{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:22:03Z","timestamp":1782800523048,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Problems in Cardiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cpcardiol.2025.103189","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:34Z","timestamp":1760144974000},"page":"103189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of neuromodulation in heart failure with preserved ejection fraction"],"prefix":"10.1016","volume":"50","author":[{"given":"Jumana","family":"Algheffari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Rahman","family":"Salameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Adil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-6185","authenticated-orcid":false,"given":"Aamir","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurdo","family":"Araz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cpcardiol.2025.103189_bib0001","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-027984","article-title":"Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design","volume":"9","author":"Ali","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.cpcardiol.2025.103189_bib0002","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.15420\/ecr.2022.44","article-title":"The DELIVER trial: the beginning of the end of ejection fraction tyranny","volume":"17","author":"Bayes-Genis","year":"2022","journal-title":"Eur Cardiol"},{"issue":"1","key":"10.1016\/j.cpcardiol.2025.103189_bib0003","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002477","article-title":"Clinical phenotypes in heart failure with preserved ejection fraction","volume":"5","author":"Samson","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.cpcardiol.2025.103189_bib0004","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","article-title":"Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association","volume":"6","author":"Heidenreich","year":"2013","journal-title":"Circ Heart Fail"},{"issue":"9","key":"10.1016\/j.cpcardiol.2025.103189_bib0005","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41569-020-0363-2","article-title":"Evaluation and management of heart failure with preserved ejection fraction","volume":"17","author":"Borlaug","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"10.1016\/j.cpcardiol.2025.103189_bib0006","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/eurjhf\/hfq121","article-title":"Epidemiology and clinical course of heart failure with preserved ejection fraction","volume":"13","author":"Lam","year":"2011","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.cpcardiol.2025.103189_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2024.102411","article-title":"Unraveling the complex pathophysiology of heart failure: insights into the role of renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system (SNS)","volume":"49","author":"Maryam","year":"2024","journal-title":"Curr Probl Cardiol"},{"issue":"9-10","key":"10.1016\/j.cpcardiol.2025.103189_bib0008","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jacbts.2021.06.002","article-title":"Device-based solutions to improve cardiac physiology and hemodynamics in heart failure with preserved ejection fraction","volume":"6","author":"Rosalia","year":"2021","journal-title":"JACC Basic Transl Sci"},{"issue":"3","key":"10.1016\/j.cpcardiol.2025.103189_bib0009","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024481","article-title":"Tackling inflammation in heart failure with preserved ejection fraction: resurrection of vagus nerve stimulation?","volume":"11","author":"Kittipibul","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"10.1016\/j.cpcardiol.2025.103189_bib0010","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ejhf.502","article-title":"Renal denervation in heart failure with preserved ejection fraction (RDT-PEF): a randomized controlled trial","volume":"18","author":"Patel","year":"2016","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.cpcardiol.2025.103189_bib0011","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cardfail.2010.09.004","article-title":"Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction","volume":"17","author":"Georgakopoulos","year":"2011","journal-title":"J Card Fail"},{"issue":"7","key":"10.1016\/j.cpcardiol.2025.103189_bib0012","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jacc.2011.06.008","article-title":"Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial","volume":"58","author":"Bisognano","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cpcardiol.2025.103189_bib0013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijcard.2023.03.030","article-title":"Autonomic regulation therapy in chronic heart failure with preserved\/mildly reduced ejection fraction: ANTHEM-HFpEF study results","volume":"381","author":"Kumar","year":"2023","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.cpcardiol.2025.103189_bib0014","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023582","article-title":"Neuromodulation of inflammation to treat heart failure with preserved ejection fraction: a pilot randomized clinical trial","volume":"11","author":"Stavrakis","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.cpcardiol.2025.103189_bib0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12265-018-9853-6","article-title":"Autonomic neuromodulation acutely ameliorates left ventricular strain in humans","volume":"12","author":"Tran","year":"2019","journal-title":"J Cardiovasc Transl Res"},{"issue":"7","key":"10.1016\/j.cpcardiol.2025.103189_bib0016","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/ejhf.2209","article-title":"Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first-in-human clinical trial","volume":"23","author":"Malek","year":"2021","journal-title":"Eur J Heart Fail"},{"issue":"10","key":"10.1016\/j.cpcardiol.2025.103189_bib0017","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jchf.2022.05.009","article-title":"Transvenous right greater splanchnic nerve ablation in heart failure and preserved ejection fraction: first-in-human study","volume":"10","author":"Fudim","year":"2022","journal-title":"JACC Heart Fail"},{"issue":"12","key":"10.1016\/j.cpcardiol.2025.103189_bib0018","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jamacardio.2024.2612","article-title":"Endovascular ablation of the greater splanchnic nerve in heart failure with preserved ejection fraction: the REBALANCE-HF randomized clinical trial","volume":"9","author":"Fudim","year":"2024","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.cpcardiol.2025.103189_bib0019","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11886-012-0258-x","article-title":"The role of renal denervation in the treatment of heart failure","volume":"14","author":"Sobotka","year":"2012","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"10.1016\/j.cpcardiol.2025.103189_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.resp.2005.04.005","article-title":"Lactic acid buffering, nonmetabolic CO2 and exercise hyperventilation: a critical reappraisal","volume":"150","author":"Peronnet","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"issue":"5","key":"10.1016\/j.cpcardiol.2025.103189_bib0021","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jjcc.2024.02.004","article-title":"Role of splanchnic circulation in the pathogenesis of heart failure: state-of-the-art review","volume":"83","author":"Yaku","year":"2024","journal-title":"J Cardiol"}],"container-title":["Current Problems in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146280625002087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146280625002087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:08:26Z","timestamp":1761818906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146280625002087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0146280625002087"],"URL":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2025.103189","relation":{},"ISSN":["0146-2806"],"issn-type":[{"value":"0146-2806","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of neuromodulation in heart failure with preserved ejection fraction","name":"articletitle","label":"Article Title"},{"value":"Current Problems in Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2025.103189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103189"}}