{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:19Z","timestamp":1791492619956,"version":"4.3.4"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012680","name":"The Nathaniel Wharton Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Press Blue"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cpblue.2026.100129","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:58:39Z","timestamp":1791385119000},"page":"100129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context-specific hypermetabolism in humans with mitochondrial defects"],"prefix":"10.1016","author":[{"given":"Evan D.","family":"Shaulson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Sercel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Rausser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Whyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Zuraikat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Seid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Junker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshana","family":"Kapri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh","family":"Kurade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Trumpff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Bobba-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Engelstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Pontzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-4923","authenticated-orcid":false,"given":"Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Creasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-9745","authenticated-orcid":false,"given":"Edward L.","family":"Melanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"St-Onge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dympna","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2835-0478","authenticated-orcid":false,"given":"Martin","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpblue.2026.100129_bib1","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1113\/JP273839","article-title":"Oxidative phosphorylation: regulation and role in cellular and tissue metabolism","volume":"595","author":"Wilson","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib2","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI104637","article-title":"A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: A correlated clinical, biochemical and morphological study","volume":"41","author":"Luft","year":"1962","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cpblue.2026.100129_bib3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa2202949","article-title":"Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation","volume":"387","author":"Ganetzky","year":"2022","journal-title":"N. Engl. J. Med. Overseas. Ed."},{"key":"10.1016\/j.cpblue.2026.100129_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s42003-022-04303-x","article-title":"OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases","volume":"6","author":"Sturm","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cpblue.2026.100129_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s42255-023-00968-8","article-title":"Hypermetabolism and energetic constraints in mitochondrial disorders","volume":"6","author":"Sercel","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib6","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/jcm8091374","article-title":"ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency","volume":"8","author":"V\u00e1zquez-Fonseca","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib7","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.celrep.2018.03.127","article-title":"Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity","volume":"23","author":"Fu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cpblue.2026.100129_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45873","article-title":"Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness","volume":"8","author":"Sharma","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.cpblue.2026.100129_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102181","article-title":"Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response","volume":"24","author":"Kang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.cpblue.2026.100129_bib10","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.15252\/embj.201696179","article-title":"OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance","volume":"36","author":"Pereira","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.cpblue.2026.100129_bib11","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/cells8080916","article-title":"Absence of Uncoupling Protein-3 at Thermoneutrality Impacts Lipid Handling and Energy Homeostasis in Mice","volume":"8","author":"Lombardi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cpblue.2026.100129_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809456","article-title":"Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy","volume":"11","author":"Rajendran","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib13","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/emboj.2012.70","article-title":"Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice","volume":"31","author":"Quir\u00f3s","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cpblue.2026.100129_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.mito.2013.03.006","article-title":"Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice","volume":"13","author":"Dai","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cpblue.2026.100129_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archneurol.2008.526","article-title":"Protean Phenotypic Features of the A3243G Mitochondrial DNA Mutation","volume":"66","author":"Kaufmann","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.cpblue.2026.100129_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cpblue.2026.100129_bib17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.nmd.2015.03.001","article-title":"Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease","volume":"25","author":"Gorman","year":"2015","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.cpblue.2026.100129_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022294","article-title":"Habitual Physical Activity in Mitochondrial Disease","volume":"6","author":"Apabhai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cpblue.2026.100129_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/07853890410028456","article-title":"Cardiovascular autonomic regulation in patients with 3243A > G mitochondrial DNA mutation","volume":"36","author":"Majamaa-Voltti","year":"2004","journal-title":"Ann. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/JCI136055","article-title":"Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity","volume":"131","author":"Sharma","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cpblue.2026.100129_bib21","doi-asserted-by":"crossref","first-page":"R873","DOI":"10.1152\/ajpregu.00001.2011","article-title":"Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms","volume":"301","author":"Heinicke","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/brain\/awg028","article-title":"The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients","volume":"126","author":"Taivassalo","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.cpblue.2026.100129_bib23","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1016\/j.ijcard.2013.05.062","article-title":"Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease","volume":"168","author":"Bates","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/jpen.1965","article-title":"Optimal Estimate for Energy Requirements in Adult Patients With the m.3243A>G Mutation in Mitochondrial DNA","volume":"45","author":"Zweers","year":"2021","journal-title":"JPEN - J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jada.2006.02.009","article-title":"Best Practice Methods to Apply to Measurement of Resting Metabolic Rate in Adults: A Systematic Review","volume":"106","author":"Compher","year":"2006","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.cpblue.2026.100129_bib26","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1172\/JCI112749","article-title":"Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber","volume":"78","author":"Ravussin","year":"1986","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cpblue.2026.100129_bib27","first-page":"348S","article-title":"Reliability of the doubly labeled water method for the measurement of total daily energy expenditure in free-living subjects","volume":"126","author":"Schoeller","year":"1996","journal-title":"J. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib28","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cub.2026.01.025","article-title":"The evidence for constrained total energy expenditure in humans and other animals","volume":"36","author":"Pontzer","year":"2026","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cpblue.2026.100129_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1249\/JES.0000000000000048","article-title":"Constrained Total Energy Expenditure and the Evolutionary Biology of Energy Balance","volume":"43","author":"Pontzer","year":"2015","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.cpblue.2026.100129_bib30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/ejcn.2016.237","article-title":"Control of energy expenditure in humans","volume":"71","author":"Westerterp","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2420902122","article-title":"Energy expenditure and obesity across the economic spectrum","volume":"122","author":"McGrosky","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cpblue.2026.100129_bib32","doi-asserted-by":"crossref","first-page":"R709","DOI":"10.1016\/j.cub.2022.05.018","article-title":"Balancing growth, reproduction, maintenance, and activity in evolved energy economies","volume":"32","author":"Pontzer","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cpblue.2026.100129_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2025.109179","article-title":"The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity","volume":"145","author":"Huang","year":"2025","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.cpblue.2026.100129_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148709","article-title":"GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction","volume":"11","author":"Montero","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cpblue.2026.100129_bib35","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","author":"Yatsuga","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cpblue.2026.100129_bib36","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa007","article-title":"GDF15: A Hormone Conveying Somatic Distress to the Brain","volume":"41","author":"Lockhart","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cpblue.2026.100129_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.201607110","article-title":"Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis","volume":"216","author":"Chung","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cpblue.2026.100129_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102070","article-title":"GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem","volume":"91","author":"Hes","year":"2025","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.cpblue.2026.100129_bib39","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cpblue.2026.100129_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107543","article-title":"GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss","volume":"31","author":"Borner","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cpblue.2026.100129_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2019.12.004","article-title":"GDF15 Induces Anorexia through Nausea and Emesis","volume":"31","author":"Borner","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbi.2022.11.008","article-title":"The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice","volume":"108","author":"Chelette","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cpblue.2026.100129_bib44","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41467-021-21309-x","article-title":"Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise","volume":"12","author":"Klein","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cpblue.2026.100129_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111947","article-title":"GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia","volume":"42","author":"Kim-Muller","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.cpblue.2026.100129_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-06249-4","article-title":"GDF15 promotes weight loss by enhancing energy expenditure in muscle","volume":"619","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cpblue.2026.100129_bib47","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/s12276-025-01543-9","article-title":"GDF15 regulates development and growth of sympathetic neurons to enhance energy expenditure and thermogenesis","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib48","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1056\/NEJMoa2409515","article-title":"Ponsegromab for the Treatment of Cancer Cachexia","volume":"391","author":"Groarke","year":"2024","journal-title":"N. Engl. J. Med. Overseas. Ed."},{"key":"10.1016\/j.cpblue.2026.100129_bib49","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.tem.2024.08.006","article-title":"A platform to map the mind\u2013mitochondria connection and the hallmarks of psychobiology: the MiSBIE study","volume":"35","author":"Kelly","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s42255-025-01445-0","article-title":"Standardizing the analysis and visualization of human energy expenditure data","volume":"8","author":"Fern\u00e1ndez-Verdejo","year":"2026","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib51","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.abe5017","article-title":"Daily energy expenditure through the human life course","volume":"373","author":"Pontzer","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cpblue.2026.100129_bib52","doi-asserted-by":"crossref","first-page":"E62","DOI":"10.1152\/ajpendo.1984.246.1.E62","article-title":"Nutritional influences on lipogenesis and thermogenesis after a carbohydrate meal","volume":"246","author":"Acheson","year":"1984","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.cpblue.2026.100129_bib53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ajcn\/85.1.73","article-title":"Validation study of energy expenditure and intake during calorie restriction using doubly labeled water and changes in body composition","volume":"85","author":"de Jonge","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib54","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1126\/science.150.3703.1621","article-title":"Oxygen consumption rate and electroencephalographic stage of sleep","volume":"150","author":"Brebbia","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.cpblue.2026.100129_bib55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/ajcn\/35.3.566","article-title":"Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects","volume":"35","author":"Ravussin","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.sleep.2021.12.007","article-title":"A meta-analysis of the first-night effect in healthy individuals for the full age spectrum","volume":"89","author":"Ding","year":"2022","journal-title":"Sleep Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib57","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1172\/JCI116336","article-title":"Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease","volume":"91","author":"Vigushin","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cpblue.2026.100129_bib58","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/clinchem\/47.3.426","article-title":"Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects","volume":"47","author":"Meier-Ewert","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cpblue.2026.100129_bib59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fphys.2013.00090","article-title":"Physical activity and physical activity induced energy expenditure in humans: measurement, determinants, and effects","volume":"4","author":"Westerterp","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/gerona\/glz071","article-title":"Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults","volume":"75","author":"Semba","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.cpblue.2026.100129_bib61","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3389\/fimmu.2020.00915","article-title":"GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness","volume":"11","author":"Conte","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cpblue.2026.100129_bib62","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.cmet.2025.09.002","article-title":"The energy resistance principle","volume":"37","author":"Picard","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib63","first-page":"1","article-title":"Evolutionary Aspects of Infections: Inflammation and Sickness Behaviors","volume":"61","author":"Dantzer","year":"2023","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.cpblue.2026.100129_bib64","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2024.10.045","article-title":"Atlas of the plasma proteome in health and disease in 53,026 adults","volume":"188","author":"Deng","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cpblue.2026.100129_bib65","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1249\/MSS.0000000000002056","article-title":"Translational Medicine: Exercise Physiology Applied to Metabolic Myopathies","volume":"51","author":"Grassi","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.cpblue.2026.100129_bib66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/brain\/awr293","article-title":"Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery","volume":"135","author":"Taivassalo","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.cpblue.2026.100129_bib67","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/mus.20708","article-title":"Impaired oxygen extraction in metabolic myopathies: Detection and quantification by near-infrared spectroscopy","volume":"35","author":"Grassi","year":"2007","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.cpblue.2026.100129_bib68","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/brain\/awl282","article-title":"Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions","volume":"129","author":"Taivassalo","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.cpblue.2026.100129_bib69","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cub.2015.12.046","article-title":"Constrained Total Energy Expenditure and Metabolic Adaptation to Physical Activity in Adult Humans","volume":"26","author":"Pontzer","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cpblue.2026.100129_bib70","doi-asserted-by":"crossref","first-page":"E3914","DOI":"10.1073\/pnas.1717522115","article-title":"Tradeoffs between immune function and childhood growth among Amazonian forager-horticulturalists","volume":"115","author":"Urlacher","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cpblue.2026.100129_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax1065","article-title":"Constraint and trade-offs regulate energy expenditure during childhood","volume":"5","author":"Urlacher","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cpblue.2026.100129_bib72","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/ajcn\/79.6.1078","article-title":"Energy requirements during pregnancy based on total energy expenditure and energy deposition","volume":"79","author":"Butte","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib73","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/s43587-024-00716-x","article-title":"The brain\u2013body energy conservation model of aging","volume":"4","author":"Shaulson","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cpblue.2026.100129_bib74","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/PSY.0000000000001498","article-title":"Mitoception via the Metabokine GDF15 and Human Health","volume":"88","author":"Liu","year":"2026","journal-title":"Biopsychosoc. Sci. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib84","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41586-023-06921-9","article-title":"GDF15 linked to maternal risk of nausea and vomiting during pregnancy","volume":"625","author":"Fejzo","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cpblue.2026.100129_bib76","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/jgs.70399","article-title":"Potential Risks of Blocking GDF15-Based Brain Energy Sensing","volume":"74","author":"Cohen","year":"2026","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.cpblue.2026.100129_bib75","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","article-title":"Stress, adaptation, and disease. Allostasis and allostatic load","volume":"840","author":"McEwen","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cpblue.2026.100129_bib77","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/PSY.0000000000000544","article-title":"Psychological Stress and Mitochondria: A Conceptual Framework","volume":"80","author":"Picard","year":"2018","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","article-title":"An energetic view of stress: Focus on mitochondria","volume":"49","author":"Picard","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.cpblue.2026.100129_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2022.105951","article-title":"The energetic cost of allostasis and allostatic load","volume":"146","author":"Bobba-Alves","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cpblue.2026.100129_bib79","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cpblue.2026.100129_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2026.02.010","article-title":"Energy constraint on human health","author":"Behnke","year":"2026","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib81","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/imj.15505","article-title":"Patient care standards for primary mitochondrial disease in Australia: an Australian adaptation of the Mitochondrial Medicine Society recommendations","volume":"52","author":"Sue","year":"2022","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.cpblue.2026.100129_bib82","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s13311-023-01418-9","article-title":"Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life","volume":"20","author":"DiVito","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cpblue.2026.100129_bib83","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/gim.2014.177","article-title":"Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society","volume":"17","author":"Parikh","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib86","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12986-015-0043-0","article-title":"Evaluation of a new whole room indirect calorimeter specific for measurement of resting metabolic rate","volume":"12","author":"Rising","year":"2015","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","journal-title":"J. Physiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib88","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1017\/S0007114500000155","article-title":"Evaluation of the novel Tanita body-fat analyser to measure body composition by comparison with a four-compartment model","volume":"83","author":"Jebb","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib89","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mrm.20624","article-title":"Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging","volume":"54","author":"Reeder","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib90","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/ajcn\/80.2.271","article-title":"Visceral adipose tissue: relations between single-slice areas and total volume","volume":"80","author":"Shen","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cpblue.2026.100129_bib91","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-83762-0","article-title":"Effect of caloric restriction on organ size and its contribution to metabolic adaptation: an ancillary analysis of CALERIE 2","volume":"15","author":"Falkenhain","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cpblue.2026.100129_bib92","series-title":"Doubly Labelled Water: Theory and Practice","author":"Speakman","year":"1997"},{"key":"10.1016\/j.cpblue.2026.100129_bib93","doi-asserted-by":"crossref","first-page":"R823","DOI":"10.1152\/ajpregu.1986.250.5.R823","article-title":"Energy expenditure by doubly labeled water: validation in humans and proposed calculation","volume":"250","author":"Schoeller","year":"1986","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cpblue.2026.100129_bib94","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1021\/ac3016642","article-title":"Direct analysis of \u03b42H and \u03b418O in natural and enriched human urine using laser-based, Off-Axis Integrated Cavity Output Spectroscopy","volume":"84","author":"Berman","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cpblue.2026.100129_bib95","doi-asserted-by":"crossref","first-page":"E124","DOI":"10.1152\/ajpendo.00241.2017","article-title":"Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry","volume":"314","author":"Melanson","year":"2018","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.cpblue.2026.100129_bib96","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1096\/fasebj.30.1_supplement.724.1","article-title":"Validation of the doubly labeled water method using integrated cavity output spectroscopy against isotope ratio mass spectrometry and whole-room indirect calorimetry","volume":"30","author":"Melanson","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.cpblue.2026.100129_bib97","series-title":"The Doubly-Labelled Water Method for Measuring Energy Expenditure: Technical Recommendations for Use in Humans","first-page":"48","article-title":"Calculation of pool sizes and flux rates","author":"Coward","year":"1990"},{"key":"10.1016\/j.cpblue.2026.100129_bib98","doi-asserted-by":"crossref","first-page":"E585","DOI":"10.1152\/ajpendo.1994.267.4.E585","article-title":"Relative dilution spaces of 2H- and 18O-labeled water in humans","volume":"267","author":"Racette","year":"1994","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.cpblue.2026.100129_bib99","article-title":"A standard calculation methodology for human doubly labeled water studies","volume":"2","author":"Speakman","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cpblue.2026.100129_bib100","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/oby.22928","article-title":"Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0)","volume":"28","author":"Chen","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.cpblue.2026.100129_bib101","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/sleep\/15.5.461","article-title":"Automatic Sleep\/Wake Identification From Wrist Activity","volume":"15","author":"Cole","year":"1992","journal-title":"Sleep"},{"key":"10.1016\/j.cpblue.2026.100129_bib102","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1139\/apnm-2017-0860","article-title":"Can an automated sleep detection algorithm for waist-worn accelerometry replace sleep logs?","volume":"43","author":"Barreira","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.cpblue.2026.100129_bib103","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/sleep\/30.4.519","article-title":"Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007","volume":"30","author":"Morgenthaler","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.cpblue.2026.100129_bib104","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jand.2012.04.016","article-title":"The Automated Self-Administered 24-Hour Dietary Recall (ASA24): A Resource for Researchers, Clinicians, and Educators from the National Cancer Institute","volume":"112","author":"Subar","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.cpblue.2026.100129_bib105","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1016\/S0893-133X(01)00315-3","article-title":"Circadian Clues to Sleep Onset Mechanisms","volume":"25","author":"Kr\u00e4uchi","year":"2001","journal-title":"Neuropsychopharmacology"}],"container-title":["Cell Press Blue"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3051383926001271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3051383926001271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:16:18Z","timestamp":1791490578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3051383926001271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":105,"alternative-id":["S3051383926001271"],"URL":"https:\/\/doi.org\/10.1016\/j.cpblue.2026.100129","relation":{},"ISSN":["3051-3839"],"issn-type":[{"value":"3051-3839","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Context-specific hypermetabolism in humans with mitochondrial defects","name":"articletitle","label":"Article Title"},{"value":"Cell Press Blue","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpblue.2026.100129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100129"}}