inhibition of the electrogenic Na+\/K+ pump on the mechanical activity in the rat uterus","volume":"10","author":"Ausina","year":"1996","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0110","series-title":"Ion Channels of Excitable Membranes","first-page":"814","author":"Hille","year":"2001"},{"key":"10.1016\/j.cophys.2019.11.011_bib0115","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1085\/jgp.58.3.322","article-title":"Studies on calcium and sodium in uterine smooth muscle excitation under current-clamp and voltage-clamp conditions","volume":"58","author":"Anderson","year":"1971","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0120","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0006-291X(86)91131-9","article-title":"The presence of Na+ channels in myometrial smooth muscle cells is revealed by specific neurotoxins","volume":"137","author":"Amedee","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cophys.2019.11.011_bib0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/107155769700400204","article-title":"Effects of sodium and calcium channel blockade on cytosolic calcium oscillations and phasic contractions of myometrial tissue","volume":"4","author":"Phillippe","year":"1997","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.cophys.2019.11.011_bib0130","doi-asserted-by":"crossref","first-page":"C130","DOI":"10.1152\/ajpcell.1989.256.1.C130","article-title":"Improved propagation in myometrium associated with gap junctions during parturition","volume":"256","author":"Miller","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0135","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1085\/jgp.110.5.565","article-title":"Sodium and calcium inward currents in freshly dissociated smooth myocytes of rat uterus","volume":"110","author":"Yoshino","year":"1997","journal-title":"J Gen Physiol"},{"issue":"2 Pt 1","key":"10.1016\/j.cophys.2019.11.011_bib0140","first-page":"257","article-title":"Fast Na+ and slow Ca2+ channels in single uterine muscle cells from pregnant rats","author":"Ohya","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0145","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1095\/biolreprod.107.063016","article-title":"Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats","volume":"77","author":"Seda","year":"2007","journal-title":"Biol Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0002-9378(91)90650-G","article-title":"Characterization of sodium channels in cultured human uterine smooth muscle cells","volume":"164","author":"Young","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0155","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1073\/pnas.89.11.4893","article-title":"Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family","volume":"89","author":"George","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cophys.2019.11.011_bib0160","doi-asserted-by":"crossref","first-page":"30125","DOI":"10.1016\/S0021-9258(18)43786-6","article-title":"Primary structure and differential expression during development and pregnancy of a novel voltage-gated sodium channel in the mouse","volume":"269","author":"Felipe","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cophys.2019.11.011_bib0165","first-page":"249","article-title":"Voltage-dependent Na+ channel mRNA expression in pregnant myometrium","volume":"2","author":"Boyle","year":"1994","journal-title":"Receptors Channels"},{"key":"10.1016\/j.cophys.2019.11.011_bib0170","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1113\/expphysiol.2013.072868","article-title":"Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq","volume":"99","author":"Chan","year":"2014","journal-title":"Exp Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_sbref0175","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00424-003-1175-z","article-title":"Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats","volume":"447","author":"Miyoshi","year":"2004","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.cophys.2019.11.011_sbref0180","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/molehr\/gav038","article-title":"Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women","volume":"21","author":"Reinl","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/d317e049-4927-4906-95a5-cd0198a3feb9","article-title":"A computational model of the ionic currents, Ca2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle","volume":"6","author":"Tong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cophys.2019.11.011_bib0190","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2007.02.041","article-title":"The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm","volume":"129","author":"Lu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cophys.2019.11.011_sbref0195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000491805","article-title":"Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition","volume":"48","author":"Reinl","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.cophys.2019.11.011_sbref0200","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1113\/JP276806","article-title":"Oxytocin can regulate myometrial smooth muscle excitability by inhibiting the Na(+) \u2013 activated K(+) channel, Slo2.1","volume":"597","author":"Ferreira","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0205","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1095\/biolreprod.103.023325","article-title":"Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy","volume":"70","author":"Babich","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0210","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/molehr\/gal110","article-title":"Mechanical stretch regulates TRPC expression and calcium entry in human myometrial smooth muscle cells","volume":"13","author":"Dalrymple","year":"2007","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jsgi.2005.12.007","article-title":"Expression of transient receptor channel proteins in human fundal myometrium in pregnancy","volume":"13","author":"Ku","year":"2006","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.cophys.2019.11.011_bib0220","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/molehr\/8.10.946","article-title":"Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus","volume":"8","author":"Dalrymple","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0225","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/2071378a0","article-title":"Stretch-induced uterine growth, protein synthesis and function","volume":"207","author":"Csapo","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.cophys.2019.11.011_bib0230","first-page":"E543","article-title":"Influence of mechanical stretch on growth and protein turnover of rat uterus","volume":"254","author":"Douglas","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0235","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1095\/biolreprod63.3.748","article-title":"Calcium homeostatic pathways change with gestation in human myometrium","volume":"63","author":"Tribe","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.cophys.2019.11.011_bib0240","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/eph8602180","article-title":"Regulation of human myometrial contractility during pregnancy and labour: are calcium homeostatic pathways important?","volume":"86","author":"Tribe","year":"2001","journal-title":"Exp Physiol"},{"key":"10.1016\/j.cophys.2019.11.011_bib0245","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1210\/en.2009-0085","article-title":"Attenuation of canonical transient receptor potential-like channel 6 expression specifically reduces the diacylglycerol-mediated increase in intracellular calcium in human myometrial cells","volume":"151","author":"Chung","year":"2010","journal-title":"Endocrinology"}],"updated-by":[{"DOI":"10.1016\/j.cophys.2021.02.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000}}],"container-title":["Current Opinion in Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246886731930183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246886731930183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:11:03Z","timestamp":1762859463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246886731930183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":49,"alternative-id":["S246886731930183X"],"URL":"https:\/\/doi.org\/10.1016\/j.cophys.2019.11.011","relation":{},"ISSN":["2468-8673"],"issn-type":[{"value":"2468-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium channels and transporters in the myometrium","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cophys.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}