{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:06:23Z","timestamp":1788977183250,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019438","name":"Nederlandse Hersenbank","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cortex"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cortex.2026.06.021","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:42:22Z","timestamp":1783060942000},"page":"97-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Symptomatic conversion in a case of sporadic frontotemporal dementia: Longitudinal neuroimaging of the presymptomatic stage"],"prefix":"10.1016","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9936-3472","authenticated-orcid":false,"given":"Willem Lucas","family":"Hartog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8410-5078","authenticated-orcid":false,"given":"Diederick M.","family":"de Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-7221","authenticated-orcid":false,"given":"Sterre C.M.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina L.","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-8090","authenticated-orcid":false,"given":"Ram\u03ccn","family":"Landin-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-7199","authenticated-orcid":false,"given":"Giorgio G.","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A.L.","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cortex.2026.06.021_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ebiom.2018.10.021","article-title":"Surgery, neuroinflammation and cognitive impairment","volume":"37","author":"Alam","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cortex.2026.06.021_bib2","series-title":"WMA Declaration of Helsinki - Ethical principles for medical research involving human subjects","year":"1964"},{"issue":"1","key":"10.1016\/j.cortex.2026.06.021_bib3","article-title":"Diagnostic accuracy of research criteria for prodromal frontotemporal dementia","volume":"16","author":"Benussi","year":"2024","journal-title":"Alzheimer\u2019s Research and Therapy"},{"issue":"2","key":"10.1016\/j.cortex.2026.06.021_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad061","article-title":"Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: Findings from the GENetic frontotemporal dementia initiative cohort","volume":"5","author":"Bocchetta","year":"2023","journal-title":"Brain Communications"},{"key":"10.1016\/j.cortex.2026.06.021_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2017.10.008","article-title":"Patterns of gray matter atrophy in genetic frontotemporal dementia: Results from the GENFI study","volume":"62","author":"Cash","year":"2018","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.cortex.2026.06.021_bib6","article-title":"Imaging biomarkers for neurodegeneration in presymptomatic familial frontotemporal lobar degeneration","volume":"11","author":"Chen","year":"2020","journal-title":"Frontiers in Neurology"},{"issue":"4","key":"10.1016\/j.cortex.2026.06.021_bib7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3233\/JAD-215127","article-title":"Investigating the roles of anterior cingulate in behavioral variant frontotemporal dementia: A PET\/MRI study","volume":"84","author":"Chu","year":"2021","journal-title":"Journal of Alzheimer \u2019s Disease"},{"issue":"11","key":"10.1016\/j.cortex.2026.06.021_bib8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1001\/archneur.63.11.1627","article-title":"Progression in frontotemporal dementia: Identifying a benign behavioral variant by magnetic resonance imaging","volume":"63","author":"Davies","year":"2006","journal-title":"Archives of Neurology"},{"issue":"8","key":"10.1016\/j.cortex.2026.06.021_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00234-009-0521-z","article-title":"Development of an MRI rating scale for multiple brain regions: Comparison with volumetrics and with voxel-based morphometry","volume":"51","author":"Davies","year":"2009","journal-title":"Neuroradiology"},{"issue":"3\u20134","key":"10.1016\/j.cortex.2026.06.021_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000369787","article-title":"Interactions between traumatic brain injury and frontotemporal degeneration","volume":"39","author":"Deutsch","year":"2015","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"1","key":"10.1016\/j.cortex.2026.06.021_bib11","article-title":"Distinct patterns of brain atrophy in genetic frontotemporal dementia initiative (GENFI) cohort revealed by visual rating scales","volume":"10","author":"Fumagalli","year":"2018","journal-title":"Alzheimer\u2019s Research and Therapy"},{"issue":"11","key":"10.1016\/j.cortex.2026.06.021_bib12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding neurodegeneration after traumatic brain injury: From mechanisms to clinical trials in dementia","volume":"90","author":"Graham","year":"2019","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"11","key":"10.1016\/j.cortex.2026.06.021_bib13","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/jnnp-2014-310090","article-title":"Using visual rating to diagnose dementia: A critical evaluation of MRI atrophy scales","volume":"86","author":"Harper","year":"2015","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"Pt 4","key":"10.1016\/j.cortex.2026.06.021_bib14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/brain\/aww005","article-title":"MRI visual rating scales in the diagnosis of dementia: Evaluation in 184 post-mortem confirmed cases","volume":"139","author":"Harper","year":"2016","journal-title":"Brain"},{"issue":"Suppl 1","key":"10.1016\/j.cortex.2026.06.021_bib15","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1017\/cjn.2016.25","article-title":"The prevalence and incidence of frontotemporal dementia: A systematic review","volume":"43","author":"Hogan","year":"2016","journal-title":"Canadian Journal of Neurological Science"},{"issue":"1","key":"10.1016\/j.cortex.2026.06.021_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/WCO.0000000000000767","article-title":"Update on posterior cortical atrophy","volume":"33","author":"Holden","year":"2020","journal-title":"Current Opinion in Neurology"},{"issue":"5609","key":"10.1016\/j.cortex.2026.06.021_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/bmj.3.5609.9","article-title":"Three cases of frontal meningiomas presenting psychiatrically","volume":"3","author":"Hunter","year":"1968","journal-title":"British Medical Journal"},{"issue":"1","key":"10.1016\/j.cortex.2026.06.021_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/brain\/awy288","article-title":"Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia","volume":"142","author":"Jiskoot","year":"2019","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.cortex.2026.06.021_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000100973","article-title":"Clinical significance of lobar atrophy in frontotemporal dementia: Application of an MRI visual rating scale","volume":"23","author":"Kipps","year":"2007","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"Pt 11","key":"10.1016\/j.cortex.2026.06.021_bib20","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awn234","article-title":"Development of methodology for conducting clinical trials in frontotemporal lobar degeneration","volume":"131","author":"Knopman","year":"2008","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.cortex.2026.06.021_bib21","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1007\/s00330-011-2205-4","article-title":"Visual assessment of posterior atrophy development of a MRI rating scale","volume":"21","author":"Koedam","year":"2011","journal-title":"European Radiology"},{"issue":"1","key":"10.1016\/j.cortex.2026.06.021_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000194658","article-title":"Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration","volume":"27","author":"Massimo","year":"2009","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"6","key":"10.1016\/j.cortex.2026.06.021_bib23","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s11682-022-00711-z","article-title":"Pre-symptomatic radiological changes in frontotemporal dementia: Propagation characteristics, predictive value and implications for clinical trials","volume":"16","author":"McKenna","year":"2022","journal-title":"Brain Imaging and Behavior"},{"issue":"2","key":"10.1016\/j.cortex.2026.06.021_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(19)30394-1","article-title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: An international retrospective cohort study","volume":"19","author":"Moore","year":"2020","journal-title":"Lancet Neurology"},{"issue":"2","key":"10.1016\/j.cortex.2026.06.021_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ncl.2017.01.008","article-title":"Frontotemporal dementia","volume":"35","author":"Olney","year":"2017","journal-title":"Neurologic Clinics"},{"key":"10.1016\/j.cortex.2026.06.021_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-3-030-51140-1_2","article-title":"The neuropsychiatric features of behavioral variant frontotemporal dementia","volume":"1281","author":"Peet","year":"2021","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"Pt 9","key":"10.1016\/j.cortex.2026.06.021_bib27","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.cortex.2026.06.021_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the genetic frontotemporal dementia initiative (GENFI) study: A cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurology"},{"issue":"Pt 11","key":"10.1016\/j.cortex.2026.06.021_bib29","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awh628","article-title":"Neuroanatomical correlates of behavioural disorders in dementia","volume":"128","author":"Rosen","year":"2005","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.cortex.2026.06.021_bib30","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","article-title":"Atrophy of medial temporal lobes on MRI in \"probable\" alzheimer's disease and normal ageing: dDagnostic value and neuropsychological correlates","volume":"55","author":"Scheltens","year":"1992","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"4","key":"10.1016\/j.cortex.2026.06.021_bib31","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/WAD.0b013e31815c0f14","article-title":"Divergent social functioning in behavioral variant frontotemporal dementia and alzheimer disease: Reciprocal networks and neuronal evolution","volume":"21","author":"Seeley","year":"2007","journal-title":"Alzheimer Disease and Associated Disorders"},{"issue":"10","key":"10.1016\/j.cortex.2026.06.021_bib32","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/archneurol.2011.3747","article-title":"Dementia resulting from traumatic brain injury: What is the pathology?","volume":"69","author":"Shively","year":"2012","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.cortex.2026.06.021_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cortex.2017.08.024","article-title":"Semantic dementia and the left and right temporal lobes","volume":"107","author":"Snowden","year":"2018","journal-title":"Cortex"},{"issue":"4","key":"10.1016\/j.cortex.2026.06.021_bib34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/jnnp.2005.075341","article-title":"Hippocampal atrophy on MRI in frontotemporal lobar degeneration and alzheimer's disease","volume":"77","author":"van de Pol","year":"2006","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"14","key":"10.1016\/j.cortex.2026.06.021_bib35","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1212\/01.wnl.0000277461.06713.23","article-title":"Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia","volume":"69","author":"Woolley","year":"2007","journal-title":"Neurology"}],"container-title":["Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010945226001802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010945226001802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:07:25Z","timestamp":1788973645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010945226001802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0010945226001802"],"URL":"https:\/\/doi.org\/10.1016\/j.cortex.2026.06.021","relation":{},"ISSN":["0010-9452"],"issn-type":[{"value":"0010-9452","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptomatic conversion in a case of sporadic frontotemporal dementia: Longitudinal neuroimaging of the presymptomatic stage","name":"articletitle","label":"Article Title"},{"value":"Cortex","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cortex.2026.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}