{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:12:29Z","timestamp":1787321549937,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006256","name":"University of Aquila","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Problems in Cardiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cpcardiol.2026.103405","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:19:03Z","timestamp":1784387943000},"page":"103405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heatwaves and cardiovascular mortality: Pathophysiological pathways, environmental co-determinants, and the role of autonomic monitoring"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-9097","authenticated-orcid":false,"given":"Federica","family":"Moscucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Sciomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Piccirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovambattista","family":"Desideri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpcardiol.2026.103405_bib0001","unstructured":"WHO. Heat and health fact sheet. Updated April 2026. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/climate-change-heat-and-health."},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0002","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.crvi.2007.12.001","article-title":"Death toll exceeded 70,000 in Europe during the summer of 2003","volume":"331","author":"Robine","year":"2008","journal-title":"C R Biol"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0003","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/s41591-023-02419-z","article-title":"Heat-related mortality in Europe during the summer of 2022","volume":"29","author":"Ballester","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0004","series-title":"Climate Change Tripled Heat Deaths in European Heatwave","author":"Konstantinoudis","year":"2025"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0005","series-title":"Climate Change Drove 16,500 Additional Heat Deaths Across 854 European Cities, Summer 2025","author":"Masselot","year":"2025"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0006","unstructured":"Al Jazeera. Europe faces further extreme heat as temperature records broken. 2026. Available at: https:\/\/www.aljazeera.com\/news\/2026\/6\/25."},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0007","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-075203","article-title":"Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis","volume":"383","author":"Liu","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0008","article-title":"Interactive effects of atmospheric oxidative pollutants and heat on circulatory disease mortality","volume":"13","author":"Ma","year":"2025","journal-title":"Front Public Health"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1680783","article-title":"Heart rate variability in cardiovascular disease diagnosis, prognosis and management","volume":"12","author":"Wang","year":"2026","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20247146","article-title":"Heart rate variability measurement through a smart wearable device: another breakthrough for personal health monitoring?","volume":"20","author":"Li","year":"2023","journal-title":"Int J Env Res Public Health"},{"issue":"1","key":"10.1016\/j.cpcardiol.2026.103405_bib0011","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1038\/s41467-025-62871-y","article-title":"Future heat-related mortality in Europe driven by compound day-night heatwaves and demographic shifts","volume":"16","author":"Wu","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0024","first-page":"1280","article-title":"Interaction effects of high temperature and ozone on cardiovascular disease mortality in Chengdu, 2014\u20132023","volume":"21","author":"Cheng","year":"2024","journal-title":"Int J Env Res Public Health"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0025","article-title":"Heat wave, fine particulate matter, and cardiovascular disease mortality: a time-stratified case-crossover study in Shenzhen, China","volume":"368","author":"Wang","year":"2025","journal-title":"Environ Pollut"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0012","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1056\/NEJM199312093292401","article-title":"An association between air pollution and mortality in six U.S. cities","volume":"329","author":"Dockery","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0013","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American heart association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0014","article-title":"Mortality burden of cardiovascular disease attributable to ambient PM2.5 exposure in Portugal, 2011\u20132021","volume":"19","author":"Miranda","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0015","first-page":"1041","article-title":"Short-term interaction effects of PM2.5 and O3 on daily mortality: a time-series study of multiple cities in China","volume":"21","author":"Ma","year":"2024","journal-title":"Int J Env Res Public Health"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0016","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/acs.est.3c06889","article-title":"Ozone, heat wave, and cardiovascular disease mortality: a population-based case-crossover study","volume":"58","author":"Xu","year":"2024","journal-title":"Env Sci Technol"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0017","first-page":"450","article-title":"Heat stress and cardiovascular disease: mechanisms and epidemiology","volume":"37","author":"Hoffmann","year":"2022","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0018","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacc.2004.03.044","article-title":"Electrophysiologic and electroanatomic changes in the human atrium associated with age","volume":"44","author":"Kistler","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0019","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0020","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.hrthm.2005.09.021","article-title":"Neural modulation of cardiac arrhythmias and sudden cardiac death","volume":"3","author":"Zipes","year":"2006","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0021","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pcad.2008.01.003","article-title":"The role of the autonomic nervous system in sudden cardiac death","volume":"50","author":"Vaseghi","year":"2008","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0022","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1172\/JCI26381","article-title":"Mechanisms of sudden cardiac death","volume":"115","author":"Rubart","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0023","article-title":"Heart rate variability: a multidimensional perspective from physiological marker to brain-heart axis disorders prediction","volume":"12","author":"Guo","year":"2025","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0026","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1056\/NEJMra2301903","article-title":"Wearable digital health technologies for monitoring in cardiovascular medicine","volume":"390","author":"Spatz","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0027","article-title":"AI-driven real-time monitoring of cardiovascular conditions with wearable devices: scoping review","volume":"13","author":"Ahmad","year":"2025","journal-title":"JMIR Mhealth Uhealth"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0028","article-title":"Continuous monitoring of heart rate variability in free-living conditions using wearable sensors: exploratory observational study","volume":"8","author":"Babadi","year":"2024","journal-title":"JMIR Form Res"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41746-025-02010-5","article-title":"Diurnal variation of wearable device-based heart rate variability in the chronic renal insufficiency cohort study","volume":"8","author":"Skarke","year":"2025","journal-title":"Npj Digit Med"},{"key":"10.1016\/j.cpcardiol.2026.103405_bib0030","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"issue":"30","key":"10.1016\/j.cpcardiol.2026.103405_bib0031","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/eurheartj\/ehaf326","volume":"46","author":"Chaseling","year":"2025","journal-title":"Eur Heart J"}],"container-title":["Current Problems in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146280626001477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146280626001477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:12:44Z","timestamp":1787317964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146280626001477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0146280626001477"],"URL":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2026.103405","relation":{},"ISSN":["0146-2806"],"issn-type":[{"value":"0146-2806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heatwaves and cardiovascular mortality: Pathophysiological pathways, environmental co-determinants, and the role of autonomic monitoring","name":"articletitle","label":"Article Title"},{"value":"Current Problems in Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpcardiol.2026.103405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103405"}}