{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:43:18Z","timestamp":1790836998675,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R21 AI083984 and NIAID R01 AI76331"],"award-info":[{"award-number":["R21 AI083984 and NIAID R01 AI76331"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.coviro.2014.09.020","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T21:45:15Z","timestamp":1413582315000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":192,"special_numbering":"C","title":["Coupling of replication and assembly in flaviviruses"],"prefix":"10.1016","volume":"9","author":[{"given":"Swapna","family":"Apte-Sengupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Sirohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2014.09.020_bib0005","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20092545","article-title":"Antagonism of the complement component C4 by flavivirus nonstructural protein NS1","volume":"207","author":"Avirutnan","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.coviro.2014.09.020_bib0010","series-title":"Fields Virology","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2013"},{"key":"10.1016\/j.coviro.2014.09.020_bib0015","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1128\/JVI.00002-08","article-title":"Role of nonstructural protein NS2A in flavivirus assembly","volume":"82","author":"Leung","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0020","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1128\/JVI.02424-12","article-title":"Membrane topology and function of dengue virus NS2A protein","volume":"87","author":"Xie","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0025","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1128\/JVI.76.10.4773-4784.2002","article-title":"Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles","volume":"76","author":"K\u00fcmmerer","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0030","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1074\/jbc.M609919200","article-title":"The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner","volume":"282","author":"Miller","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coviro.2014.09.020_bib0035","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1128\/JVI.80.9.4623-4632.2006","article-title":"Regulated cleavages at the West Nile Virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein","volume":"80","author":"Roosendaal","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0040","doi-asserted-by":"crossref","first-page":"22147","DOI":"10.1074\/jbc.M110.192500","article-title":"Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication","volume":"286","author":"McLean","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coviro.2014.09.020_bib0045","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1128\/JVI.79.13.8004-8013.2005","article-title":"Inhibition of alpha\/beta interferon signaling by the NS4B protein of flaviviruses","volume":"79","author":"Mu\u00f1oz-Jord\u00e1n","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0050","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1099\/vir.0.81844-0","article-title":"Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA","volume":"87","author":"Umareddy","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0055","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1128\/JVI.00986-10","article-title":"The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex","volume":"84","author":"Gillespie","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0060","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1600-0854.2005.00339.x","article-title":"Wrapping things up about virus RNA replication","volume":"6","author":"Mackenzie","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.coviro.2014.09.020_bib0065","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1128\/JVI.71.9.6650-6661.1997","article-title":"Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures","volume":"71","author":"Westaway","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","article-title":"Composition three-dimensional architecture of the dengue virus replication and assembly sites","volume":"5","author":"Welsch","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0075","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1128\/JVI.00118-14","article-title":"Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells","volume":"88","author":"Junjhon","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0080","doi-asserted-by":"crossref","first-page":"e47912","DOI":"10.1371\/journal.pone.0047912","article-title":"A three-dimensional comparison of tick-borne flavivirus infection in mammalian and tick cell lines","volume":"7","author":"Offerdahl","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_bib0085","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature04396","article-title":"Membrane curvature and mechanisms of dynamic cell membrane remodelling","volume":"438","author":"McMahon","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2014.09.020_bib0090","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1600-0854.2003.00086.x","article-title":"Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid","volume":"4","author":"Kooijman","year":"2003","journal-title":"Traffic"},{"key":"10.1016\/j.coviro.2014.09.020_bib0095","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.bbamem.2008.03.007","article-title":"How lipid flippases can modulate membrane structure","volume":"1778","author":"Devaux","year":"2008","journal-title":"Biochem Biophys Acta (BBA): Biomembr"},{"key":"10.1016\/j.coviro.2014.09.020_bib0100","doi-asserted-by":"crossref","first-page":"e84040","DOI":"10.1371\/journal.pone.0084040","article-title":"Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile Virus non-structural protein 4B","volume":"9","author":"Kaufusi","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_bib0105","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1128\/JVI.01900-12","article-title":"An N-terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication","volume":"87","author":"Stern","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0110","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1128\/JVI.01249-13","article-title":"Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein","volume":"88","author":"Teo","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0115","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1247749","article-title":"Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system","volume":"343","author":"Akey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.coviro.2014.09.020_bib0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/viro.1996.0307","article-title":"Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication","volume":"220","author":"Mackenzie","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/viro.1998.9156","article-title":"Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A","volume":"245","author":"Mackenzie","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.chom.2007.09.003","article-title":"Cholesterol manipulation by West Nile Virus perturbs the cellular immune response","volume":"2","author":"Mackenzie","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2014.09.020_bib0135","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1128\/JVI.75.20.9633-9643.2001","article-title":"Mutagenesis of the dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication","volume":"75","author":"Matusan","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0140","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.virol.2013.08.006","article-title":"Protein\u2013protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells","volume":"446","author":"Yu","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0145","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1128\/JVI.00157-12","article-title":"Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile Virus","volume":"86","author":"Youn","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0150","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/JVI.73.6.4611-4621.1999","article-title":"Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function","volume":"73","author":"Lindenbach","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0155","doi-asserted-by":"crossref","first-page":"11815","DOI":"10.1128\/JVI.01022-12","article-title":"Flavivirus replication complex assembly revealed by DNAJC14 functional mapping","volume":"86","author":"Yi","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0160","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.febslet.2011.06.038","article-title":"RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins","volume":"585","author":"Pong","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.coviro.2014.09.020_bib0165","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1128\/JVI.00940-14","article-title":"Maintenance of dimer conformation by the dengue virus core protein \u03b14\u2013\u03b14\u2032 helix pair is critical for nucleocapsid formation and virus production","volume":"88","author":"Teoh","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0170","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1128\/JVI.75.10.4633-4640.2001","article-title":"Coupling between replication and packaging of flavivirus RNA: evidence derived from the use of DNA-based full-length cDNA clones of Kunjin virus","volume":"75","author":"Khromykh","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0175","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/JVI.05937-11","article-title":"Complex dynamic development of poliovirus membranous replication complexes","volume":"86","author":"Belov","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0180","first-page":"2","article-title":"The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments","author":"Limpens","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.coviro.2014.09.020_bib0185","doi-asserted-by":"crossref","first-page":"e1003056","DOI":"10.1371\/journal.ppat.1003056","article-title":"Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication","volume":"8","author":"Romero-Brey","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2014.09.020_bib0190","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1128\/JVI.73.8.6257-6264.1999","article-title":"Membrane permeabilization by small hydrophobic nonstructural proteins of Japanese encephalitis virus","volume":"73","author":"Chang","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0195","doi-asserted-by":"crossref","first-page":"e1000632","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2014.09.020_bib0200","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00705-009-0350-8","article-title":"In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virus","volume":"154","author":"L\u00f3pez","year":"2009","journal-title":"Arch Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0205","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1128\/JVI.78.15.8078-8084.2004","article-title":"Isolation of capsid protein dimers from the tick-borne encephalitis flavivirus and in vitro assembly of capsid-like particles","volume":"78","author":"Kiermayr","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nsmb.2463","article-title":"Cryo-EM structure of the mature dengue virus at 3.5-\u00c5 resolution","volume":"20","author":"Zhang","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0215","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1089316","article-title":"Structure of West Nile virus","volume":"302","author":"Mukhopadhyay","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.coviro.2014.09.020_bib0220","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","article-title":"Structure of dengue virus: implications for flavivirus organization, maturation, and fusion","volume":"108","author":"Kuhn","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.coviro.2014.09.020_bib0225","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1128\/JVI.70.7.4549-4557.1996","article-title":"Recombinant subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope glycoprotein functions","volume":"70","author":"Schalich","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0230","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/JVI.74.1.24-32.2000","article-title":"Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage in vitro is lethal for virus production","volume":"74","author":"Lee","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0235","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/JVI.78.1.178-186.2004","article-title":"Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes","volume":"78","author":"Lobigs","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0240","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virol.2010.02.008","article-title":"A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis","volume":"401","author":"Lobigs","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0245","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.coviro.2012.02.011","article-title":"Degrees of maturity: the complex structure and biology of flaviviruses","volume":"2","author":"Pierson","year":"2012","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0250","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tim.2011.02.002","article-title":"Partial maturation: an immune-evasion strategy of dengue virus?","volume":"19","author":"Rodenhuis-Zybert","year":"2011","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0255","doi-asserted-by":"crossref","first-page":"e38202","DOI":"10.1371\/journal.pone.0038202","article-title":"Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway","volume":"7","author":"Pe\u00f1a","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0260","doi-asserted-by":"crossref","first-page":"17345","DOI":"10.1073\/pnas.1010811107","article-title":"Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis","volume":"107","author":"Heaton","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2014.09.020_bib0265","doi-asserted-by":"crossref","first-page":"6793","DOI":"10.1128\/JVI.00045-14","article-title":"Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication","volume":"88","author":"Tang","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0270","doi-asserted-by":"crossref","first-page":"e24970","DOI":"10.1371\/journal.pone.0024970","article-title":"West Nile Virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids","volume":"6","author":"Mart\u00edn-Acebes","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_bib0275","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.chom.2010.10.006","article-title":"Dengue virus-induced autophagy regulates lipid metabolism","volume":"8","author":"Heaton","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2014.09.020_sbref0280","doi-asserted-by":"crossref","first-page":"e1002584","DOI":"10.1371\/journal.ppat.1002584","article-title":"Dengue virus infection perturbs lipid homeostasis in infected mosquito cells","volume":"8","author":"Perera","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2014.09.020_bib0285","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1471-4159.2010.06951.x","article-title":"Critical role of lipid rafts in virus entry and activation of phosphoinositide 3\u2032 kinase\/Akt signaling during early stages of Japanese encephalitis virus infection in neural stem\/progenitor cells","volume":"115","author":"Das","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.coviro.2014.09.020_bib0290","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.virol.2013.04.003","article-title":"The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity","volume":"442","author":"Soto-Acosta","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0295","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1128\/JVI.01399-12","article-title":"Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism","volume":"87","author":"Kalia","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0300","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1128\/JVI.00008-08","article-title":"West Nile Virus entry requires cholesterol-rich membrane microdomains and is independent of \u03b1v\u03b23 integrin","volume":"82","author":"Medigeshi","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1099\/vir.0.034637-0","article-title":"Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells","volume":"93","author":"Zhu","year":"2012","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0310","doi-asserted-by":"crossref","first-page":"e1001131","DOI":"10.1371\/journal.ppat.1001131","article-title":"Dengue virus ensures its fusion in late endosomes using compartment-specific lipids","volume":"6","author":"Zaitseva","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2014.09.020_bib0315","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virol.2009.03.025","article-title":"Cholesterol biosynthesis modulation regulates dengue viral replication","volume":"389","author":"Rothwell","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0320","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1128\/JVI.00117-08","article-title":"Cholesterol effectively blocks entry of flavivirus","volume":"82","author":"Lee","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0325","doi-asserted-by":"crossref","first-page":"e28741","DOI":"10.1371\/journal.pone.0087412","article-title":"Lovastatin delays infection and increases survival rates in AG129 mice infected with dengue virus serotype 2","volume":"9","author":"Martinez-Gutierrez","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_bib0330","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1128\/JVI.02499-09","article-title":"Involvement of ceramide in the propagation of Japanese encephalitis virus","volume":"84","author":"Tani","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0335","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02061-14","article-title":"The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism on flavivirus biogenesis","author":"Mart\u00edn-Acebes","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0340","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/JVI.01788-07","article-title":"Crystal structure of the NS3 protease-helicase from dengue virus","volume":"82","author":"Luo","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0345","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/emboj\/21.11.2757","article-title":"An RNA cap (nucleoside-2\u2032-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization","volume":"21","author":"Egloff","year":"2002","journal-title":"EMBO"},{"key":"10.1016\/j.coviro.2014.09.020_bib0350","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1128\/JVI.02283-06","article-title":"Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-Angstrom resolution","volume":"81","author":"Yap","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0355","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.virol.2011.09.007","article-title":"Analyses of mutations selected by passaging a chimeric flavivirus identify mutations that alter infectivity and reveal an interaction between the structural proteins and the nonstructural glycoprotein NS1","volume":"421","author":"Winkelmann","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0360","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1128\/JVI.77.14.7804-7813.2003","article-title":"Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential roles for NS2A in virus assembly and for a nonconservative residue in NS3 in RNA replication","volume":"77","author":"Liu","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0365","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1128\/JVI.74.7.3253-3263.2000","article-title":"Cis- and trans-acting elements in flavivirus RNA replication","volume":"74","author":"Khromykh","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0370","doi-asserted-by":"crossref","first-page":"10766","DOI":"10.1128\/JVI.76.21.10766-10775.2002","article-title":"Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly","volume":"76","author":"Liu","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0375","doi-asserted-by":"crossref","first-page":"11255","DOI":"10.1128\/JVI.01559-06","article-title":"Translation of the flavivirus Kunjin NS3 gene in cis but not its RNA sequence or secondary structure is essential for efficient RNA packaging","volume":"80","author":"Pijlman","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0380","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2004.10.034","article-title":"Construction and applications of yellow fever virus replicons","volume":"331","author":"Jones","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0385","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1128\/JVI.02447-07","article-title":"Yellow fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions","volume":"82","author":"Patkar","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0390","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.micinf.2010.10.010","article-title":"Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles","volume":"13","author":"Carpp","year":"2011","journal-title":"Microbes Infect"},{"key":"10.1016\/j.coviro.2014.09.020_bib0395","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1128\/JVI.01933-10","article-title":"The capsid-binding nucleolar helicase DDX56 is important for infectivity of West Nile Virus","volume":"85","author":"Xu","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0400","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.virol.2012.08.011","article-title":"The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles","volume":"433","author":"Xu","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2014.09.020_bib0405","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1128\/JVI.00704-13","article-title":"Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles","volume":"87","author":"Balinsky","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2014.09.020_bib0410","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2011.11.014","article-title":"U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication","volume":"93","author":"Poh","year":"2012","journal-title":"Antiviral Res"},{"key":"10.1016\/j.coviro.2014.09.020_bib0415","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.virusres.2013.03.005","article-title":"Requirement of cholesterol in the viral envelope for dengue virus infection","volume":"174","author":"Carro","year":"2013","journal-title":"Virus Res"},{"key":"10.1016\/j.coviro.2014.09.020_bib0420","doi-asserted-by":"crossref","first-page":"e62324","DOI":"10.1371\/journal.pone.0023246","article-title":"The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly","volume":"6","author":"Anwar","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.coviro.2014.09.020_bib0425","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1128\/JVI.02177-12","article-title":"Inhibition of cellular autophagy deranges dengue virion maturation","volume":"87","author":"Mateo","year":"2013","journal-title":"J Virol"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625714002028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625714002028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T18:48:44Z","timestamp":1598381324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625714002028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":85,"alternative-id":["S1879625714002028"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2014.09.020","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coupling of replication and assembly in flaviviruses","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2014.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}