{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T19:27:24Z","timestamp":1794425244506,"version":"4.9.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["T2EP30124-0035"],"award-info":[{"award-number":["T2EP30124-0035"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Virology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.coviro.2026.101536","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:19:24Z","timestamp":1776471564000},"page":"101536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Flavivirus NS1 as a pivotal virulence factor and a tractable target for next-generation antivirals, vaccines, and immunodiagnostics"],"prefix":"10.1016","volume":"76","author":[{"given":"Yaoguang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Ying","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.coviro.2026.101536_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2025.107940","article-title":"Global dengue epidemic worsens with record 14 million cases and 9000 deaths reported in 2024","volume":"158","author":"Haider","year":"2025","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.coviro.2026.101536_bib2","unstructured":"CDC: Dengue. Dengue Vaccine; 2025. Available from: \u3008https:\/\/www.cdc.gov\/dengue\/hcp\/vaccine\/index.html\u3009."},{"key":"10.1016\/j.coviro.2026.101536_bib3","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1080\/21645515.2019.1643676","article-title":"Does structurally-mature dengue virion matter in vaccine preparation in post-Dengvaxia era?","volume":"15","author":"Galula","year":"2019","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.coviro.2026.101536_bib4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/vaccines13050532","article-title":"Development of new live-attenuated vaccine candidates lacking antibody-dependent enhancement (ADE) against dengue","volume":"13","author":"Tan","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.coviro.2026.101536_bib5","doi-asserted-by":"crossref","unstructured":"S.A. Moquin, O. Simon and R. Karuna, NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models, 13, 2021,eabb2181.","DOI":"10.1126\/scitranslmed.abb2181"},{"key":"10.1016\/j.coviro.2026.101536_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-50437-3","article-title":"Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B\/NS3 and blocks replication organelle formation","volume":"15","author":"Kiemel","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2026.101536_bib7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(08)60238-X","article-title":"Pathogenic flaviviruses","volume":"371","author":"Gould","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.coviro.2026.101536_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002203","article-title":"Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barr\u00e9 syndrome: systematic review","volume":"14","author":"Krauer","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.coviro.2026.101536_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-virology-101416-041848","article-title":"The good, the bad, and the shocking: the multiple roles of dengue virus nonstructural protein 1 in protection and pathogenesis","volume":"5","author":"Glasner","year":"2018","journal-title":"Annu Rev Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12985-016-0590-7","article-title":"Flavivirus NS1: a multifaceted enigmatic viral protein","volume":"13","author":"Rastogi","year":"2016","journal-title":"Virol J"},{"key":"10.1016\/j.coviro.2026.101536_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2025.101088","article-title":"Evaluating the performance of common reference laboratory tests for acute dengue diagnosis: a systematic review and meta-analysis of RT-PCR, NS1 ELISA, and IgM ELISA","volume":"6","author":"Pillay","year":"2025","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.coviro.2026.101536_bib12","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/vaccines9060622","article-title":"Flavivirus NS1 and its potential in vaccine development","volume":"9","author":"Carpio","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.coviro.2026.101536_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1126\/science.abb9425","article-title":"A broadly protective antibody that targets the flavivirus NS1 protein","volume":"371","author":"Modhiran","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.coviro.2026.101536_bib14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nsmb.3268","article-title":"Extended surface for membrane association in Zika virus NS1 structure","volume":"23","author":"Brown","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.coviro.2026.101536_bib15","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.15252\/embj.201695290","article-title":"Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure","volume":"35","author":"Xu","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.coviro.2026.101536_bib16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1247749","article-title":"Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system","volume":"343","author":"Akey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.coviro.2026.101536_bib17","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1073\/pnas.1322036111","article-title":"Structural basis of Flavivirus NS1 assembly and antibody recognition","volume":"111","author":"Edeling","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2026.101536_bib18","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s11427-017-9238-8","article-title":"Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus","volume":"60","author":"Wang","year":"2017","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.coviro.2026.101536_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01868-17","article-title":"Structural study of the C-terminal domain of nonstructural protein 1 from Japanese encephalitis virus","volume":"92","author":"Poonsiri","year":"2018","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12929-024-01048-z","article-title":"The glycosylation deficiency of flavivirus NS1 attenuates virus replication through interfering with the formation of viral replication compartments","volume":"31","author":"Huang","year":"2024","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.coviro.2026.101536_bib21","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1038\/s41467-022-34415-1","article-title":"CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever","volume":"13","author":"Shu","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2026.101536_sbref20","article-title":"The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution","volume":"10","author":"P","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.coviro.2026.101536_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2024.105915","article-title":"Structural biology of flavivirus NS1 protein and its antibody complexes","volume":"227","author":"Alvin Chew","year":"2024","journal-title":"Antivir Res"},{"key":"10.1016\/j.coviro.2026.101536_bib24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s44298-024-00024-6","article-title":"Structural basis of Zika virus NS1 multimerization and human antibody recognition","volume":"2","author":"Chew","year":"2024","journal-title":"Npj Viruses"},{"key":"10.1016\/j.coviro.2026.101536_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007736","article-title":"A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle","volume":"15","author":"P\u0142aszczyca","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib26","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1016\/j.celrep.2017.11.094","article-title":"A Global interactome map of the dengue virus NS1 identifies virus restriction and dependency host factors","volume":"21","author":"Hafirassou","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.coviro.2026.101536_bib27","doi-asserted-by":"crossref","first-page":"e02396","DOI":"10.1128\/JVI.02396-16","article-title":"West Nile virus NS1 antagonizes interferon beta production by targeting RIG-I and MDA5","volume":"91","author":"Zhang","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib28","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899347","article-title":"Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS 1\u2013caspase-1 axis","volume":"37","author":"Zheng","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.coviro.2026.101536_bib29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1128\/jvi.6.4.500-506.1970","article-title":"Dengue virions and antigens in brain and serum of infected mice","volume":"6","author":"Brandt","year":"1970","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000149171","article-title":"Nomenclature of flavivirus-specified proteins","volume":"14","author":"Westaway","year":"1980","journal-title":"Intervirology"},{"issue":"Pt 3","key":"10.1016\/j.coviro.2026.101536_bib31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1099\/0022-1317-66-3-559","article-title":"Synthesis of proteins and glycoproteins in dengue type 2 virus-infected vero and Aedes albopictus cells","volume":"66","author":"Smith","year":"1985","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib32","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.135.4.2805","article-title":"Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48","volume":"135","author":"Schlesinger","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2026.101536_bib33","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.4023707","article-title":"Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution","volume":"229","author":"Rice","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.coviro.2026.101536_bib34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20092545","article-title":"Antagonism of the complement component C4 by flavivirus nonstructural protein NS1","volume":"207","author":"Avirutnan","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.coviro.2026.101536_bib35","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.4049\/jimmunol.1600323","article-title":"Secreted NS1 protects dengue virus from mannose-binding lectin-mediated neutralization","volume":"197","author":"Thiemmeca","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2026.101536_bib36","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.1128\/JVI.00912-16","article-title":"Inhibition of the membrane attack complex by dengue virus NS1 through interaction with vitronectin and terminal complement proteins","volume":"90","author":"Conde","year":"2016","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.virol.2016.06.008","article-title":"Dengue virus NS1 enhances viral replication and pro-inflammatory cytokine production in human dendritic cells","volume":"496","author":"Alayli","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.coviro.2026.101536_bib38","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1128\/JVI.00085-13","article-title":"The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability","volume":"87","author":"Puerta-Guardo","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3863","article-title":"Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity","volume":"7","author":"Modhiran","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.coviro.2026.101536_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007625","article-title":"Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage","volume":"15","author":"Chao","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013695","article-title":"Dengue virus NS1 protein does not activate TLR4 and has a modest effect on endothelial monolayer integrity compared to TNF","volume":"21","author":"Vajjhala","year":"2025","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_sbref40","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153600","article-title":"Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins","volume":"23","author":"Benfrid","year":"2022","journal-title":"EMBO Rep"},{"key":"10.1016\/j.coviro.2026.101536_bib43","doi-asserted-by":"crossref","first-page":"RP90762","DOI":"10.7554\/eLife.90762.3","article-title":"Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein","volume":"12","author":"Chew","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.coviro.2026.101536_sbref42","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12929-024-01077-8","article-title":"Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages","volume":"31","author":"Dayarathna","year":"2024","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.coviro.2026.101536_sbref43","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2024.106002","article-title":"The ApoA1-mimetic peptide 4F blocks flavivirus NS1-triggered endothelial dysfunction and protects against lethal dengue virus challenge","volume":"231","author":"Carneiro","year":"2024","journal-title":"Antiviral Res"},{"key":"10.1016\/j.coviro.2026.101536_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199222","article-title":"Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage","volume":"336","author":"Zeng","year":"2023","journal-title":"Virus Res"},{"key":"10.1016\/j.coviro.2026.101536_bib47","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.celrep.2019.01.036","article-title":"Flavivirus NS1 triggers tissue-specific vascular endothelial dysfunction reflecting disease tropism","volume":"26","author":"Puerta-Guardo","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.coviro.2026.101536_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013811","article-title":"Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination","volume":"21","author":"Puerta-Guardo","year":"2025","journal-title":"PloS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib49","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/pathogens11060615","article-title":"Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3\u03b2-Dependent Manner.","volume":"11","author":"Puerta-Guardo","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.coviro.2026.101536_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005738","article-title":"Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability","volume":"12","author":"Puerta-Guardo","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006673","article-title":"Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components","volume":"13","author":"Glasner","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007033","article-title":"Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability","volume":"14","author":"Chen","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008603","article-title":"DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction","volume":"17","author":"Pan","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109082","article-title":"Atorvastatin attenuates NS1 (Non-structural protein-1) of dengue type-2 serotype-induced expressions of matrix metalloproteinases in HL-60 cells, differentiated to neutrophils: implications for the immunopathogenesis of dengue viral disease","volume":"112","author":"Niranjan","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.coviro.2026.101536_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004828","article-title":"Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy","volume":"10","author":"Chen","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.coviro.2026.101536_sbref54","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/v17040541","article-title":"Dengue viral infection induces alteration of CD95 expression in B cell subsets with potential involvement of dengue viral non-structural protein 1","volume":"17","author":"Wang","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.coviro.2026.101536_sbref55","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1038\/s41598-025-91099-5","article-title":"Kinetics of NS1 and anti-NS1 IgG following dengue infection reveals likely early formation of immune complexes in secondary infected patients","volume":"15","author":"Muller","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.coviro.2026.101536_sbref56","doi-asserted-by":"crossref","first-page":"e1226","DOI":"10.1093\/infdis\/jiae299","article-title":"Dengue NS1 antibodies are associated with clearance of viral nonstructural protein-1","volume":"230","author":"Premazzi Papa","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.coviro.2026.101536_sbref57","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/infdis\/jiae137","article-title":"Protective role of NS1-specific antibodies in the immune response to dengue virus through antibody-dependent cellular Cytotoxicity","volume":"230","author":"Sanchez-Vargas","year":"2024","journal-title":"J Infect Dis"},{"issue":"Pt 4","key":"10.1016\/j.coviro.2026.101536_bib60","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1099\/0022-1317-72-4-961","article-title":"Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1","volume":"72","author":"Falconar","year":"1991","journal-title":"J Gen Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib61","doi-asserted-by":"crossref","first-page":"19111","DOI":"10.1073\/pnas.0605668103","article-title":"West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H","volume":"103","author":"Chung","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.coviro.2026.101536_bib62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pep.2011.11.003","article-title":"Expression and immunoaffinity purification of recombinant dengue virus 2 NS1 protein as a cleavable SUMOstar fusion","volume":"82","author":"Rozen-Gagnon","year":"2012","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.coviro.2026.101536_bib63","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.4049\/jimmunol.1601523","article-title":"Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection","volume":"199","author":"Wan","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2026.101536_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010469","article-title":"Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model","volume":"18","author":"Tien","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.coviro.2026.101536_bib65","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1038\/s41467-018-07008-0","article-title":"Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model","volume":"9","author":"Bailey","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2026.101536_bib66","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12879-018-3173-y","article-title":"Delayed and highly specific antibody response to nonstructural protein 1 (NS1) revealed during natural human ZIKV infection by NS1-based capture ELISA","volume":"18","author":"Gao","year":"2018","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.coviro.2026.101536_bib67","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1038\/s41467-020-19096-y","article-title":"Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy","volume":"11","author":"Wessel","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.coviro.2026.101536_bib68","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1126\/science.abb9425","article-title":"A broadly protective antibody that targets the flavivirus NS1 protein","volume":"371","author":"Modhiran","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.coviro.2026.101536_bib69","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1038\/s41598-017-07308-3","article-title":"Antibodies against modified NS1 wing domain peptide protect against dengue virus infection","volume":"7","author":"Lai","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.coviro.2026.101536_sbref68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.hlife.2024.05.003","article-title":"Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1","volume":"2","author":"Pan","year":"2024","journal-title":"hLife"},{"key":"10.1016\/j.coviro.2026.101536_bib71","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.abc0476","article-title":"Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction","volume":"371","author":"Biering","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.coviro.2026.101536_bib72","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s007050050127","article-title":"The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin\/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis","volume":"142","author":"Falconar","year":"1997","journal-title":"Arch Virol"},{"key":"10.1016\/j.coviro.2026.101536_bib73","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1258\/ebm.2011.010339","article-title":"Molecular mimicry between virus and host and its implications for dengue disease pathogenesis","volume":"236","author":"Lin","year":"2011","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.coviro.2026.101536_bib74","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1074\/jbc.M110.170993","article-title":"Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus","volume":"286","author":"Liu","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.coviro.2026.101536_bib75","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.coviro.2026.101536_bib76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.1103350","article-title":"Association between magnitude of the virus-specific plasmablast response and disease severity in dengue patients","volume":"190","author":"Garcia-Bates","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2026.101536_bib77","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.4049\/jimmunol.1600323","article-title":"Secreted NS1 protects dengue virus from mannose-binding lectin\u2013mediated neutralization","volume":"197","author":"Thiemmeca","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.coviro.2026.101536_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2016.87","article-title":"Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes","volume":"1","author":"Liu","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.coviro.2026.101536_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1330600","article-title":"Intrinsic factors driving mosquito vector competence and viral evolution: a review","volume":"13","author":"Lewis","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.coviro.2026.101536_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci"},{"key":"10.1016\/j.coviro.2026.101536_bib81","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic diagramming platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res"}],"container-title":["Current Opinion in Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625726000283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879625726000283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T19:17:42Z","timestamp":1794424662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879625726000283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":81,"alternative-id":["S1879625726000283"],"URL":"https:\/\/doi.org\/10.1016\/j.coviro.2026.101536","relation":{},"ISSN":["1879-6257"],"issn-type":[{"value":"1879-6257","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavivirus NS1 as a pivotal virulence factor and a tractable target for next-generation antivirals, vaccines, and immunodiagnostics","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.coviro.2026.101536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101536"}}