{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:59:18Z","timestamp":1790888358100,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["G1000758"],"award-info":[{"award-number":["G1000758"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Predicta FP7 Collaborative Project","award":["260895"],"award-info":[{"award-number":["260895"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.coviro.2015.03.004","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T07:12:06Z","timestamp":1427613126000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Challenges in developing a cross-serotype rhinovirus vaccine"],"prefix":"10.1016","volume":"11","author":[{"given":"Nicholas","family":"Glanville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian L","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2015.03.004_bib0245","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1081-1206(10)63213-9","article-title":"Epidemiology, pathogenesis, and treatment of the common cold","volume":"78","author":"Turner","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0250","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1164\/rccm.200412-1621OC","article-title":"Interleukin-10 gene expression in acute virus-induced asthma","volume":"172","author":"Grissell","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0255","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1164\/rccm.200506-859OC","article-title":"Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations","volume":"173","author":"Papi","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0260","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.micinf.2011.12.011","article-title":"Clinical and molecular features of human rhinovirus C","volume":"14","author":"Bochkov","year":"2012","journal-title":"Microbes Infect"},{"key":"10.1016\/j.coviro.2015.03.004_bib0265","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0270","first-page":"281","article-title":"Studies on some viruses (Rhinoviruses) isolated from common colds","volume":"13","author":"Taylor-Robinson","year":"1963","journal-title":"Arch Virol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0275","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI104894","article-title":"Studies with rhinoviruses in volunteers: production of illness, effect of naturallly acquired antibody, and demonstration of a protective effect not associated with serum antibody","volume":"43","author":"Cate","year":"1964","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coviro.2015.03.004_bib0280","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/00005537-199610000-00025","article-title":"Prechallenge antibodies: moderators of infection rate, signs, and symptoms in adults experimentally challenged with rhinovirus type 39","volume":"106","author":"Alper","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.coviro.2015.03.004_bib0285","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1017\/S095026880003106X","article-title":"The time course of the humoral immune response to rhinovirus infection","volume":"103","author":"Barclay","year":"1989","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.coviro.2015.03.004_bib0290","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trivac.2014.02.003","article-title":"Prophylactic antibody treatment and intramuscular immunization reduce infectious human rhinovirus 16 load in the lower respiratory tract of challenged cotton rats","volume":"3","author":"Blanco","year":"2014","journal-title":"Trials Vaccinol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0295","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaci.2014.03.014","article-title":"Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection","volume":"134","author":"Iwasaki","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.coviro.2015.03.004_sbref0300","doi-asserted-by":"crossref","first-page":"e70552","DOI":"10.1371\/journal.pone.0070552","article-title":"Species-specific and cross-reactive IgG1 antibody binding to viral capsid protein 1 (VP1) antigens of human rhinovirus species A, B and C","volume":"8","author":"Iwasaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.coviro.2015.03.004_bib0305","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.virol.2012.11.002","article-title":"Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells","volume":"436","author":"Ashraf","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2015.03.004_bib0310","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nm.2358","article-title":"Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C","volume":"17","author":"Bochkov","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0315","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1136\/bmj.1.5446.1344","article-title":"Prevention of colds by vaccination against a rhinovirus: a report by the scientific committee on common cold vaccines","volume":"1","author":"Mitchison","year":"1965","journal-title":"Br Med J"},{"key":"10.1016\/j.coviro.2015.03.004_bib0320","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/oxfordjournals.aje.a121076","article-title":"Evidence for protective effect of an inactivated rhinovirus vaccine administered by the nasal route","volume":"90","author":"Perkins","year":"1969","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0325","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4049\/jimmunol.108.1.169","article-title":"Further characterization of the local respiratory tract antibody response induced by intranasal instillation of inactivated rhinovirus 13 vaccine","volume":"108","author":"Buscho","year":"1972","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0330","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/213761a0","article-title":"Rhinoviruses: a numbering system","volume":"213","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2015.03.004_bib0335","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0042-6822(87)90367-9","article-title":"A collaborative report: rhinoviruses\u2014extension of the numbering system from 89 to 100","volume":"159","author":"Hamparian","year":"1987","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2015.03.004_bib0340","doi-asserted-by":"crossref","first-page":"pe88981","DOI":"10.1371\/journal.pone.0088981","article-title":"Population structure and evolution of Rhinoviruses","volume":"9","author":"Waman","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.coviro.2015.03.004_bib0345","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1165557","article-title":"Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution","volume":"324","author":"Palmenberg","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.coviro.2015.03.004_bib0350","doi-asserted-by":"crossref","first-page":"pe966","DOI":"10.1371\/journal.pone.0000966","article-title":"A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.coviro.2015.03.004_bib0355","first-page":"1","article-title":"Molecular epidemiology of rhinoviruses in Cyprus over three consecutive seasons","author":"Richter","year":"2014","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.coviro.2015.03.004_bib0360","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcv.2014.11.006","article-title":"Molecular epidemiology of human rhinovirus infections in the pediatric emergency department","volume":"62","author":"Martin","year":"2015","journal-title":"J Clin Virol"},{"issue":"Pt 1","key":"10.1016\/j.coviro.2015.03.004_bib0365","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4049\/jimmunol.114.2_Part_1.635","article-title":"Broad antigenic relationships among rhinovirus serotypes revealed by cross-immunization of rabbits with different serotypes","volume":"114","author":"Cooney","year":"1975","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0370","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/IAI.7.3.335-340.1973","article-title":"Cross relationships among 37 rhinoviruses demonstrated by virus neutralization with potent monotypic rabbit antisera","volume":"7","author":"Cooney","year":"1973","journal-title":"Infect Immun"},{"key":"10.1016\/j.coviro.2015.03.004_bib0375","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/infdis\/132.6.623","article-title":"Human responses to two decavalent rhinovirus vaccines","volume":"132","author":"Hamory","year":"1975","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2015.03.004_bib0380","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/bmj.1.5322.34","article-title":"Some attempts to produce an experimental vaccine with rhinoviruses","volume":"1","author":"Doggett","year":"1963","journal-title":"Br Med J"},{"key":"10.1016\/j.coviro.2015.03.004_bib0385","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/oxfordjournals.aje.a120543","article-title":"Homologous and heterologous resistance to rhinovirus common cold","volume":"82","author":"Fleet","year":"1965","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0390","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.antiviral.2012.06.006","article-title":"Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1","volume":"95","author":"McLean","year":"2012","journal-title":"Antiviral Res"},{"key":"10.1016\/j.coviro.2015.03.004_bib0395","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1128\/JVI.57.1.246-257.1986","article-title":"Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14","volume":"57","author":"Sherry","year":"1986","journal-title":"J Virol"},{"issue":"Pt 6","key":"10.1016\/j.coviro.2015.03.004_bib0400","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1099\/0022-1317-71-6-1275","article-title":"Neutralization epitopes of human rhinovirus type 2","volume":"71","author":"Appleyard","year":"1990","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2015.03.004_sbref0405","doi-asserted-by":"crossref","first-page":"e1003669","DOI":"10.1371\/journal.ppat.1003669","article-title":"Cross-serotype immunity induced by immunization with a conserved rhinovirus capsid protein","volume":"9","author":"Glanville","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2015.03.004_sbref0410","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1096\/fj.11-193557","article-title":"Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections","volume":"26","author":"Niespodziana","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.coviro.2015.03.004_bib0415","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1183\/09031936.00149109","article-title":"Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation","volume":"37","author":"Edlmayr","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.coviro.2015.03.004_bib0420","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/329736a0","article-title":"Different rhinovirus serotypes neutralized by antipeptide antibodies","volume":"329","author":"McCray","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2015.03.004_bib0425","doi-asserted-by":"crossref","first-page":"70408","DOI":"10.1128\/JVI.00557-09","article-title":"Antibodies to the buried N terminus of rhinovirus VP4 exhibit cross-serotypic neutralization","volume":"83","author":"Katpally","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0430","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/329668a0","article-title":"Antipeptide antibodies. A vaccine for the common cold?","volume":"329","author":"Palmenberg","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2015.03.004_bib0435","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1086\/516449","article-title":"Rhinovirus-specific T cells recognize both shared and serotype-restricted viral epitopes","volume":"175","author":"Gern","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2015.03.004_bib0440","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1002\/eji.1830230937","article-title":"Epitope analysis of the T cell response to a complex antigen: proliferative responses to human rhinovirus capsids","volume":"23","author":"Hastings","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.coviro.2015.03.004_bib0445","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nm.2612","article-title":"Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans","volume":"18","author":"Wilkinson","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2015.03.004_sbref0450","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular immune correlates of protection against symptomatic pandemic influenza","volume":"19","author":"Sridhar","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0455","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nm1713","article-title":"Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation","volume":"14","author":"Bartlett","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0460","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.0804181105","article-title":"Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1\/2 cytokine and IL-10 production","volume":"105","author":"Message","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2015.03.004_bib0465","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type III interferon-lambda production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0470","doi-asserted-by":"crossref","first-page":"256ra134","DOI":"10.1126\/scitranslmed.3009124","article-title":"Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation","volume":"6","author":"Beale","year":"2014","journal-title":"Sci Transl Med"},{"issue":"12","key":"10.1016\/j.coviro.2015.03.004_bib0475","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.coviro.2015.03.004_bib0480","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1164\/rccm.201006-0833OC","article-title":"Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation","volume":"183","author":"Mallia","year":"2011","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625715000358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625715000358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T22:14:18Z","timestamp":1691532858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625715000358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":48,"alternative-id":["S1879625715000358"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2015.03.004","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Challenges in developing a cross-serotype rhinovirus vaccine","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2015.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}