{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:28:21Z","timestamp":1791390501504,"version":"4.3.3"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Problems in Cardiology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.cpcardiol.2019.06.002","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T08:17:55Z","timestamp":1561105075000},"page":"100428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Risk Stratification in Bicuspid Aortic Valve Aortopathy: Emerging Evidence and Future Perspectives"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-3339","authenticated-orcid":false,"given":"Alessandro","family":"Della Corte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector I.","family":"Michelena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Citarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Votta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Piatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Lo Presti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasul","family":"Ashurov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Cipollaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Forte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0001","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ijcard.2015.08.106","article-title":"Bicuspid aortic valve aortopathy in adults: incidence, etiology, and clinical significance","volume":"201","author":"Michelena","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0002","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0003","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jcmg.2013.10.005","article-title":"Surgical thresholds for bicuspid aortic valve associated aortopathy","volume":"6","author":"Hardikar","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0004","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"Aortic diameter >or\u202f=\u202f5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0005","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jacc.2013.12.028","article-title":"How does the ascending aorta geometry change when it dissects?","volume":"63","author":"Rylski","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0006","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0007","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fphys.2017.00475","article-title":"Evolution of precision medicine and surgical strategies for bicuspid aortic valve-associated aortopathy","volume":"8","author":"Fatehi Hassanabad","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0008","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/HCO.0000000000000481","article-title":"Bicuspid aortic valve-associated aortopathy: update on biomarkers","volume":"33","author":"Maredia","year":"2018","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0009","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.jtcvs.2014.01.021","article-title":"Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives","volume":"147","author":"Della Corte","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0010","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejcts.2006.12.006","article-title":"Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression","volume":"31","author":"Della Corte","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0011","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/hrt.2007.132092","article-title":"The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape","volume":"94","author":"Schaefer","year":"2008","journal-title":"Heart"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0012","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jtcvs.2008.01.022","article-title":"The aortopathy of bicuspid aortic valve disease has distinctive patterns and usually involves the transverse aortic arch","volume":"135","author":"Fazel","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0013","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijcard.2015.06.059","article-title":"The natural history of guidelines: the case of aortopathy related to bicuspid aortic valves","volume":"199","author":"Hardikar","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0014","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jtcvs.2013.06.037","article-title":"Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons","volume":"146","author":"Verma","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0015","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/heartjnl-2013-304920","article-title":"Aortic dilatation patterns and rates in adults with bicuspid aortic valves: a comparative study with Marfan syndrome and degenerative aortopathy","volume":"100","author":"Detaint","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0016","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ejcts.2011.02.007","article-title":"Aortopathy in bicuspid aortic valve disease - genes or hemodynamics? or Scylla and Charybdis","volume":"39","author":"Sievers","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0017","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/heartjnl-2013-305004","article-title":"Phenotypic heterogeneity of bicuspid aortopathy: a potential key to decode the prognosis?","volume":"100","author":"Della Corte","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0018","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jcmg.2012.11.007","article-title":"Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction and bicuspid aortopathy: comprehensive evaluation using MDCT and echocardiography","volume":"6","author":"Kang","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0019","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ejcts\/ezt621","article-title":"The ascending aorta with bicuspid aortic valve: a phenotypic classification with potential prognostic significance","volume":"46","author":"Della Corte","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0020","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jcmg.2013.07.009","article-title":"Pattern of ascending aortic dimensions predicts the growth rate of the aorta in patients with bicuspid aortic valve","volume":"6","author":"Della Corte","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0021","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/ejcts\/ezs137","article-title":"Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation","volume":"42","author":"Girdauskas","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0022","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2350-15-23","article-title":"Identification of fibrillin 1 gene mutations in patients with bicuspid aortic valve (BAV) without Marfan syndrome","volume":"15","author":"Pepe","year":"2014","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0023","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ejcts\/ezx065","article-title":"Genetic abnormalities in bicuspid aortic valve root phenotype: preliminary results","volume":"52","author":"Girdauskas","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0024","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.jtcvs.2018.02.115","article-title":"The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve-related aortopathy: full online-only version","volume":"156","author":"Borger","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0025","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.acra.2015.01.010","article-title":"Bicuspid valve-related aortic disease: flow assessment with conventional phase-contrast MRI","volume":"22","author":"Burris","year":"2015","journal-title":"Acad Radiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0026","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12968-018-0451-1","article-title":"Aortic flow patterns and wall shear stress maps by 4D-flow cardiovascular magnetic resonance in the assessment of aortic dilatation in bicuspid aortic valve disease","volume":"20","author":"Rodr\u00edguez-Palomares","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0027","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/CIRCULATIONAHA.113.003026","article-title":"Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy","volume":"129","author":"Mahadevia","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0028","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jcmg.2011.05.004","article-title":"4D flow CMR in assessment of valve-related ascending aortic disease","volume":"4","author":"Hope","year":"2011","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1148\/radiol.09091437","article-title":"Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns","volume":"255","author":"Hope","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0030","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1532-429X-14-84","article-title":"Evaluation of 3D blood flow patterns and wall shear stress in the normal and dilated thoracic aorta using flow-sensitive 4D CMR","volume":"14","author":"B\u00fcrk","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0031","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/CIRCIMAGING.112.973370","article-title":"Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta","volume":"5","author":"Barker","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0032","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCIMAGING.113.000528","article-title":"Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type","volume":"6","author":"Bissell","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0033","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12968-018-0431-5","article-title":"Differential flow improvements after valve replacements in bicuspid aortic valve disease: a cardiovascular magnetic resonance assessment","volume":"20","author":"Bissell","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0034","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCIMAGING.113.001497","article-title":"Response to letter regarding article, \u201cAortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type\u201d","volume":"7","author":"Bissell","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0035","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jacc.2015.06.1310","article-title":"Valve-related hemodynamics mediate human bicuspid aortopathy: insights from wall shear stress mapping","volume":"25","author":"Guzzardi","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0036","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jtcvs.2007.09.009","article-title":"Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling","volume":"135","author":"Della Corte","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0037","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/CS20120324","article-title":"Early cell changes and TGF\u03b2 pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis","volume":"124","author":"Forte","year":"2013","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0038","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.jtcvs.2018.05.095","article-title":"Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy","volume":"156","author":"Bollache","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0039","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10237-014-0567-7","article-title":"Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas","volume":"13","author":"Atkins","year":"2014","journal-title":"Biomech Model Mechanobiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4330\/wjc.v8.i1.89","article-title":"Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity","volume":"26","author":"Atkins","year":"2016","journal-title":"World J Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0041","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/jmri.24847","article-title":"Thoracic aorta 3D hemodynamics in pediatric and young adult patients with bicuspid aortic valve","volume":"42","author":"Allen","year":"2015","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0042","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jmri.24362","article-title":"MRI hemodynamic markers of progressive bicuspid aortic valve-related aortic disease","volume":"40","author":"Hope","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0043","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s10439-014-1092-7","article-title":"Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy","volume":"43","author":"van Ooij","year":"2015","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0044","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3389\/fphys.2018.00993","article-title":"Wall shear stress directional abnormalities in BAV aortas: toward a new hemodynamic predictor of aortopathy?","volume":"9","author":"Liu","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0045","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3389\/fphys.2017.00441","article-title":"4D flow analysis of BAV-related fluid-dynamic alterations: evidences of wall shear stress alterations in absence of clinically-relevant aortic anatomical remodeling","volume":"8","author":"Piatti","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0046","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ehjci\/jes273","article-title":"Wall shear stress and flow patterns in the ascending aorta in patients with bicuspid aortic valves differ significantly from tricuspid aortic valves: a prospective study","volume":"14","author":"Meierhofer","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0047","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jjcc.2016.05.007","article-title":"Hypothesis-free secretome analysis of thoracic aortic aneurysm reinforces the central role of TGF-\u03b2 cascade in patients with bicuspid aortic valve","volume":"69","author":"Rocchiccioli","year":"2017","journal-title":"J Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0048","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00380-011-0161-1","article-title":"Dilatation of the ascending aorta and serum alpha 1-antitrypsin level in patients with bicuspid aortic valve","volume":"27","author":"Kilickesmez","year":"2012","journal-title":"Heart Vessels"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0049","doi-asserted-by":"crossref","first-page":"210","DOI":"10.12945\/j.aorta.2013.13-047","article-title":"Reasons to investigate the soluble receptor for advanced glycation end-product (sRAGE) pathway in aortic disease","volume":"1","author":"Sarkar","year":"2013","journal-title":"Aorta (Stamford)"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0050","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1161\/ATVBAHA.114.303784","article-title":"Circulating soluble receptor for advanced glycation end product identifies patients with bicuspid aortic valve and associated aortopathies","volume":"34","author":"Branchetti","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0051","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2459\/JCM.0b013e3283588dfa","article-title":"Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine","volume":"14","author":"Drapisz","year":"2013","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0052","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-94-007-7893-1_8","article-title":"Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling","volume":"802","author":"Wheeler","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0053","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2015.01.040","article-title":"Mutations in a TGF-\u03b2 ligand, TGFB3, cause syndromic aortic aneurysms and dissections","volume":"65","author":"Bertoli-Avella","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0054","doi-asserted-by":"crossref","first-page":"E2125","DOI":"10.3390\/ijms19072125","article-title":"TGF-\u03b2 signaling-related genes and thoracic aortic aneurysms and dissections","volume":"19","author":"Takeda","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0055","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/CIRCRESAHA.117.310833","article-title":"A possible early biomarker for bicuspid aortopathy: circulating transforming growth factor \u03b2-1 to soluble endoglin ratio","volume":"120","author":"Forte","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0056","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/clc.22320","article-title":"Total serum transforming growth factor-\u03b21 is elevated in the entire spectrum of genetic aortic syndromes","volume":"37","author":"Hillebrand","year":"2014","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0057","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00380-016-0942-7","article-title":"Patients with bicuspid and tricuspid aortic valve exhibit distinct regional microrna signatures in mildly dilated ascending aorta","volume":"32","author":"Albinsson","year":"2017","journal-title":"Heart Vessels"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0058","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fphys.2017.00429","article-title":"Non-coding RNA contribution to thoracic and abdominal aortic aneurysm disease development and progression","volume":"8","author":"Li","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0059","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/ejcts\/ezu215","article-title":"BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro","volume":"47","author":"Wang","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0060","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejvs.2017.06.010","article-title":"Long non-coding RNA-mRNA correlation analysis reveals the potential role of HOTAIR in pathogenesis of sporadic thoracic aortic aneurysm","volume":"54","author":"Guo","year":"2017","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0061","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/ATVBAHA.112.300139","article-title":"Intercellular transport of microRNAs","volume":"33","author":"Boon","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0062","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12967-017-1176-x","article-title":"Specific circulating microRNA signature of bicuspid aortic valve disease","volume":"15","author":"Mart\u00ednez-Micaelo","year":"2017","journal-title":"J Transl Med"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0063","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jtcvs.2012.12.027","article-title":"Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease","volume":"145","author":"Ikonomidis","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0064","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/icvts\/ivy033","article-title":"Evaluation of microribonucleic acids as potential biomarkers in the bicuspid aortic valve-associated aortopathy","volume":"27","author":"Girdauskas","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijcard.2018.10.005","article-title":"On the prospect of serum exosomal miRNA profiling and protein biomarkers for the diagnosis of ascending aortic dilatation in patients with bicuspid and tricuspid aortic valve","volume":"273","author":"Gallo","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0066","doi-asserted-by":"crossref","first-page":"13834","DOI":"10.1038\/s41598-018-32170-2","article-title":"Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm","volume":"8","author":"Balistreri","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.cpcardiol.2019.06.002_bib0067","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5879281","article-title":"A typical immune T\/B subset profile characterizes bicuspid aortic valve: in an old status?","author":"Balistreri","year":"2018","journal-title":"Oxid Med Cell Longev"}],"container-title":["Current Problems in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014628061930101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014628061930101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:26:16Z","timestamp":1758939976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014628061930101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S014628061930101X"],"URL":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2019.06.002","relation":{},"ISSN":["0146-2806"],"issn-type":[{"value":"0146-2806","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Stratification in Bicuspid Aortic Valve Aortopathy: Emerging Evidence and Future Perspectives","name":"articletitle","label":"Article Title"},{"value":"Current Problems in Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2019.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}],"article-number":"100428"}}