{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:46:40Z","timestamp":1791654400624,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Toxicology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.cotox.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T19:48:39Z","timestamp":1562269719000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Polychlorinated biphenyls and nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"14","author":[{"given":"Banrida","family":"Wahlang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiah E.","family":"Hardesty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Cameron","family":"Falkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Cave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cotox.2019.06.001_bib1","first-page":"283","article-title":"The problem of possible systemic effects from certain chlorinated hydrocarbons","volume":"19","author":"Drinker","year":"1937","journal-title":"J\u00a0Ind Hyg Toxicol"},{"key":"10.1016\/j.cotox.2019.06.001_bib2","first-page":"55","article-title":"Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects","volume":"38","author":"Maroni","year":"1981","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.cotox.2019.06.001_bib3","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1289\/ehp.1002720","article-title":"Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004","volume":"118","author":"Cave","year":"2010","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.cotox.2019.06.001_sref4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/toxsci\/kfy076","article-title":"Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures","volume":"164","author":"Clair","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0192623314549960","article-title":"Identification of environmental chemicals associated with the development of toxicant-associated fatty liver disease in rodents","volume":"43","author":"Al-Eryani","year":"2015","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.cotox.2019.06.001_bib6","series-title":"Fourth report on human exposure to environmental chemicals, updated tables","year":"2019"},{"key":"10.1016\/j.cotox.2019.06.001_bib7","first-page":"47","article-title":"PCBs: structure-function relationships and mechanism of action","volume":"60","author":"Safe","year":"1985","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.cotox.2019.06.001_bib8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.envpol.2018.07.039","article-title":"Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis","volume":"242","author":"Petriello","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.cotox.2019.06.001_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.scitotenv.2018.10.387","article-title":"Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease","volume":"653","author":"Chi","year":"2019","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.cotox.2019.06.001_sref10","first-page":"269","article-title":"Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis","volume":"166","author":"Cheng","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2019.03.011","article-title":"Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice","volume":"420","author":"Chi","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.cotox.2019.06.001_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.anaerobe.2018.11.008","article-title":"Environmental pollutant-mediated disruption of gut microbial metabolism of the prebiotic inulin","volume":"55","author":"Hoffman","year":"2019","journal-title":"Anaerobe"},{"key":"10.1016\/j.cotox.2019.06.001_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cotox.2019.06.001_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0192623312468517","article-title":"Toxicant-associated steatohepatitis","volume":"41","author":"Wahlang","year":"2013","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.cotox.2019.06.001_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.cotox.2019.06.001_sref16","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/toxsci\/kfy004","article-title":"Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals","volume":"162","author":"Hardesty","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_sref17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cellsig.2018.10.004","article-title":"Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis","volume":"53","author":"Hardesty","year":"2019","journal-title":"Cell Signal"},{"key":"10.1016\/j.cotox.2019.06.001_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2017.02.001","article-title":"A\u00a0compromised liver alters polychlorinated biphenyl-mediated toxicity","volume":"380","author":"Wahlang","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.cotox.2019.06.001_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.taap.2018.10.011","article-title":"Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: implications for nonalcoholic steatohepatitis and diabetes","volume":"363","author":"Shi","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cotox.2019.06.001_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/toxsci\/kfy041","article-title":"PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver","volume":"163","author":"Gadupudi","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/00498254.2016.1217572","article-title":"Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling","volume":"47","author":"Hardesty","year":"2017","journal-title":"Xenobiotica"},{"key":"10.1016\/j.cotox.2019.06.001_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.fct.2019.04.007","article-title":"Sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease","volume":"129","author":"Wahlang","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.cotox.2019.06.001_sref23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acs.jproteome.8b00886","article-title":"Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis","volume":"18","author":"Hardesty","year":"2019","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.cotox.2019.06.001_bib24","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jnutbio.2013.01.009","article-title":"Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6\/J mice","volume":"24","author":"Wahlang","year":"2013","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.cotox.2019.06.001_bib25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.taap.2014.06.019","article-title":"Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease","volume":"279","author":"Wahlang","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cotox.2019.06.001_bib26","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1021\/pr300297z","article-title":"Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease","volume":"11","author":"Shi","year":"2012","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.cotox.2019.06.001_bib27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.redox.2017.02.026","article-title":"Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS\/NF-kappaB signaling via downregulation of HNF1b","volume":"12","author":"Wu","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.cotox.2019.06.001_sref28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfx180","article-title":"PCB126 exposure increases risk for peripheral vascular diseases in a liver injury mouse model","volume":"160","author":"Wahlang","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/toxsci\/kfv215","article-title":"PCB126-Induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats","volume":"149","author":"Gadupudi","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tox.2017.09.005","article-title":"Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver","volume":"390","author":"Kania-Korwel","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.cotox.2019.06.001_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/toxsci\/kfw018","article-title":"Tipping the balance: hepatotoxicity and the four apical key events of hepatic steatosis","volume":"150","author":"Angrish","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib32","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbagrm.2016.03.002","article-title":"Nuclear receptors and nonalcoholic fatty liver disease","volume":"1859","author":"Cave","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cotox.2019.06.001_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/toxsci\/kfu083","article-title":"Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture","volume":"140","author":"Wahlang","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/toxsci\/kfv250","article-title":"Polychlorinated biphenyl-xenobiotic nuclear receptor interactions regulate energy metabolism, behavior, and inflammation in non-alcoholic-steatohepatitis","volume":"149","author":"Wahlang","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.cotox.2019.06.001_bib35","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/ijc.29504","article-title":"Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a meta-analysis of two highly exposed cohorts","volume":"137","author":"Li","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cotox.2019.06.001_bib36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3892\/mmr.2016.6046","article-title":"Noninfective occupational risk factors for hepatocellular carcinoma: a review (Review)","volume":"15","author":"Ledda","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.cotox.2019.06.001_bib37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1476-069X-13-114","article-title":"Potential effects of polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) on immune cells and blood biochemistry measures: a cross-sectional assessment of the NHANES 2003-2004 data","volume":"13","author":"Serdar","year":"2014","journal-title":"Environ Health"},{"key":"10.1016\/j.cotox.2019.06.001_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.envres.2014.07.023","article-title":"Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women","volume":"134","author":"Kumar","year":"2014","journal-title":"Environ Res"},{"key":"10.1016\/j.cotox.2019.06.001_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ijheh.2013.01.005","article-title":"Multiple classes of environmental chemicals are associated with liver disease: NHANES 2003-2004","volume":"216","author":"Yorita Christensen","year":"2013","journal-title":"Int J Hyg Environ Health"},{"key":"10.1016\/j.cotox.2019.06.001_bib40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1289\/ehp.1002848","article-title":"Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss","volume":"119","author":"Kim","year":"2011","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.cotox.2019.06.001_bib41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12940-015-0066-z","article-title":"Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study","volume":"14","author":"Rantakokko","year":"2015","journal-title":"Environ Health"},{"key":"10.1016\/j.cotox.2019.06.001_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chemosphere.2018.10.196","article-title":"Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction","volume":"217","author":"Deng","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cotox.2019.06.001_bib43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.envpol.2018.04.001","article-title":"PCBs-high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice","volume":"239","author":"Chi","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.cotox.2019.06.001_bib44","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1124\/dmd.115.064246","article-title":"Indole and tryptophan metabolism: endogenous and dietary routes to ah receptor activation","volume":"43","author":"Hubbard","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.cotox.2019.06.001_bib45","series-title":"Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: implications for aroclor mixtures","author":"Shi","year":"2019"},{"key":"10.1016\/j.cotox.2019.06.001_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2016.10.004","article-title":"Phosphorylation is a central mechanism for circadian control of metabolism and physiology","volume":"25","author":"Robles","year":"2017","journal-title":"Cell Metabol"},{"key":"10.1016\/j.cotox.2019.06.001_bib47","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M109.016808","article-title":"The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity","volume":"284","author":"Gao","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cotox.2019.06.001_bib48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gdata.2015.05.037","article-title":"Global gene expression changes in liver following hepatocyte nuclear factor 4 alpha deletion in adult mice","volume":"5","author":"Gunewardena","year":"2015","journal-title":"Genom Data"},{"key":"10.1016\/j.cotox.2019.06.001_bib49","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0026-895X(25)13040-X","article-title":"Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity","volume":"32","author":"Sunahara","year":"1987","journal-title":"Mol Pharmacol"}],"container-title":["Current Opinion in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468202019300282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468202019300282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:14:20Z","timestamp":1762838060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468202019300282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":49,"alternative-id":["S2468202019300282"],"URL":"https:\/\/doi.org\/10.1016\/j.cotox.2019.06.001","relation":{},"ISSN":["2468-2020"],"issn-type":[{"value":"2468-2020","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polychlorinated biphenyls and nonalcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cotox.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}