{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:43:44Z","timestamp":1789947824313,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002749","name":"BELSPO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IUAP-project BELVIR"},{"DOI":"10.13039\/501100000654","name":"Marie Curie COFUND William Harvey International Translational Research Academy","doi-asserted-by":"publisher","award":["WHRI-ACADEMY #343"],"award-info":[{"award-number":["WHRI-ACADEMY #343"]}],"id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002913","name":"Scientific Fund for Research of Flanders (FWO)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.coviro.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T04:33:12Z","timestamp":1476160392000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Norovirus genetic diversity and evolution: implications for antiviral therapy"],"prefix":"10.1016","volume":"20","author":[{"given":"Joana","family":"Rocha-Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Van Dycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2016.09.009_bib0380","doi-asserted-by":"crossref","first-page":"e0142927","DOI":"10.1371\/journal.pone.0142927","article-title":"Aetiology-specific estimates of the global and regional incidence and mortality of diarrhoeal diseases commonly transmitted through food","volume":"10","author":"Pires","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0385","doi-asserted-by":"crossref","first-page":"e0151219","DOI":"10.1371\/journal.pone.0151219","article-title":"Global economic burden of norovirus gastroenteritis","volume":"11","author":"Bartsch","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.coviro.2016.09.009_bib0390","first-page":"12","article-title":"World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010: a data synthesis","author":"Kirk","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0395","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11908-016-0524-y","article-title":"Norovirus in transplantation","volume":"18","author":"Angarone","year":"2016","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.coviro.2016.09.009_bib0400","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1086\/605557","article-title":"Allogeneic hematopoietic stem cell transplantation and norovirus gastroenteritis: a previously unrecognized cause of morbidity","volume":"49","author":"Roddie","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0405","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/TP.0b013e31821c9392","article-title":"Impact of norovirus\/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea","volume":"92","author":"Roos-Weil","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.coviro.2016.09.009_bib0410","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1399-3046.2011.01500.x","article-title":"Chronic norovirus infection in pediatric hematopoietic stem cell transplant recipients: a cause of prolonged intestinal failure requiring intensive nutritional support","volume":"15","author":"Saif","year":"2011","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.coviro.2016.09.009_bib0415","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1086\/653939","article-title":"Chronic norovirus infection after kidney transplantation: molecular evidence for immune-driven viral evolution","volume":"51","author":"Schorn","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0420","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/JCM.02680-13","article-title":"Genotypic and epidemiologic trends of norovirus outbreaks in the United States, 2009 to 2013","volume":"52","author":"Vega","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0425","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coviro.2011.11.005","article-title":"Environmental transmission of norovirus gastroenteritis","volume":"2","author":"Lopman","year":"2012","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0430","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1086\/591627","article-title":"High prevalence of prolonged norovirus shedding and illness among hospitalized patients: a model for in vivo molecular evolution","volume":"198","author":"Siebenga","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0435","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jmv.21237","article-title":"Norwalk virus: how infectious is it?","volume":"80","author":"Teunis","year":"2008","journal-title":"J Med Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0440","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1365-2036.2006.03128.x","article-title":"Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial","volume":"24","author":"Rossignol","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.coviro.2016.09.009_bib0445","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jinf.2011.08.002","article-title":"Norovirus gastroenteritis successfully treated with nitazoxanide","volume":"63","author":"Siddiq","year":"2011","journal-title":"J Infect"},{"key":"10.1016\/j.coviro.2016.09.009_bib0450","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ajg.2014.432","article-title":"The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency","volume":"110","author":"Woodward","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0455","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1128\/JVI.00783-07","article-title":"Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence","volume":"81","author":"Thackray","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0460","doi-asserted-by":"crossref","first-page":"e1002413","DOI":"10.1371\/journal.ppat.1002413","article-title":"Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4","volume":"7","author":"McFadden","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.09.009_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000348","article-title":"Norovirus\u2013host interaction: implications for disease control and prevention","volume":"9","author":"Tan","year":"2007","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.coviro.2016.09.009_bib0470","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1128\/JVI.03508-12","article-title":"Norwalk virus minor capsid protein VP2 associates within the VP1 shell domain","volume":"87","author":"Vongpunsawad","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0475","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00705-013-1708-5","article-title":"Proposal for a unified norovirus nomenclature and genotyping","volume":"158","author":"Kroneman","year":"2013","journal-title":"Arch Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0480","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3201\/eid2207.151740","article-title":"Natural norovirus infections in rhesus macaques","volume":"22","author":"Farkas","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0485","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3201\/eid1308.070005","article-title":"Human noroviruses in swine and cattle","volume":"13","author":"Mattison","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0490","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jcv.2011.12.014","article-title":"Pet dogs \u2013 a transmission route for human noroviruses?","volume":"53","author":"Summa","year":"2012","journal-title":"J Clin Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0495","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1743-422X-10-176","article-title":"Presence of antibodies against genogroup VI norovirus in humans","volume":"10","author":"Mesquita","year":"2013","journal-title":"Virol J"},{"key":"10.1016\/j.coviro.2016.09.009_bib0500","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jmv.20333","article-title":"Detection of serum antibodies to bovine norovirus in veterinarians and the general population in the Netherlands","volume":"76","author":"Widdowson","year":"2005","journal-title":"J Med Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0505","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.3201\/eid2011.131601","article-title":"Seroprevalence of norovirus genogroup IV antibodies among humans, Italy, 2010\u20132011","volume":"20","author":"Barbara Di","year":"2014","journal-title":"Emerg Infect Dis journal"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0510","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1128\/JCM.02778-14","article-title":"Evidence for human norovirus infection of dogs in the United kingdom","volume":"53","author":"Caddy","year":"2015","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0515","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1073\/pnas.1014577107","article-title":"Chimpanzees as an animal model for human norovirus infection and vaccine development","volume":"108","author":"Bok","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2016.09.009_bib0520","doi-asserted-by":"crossref","first-page":"10372","DOI":"10.1128\/JVI.00809-06","article-title":"Pathogenesis of a genogroup II human norovirus in gnotobiotic pigs","volume":"80","author":"Cheetham","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0525","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1128\/JVI.01347-07","article-title":"Pathogenesis and immune responses in gnotobiotic calves after infection with the genogroup II.4-HS66 strain of human norovirus","volume":"82","author":"Souza","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0530","doi-asserted-by":"crossref","first-page":"e00413","DOI":"10.1128\/mBio.00450-13","article-title":"A mouse model for human norovirus","volume":"4","author":"Taube","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.coviro.2016.09.009_bib0535","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pmed.0050031","article-title":"Mechanisms of GII.4 norovirus persistence in human populations","volume":"5","author":"Lindesmith","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.coviro.2016.09.009_bib0540","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1056\/NEJMra0804575","article-title":"Norovirus gastroenteritis","volume":"361","author":"Glass","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2016.09.009_bib0545","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/JCM.01535-14","article-title":"Advances in laboratory methods for detection and typing of norovirus","volume":"53","author":"Vinje","year":"2015","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0550","doi-asserted-by":"crossref","first-page":"e1002921","DOI":"10.1371\/journal.ppat.1002921","article-title":"Norovirus immunity and the great escape","volume":"8","author":"Debbink","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.09.009_bib0555","doi-asserted-by":"crossref","first-page":"e1002705","DOI":"10.1371\/journal.ppat.1002705","article-title":"Immunogenetic mechanisms driving norovirus GII.4 antigenic variation","volume":"8","author":"Lindesmith","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.09.009_bib0560","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1128\/JVI.79.11.6714-6722.2005","article-title":"Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns","volume":"79","author":"Huang","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0565","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3201\/eid1107.041273","article-title":"Norovirus recombination in ORF1\/ORF2 overlap","volume":"11","author":"Bull","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0570","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1128\/JVI.03464-12","article-title":"Recombination within the pandemic norovirus GII.4 lineage","volume":"87","author":"Eden","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0575","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1128\/JVI.03056-12","article-title":"The importance of intergenic recombination in norovirus GII.3 evolution","volume":"87","author":"Mahar","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0580","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1128\/JCM.02168-08","article-title":"Genetic diversity among food-borne and waterborne norovirus strains causing outbreaks in Sweden","volume":"47","author":"Lys\u00e9n","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0585","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1128\/JVI.06712-11","article-title":"Contribution of intra- and interhost dynamics to norovirus evolution","volume":"86","author":"Bull","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0590","doi-asserted-by":"crossref","first-page":"e01013","DOI":"10.1128\/mBio.01032-13","article-title":"The effect of malnutrition on norovirus infection","volume":"5","author":"Hickman","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.coviro.2016.09.009_bib0595","doi-asserted-by":"crossref","first-page":"27841","DOI":"10.1074\/jbc.M115.688234","article-title":"A cell-based fluorescence resonance energy transfer (FRET) sensor reveals inter- and intragenogroup variations in norovirus protease activity and polyprotein cleavage","volume":"290","author":"Emmott","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coviro.2016.09.009_bib0600","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/nar\/gku1292","article-title":"Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases","volume":"43","author":"Lin","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.coviro.2016.09.009_bib0605","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1128\/JVI.06191-11","article-title":"VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay","volume":"85","author":"Subba-Reddy","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0610","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1128\/JVI.03063-14","article-title":"What is the reservoir of emergent human norovirus strains?","volume":"89","author":"Karst","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0615","first-page":"20","article-title":"Emergence of a novel GII.17 norovirus\u2014end of the GII.4 era?","author":"de Graaf","year":"2015","journal-title":"Euro Surveill"},{"key":"10.1016\/j.coviro.2016.09.009_bib0620","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1056\/NEJMra1207742","article-title":"Norovirus gastroenteritis in immunocompromised patients","volume":"367","author":"Bok","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2016.09.009_bib0625","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrmicro2296","article-title":"Viral shape-shifting: norovirus evasion of the human immune system","volume":"8","author":"Donaldson","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0630","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1086\/339883","article-title":"Norwalk virus infection and disease is associated with ABO histo-blood group type","volume":"185","author":"Hutson","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0635","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.smim.2006.07.009","article-title":"Mendelian resistance to human norovirus infections","volume":"18","author":"Le Pendu","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0640","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1126\/science.1257147","article-title":"Enteric bacteria promote human and mouse norovirus infection of B cells","volume":"346","author":"Jones","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.coviro.2016.09.009_bib0645","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/cid\/ciw060","article-title":"Norovirus infections occur in B-cell-deficient patients","volume":"62","author":"Brown","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0650","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrmicro.2015.25","article-title":"The influence of commensal bacteria on infection with enteric viruses","volume":"14","author":"Karst","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0655","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1128\/JVI.02872-15","article-title":"Oral norovirus infection is blocked in mice lacking Peyer's patches and mature M cells","volume":"90","author":"Kolawole","year":"2016","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0660","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1600-065X.2008.00680.x","article-title":"Norovirus pathogenesis: mechanisms of persistence and immune evasion in human populations","volume":"225","author":"Donaldson","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.coviro.2016.09.009_bib0665","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/infdis\/jiu497","article-title":"Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults","volume":"211","author":"Bernstein","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2016.09.009_bib0670","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.vaccine.2012.03.050","article-title":"Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations","volume":"30","author":"Parra","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0675","doi-asserted-by":"crossref","first-page":"e1001807","DOI":"10.1371\/journal.pmed.1001807","article-title":"Broad blockade antibody responses in human volunteers after immunization with a multivalent norovirus VLP candidate vaccine: immunological analyses from a phase I clinical trial","volume":"12","author":"Lindesmith","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.coviro.2016.09.009_bib0680","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/CVI.00411-12","article-title":"Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered norwalk virus","volume":"19","author":"Ajami","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0685","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/CVI.00595-15","article-title":"Serological responses to a norovirus nonstructural fusion protein after vaccination and infection","volume":"23","author":"Hesse","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0690","doi-asserted-by":"crossref","first-page":"e1005334","DOI":"10.1371\/journal.ppat.1005334","article-title":"Correlates of protection against norovirus infection and disease\u2014where are we now, where do we go?","volume":"12","author":"Ramani","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2016.09.009_bib0695","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/AAC.02546-13","article-title":"The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon","volume":"58","author":"Rocha-Pereira","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0700","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coviro.2014.08.004","article-title":"Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus","volume":"9","author":"Deval","year":"2014","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0705","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.antiviral.2016.05.011","article-title":"Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model","volume":"132","author":"Kolawole","year":"2016","journal-title":"Antiviral Res"},{"key":"10.1016\/j.coviro.2016.09.009_bib0710","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bbrc.2012.10.003","article-title":"Inhibition of norovirus replication by the nucleoside analogue 2\u2032-C-methylcytidine","volume":"427","author":"Rocha-Pereira","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.coviro.2016.09.009_bib0715","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1128\/JVI.02064-13","article-title":"The viral polymerase inhibitor 2\u2032-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model","volume":"87","author":"Rocha-Pereira","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0720","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jac\/dku363","article-title":"Prophylactic treatment with the nucleoside analogue 2\u2032-C-methylcytidine completely prevents transmission of norovirus","volume":"70","author":"Rocha-Pereira","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.coviro.2016.09.009_bib0725","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.antiviral.2016.05.022","article-title":"Post-exposure antiviral treatment of norovirus infections effectively protects against diarrhea and reduces virus shedding in the stool in a mortality mouse model","volume":"132","author":"Rocha-Pereira","year":"2016","journal-title":"Antiviral Res"},{"key":"10.1016\/j.coviro.2016.09.009_bib0730","article-title":"Treatment with a nucleoside polymerase inhibitor reduces shedding of murine norovirus in stool to undetectable levels without emergence of drug-resistant variants","author":"Rocha-Pereira","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.coviro.2016.09.009_sbref0735","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1053\/j.gastro.2014.08.040","article-title":"A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients","volume":"147","author":"Debing","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.coviro.2016.09.009_bib0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2016.05.002","article-title":"Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity","author":"Debing","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2016.09.009_bib0745","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1128\/AAC.03021-15","article-title":"Anti-infective activity of 2-cyano-3-acrylamide inhibitors with improved drug-like properties against two intracellular pathogens","volume":"60","author":"Passalacqua","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.coviro.2016.09.009_bib0750","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1128\/JVI.00315-15","article-title":"Molecular chaperone Hsp90 is a therapeutic target for noroviruses","volume":"89","author":"Vashist","year":"2015","journal-title":"J Virol"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625716301419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625716301419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T12:38:27Z","timestamp":1568464707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625716301419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":75,"alternative-id":["S1879625716301419"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2016.09.009","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Norovirus genetic diversity and evolution: implications for antiviral therapy","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}