{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:06:45Z","timestamp":1790467605603,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"am","delay-in-days":266,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Physiology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cophys.2020.10.004","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T02:00:20Z","timestamp":1603072820000},"page":"80-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Chemokines in cardiac fibrosis"],"prefix":"10.1016","volume":"19","author":[{"given":"Ruoshui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G","family":"Frangogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cophys.2020.10.004_bib0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fphys.2020.00301","article-title":"Leukocyte-dependent regulation of cardiac fibrosis","volume":"11","author":"Okyere","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0015","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0020","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2741\/s33","article-title":"Chemokines and cardiac fibrosis","volume":"1","author":"Dobaczewski","year":"2009","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.cophys.2020.10.004_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-981-10-8684-7_4","article-title":"Chemokines and chemokine receptors in the development of NAFLD","volume":"1061","author":"Roh","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0030","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00011-004-1298-5","article-title":"Chemokines in the ischemic myocardium: from inflammation to fibrosis","volume":"53","author":"Frangogiannis","year":"2004","journal-title":"Inflamm Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","article-title":"Fibroblasts in the infarcted, remodeling, and failing heart","volume":"4","author":"Humeres","year":"2019","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.cophys.2020.10.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.227900","article-title":"The myofibroblast at a glance","volume":"133","author":"Pakshir","year":"2020","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cophys.2020.10.004_bib0045","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming Growth Factor (TGF)-beta in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0050","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cophys.2020.10.004_bib0055","doi-asserted-by":"crossref","first-page":"H124","DOI":"10.1152\/ajpheart.00028.2019","article-title":"T-cell recruitment to the heart: friendly guests or unwelcome visitors?","volume":"317","author":"Blanton","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/cvr\/cvq272","article-title":"Cardiac mast cells: the centrepiece in adverse myocardial remodelling","volume":"89","author":"Levick","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0065","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/01.CIR.98.7.687","article-title":"Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion","volume":"98","author":"Frangogiannis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair","volume":"1","author":"Bucala","year":"1994","journal-title":"Mol Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0075","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1016\/j.jacc.2019.10.036","article-title":"Transition of macrophages to fibroblast-like cells in healing myocardial infarction","volume":"74","author":"Haider","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0080","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12260","article-title":"Genetic lineage tracing defines myofibroblast origin and function in the injured heart","volume":"7","author":"Kanisicak","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.cophys.2020.10.004_bib0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/CIRCRESAHA.117.311490","article-title":"Infarct fibroblasts do not derive from bone marrow lineages","volume":"122","author":"Moore-Morris","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0090","article-title":"Chemokines in myocardial infarction","author":"Chen","year":"2020","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0095","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.0438035100","article-title":"Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species","volume":"100","author":"Dewald","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cophys.2020.10.004_bib0100","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0002-9440(10)62568-0","article-title":"Evidence for an active inflammatory process in the hibernating human myocardium","volume":"160","author":"Frangogiannis","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0105","doi-asserted-by":"crossref","first-page":"26688","DOI":"10.1074\/jbc.M115.661835","article-title":"Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via toll-like receptor 7 signaling","volume":"290","author":"Feng","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cophys.2020.10.004_bib0110","doi-asserted-by":"crossref","first-page":"H877","DOI":"10.1152\/ajpheart.00223.2019","article-title":"Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling","volume":"317","author":"Suetomi","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0115","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","article-title":"CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration","volume":"39","author":"Wang","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cophys.2020.10.004_bib0120","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","article-title":"Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca(2+)\/calmodulin-dependent protein kinase II delta signaling in cardiomyocytes are essential for adverse cardiac remodeling","volume":"138","author":"Suetomi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97054","article-title":"CaMKIIdelta-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis","volume":"3","author":"Willeford","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.cophys.2020.10.004_bib0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/ars.2018.7548","article-title":"NADPH oxidase 4 regulates inflammation in ischemic heart failure: role of soluble epoxide hydrolase","volume":"31","author":"Stevenson","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.cophys.2020.10.004_bib0135","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.106.646091","article-title":"Critical role of monocyte chemoattractant protein-1\/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy","volume":"115","author":"Frangogiannis","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0140","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/01.CIR.102.18.2243","article-title":"Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis","volume":"102","author":"Koyanagi","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0145","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/01.HYP.0000118584.33350.7d","article-title":"Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation?","volume":"43","author":"Kuwahara","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.cophys.2020.10.004_bib0150","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/01.RES.0000163017.13772.3a","article-title":"CCL2\/monocyte chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts","volume":"96","author":"Dewald","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0155","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2337\/db18-1231","article-title":"Role of CCR2 in the development of streptozotocin-treated diabetic cardiomyopathy","volume":"68","author":"Tan","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.cophys.2020.10.004_bib0160","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1189\/jlb.0305127","article-title":"MCP-1\/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes","volume":"79","author":"Sakai","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cophys.2020.10.004_sbref0165","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jacbts.2017.12.006","article-title":"CCR2(+) monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload","volume":"3","author":"Patel","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.cophys.2020.10.004_bib0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","article-title":"Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation","volume":"40","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cophys.2020.10.004_sbref0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0180","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.115.303567","article-title":"Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction","author":"Heidt","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCRESAHA.119.315069","article-title":"Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation","volume":"125","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_sbref0190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","article-title":"Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_sbref0195","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","article-title":"The human heart contains distinct macrophage subsets with divergent origins and functions","volume":"24","author":"Bajpai","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0200","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1084\/jem.20161791","article-title":"Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure","volume":"214","author":"Nevers","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0205","doi-asserted-by":"crossref","first-page":"G765","DOI":"10.1152\/ajpgi.00308.2005","article-title":"Secretion of MCP-1\/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts","volume":"290","author":"Kruglov","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0210","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0002-9440(10)63154-9","article-title":"Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction","volume":"164","author":"Dewald","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0215","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00395-020-0803-5","article-title":"Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy","volume":"115","author":"Lubos","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/cvr\/cvv128","article-title":"Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence","volume":"106","author":"Ma","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0225","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1161\/CIRCULATIONAHA.108.788711","article-title":"Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis","volume":"118","author":"Kaya","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0230","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad5330","article-title":"Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5","volume":"7","author":"Alard","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0235","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/eurheartj\/ehr127","article-title":"CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice","volume":"33","author":"Montecucco","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cophys.2020.10.004_bib0240","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2353\/ajpath.2010.090759","article-title":"CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells","volume":"176","author":"Dobaczewski","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0245","doi-asserted-by":"crossref","first-page":"H1233","DOI":"10.1152\/ajpheart.00328.2014","article-title":"Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function","volume":"307","author":"Saxena","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0250","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ajh.2011.243","article-title":"CCR5 deficiency does not reduce hypertensive end-organ damage in mice","volume":"25","author":"Krebs","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cophys.2020.10.004_bib0255","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/annrheumdis-2019-215119","article-title":"Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis","volume":"78","author":"Mor","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cophys.2020.10.004_bib0260","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1002\/eji.201646557","article-title":"Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart","volume":"46","author":"Diny","year":"2016","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0265","doi-asserted-by":"crossref","first-page":"18455","DOI":"10.1073\/pnas.1905824116","article-title":"Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling","volume":"116","author":"Wang","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cophys.2020.10.004_bib0270","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","article-title":"The functional role of the ELR motif in CXC chemokine-mediated angiogenesis","volume":"270","author":"Strieter","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cophys.2020.10.004_bib0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165551","article-title":"Chronic inhibition of chemokine receptor CXCR2 attenuates cardiac remodeling and dysfunction in spontaneously hypertensive rats","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.cophys.2020.10.004_bib0280","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/HYPERTENSIONAHA.120.14698","article-title":"Chemokine receptor CXCR-2 Initiates atrial fibrillation by triggering monocyte mobilization in mice","volume":"76","author":"Zhang","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.cophys.2020.10.004_bib0285","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.20160530","article-title":"Peptidylarginine deiminase 4 promotes age-related organ fibrosis","volume":"214","author":"Martinod","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0290","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","article-title":"Neutrophil extracellular traps promote differentiation and function of fibroblasts","volume":"233","author":"Chrysanthopoulou","year":"2014","journal-title":"J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0295","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1084\/jem.20181102","article-title":"Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis","volume":"216","author":"Weckbach","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0300","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1096\/fj.00-0745fje","article-title":"Induction and suppression of interferon-inducible protein 10 in reperfused myocardial infarcts may regulate angiogenesis","volume":"15","author":"Frangogiannis","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.cophys.2020.10.004_bib0305","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCRESAHA.109.199471","article-title":"Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction","volume":"105","author":"Bujak","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0310","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/cvr\/cvu138","article-title":"CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans","volume":"103","author":"Saxena","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0315","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/cvr\/cvy211","article-title":"Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality","volume":"115","author":"Lindsey","year":"2019","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0320","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1189\/jlb.1006645","article-title":"CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3","volume":"83","author":"Mueller","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0325","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29026-0","article-title":"Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis","volume":"8","author":"Vajen","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.cophys.2020.10.004_bib0330","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/382635a0","article-title":"Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF\/SDF-1","volume":"382","author":"Nagasawa","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cophys.2020.10.004_bib0335","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1182\/blood.V99.8.2703","article-title":"Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1","volume":"99","author":"Salvucci","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.cophys.2020.10.004_bib0340","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0002-9440(10)65365-5","article-title":"Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha","volume":"154","author":"Salcedo","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0345","first-page":"212","article-title":"The CXCL12\/CXCR4 chemokine ligand\/receptor axis in cardiovascular disease","volume":"5","author":"Doring","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0350","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/gt.2012.32","article-title":"SDF-1 in myocardial repair","volume":"19","author":"Penn","year":"2012","journal-title":"Gene Ther"},{"key":"10.1016\/j.cophys.2020.10.004_bib0355","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fphar.2019.00117","article-title":"CXCR4 antagonism reduces cardiac fibrosis and improves cardiac performance in dilated cardiomyopathy","volume":"10","author":"Chu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133616","article-title":"CXCR4 antagonism attenuates the development of diabetic cardiac fibrosis","volume":"10","author":"Chu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cophys.2020.10.004_bib0365","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/CIRCHEARTFAILURE.110.960831","article-title":"CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess","volume":"4","author":"Chu","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cophys.2020.10.004_bib0370","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yjmcc.2019.10.006","article-title":"Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells","volume":"137","author":"Li","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0375","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.2353\/ajpath.2010.090574","article-title":"Bone marrow-derived cells contribute to fibrosis in the chronically failing heart","volume":"176","author":"Chu","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0380","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007253","article-title":"SDF-1alpha (Stromal Cell-Derived Factor 1alpha) induces cardiac fibroblasts, renal microvascular smooth muscle cells, and glomerular mesangial cells to proliferate, cause hypertrophy, and produce collagen","volume":"6","author":"Jackson","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cophys.2020.10.004_bib0385","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1016\/j.bbadis.2017.07.012","article-title":"Non-oxidizable HMGB1 induces cardiac fibroblasts migration via CXCR4 in a CXCL12-independent manner and worsens tissue remodeling after myocardial infarction","volume":"1863","author":"Di Maggio","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.cophys.2020.10.004_bib0390","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1021\/acs.jmedchem.8b00190","article-title":"Discovery of a novel small-molecule modulator of C-X-C chemokine receptor Type 7 as a treatment for cardiac fibrosis","volume":"61","author":"Menhaji-Klotz","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.cophys.2020.10.004_bib0395","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1172\/JCI80055","article-title":"T lymphocytes and fractalkine contribute to myocardial ischemia\/reperfusion injury in patients","volume":"125","author":"Boag","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cophys.2020.10.004_bib0400","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/hep.23894","article-title":"The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes","volume":"52","author":"Karlmark","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cophys.2020.10.004_bib0405","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/hr.2011.23","article-title":"Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney","volume":"34","author":"Shimizu","year":"2011","journal-title":"Hypertens Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0410","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182643","article-title":"CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis","volume":"12","author":"Muller","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cophys.2020.10.004_bib0420","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/cvr\/cvr221","article-title":"Detrimental effect of fractalkine on myocardial ischaemia and heart failure","volume":"92","author":"Xuan","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0425","doi-asserted-by":"crossref","first-page":"F1526","DOI":"10.1152\/ajprenal.00149.2018","article-title":"The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II-induced hypertension","volume":"315","author":"Ahadzadeh","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0430","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-8587(15)00261-2","article-title":"The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial","volume":"3","author":"de Zeeuw","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0435","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ndt\/gfv459","article-title":"C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria","volume":"32","author":"Menne","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cophys.2020.10.004_bib0440","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/25787489.2020.1719319","article-title":"Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy","volume":"20","author":"Bowler","year":"2019","journal-title":"HIV Res Clin Pract"},{"key":"10.1016\/j.cophys.2020.10.004_bib0445","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cct.2016.02.012","article-title":"Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design","volume":"47","author":"Friedman","year":"2016","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.cophys.2020.10.004_bib0450","doi-asserted-by":"crossref","DOI":"10.1002\/hep.31108","article-title":"Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the Phase 2b CENTAUR study","author":"Ratziu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cophys.2020.10.004_bib0455","article-title":"Metabolic Inflammation in heart failure with preserved ejection fraction","author":"Schiattarella","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0460","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cophys.2020.10.004_sbref0465","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.cophys.2020.10.004_bib0470","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0008-6363(00)00243-1","article-title":"Time course of arteriogenesis following femoral artery occlusion in the rabbit","volume":"49","author":"Hoefer","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0475","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1161\/CIRCULATIONAHA.107.694992","article-title":"Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction","volume":"117","author":"Saxena","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0480","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/CIRCHEARTFAILURE.110.960302","article-title":"Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium","volume":"4","author":"Kanki","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cophys.2020.10.004_bib0485","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1161\/CIRCRESAHA.116.309001","article-title":"Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure","volume":"119","author":"Sager","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.cophys.2020.10.004_bib0490","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0495","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/labinvest.3780303","article-title":"Macrophage inflammatory protein-1alpha relates to the recruitment of inflammatory cells in myosin-induced autoimmune myocarditis in rats","volume":"81","author":"Toyozaki","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.cophys.2020.10.004_bib0500","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1161\/CIRCULATIONAHA.105.572396","article-title":"Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy","volume":"112","author":"Goser","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cophys.2020.10.004_bib0505","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.7667639","article-title":"Requirement of MIP-1 alpha for an inflammatory response to viral infection","volume":"269","author":"Cook","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.cophys.2020.10.004_bib0510","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1172\/JCI117680","article-title":"Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo","volume":"95","author":"Kukielka","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cophys.2020.10.004_bib0515","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1172\/JCI117974","article-title":"Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8","volume":"95","author":"Ivey","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cophys.2020.10.004_bib0520","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1369\/jhc.6A7050.2006","article-title":"Structural localization and expression of CXCL12 and CXCR4 in rat heart and isolated cardiac myocytes","volume":"55","author":"Segret","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.cophys.2020.10.004_bib0525","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000330685","article-title":"Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis","volume":"34","author":"Ble","year":"2011","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.cophys.2020.10.004_bib0530","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1183\/13993003.01558-2014","article-title":"CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab","volume":"46","author":"Raghu","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cophys.2020.10.004_bib0535","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/cid\/ciy807","article-title":"Improvement in hepatic fibrosis biomarkers associated with chemokine receptor inactivation through mutation or therapeutic blockade","volume":"68","author":"Sherman","year":"2019","journal-title":"Clin Infect Dis"}],"container-title":["Current Opinion in Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468867320301322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468867320301322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:15:17Z","timestamp":1762859717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468867320301322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":107,"alternative-id":["S2468867320301322"],"URL":"https:\/\/doi.org\/10.1016\/j.cophys.2020.10.004","relation":{},"ISSN":["2468-8673"],"issn-type":[{"value":"2468-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemokines in cardiac fibrosis","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cophys.2020.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}