{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:06:30Z","timestamp":1791522390324,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PE00000013"],"award-info":[{"award-number":["PE00000013"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PE00000006 CUP H93C22000660006"],"award-info":[{"award-number":["PE00000006 CUP H93C22000660006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cortex"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cortex.2026.03.022","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:26:15Z","timestamp":1777073175000},"page":"200-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Baseline brain volumes predict cognitive decline more robustly than atrophy rates: Evidence for brain reserve"],"prefix":"10.1016","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8941-1049","authenticated-orcid":false,"given":"Nicola","family":"Sambuco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9518-9252","authenticated-orcid":false,"given":"Giorgia F.","family":"Scaramuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0443-2527","authenticated-orcid":false,"given":"Daphne","family":"Gasparre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Cornacchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Bonvino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Antonucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Pergola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-9326","authenticated-orcid":false,"given":"Paolo","family":"Taurisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1017\/S0140525X99002034","article-title":"Episodic memory, amnesia, and the hippocampal\u2013anterior thalamic axis","volume":"22","author":"Aggleton","year":"1999","journal-title":"Behavioral and Brain Sciences"},{"issue":"7","key":"10.1016\/j.cortex.2026.03.022_bib2","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/brain\/aww083","article-title":"Thalamic pathology and memory loss in early Alzheimer's disease: Moving the focus from the medial temporal lobe to papez circuit","volume":"139","author":"Aggleton","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.cortex.2026.03.022_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neubiorev.2021.01.014","article-title":"Flexible and specific contributions of thalamic subdivisions to human cognition","volume":"124","author":"Antonucci","year":"2021","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.cortex.2026.03.022_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.896285","article-title":"Emotional memory and amygdala activation","volume":"16","author":"Bradley","year":"2022","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"11","key":"10.1016\/j.cortex.2026.03.022_bib7","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1002\/alz.13083","article-title":"Comparing machine learning-derived MRI-based and blood-based neurodegeneration biomarkers in predicting syndromal conversion in early AD","volume":"19","author":"Cai","year":"2023","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neurobiolaging.2010.01.021","article-title":"MRI predictors of cognitive change in a diverse and carefully characterized elderly population","volume":"33","author":"Carmichael","year":"2012","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.cortex.2026.03.022_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1387196","article-title":"Comparison of deep learning architectures for predicting amyloid positivity in Alzheimer's disease, mild cognitive impairment, and healthy aging, from T1-weighted brain structural MRI","volume":"18","author":"Chattopadhyay","year":"2024","journal-title":"Frontiers in Neuroscience"},{"issue":"12","key":"10.1016\/j.cortex.2026.03.022_bib10","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1002\/hbm.22926","article-title":"Detection of Alzheimer's disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosis","volume":"36","author":"Coup\u00e9","year":"2015","journal-title":"Human Brain Mapping"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/alz.12009","article-title":"Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices","volume":"16","author":"Dawe","year":"2020","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"12","key":"10.1016\/j.cortex.2026.03.022_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhae476","article-title":"Mediodorsal thalamus nucleus\u2013medial prefrontal cortex circuitry regulates cost\u2013benefit decision-making selections","volume":"34","author":"Ding","year":"2024","journal-title":"Cerebral Cortex"},{"issue":"7","key":"10.1016\/j.cortex.2026.03.022_bib13","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1002\/alz.13882","article-title":"Diabetes accelerates Alzheimer's disease progression in the first year post mild cognitive impairment diagnosis","volume":"20","author":"Ding","year":"2024","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib14","article-title":"Peripheral and central effects of \u03b3-secretase inhibition by semagacestat in Alzheimer's disease","volume":"7","author":"Doody","year":"2015","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"24","key":"10.1016\/j.cortex.2026.03.022_bib15","doi-asserted-by":"crossref","first-page":"e2532","DOI":"10.1212\/WNL.0000000000009462","article-title":"Patterns of longitudinal cortical atrophy over 3 years in empirically derived MCI subtypes","volume":"94","author":"Edmonds","year":"2020","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-26151-8","article-title":"The A\/T\/N biomarker scheme and patterns of brain atrophy assessed in mild cognitive impairment","volume":"8","author":"Ekman","year":"2018","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/j.cortex.2026.03.022_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nature Reviews Neurology"},{"key":"10.1016\/j.cortex.2026.03.022_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giae049","article-title":"CAT: A computational anatomy toolbox for the analysis of structural MRI data","volume":"13","author":"Gaser","year":"2024","journal-title":"GigaScience"},{"issue":"6","key":"10.1016\/j.cortex.2026.03.022_bib19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/neu0000761","article-title":"The latent factor structure underlying regional brain volume change and its relation to cognitive change in older adults","volume":"35","author":"Gavett","year":"2021","journal-title":"Neuropsychology"},{"key":"10.1016\/j.cortex.2026.03.022_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neurobiolaging.2016.12.002","article-title":"Longitudinal association between hippocampus atrophy and episodic-memory decline","volume":"51","author":"Gorbach","year":"2017","journal-title":"Neurobiology of Aging"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib21","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1007\/s11357-024-01328-4","article-title":"The effect of cognitive reserve on the cognitive connectome in healthy ageing","volume":"47","author":"Habich","year":"2025","journal-title":"GeroScience"},{"issue":"4","key":"10.1016\/j.cortex.2026.03.022_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hbm.10123","article-title":"Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe","volume":"19","author":"Hammers","year":"2003","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.cortex.2026.03.022_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cortex.2025.02.003","article-title":"A cognitive\u2013motor framework for spatial navigation in aging and early-stage Alzheimer's disease","volume":"185","author":"Hill","year":"2025","journal-title":"Cortex"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3233\/JAD-150478","article-title":"Cerebrospinal fluid biomarkers and reserve variables as predictors of future \u201cNon-Cognitive\u201d outcomes of Alzheimer's disease","volume":"52","author":"Ingber","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"4","key":"10.1016\/j.cortex.2026.03.022_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods","volume":"27","author":"Jack","year":"2008","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"5","key":"10.1016\/j.cortex.2026.03.022_bib26","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/brain\/awp062","article-title":"Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease","volume":"132","author":"Jack","year":"2009","journal-title":"Brain"},{"issue":"19","key":"10.1016\/j.cortex.2026.03.022_bib27","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.cortex.2026.03.022_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cortex.2024.11.013","article-title":"Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis","volume":"183","author":"Jauny","year":"2025","journal-title":"Cortex"},{"key":"10.1016\/j.cortex.2026.03.022_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cortex.2024.12.004","article-title":"Structure\u2013function relationships in the human aging brain: An account of cross-sectional and longitudinal multimodal neuroimaging studies","volume":"183","author":"Kalpouzos","year":"2025","journal-title":"Cortex"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib30","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuroimage.2008.12.037","article-title":"Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration","volume":"46","author":"Klein","year":"2009","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.cortex.2026.03.022_bib31","article-title":"Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer's disease? A 2-year longitudinal study","volume":"15","author":"Lagarde","year":"2023","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller hippocampal volume in posttraumatic stress disorder: A multisite ENIGMA-PGC Study: Subcortical volumetry results from posttraumatic stress disorder consortia","volume":"83","author":"Logue","year":"2018","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.cortex.2026.03.022_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neurobiolaging.2020.05.012","article-title":"Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories","volume":"94","author":"Lopresti","year":"2020","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.cortex.2026.03.022_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neurobiolaging.2019.12.022","article-title":"Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology","volume":"88","author":"McKenzie","year":"2020","journal-title":"Neurobiology of Aging"},{"issue":"11","key":"10.1016\/j.cortex.2026.03.022_bib35","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.1007\/s00415-024-12674-w","article-title":"Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: A systematic review","volume":"271","author":"Mitolo","year":"2024","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.cortex.2026.03.022_bib36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuroimage.2014.10.002","article-title":"Machine learning framework for early MRI-based Alzheimer's conversion prediction in MCI subjects","volume":"104","author":"Moradi","year":"2015","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000524731","article-title":"Brain imaging features associated with 20-year cognitive decline in a community-based multiethnic cohort without dementia","volume":"56","author":"Orlando","year":"2022","journal-title":"Neuroepidemiology"},{"issue":"8","key":"10.1016\/j.cortex.2026.03.022_bib38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biopsych.2017.11.008","article-title":"The mediodorsal thalamus: An essential partner of the prefrontal cortex for cognition","volume":"83","author":"Parnaudeau","year":"2018","journal-title":"Biological Psychiatry"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib39","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.neuroimage.2009.10.068","article-title":"Registration accuracy for VBM studies varies according to region and degenerative disease grouping","volume":"49","author":"Pereira","year":"2010","journal-title":"NeuroImage"},{"issue":"11","key":"10.1016\/j.cortex.2026.03.022_bib40","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.tics.2018.08.006","article-title":"The regulatory role of the human mediodorsal thalamus","volume":"22","author":"Pergola","year":"2018","journal-title":"Trends in Cognitive Sciences"},{"key":"10.1016\/j.cortex.2026.03.022_bib41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroimage.2013.02.017","article-title":"The role of the thalamic nuclei in recognition memory accompanied by recall during encoding and retrieval: An fMRI study","volume":"74","author":"Pergola","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.cortex.2026.03.022_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2013.00162","article-title":"Associative learning beyond the medial temporal lobe: Many actors on the memory stage","volume":"7","author":"Pergola","year":"2013","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"3","key":"10.1016\/j.cortex.2026.03.022_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac109","article-title":"Structural progression of Alzheimer's disease over decades: The MRI staging scheme","volume":"4","author":"Planche","year":"2022","journal-title":"Brain Communications"},{"issue":"8","key":"10.1016\/j.cortex.2026.03.022_bib44","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/brain\/awq154","article-title":"Measuring cognitive reserve based on the decomposition of episodic memory variance","volume":"133","author":"Reed","year":"2010","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.cortex.2026.03.022_bib45","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.neuroimage.2010.02.040","article-title":"Sparse logistic regression for whole-brain classification of fMRI data","volume":"51","author":"Ryali","year":"2010","journal-title":"NeuroImage"},{"issue":"16","key":"10.1016\/j.cortex.2026.03.022_bib46","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/WNR.0000000000001728","article-title":"Sex differences in the aging brain? A voxel-based morphometry analysis of the hippocampus and the amygdala","volume":"32","author":"Sambuco","year":"2021","journal-title":"NeuroReport"},{"key":"10.1016\/j.cortex.2026.03.022_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsycho.2023.108501","article-title":"Hippocampal and amygdala volumes vary with transdiagnostic psychopathological dimensions of distress, anxious arousal, and trauma","volume":"177","author":"Sambuco","year":"2023","journal-title":"Biological Psychology"},{"key":"10.1016\/j.cortex.2026.03.022_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cortex.2024.09.014","article-title":"Age- and task-setting-related performance predictions in prospective memory: Can metacognition explain the age-prospective memory paradox?","volume":"181","author":"Scarampi","year":"2024","journal-title":"Cortex"},{"key":"10.1016\/j.cortex.2026.03.022_bib49","first-page":"1","article-title":"A roadmap towards standardized neuroimaging approaches for human thalamic nuclei","author":"Segobin","year":"2024","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.cortex.2026.03.022_bib50","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer's disease: Advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurology"},{"issue":"2","key":"10.1016\/j.cortex.2026.03.022_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae046","article-title":"Dementia risk and thalamic nuclei volumetry in healthy midlife adults: The PREVENT Dementia study","volume":"6","author":"Shah","year":"2024","journal-title":"Brain Communications"},{"issue":"10","key":"10.1016\/j.cortex.2026.03.022_bib52","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.neuropsychologia.2009.03.004","article-title":"Cognitive reserve","volume":"47","author":"Stern","year":"2009","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.cortex.2026.03.022_bib53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neurobiolaging.2019.03.022","article-title":"Brain reserve, cognitive reserve, compensation, and maintenance: Operationalization, validity, and mechanisms of cognitive resilience","volume":"83","author":"Stern","year":"2019","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.cortex.2026.03.022_bib54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroimage.2019.03.021","article-title":"Thalamus optimized multi atlas segmentation (THOMAS): Fast, fully automated segmentation of thalamic nuclei from structural MRI","volume":"194","author":"Su","year":"2019","journal-title":"NeuroImage"},{"issue":"20","key":"10.1016\/j.cortex.2026.03.022_bib55","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1212\/WNL.0000000000000433","article-title":"Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS","volume":"82","author":"Sumowski","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.cortex.2026.03.022_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1287122","article-title":"Atrophy of hippocampal subfields relates to memory decline during the pathological progression of Alzheimer's disease","volume":"15","author":"Xiao","year":"2023","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"4","key":"10.1016\/j.cortex.2026.03.022_bib57","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-151010","article-title":"Prediction of progressive mild cognitive impairment by multi-modal neuroimaging biomarkers","volume":"51","author":"Xu","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"}],"container-title":["Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010945226001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010945226001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:20:47Z","timestamp":1783171247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010945226001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":57,"alternative-id":["S0010945226001140"],"URL":"https:\/\/doi.org\/10.1016\/j.cortex.2026.03.022","relation":{},"ISSN":["0010-9452"],"issn-type":[{"value":"0010-9452","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline brain volumes predict cognitive decline more robustly than atrophy rates: Evidence for brain reserve","name":"articletitle","label":"Article Title"},{"value":"Cortex","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cortex.2026.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}