{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:14:49Z","timestamp":1792631689396,"version":"4.5.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIH Institute for Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI04667"],"award-info":[{"award-number":["RO1AI04667"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIH Institute for Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21 AI129508"],"award-info":[{"award-number":["R21 AI129508"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIH Institute for Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI124493"],"award-info":[{"award-number":["RO1AI124493"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.coviro.2017.11.008","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T17:25:05Z","timestamp":1512581105000},"page":"48-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo"],"prefix":"10.1016","volume":"27","author":[{"given":"Matthew","family":"Petitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Puerta-Guardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2017.11.008_sbref0005","article-title":"Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management","author":"Devakumar","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0010","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jcv.2005.09.015","article-title":"Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome","volume":"35","author":"Pass","year":"2006","journal-title":"J Clin Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2009.11.018","article-title":"Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population","volume":"202","author":"Yamamoto","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0020","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1128\/JVI.74.15.6808-6820.2000","article-title":"Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis","volume":"74","author":"Fisher","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0025","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1128\/JVI.77.24.13301-13314.2003","article-title":"Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity","volume":"77","author":"Pereira","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0030","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/infdis\/jiu019","article-title":"Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection","volume":"209","author":"Pereira","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0035","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1128\/JVI.02748-06","article-title":"Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta","volume":"81","author":"Maidji","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0040","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.placenta.2006.05.006","article-title":"Cytotrophoblasts infected with a pathogenic human cytomegalovirus strain dysregulate cell-matrix and cell-cell adhesion molecules: a quantitative analysis","volume":"28","author":"Tabata","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.coviro.2017.11.008_bib0045","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.ajpath.2012.08.003","article-title":"Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model","volume":"181","author":"Tabata","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0050","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1128\/JVI.03674-14","article-title":"Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta","volume":"89","author":"Tabata","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0055","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.ajpath.2016.07.016","article-title":"Persistent cytomegalovirus infection in amniotic membranes of the human placenta","volume":"186","author":"Tabata","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0060","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2006.050482","article-title":"Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis","volume":"168","author":"Maidji","year":"2006","journal-title":"Am J Pathol"},{"issue":"Suppl. 4","key":"10.1016\/j.coviro.2017.11.008_bib0065","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jcv.2009.10.004","article-title":"Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream","volume":"46","author":"Nozawa","year":"2009","journal-title":"J Clin Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0070","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.2353\/ajpath.2010.091210","article-title":"Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection","volume":"177","author":"Maidji","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0075","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3390\/v6031346","article-title":"HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex","volume":"6","author":"Zydek","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.coviro.2017.11.008_bib0080","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1128\/AAC.04295-14","article-title":"A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types","volume":"59","author":"Kauvar","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.coviro.2017.11.008_bib0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jcv.2007.11.008","article-title":"Human CMV vaccine trials: what if CMV caused a rash?","volume":"41","author":"Adler","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tim.2005.02.009","article-title":"Insights into viral transmission at the uterine\u2013placental interface","volume":"13","author":"Pereira","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0095","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4269\/ajtmh.2005.73.1063","article-title":"Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua","volume":"73","author":"Hammond","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.coviro.2017.11.008_bib0100","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1086\/518007","article-title":"Dengue virus infects macrophages and dendritic cells in a mouse model of infection","volume":"195","author":"Kyle","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0105","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4269\/ajtmh.2009.80.416","article-title":"Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining","volume":"80","author":"Balsitis","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.coviro.2017.11.008_bib0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity","volume":"8","author":"Beltramello","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2017.11.008_bib0115","doi-asserted-by":"crossref","first-page":"e2451","DOI":"10.1371\/journal.pntd.0002451","article-title":"Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases","volume":"7","author":"Lai","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1099\/jgv.0.000381","article-title":"Zika virus: a previously slow pandemic spreads rapidly through the Americas","volume":"97","author":"Gatherer","year":"2015","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0125","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12616","article-title":"Zika virus and pregnancy: an overview","volume":"77","author":"de Carvalho","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0130","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0135","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3389\/fmicb.2016.01667","article-title":"Emergence and spreading potential of Zika virus","volume":"7","author":"Fajardo","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.15585\/mmwr.mm6506e1","article-title":"Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses\u2014Brazil, 2015","volume":"65","author":"Martines","year":"2016","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0145","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0150","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0155","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"16","author":"Calvet","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0160","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.15585\/mmwr.mm6547e2","article-title":"Description of 13 infants born during October 2015\u2013January 2016 with congenital Zika virus infection without microcephaly at birth\u2014Brazil","volume":"65","author":"van der Linden","year":"2016","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0165","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jamaneurol.2016.3720","article-title":"Congenital Zika virus infection: beyond neonatal microcephaly","volume":"73","author":"Melo","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0170","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation","volume":"388","author":"Franca","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.coviro.2017.11.008_bib0175","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects\u2014reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0180","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nature22400","article-title":"Genomic epidemiology reveals multiple introductions of Zika virus into the United States","volume":"546","author":"Grubaugh","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2017.11.008_bib0185","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/infdis\/jix182","article-title":"Continued transmission of Zika virus in humans in West Africa, 1992\u20132016","volume":"215","author":"Herrera","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0190","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature22401","article-title":"Establishment and cryptic transmission of Zika virus in Brazil and the Americas","volume":"546","author":"Faria","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2017.11.008_bib0195","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1618029113","article-title":"Zika virus cell tropism in the developing human brain and inhibition by azithromycin","volume":"113","author":"Retallack","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2017.11.008_bib0200","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0205","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0210","doi-asserted-by":"crossref","first-page":"e1005738","DOI":"10.1371\/journal.ppat.1005738","article-title":"Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability","volume":"12","author":"Puerta-Guardo","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0215","doi-asserted-by":"crossref","first-page":"304ra142","DOI":"10.1126\/scitranslmed.aaa3863","article-title":"Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity","volume":"7","author":"Modhiran","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0220","doi-asserted-by":"crossref","first-page":"304ra141","DOI":"10.1126\/scitranslmed.aaa3787","article-title":"Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination","volume":"7","author":"Beatty","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0225","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.15252\/embj.201695290","article-title":"Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure","volume":"35","author":"Xu","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0230","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature22365","article-title":"Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes","volume":"545","author":"Liu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0235","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nsmb.3213","article-title":"Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses","volume":"23","author":"Song","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0240","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nsmb.3268","article-title":"Extended surface for membrane association in Zika virus NS1 structure","volume":"23","author":"Brown","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0245","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1247749","article-title":"Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system","volume":"343","author":"Akey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0250","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/cid\/ciw589","article-title":"Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus","volume":"63","author":"Waggoner","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0255","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2471\/BLT.16.178608","article-title":"Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016","volume":"95","author":"Jaenisch","year":"2017","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.coviro.2017.11.008_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJMp1605367","article-title":"Zika and the risk of microcephaly","volume":"375","author":"Johansson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0265","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1073\/pnas.1704984114","article-title":"Antibody-based assay discriminates Zika virus infection from other flaviviruses","volume":"114","author":"Balmaseda","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.coviro.2017.11.008_bib0270","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/jpm-2012-0034","article-title":"Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and associations with spontaneous early (<32 weeks) and late (>32 weeks) preterm delivery","volume":"40","author":"Gervasi","year":"2012","journal-title":"J Perinat Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0275","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.4049\/jimmunol.1003587","article-title":"IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes","volume":"186","author":"Lee","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0280","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.4049\/jimmunol.0803517","article-title":"Soluble TLR2 is present in human amniotic fluid and modulates the intraamniotic inflammatory response to infection","volume":"182","author":"Dulay","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0285","series-title":"Pathology of the Human Placenta","author":"Benirschke","year":"2000"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0290","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika virus infects human placental macrophages","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2017.11.008_bib0295","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0140-6736(16)30883-2","article-title":"Pathology of congenital Zika syndrome in Brazil: a case series","volume":"388","author":"Martines","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5858\/arpa.2016-0401-OA","article-title":"Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer cell) proliferation and hyperplasia","volume":"141","author":"Rosenberg","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0305","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00404-017-4361-5","article-title":"Viral infection, proliferation, and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection","volume":"295","author":"Schwartz","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0310","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2017.11.008_bib0315","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0143-4004(92)90051-T","article-title":"Villous culture of first trimester human placenta\u2014model to study extravillous trophoblast (EVT) differentiation","volume":"13","author":"Genbacev","year":"1992","journal-title":"Placenta"},{"key":"10.1016\/j.coviro.2017.11.008_bib0320","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2017.11.008_bib0325","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chom.2012.08.009","article-title":"The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry","volume":"12","author":"Meertens","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.coviro.2017.11.008_bib0330","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0335","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/nm.3974","article-title":"The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood\u2013brain barrier integrity","volume":"21","author":"Miner","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0340","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1529\/biophysj.106.101584","article-title":"Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin","volume":"93","author":"Iwamoto","year":"2007","journal-title":"Biophys J"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0345","article-title":"Zika virus replicates in proliferating cells in explants from first-trimester human placentas, potential sites of persistent infection","author":"Tabata","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0350","doi-asserted-by":"crossref","first-page":"e01905","DOI":"10.1128\/JVI.01905-16","article-title":"Zika virus infects early- and midgestation human maternal decidual tissues, inducing distinct innate tissue responses in the maternal\u2013fetal interface","volume":"91","author":"Weisblum","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0355","doi-asserted-by":"crossref","first-page":"35296","DOI":"10.1038\/srep35296","article-title":"ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy","volume":"6","author":"El Costa","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0360","doi-asserted-by":"crossref","first-page":"e1006219","DOI":"10.1371\/journal.ppat.1006219","article-title":"Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues","volume":"13","author":"Hirsch","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.04.008","article-title":"Zika virus persistence in the central nervous system and lymph nodes of Rhesus monkeys","volume":"169","author":"Aid","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.coviro.2017.11.008_bib0370","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.placenta.2015.05.002","article-title":"The role of chorionic cytotrophoblasts in the smooth chorion fusion with parietal decidua","volume":"36","author":"Genbacev","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.coviro.2017.11.008_bib0375","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ana.24839","article-title":"Immune activation in amniotic fluid from Zika virus-associated microcephaly","volume":"81","author":"Ornelas","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0380","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1473-3099(17)30102-0","article-title":"Analysis of blood from Zika virus-infected fetuses: a prospective case series","volume":"17","author":"Schaub","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_bib0385","doi-asserted-by":"crossref","DOI":"10.3201\/eid2306.161702","article-title":"Severe neurologic disorders in 2 fetuses with Zika virus infection, Colombia","volume":"23","author":"Acosta-Reyes","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0390","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.immuni.2017.02.005","article-title":"Prospects for a Zika virus vaccine","volume":"46","author":"Barouch","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.coviro.2017.11.008_bib0395","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aai9137","article-title":"Rapid development of a DNA vaccine for Zika virus","volume":"354","author":"Dowd","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.coviro.2017.11.008_bib0400","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature18952","article-title":"Vaccine protection against Zika virus from Brazil","volume":"536","author":"Larocca","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.coviro.2017.11.008_bib0405","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.aah6157","article-title":"Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys","volume":"353","author":"Abbink","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.coviro.2017.11.008_bib0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.06.040","article-title":"Vaccine mediated protection against Zika virus-induced congenital disease","volume":"170","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.coviro.2017.11.008_bib0415","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.1038\/npjvaccines.2016.21","article-title":"In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine","volume":"1","author":"Muthumani","year":"2016","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.coviro.2017.11.008_bib0420","doi-asserted-by":"crossref","first-page":"e1006487","DOI":"10.1371\/journal.ppat.1006487","article-title":"Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques","volume":"13","author":"McCracken","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2017.11.008_bib0425","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1604037","article-title":"Zika virus disease in Colombia\u2014preliminary report","author":"Pacheco","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.coviro.2017.11.008_bib0430","doi-asserted-by":"crossref","first-page":"e01049-17","DOI":"10.1128\/JVI.01049-17","article-title":"Monoclonal antibodies against Zika virus: therapeutics and their implications for vaccine design","volume":"91","author":"Wang","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0435","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3389\/fmicb.2017.01469","article-title":"Advances in developing therapies to combat Zika virus: current knowledge and future perspectives","volume":"8","author":"Munjal","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coviro.2017.11.008_sbref0440","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.coviro.2017.11.008_bib0445","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8\u00c5 resolution cryo-EM structure of Zika virus","volume":"352","author":"Sirohi","year":"2016","journal-title":"Science"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625717301293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625717301293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T15:46:51Z","timestamp":1570463211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625717301293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":89,"alternative-id":["S1879625717301293"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2017.11.008","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2017.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}