{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:46:45Z","timestamp":1792496805071,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019559","name":"Carl von Ossietzky University of Oldenburg","doi-asserted-by":"publisher","award":["2021-062"],"award-info":[{"award-number":["2021-062"]}],"id":[{"id":"10.13039\/100019559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"German Centre for Infection Research","doi-asserted-by":"publisher","award":["TTU 05.823_00"],"award-info":[{"award-number":["TTU 05.823_00"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01EK2106A"],"award-info":[{"award-number":["01EK2106A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STE 1954\/12-1"],"award-info":[{"award-number":["STE 1954\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KI 2621\/2"],"award-info":[{"award-number":["KI 2621\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006254","name":"Ruhr University Bochum","doi-asserted-by":"publisher","award":["IF-018N-22"],"award-info":[{"award-number":["IF-018N-22"]}],"id":[{"id":"10.13039\/501100006254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.coviro.2025.101508","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:07:51Z","timestamp":1767920871000},"page":"101508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Beyond the liver: the broadened tissue tropism of hepatitis E virus"],"prefix":"10.1016","volume":"74","author":[{"given":"Sarah","family":"Schlienkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olinda Pinto","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Kinast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2025.101508_bib1","unstructured":"World Health Organization. Hepatitis E: Fact Sheet, WHO. \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-e\u3009."},{"key":"10.1016\/j.coviro.2025.101508_bib2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/hep.25505","article-title":"The global burden of hepatitis E virus genotypes 1 and 2 in 2005","volume":"55","author":"Rein","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.coviro.2025.101508_bib3","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2002324118","article-title":"Ranking the risk of animal-to-human spillover for newly discovered viruses","volume":"118","author":"Grange","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2025.101508_bib4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jhep.2018.03.005","article-title":"EASL Clinical Practice Guidelines on hepatitis E virus infection","volume":"68","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_bib5","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1053\/j.gastro.2012.02.014","article-title":"Pathogenesis and treatment of hepatitis e virus infection","volume":"142","author":"Wedemeyer","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.coviro.2025.101508_bib6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/v11060485","article-title":"Hepatitis E virus drug development","volume":"11","author":"Kinast","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.coviro.2025.101508_bib7","article-title":"Classification of the zoonotic hepatitis e virus genotype 3 into distinct subgenotypes","volume":"11","author":"Nicot","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coviro.2025.101508_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrgastro.2017.150","article-title":"Hepatitis E virus: advances and challenges","volume":"15","author":"Nimgaonkar","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_bib9","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/gutjnl-2019-319004","article-title":"Hepatitis E virus replication in human intestinal cells","volume":"69","author":"Marion","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_sbref9","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70183","article-title":"Extrahepatic replication and genomic signatures of the hepatitis E virus in the kidney","volume":"45","author":"Wahid","year":"2025","journal-title":"Liver Int"},{"key":"10.1016\/j.coviro.2025.101508_bib11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jhep.2016.11.016","article-title":"Hepatitis E virus: infection beyond the liver?","volume":"66","author":"Pischke","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3201\/eid1702.100856","article-title":"Hepatitis E virus and neurologic disorders","volume":"17","author":"Kamar","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.coviro.2025.101508_bib13","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/apt.15704","article-title":"Mortality and morbidity of locally acquired hepatitis E in the national Scottish cohort: a multicentre retrospective study","volume":"51","author":"Wallace","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.coviro.2025.101508_bib14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jinf.2018.06.007","article-title":"Acute hepatitis E in French patients and neurological manifestations","volume":"77","author":"Abravanel","year":"2018","journal-title":"J Infect"},{"key":"10.1016\/j.coviro.2025.101508_bib15","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.1212\/NXI.0000000000000643","article-title":"Neurologic complications of acute hepatitis E virus infection","volume":"7","author":"Ripellino","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.coviro.2025.101508_bib16","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1600-6143.2010.03068.x","article-title":"Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis","volume":"10","author":"Kamar","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.coviro.2025.101508_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.revmed.2013.05.005","article-title":"H\u00e9patite E aigu\u00eb associ\u00e9e \u00e0 un syndrome de Guillain-Barr\u00e9 chez un patient immunocomp\u00e9tent","volume":"35","author":"Comont","year":"2014","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.coviro.2025.101508_bib18","doi-asserted-by":"crossref","first-page":"e939","DOI":"10.1212\/NXI.0000000000000939","article-title":"Evidence for independent hepatitis E virus replication in the brain","volume":"8","author":"Drijver","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.coviro.2025.101508_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9101205","article-title":"Hepatitis E virus quasispecies in cerebrospinal fluid with neurological manifestations","volume":"9","author":"Abravanel","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.coviro.2025.101508_bib20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201862119","article-title":"Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood\u2013brain barrier, and invades the central nervous system","volume":"119","author":"Tian","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2025.101508_bib21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/jvh.12557","article-title":"Evidence of hepatitis E virus breaking through the blood-brain barrier and replicating in the central nervous system","volume":"23","author":"Shi","year":"2016","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.coviro.2025.101508_bib22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/jvh.12515","article-title":"Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells","volume":"23","author":"Drave","year":"2016","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.coviro.2025.101508_sbref22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411434121","article-title":"Modeling extrahepatic hepatitis E virus infection in induced human primary neurons","volume":"121","author":"Jagst","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2025.101508_sbref23","article-title":"iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation","author":"Liu","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/TP.0b013e318245f14c","article-title":"Hepatitis E virus and the kidney in solid-organ transplant patients","volume":"93","author":"Kamar","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.coviro.2025.101508_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53072-0","article-title":"HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status","volume":"15","author":"Leblond","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2025.101508_sbref26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ajt.2023.11.016","article-title":"Hepatitis E virus infection of transplanted kidneys","volume":"24","author":"Schmitz","year":"2024","journal-title":"Am J Transplant"},{"key":"10.1016\/j.coviro.2025.101508_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.vetmic.2006.08.027","article-title":"Detection of hepatitis E virus in liver, mesenteric lymph node, serum, bile and faeces of naturally infected pigs affected by different pathological conditions","volume":"119","author":"Deus","year":"2007","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.coviro.2025.101508_bib29","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0168-8278(03)00115-6","article-title":"Localization of swine hepatitis E virus in liver and extrahepatic tissues from naturally infected pigs by in situ hybridization","volume":"38","author":"Choi","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jhep.2015.08.034","article-title":"Detection and assessment of infectivity of hepatitis E virus in urine","volume":"64","author":"Geng","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007471","article-title":"Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion","volume":"14","author":"Gouttenoire","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2025.101508_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.virusres.2015.12.012","article-title":"Antigen detection and apoptosis in Mongolian gerbil's kidney experimentally intraperitoneally infected by swine hepatitis E virus","volume":"213","author":"Soomro","year":"2016","journal-title":"Virus Res"},{"key":"10.1016\/j.coviro.2025.101508_bib33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/gutjnl-2016-312023","article-title":"Experimental infection of rabbits with genotype 3 hepatitis E virus produced both chronicity and kidney injury","volume":"66","author":"Wang","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2525269","article-title":"Interferon-induced immune signatures are associated with suppression of HEV infection in porcine cell culture models","volume":"14","author":"Schlienkamp","year":"2025","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.coviro.2025.101508_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.86","article-title":"Hepatitis E virus infection","volume":"3","author":"Kamar","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.coviro.2025.101508_bib36","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/gutjnl-2019-320206","article-title":"Hepatitis E virus finds its path through the gut","volume":"69","author":"Oechslin","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_bib37","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1128\/JCM.39.9.3040-3046.2001","article-title":"Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model","volume":"39","author":"Williams","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.coviro.2025.101508_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2025.110615","article-title":"Decoding the role of the intestinal epithelium in hepatitis E virus infection using a human organoid prototype of \"gut-liver\" axis","volume":"610","author":"Liu","year":"2025","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2025.101508_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.gastha.2025.100769","article-title":"Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids","volume":"5","author":"Santos-Ferreira","year":"2026","journal-title":"Gastro Hep Adv"},{"key":"10.1016\/j.coviro.2025.101508_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2024.199427","article-title":"Colon-derived Caco-2 cells support replication of hepatitis E virus genotype 1 strain Sar55 generated by reverse genetics","volume":"347","author":"Falkenhagen","year":"2024","journal-title":"Virus Res"},{"key":"10.1016\/j.coviro.2025.101508_bib41","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1152\/physrev.00021.2019","article-title":"From ancient to emerging infections: the odyssey of viruses in the male genital tract","volume":"100","author":"Le Tortorec","year":"2020","journal-title":"Physiol Rev"},{"key":"10.1016\/j.coviro.2025.101508_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jhep.2020.12.030","article-title":"Hepatitis E virus persists in the ejaculate of chronically infected men","volume":"75","author":"Horvatits","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.coviro.2025.101508_sbref42","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29735","article-title":"Proof of infectivity of hepatitis E virus particles from the ejaculate of chronically infected patients","volume":"96","author":"Schemmerer","year":"2024","journal-title":"J Med Virol"},{"key":"10.1016\/j.coviro.2025.101508_bib44","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1136\/gutjnl-2019-319027","article-title":"No link between male infertility and HEV genotype 3 infection","volume":"69","author":"Horvatits","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_bib45","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/gutjnl-2019-319234","article-title":"Absence of hepatitis E virus RNA in semen samples of infertile male in China","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.coviro.2025.101508_bib46","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/jvh.12690","article-title":"Molecular and structural changes related to hepatitis E virus antigen and its expression in testis inducing apoptosis in Mongolian gerbil model","volume":"24","author":"Soomro","year":"2017","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.coviro.2025.101508_sbref46","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1053\/j.gastro.2024.03.038","article-title":"An immunocompetent Mongolian gerbil model for hepatitis E virus genotype 1 infection","volume":"167","author":"Liu","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.coviro.2025.101508_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2332657","article-title":"Hepatitis E virus infects human testicular tissue and Sertoli cells","volume":"13","author":"Liu","year":"2024","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.coviro.2025.101508_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.1929","article-title":"Hepatitis E and pregnancy: current state","volume":"27","author":"P\u00e9rez-Gracia","year":"2017","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.coviro.2025.101508_bib50","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1099\/vir.0.063602-0","article-title":"Evidence of extrahepatic replication of hepatitis E virus in human placenta","volume":"95","author":"Bose","year":"2014","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2025.101508_bib51","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1002\/jmv.27699","article-title":"Placenta as a site of HEV replication and inflammatory cytokines modulating the immunopathogenesis of HEV in pregnant women","volume":"94","author":"Ratho","year":"2022","journal-title":"J Med Virol"},{"key":"10.1016\/j.coviro.2025.101508_bib52","article-title":"Fetal loss in pregnant rabbits infected with genotype 3 hepatitis E virus is associated with altered inflammatory responses, enhanced virus replication, and extrahepatic virus dissemination with positive correlations with increased estradiol level","volume":"14","author":"Mahsoub","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.coviro.2025.101508_bib53","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.18632\/oncotarget.23381","article-title":"Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4","volume":"9","author":"An","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.coviro.2025.101508_bib54","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1080\/22221751.2019.1643260","article-title":"Hepatitis E-related adverse pregnancy outcomes and their prevention by hepatitis E vaccine in a rabbit model","volume":"8","author":"Li","year":"2019","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.coviro.2025.101508_bib55","first-page":"483","article-title":"Pathological characteristics of pregnant tree shrews infected by zoonotic hepatitis E virus genotype and the effect of estrogen on virus replication","volume":"12","author":"Zhu","year":"2025","journal-title":"Vet Sci"},{"key":"10.1016\/j.coviro.2025.101508_bib56","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/jvh.12406","article-title":"Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission","volume":"22","author":"Xia","year":"2015","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.coviro.2025.101508_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/pathogens9040295","article-title":"Evidence of the extrahepatic replication of hepatitis E virus in human endometrial stromal cells","volume":"9","author":"El-Mokhtar","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.coviro.2025.101508_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep4.1138","article-title":"Hepatitis E virus replication and interferon responses in human placental cells","volume":"2","author":"Knegendorf","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.coviro.2025.101508_bib59","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2276336","article-title":"Vital role of autophagy flux inhibition of placental trophoblast cells in pregnancy disorders induced by HEV infection","volume":"12","author":"Yang","year":"2023","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.coviro.2025.101508_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07200-2","article-title":"Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface","volume":"9","author":"Gouilly","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2025.101508_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2501128122","article-title":"Antiviral resistance and barrier integrity at the maternal-fetal interface restrict hepatitis E virus from crossing the placental barrier","volume":"122","author":"Tian","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2025.101508_bib62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/vaccines8020239","article-title":"Replication of hepatitis E virus (HEV) in primary human-derived monocytes and macrophages in vitro","volume":"8","author":"Sayed","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.coviro.2025.101508_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.696680","article-title":"Hepatitis E virus persistence and\/or replication in the peripheral blood mononuclear cells of acute HEV-infected patients","volume":"12","author":"Sayed","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.coviro.2025.101508_bib64","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1365-2893.2010.01351.x","article-title":"Viral RNA but no evidence of replication can be detected in the peripheral blood mononuclear cells of hepatitis E virus-infected patients","volume":"18","author":"Ippagunta","year":"2011","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.coviro.2025.101508_bib65","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/pathogens14050420","article-title":"Chronic hepatitis E virus infection without liver injury in a patient with chronic kidney disease","volume":"14","author":"Viera-Segura","year":"2025","journal-title":"Pathogens"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625725000586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625725000586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:19:20Z","timestamp":1780816760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625725000586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":65,"alternative-id":["S1879625725000586"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2025.101508","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond the liver: the broadened tissue tropism of hepatitis E virus","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2025.101508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101508"}}