{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:12:49Z","timestamp":1791339169187,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.coviro.2016.08.010","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T21:15:55Z","timestamp":1472850955000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Epstein Barr virus \u2014 a tumor virus that needs cytotoxic lymphocytes to persist asymptomatically"],"prefix":"10.1016","volume":"20","author":[{"given":"Christian","family":"M\u00fcnz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2016.08.010_bib0240","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","article-title":"Virus particles in cultured lymphoblasts from Burkitt's lymphoma","volume":"1","author":"Epstein","year":"1964","journal-title":"Lancet"},{"key":"10.1016\/j.coviro.2016.08.010_bib0245","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-pathol-012513-104656","article-title":"Gammaherpesviruses and lymphoproliferative disorders","volume":"9","author":"Cesarman","year":"2014","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0250","doi-asserted-by":"crossref","first-page":"107fs107","DOI":"10.1126\/scitranslmed.3002878","article-title":"Epstein-Barr virus: an important vaccine target for cancer prevention","volume":"3","author":"Cohen","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coviro.2016.08.010_bib0255","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1128\/JVI.00497-06","article-title":"Epstein-Barr virus shed in saliva is high in B-cell-tropic glycoprotein gp42","volume":"80","author":"Jiang","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0260","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1369\/jhc.4A6339.2004","article-title":"Expression and function of tight junctions in the crypt epithelium of human palatine tonsils","volume":"52","author":"Go","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.coviro.2016.08.010_bib0265","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1074-7613(00)00049-2","article-title":"The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell","volume":"13","author":"Babcock","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.coviro.2016.08.010_bib0270","first-page":"61","article-title":"The EBNA3 family: two oncoproteins and a tumour suppressor that are central to the biology of EBV in B cells","volume":"391","author":"Allday","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0275","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","article-title":"EBV persistence in memory B cells in vivo","volume":"9","author":"Babcock","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.coviro.2016.08.010_bib0280","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1073\/pnas.2237267100","article-title":"Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo","volume":"101","author":"Hochberg","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2016.08.010_bib0285","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1128\/JVI.79.2.1296-1307.2005","article-title":"Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo","volume":"79","author":"Laichalk","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0290","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nm830","article-title":"Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells","volume":"9","author":"Tugizov","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0295","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1084\/jem.20160120","article-title":"Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells","volume":"213","author":"Kalchschmidt","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.coviro.2016.08.010_bib0300","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/ACI.0000000000000011","article-title":"Inborn errors of the development of human natural killer cells","volume":"13","author":"Jouanguy","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0305","first-page":"241","article-title":"Primary immunodeficiencies associated with EBV disease","volume":"390","author":"Cohen","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0310","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1182\/blood-2003-06-2171","article-title":"Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation","volume":"103","author":"Katano","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0080","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3324\/haematol.2010.029389","article-title":"Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases","volume":"95","author":"Rohr","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.coviro.2016.08.010_bib0315","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJM198906293202605","article-title":"Severe herpesvirus infections in an adolescent without natural killer cells","volume":"320","author":"Biron","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2016.08.010_bib0320","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1182\/blood-2012-09-453969","article-title":"Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset","volume":"121","author":"Mace","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_bib0325","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/bjh.13317","article-title":"Haematopoietic and immune defects associated with GATA2 mutation","volume":"169","author":"Collin","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0330","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2011-05-356352","article-title":"Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome","volume":"118","author":"Hsu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_bib0335","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood-2013-07-515528","article-title":"GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity","volume":"123","author":"Spinner","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_bib0340","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI61014","article-title":"Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency","volume":"122","author":"Gineau","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0345","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1240094","article-title":"Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D","volume":"341","author":"Chaigne-Delalande","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.coviro.2016.08.010_bib0350","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/2424","article-title":"Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene","volume":"20","author":"Coffey","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.coviro.2016.08.010_bib0355","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1073\/pnas.95.23.13765","article-title":"Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome","volume":"95","author":"Nichols","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2016.08.010_bib0360","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/26683","article-title":"The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM","volume":"395","author":"Sayos","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2016.08.010_bib0365","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(75)90651-0","article-title":"Letter: Monucleosis-associated subacute sclerosing panencephalitis","volume":"2","author":"Purtilo","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.coviro.2016.08.010_bib0370","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1182\/blood-2004-08-3269","article-title":"SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells","volume":"105","author":"Dupre","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_bib0375","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/90615","article-title":"Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product","volume":"2","author":"Latour","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0380","doi-asserted-by":"crossref","first-page":"e1001187","DOI":"10.1371\/journal.pbio.1001187","article-title":"Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP","volume":"9","author":"Palendira","year":"2011","journal-title":"PLoS Biol"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0155","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1084\/jem.20112391","article-title":"Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus","volume":"209","author":"Palendira","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.coviro.2016.08.010_bib0385","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiv114","article-title":"The SAP-dependent 2B4 receptor mediates CD8+ T cell dependent immune control of Epstein Barr virus infection in mice with reconstituted human immune system components","author":"Chijioke","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2016.08.010_bib0390","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/274756a0","article-title":"Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study","volume":"274","author":"de-The","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2016.08.010_bib0395","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/infdis\/jis646","article-title":"Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary epstein-barr virus infection in university students","volume":"207","author":"Balfour","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2016.08.010_bib0400","first-page":"211","article-title":"Infectious Mononucleosis","volume":"390","author":"Dunmire","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0405","doi-asserted-by":"crossref","first-page":"e1005286","DOI":"10.1371\/journal.ppat.1005286","article-title":"The incubation period of primary Epstein-Barr virus infection: viral dynamics and immunologic events","volume":"11","author":"Dunmire","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.08.010_bib0410","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1056\/NEJMoa023141","article-title":"Characteristics of Hodgkin's lymphoma after infectious mononucleosis","volume":"349","author":"Hjalgrim","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2016.08.010_bib0415","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1172\/JCI32377","article-title":"HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection","volume":"117","author":"McAulay","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.coviro.2016.08.010_bib0420","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1158\/1055-9965.EPI-06-0476","article-title":"The human leukocyte antigen class I region is associated with EBV-positive Hodgkin's lymphoma: HLA-A and HLA complex group 9 are putative candidate genes","volume":"15","author":"Niens","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.coviro.2016.08.010_bib0425","doi-asserted-by":"crossref","first-page":"e1004746","DOI":"10.1371\/journal.ppat.1004746","article-title":"Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children","volume":"11","author":"Jayasooriya","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.08.010_bib0430","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-3083.2007.01980.x","article-title":"The expression of human natural killer cell receptors in early life","volume":"66","author":"Sundstrom","year":"2007","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0435","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1182\/blood-2014-01-553024","article-title":"Role for early-differentiated natural killer cells in infectious mononucleosis","volume":"124","author":"Azzi","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_bib0440","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2141.2005.05452.x","article-title":"The immune response to primary EBV infection: a role for natural killer cells","volume":"129","author":"Williams","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0445","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.4049\/jimmunol.1303211","article-title":"Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus","volume":"192","author":"Hendricks","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0450","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/JVI.01777-06","article-title":"The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing","volume":"81","author":"Pappworth","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.08.010_bib0455","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1182\/blood-2010-02-270678","article-title":"Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence","volume":"116","author":"Strowig","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.coviro.2016.08.010_sbref0460","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.celrep.2013.11.041","article-title":"Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection","volume":"5","author":"Chijioke","year":"2013","journal-title":"Cell Rep"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625716301067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625716301067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T16:56:01Z","timestamp":1536425761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625716301067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":47,"alternative-id":["S1879625716301067"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2016.08.010","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epstein Barr virus \u2014 a tumor virus that needs cytotoxic lymphocytes to persist asymptomatically","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2016.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}