{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:00:07Z","timestamp":1761580807816},"reference-count":97,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PET Clinics"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.cpet.2010.02.007","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T09:19:47Z","timestamp":1280913587000},"page":"259-274","source":"Crossref","is-referenced-by-count":7,"title":["18F-Fluoride PET in Osteoporosis"],"prefix":"10.1016","volume":"5","author":[{"given":"Michelle L.","family":"Frost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen M.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignac","family":"Fogelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpet.2010.02.007_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","article-title":"Consensus development conference: diagnosis prophylaxis and treatment of osteoporosis","volume":"94","year":"1993","journal-title":"Am J Med"},{"issue":"6","key":"10.1016\/j.cpet.2010.02.007_bib2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1185\/03007990802115796","article-title":"Osteoporosis management: impact of fracture type on cost and quality of life in patients at risk for fracture I","volume":"24","author":"Boonen","year":"2008","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.cpet.2010.02.007_bib3","series-title":"Advisory Group on Osteoporosis","author":"Department of Health","year":"1994"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11926-008-0017-6","article-title":"Osteoporosis epidemiology update","volume":"10","author":"Cole","year":"2008","journal-title":"Curr Rheumatol Rep"},{"issue":"7","key":"10.1016\/j.cpet.2010.02.007_bib5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib6","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group","volume":"843","author":"World Health Organization (WHO)","year":"1994","journal-title":"World Health Organ Tech Rep Ser"},{"issue":"6","key":"10.1016\/j.cpet.2010.02.007_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1503\/cmaj.070234","article-title":"Low bone mineral density and fracture burden in postmenopausal women","volume":"177","author":"Cranney","year":"2007","journal-title":"CMAJ"},{"issue":"8","key":"10.1016\/j.cpet.2010.02.007_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00198-007-0343-y","article-title":"The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women","volume":"18","author":"Kanis","year":"2007","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.cpet.2010.02.007_bib9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the UK","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos Int"},{"issue":"10","key":"10.1016\/j.cpet.2010.02.007_bib10","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00198-008-0712-1","article-title":"Case finding for the management of osteoporosis with FRAX-assessment and intervention thresholds for the UK","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S8756-3282(03)00236-9","article-title":"Is the paradigm shifting?","volume":"33","author":"Heaney","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.cpet.2010.02.007_bib12","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"220","article-title":"Overview of osteoporosis treatment","author":"Kleerekoper","year":"2008"},{"issue":"Suppl 6","key":"10.1016\/j.cpet.2010.02.007_bib13","first-page":"55","article-title":"Markers of bone turnover for the prediction of fracture risk","volume":"11","author":"Garnero","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s001980200068","article-title":"Biochemical indices of bone turnover and the assessment of fracture probability","volume":"13","author":"Johnell","year":"2002","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib15","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/jbmr.2003.18.6.1051","article-title":"Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate","volume":"18","author":"Eastell","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib16","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1210\/jc.87.4.1586","article-title":"Changes in bone density and turnover explain the reduction in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents","volume":"87","author":"Hochberg","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cpet.2010.02.007_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0169-6009(91)90086-F","article-title":"Histomorphometric assessment of trabecular bone remodelling in osteoporosis","volume":"14","author":"Compston","year":"1991","journal-title":"Bone Miner"},{"key":"10.1016\/j.cpet.2010.02.007_bib18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1053\/j.ajkd.2003.12.003","article-title":"Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy","volume":"43","author":"Martin","year":"2004","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 6","key":"10.1016\/j.cpet.2010.02.007_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s001980070002","article-title":"for the Committee of Scientific Advisors of the International Osteoporosis Foundation. The use of biochemical markers of bone turnover in osteoporosis","volume":"11","author":"Delmas","year":"2000","journal-title":"Osteoporos Int"},{"issue":"Suppl 6","key":"10.1016\/j.cpet.2010.02.007_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s001980070003","article-title":"Molecular markers of bone turnover: biochemical, technical and analytical aspects","volume":"11","author":"Seibel","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1359\/jbmr.2000.15.4.763","article-title":"Differences in skeletal kinetics between vertebral and humeral bone measured by 18F-fluoride positron emission tomography in postmenopausal women","volume":"15","author":"Cook","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib22","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1359\/jbmr.2002.17.5.854","article-title":"Quantification of skeletal kinetic indices in Paget's disease using dynamic 18F-fluoride positron emission tomography","volume":"17","author":"Cook","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib23","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1359\/jbmr.2003.18.12.2215","article-title":"A prospective study of risedronate on regional bone metabolism and blood flow at the lumbar spine measured by 18F-fluoride positron emission tomography","volume":"18","author":"Frost","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1359\/JBMR.040818","article-title":"Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis","volume":"19","author":"Frost","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jocd.2006.10.006","article-title":"The relationship between regional bone turnover measured using 18F-fluoride positron emission tomography and changes in BMD is equivalent to that seen for biochemical markers of bone turnover","volume":"10","author":"Frost","year":"2006","journal-title":"J Clin Densitom"},{"issue":"5","key":"10.1016\/j.cpet.2010.02.007_bib26","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bone.2009.07.081","article-title":"Differences in regional bone perfusion and turnover between lumbar spine and distal humerus: 18F-fluoride PET study of treatment-na\u00efve and treated postmenopausal women","volume":"45","author":"Frost","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.cpet.2010.02.007_bib27","first-page":"1493","article-title":"Comparison of different quantitative approaches to 18F-fluoride PET scans","volume":"45","author":"Brenner","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib28","first-page":"633","article-title":"Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET","volume":"33","author":"Hawkins","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib29","first-page":"1650","article-title":"18F-fluoride PET for monitoring therapeutic response in Paget's disease of bone","volume":"46","author":"Installe","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib30","doi-asserted-by":"crossref","DOI":"10.1359\/jbmr.091108","article-title":"Assessment of regional changes in skeletal metabolism following 3 and 18 months of teriparatide treatment","author":"Moore","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1210\/jc.77.4.949","article-title":"Bone metabolic activity measured with positron emission tomography and 18F-fluoride ion in renal osteodystrophy: correlation with bone histomorphometry","volume":"77","author":"Messa","year":"1993","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.cpet.2010.02.007_bib32","first-page":"1091","article-title":"Assessment of porcine bone metabolism by dynamic 18F-fluoride PET: correlation with bone histomorphometry","volume":"42","author":"Piert","year":"2001","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib33","first-page":"117","article-title":"Increased sensitivity in detection of a porcine high-turnover osteopenia after total gastrectomy by dynamic 18F-fluoride ion PET and quantitative CT","volume":"44","author":"Piert","year":"2003","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib34","first-page":"1970","article-title":"Fluoride kinetics of the axial skeleton measured in vivo with fluorine-18-fluoride PET","volume":"38","author":"Schiepers","year":"1997","journal-title":"J Nucl Med"},{"issue":"8","key":"10.1016\/j.cpet.2010.02.007_bib35","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1359\/jbmr.1998.13.8.1328","article-title":"Blood flow measurements with 15OH2O and 18F-fluoride ion PET in porcine vertebrae","volume":"13","author":"Piert","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00259-002-0797-2","article-title":"Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by 15OH2O and 18F-fluoride ion positron emission tomography","volume":"29","author":"Piert","year":"2002","journal-title":"Eur J Nucl Med"},{"issue":"11","key":"10.1016\/j.cpet.2010.02.007_bib37","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2967\/jnumed.109.062570","article-title":"Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective study","volume":"50","author":"Uchida","year":"2009","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1055\/s-0038-1629797","article-title":"18F-fluoride PET indicates reduced bone formation in severe glucocorticoid-induced osteoporosis","volume":"37","author":"Berding","year":"1998","journal-title":"Nuklearmedizin"},{"key":"10.1016\/j.cpet.2010.02.007_bib39","first-page":"332","article-title":"Fluorine-18: a new isotope for bone scanning","volume":"3","author":"Blau","year":"1962","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib40","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF00296652","article-title":"Distribution of fluoride in cortical bone of human rib","volume":"52","author":"Ishiguro","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02555045","article-title":"Distribution of fluoride concentration in the rat's bone","volume":"46","author":"Narita","year":"1990","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.cpet.2010.02.007_bib42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2967\/jnumed.106.037200","article-title":"Skeletal PET with 18F-fluoride: applying new technology to an old tracer","volume":"49","author":"Grant","year":"2008","journal-title":"J Nucl Med"},{"issue":"1","key":"10.1016\/j.cpet.2010.02.007_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/snuc.2001.18742","article-title":"Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate","volume":"31","author":"Blake","year":"2001","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/cs0420153","article-title":"Studies in man with 18F","volume":"42","author":"Hosking","year":"1972","journal-title":"Clin Sci"},{"issue":"4","key":"10.1016\/j.cpet.2010.02.007_bib45","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1088\/0143-0815\/7\/4\/003","article-title":"The single-passage extraction of 18F in rabbit bone","volume":"7","author":"Wootton","year":"1986","journal-title":"Clin Phys Physiol Meas"},{"issue":"10","key":"10.1016\/j.cpet.2010.02.007_bib46","first-page":"1623","article-title":"Sensitivity in detecting osseous lesions depends on anatomic localization: planar bone scintigraphy versus 18F PET","volume":"40","author":"Schirrmeister","year":"1999","journal-title":"J Nucl Med"},{"issue":"12","key":"10.1016\/j.cpet.2010.02.007_bib47","first-page":"1800","article-title":"Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer","volume":"42","author":"Schirrmeister","year":"2001","journal-title":"J Nucl Med"},{"issue":"12","key":"10.1016\/j.cpet.2010.02.007_bib48","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1359\/jbmr.2003.18.12.2206","article-title":"F-18 NaF PET for detection of bone metastases in lung cancer: accuracy, cost-effectiveness, and impact on patient management","volume":"18","author":"Hetzel","year":"2003","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib49","first-page":"272","article-title":"Assessment of malignant skeletal disease: initial experience with 18F-fluoride PET\/CT and comparison between 18F-fluoride PET and 18F-fluoride PET\/CT","volume":"45","author":"Even-Sapir","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib50","doi-asserted-by":"crossref","first-page":"700","DOI":"10.2967\/jnumed.107.046987","article-title":"Long-term precision of 18F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism","volume":"49","author":"Frost","year":"2008","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF01880415","article-title":"Trabecular and endocortical bone remodelling in postmenopausal osteoporosis: comparison with normal postmenopausal women","volume":"1","author":"Arlot","year":"1990","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib52","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbmr.5650050402","article-title":"Cancellous bone remodelling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels","volume":"5","author":"Eriksen","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib53","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF02556560","article-title":"Decreased bone formation in osteoporotic patients compared with age-matched controls","volume":"44","author":"Garcia-Carasco","year":"1989","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0169-6009(90)90061-J","article-title":"A comparison of iliac bone histomorphometric data in postmenopausal osteoporotic and normal subjects","volume":"11","author":"Kimmel","year":"1990","journal-title":"Bone Miner"},{"key":"10.1016\/j.cpet.2010.02.007_bib55","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jbmr.5650100319","article-title":"Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis","volume":"10","author":"Parfitt","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1749-6632.2002.tb04204.x","article-title":"Mechanisms of glucocorticoid action in bone","volume":"966","author":"Canalis","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cpet.2010.02.007_bib57","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1359\/jbmr.070415","article-title":"Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats","volume":"22","author":"Prisby","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"issue":"Suppl 3","key":"10.1016\/j.cpet.2010.02.007_bib58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2106\/JBJS.F.00890","article-title":"The physiology of bone blood flow: a review","volume":"88","author":"McCarthy","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.cpet.2010.02.007_bib59","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00003086-200203000-00036","article-title":"Decreases in bone blood flow and bone material properties in aging Fischer-344 rats","volume":"396","author":"Bloomfield","year":"2002","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib60","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1359\/jbmr.080233","article-title":"Compromised bone marrow perfusion in osteoporosis","volume":"23","author":"Griffith","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1359\/jbmr.060910","article-title":"Remodeling and vascular spaces in bone","volume":"22","author":"Eriksen","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1359\/jbmr.1997.12.2.283","article-title":"Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures","volume":"12","author":"Vogt","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib63","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/gerona\/58.4.M362","article-title":"Role of vascular factors in osteoporosis","volume":"58","author":"Alagiakrishnan","year":"2003","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.cpet.2010.02.007_bib64","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.atherosclerosis.2004.05.021","article-title":"Forearm endothelial function and bone mineral loss in postmenopausal women","volume":"176","author":"Sanada","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cpet.2010.02.007_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF01774009","article-title":"Study of the intraosseous vessels of the femoral head in patients with fractures of the femoral neck or osteoarthritis of the hip","volume":"5","author":"Laroche","year":"1995","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib66","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1210\/jcem-66-6-1124","article-title":"Skeletal blood flow, iliac histomorphometry, and strontium kinetics in osteoporosis: a relationship between blood flow and corrected apposition rate","volume":"66","author":"Reeve","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cpet.2010.02.007_bib67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1152\/ajplegacy.1965.209.1.65","article-title":"Bone blood flow shown with F18 and the positron camera","volume":"209","author":"Van Dyke","year":"1965","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.cpet.2010.02.007_bib68","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1148\/radiol.2331031509","article-title":"Correlation of MR lumbar spine bone marrow perfusion with bone mineral density in female subjects","volume":"233","author":"Shih","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.cpet.2010.02.007_bib69","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiol.2413051858","article-title":"Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation","volume":"241","author":"Griffith","year":"2006","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.cpet.2010.02.007_bib70","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s004020050332","article-title":"Measurement of skeletal flow with positron emission tomography and 18F-fluoride in femoral head osteonecrosis","volume":"118","author":"Schiepers","year":"1998","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib71","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/17453670710013681","article-title":"Bone regeneration 6 years after impaction bone grafting: a PET analysis","volume":"78","author":"Ullmark","year":"2007","journal-title":"Acta Orthop"},{"issue":"5","key":"10.1016\/j.cpet.2010.02.007_bib72","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0901-5027(99)80081-2","article-title":"Monitoring of graft perfusion and osteoblast activity in revascularised fibula segments using [18F]-positron emission tomography","volume":"28","author":"Schliephake","year":"1999","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.cpet.2010.02.007_bib73","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s002590050429","article-title":"Allogenic bone graft viability after hip revision arthroplasty assessed by dynamic [18F]fluoride ion positron emission tomography","volume":"26","author":"Piert","year":"1999","journal-title":"Eur J Nucl Med"},{"issue":"5","key":"10.1016\/j.cpet.2010.02.007_bib74","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s11307-008-0153-4","article-title":"Bone metabolism after total hip revision surgery with impacted grafting: evaluation using H215O and [18F]fluoride PET; a pilot study","volume":"10","author":"Temmerman","year":"2008","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.cpet.2010.02.007_bib75","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1259\/bjr.71.847.9771387","article-title":"Contribution of the cortical shell of vertebrae to mechanical behaviour of the lumbar vertebrae with implications for predicting fracture risk","volume":"71","author":"Andresen","year":"1998","journal-title":"Br J Radiol"},{"key":"10.1016\/j.cpet.2010.02.007_bib76","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s002239900361","article-title":"The therapy of osteoporosis and the importance of cortical bone","volume":"61","author":"Rico","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib77","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00223-009-9285-z","article-title":"Bone seeking labels as markers for bone turnover: effect of dosing schedule on labeling various bone sites in rats","volume":"85","author":"Cheong","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib78","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1359\/jbmr.071020","article-title":"A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men","volume":"23","author":"Riggs","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1259\/bjr.73.865.10721315","article-title":"Differential effects of menopause and metabolic disease on trabecular and cortical bone assessed by peripheral quantitative computed tomography (pQCT)","volume":"73","author":"Tsurusaki","year":"2000","journal-title":"Br J Radiol"},{"key":"10.1016\/j.cpet.2010.02.007_bib80","doi-asserted-by":"crossref","first-page":"605","DOI":"10.7326\/0003-4819-101-5-605","article-title":"Marked disparity between trabecular and cortical bone loss with age in healthy men. Measurement by vertebral computed tomography and radial photon absorptiometry","volume":"101","author":"Meier","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib81","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/8756-3282(91)90007-6","article-title":"Differential effects of aging and disease on trabecular and compact bone density of the radius","volume":"12","author":"R\u00fcegsegger","year":"1991","journal-title":"Bone"},{"key":"10.1016\/j.cpet.2010.02.007_bib82","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(00)02217-0","article-title":"Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts","volume":"355","author":"Vico","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cpet.2010.02.007_bib83","first-page":"161","article-title":"Site-specific skeletal effects of exercise: importance of interstitial fluid pressure","volume":"24","author":"Turner","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.cpet.2010.02.007_bib84","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/jcp.52.1.23","article-title":"Differential patterns of altered bone formation in different bone compartments in established osteoporosis","volume":"52","author":"Byers","year":"1999","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.cpet.2010.02.007_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/8756-3282(91)90047-M","article-title":"Osteopenia, hematopoiesis, and bone remodelling in iliac crest and femoral biopsies: a prospective study of 102 cases of femoral neck fractures","volume":"12","author":"Eventov","year":"1991","journal-title":"Bone"},{"key":"10.1016\/j.cpet.2010.02.007_bib86","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF02556619","article-title":"Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman","volume":"40","author":"P\u00f8denphant","year":"1987","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.cpet.2010.02.007_bib87","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jbmr.5650050906","article-title":"Heterogeneity of human bone","volume":"5","author":"Ninomiya","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib88","first-page":"1478","article-title":"Different patterns of global and regional skeletal uptake of 99mTc-methylene diphosphonate with age: relevance to the pathogenesis of bone loss","volume":"41","author":"Carnevale","year":"2000","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib89","first-page":"1155","article-title":"Bone turnover in cortical and trabecular bone in normal women and in women with osteoporosis","volume":"35","author":"Israel","year":"1994","journal-title":"J Nucl Med"},{"issue":"Suppl 2","key":"10.1016\/j.cpet.2010.02.007_bib90","first-page":"40","article-title":"A comparison of regional bone turnover at the spine and hip in postmenopausal women with osteoporosis","volume":"15","author":"Frost","year":"2004","journal-title":"Osteoporos Int"},{"issue":"Suppl 1","key":"10.1016\/j.cpet.2010.02.007_bib91","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/j.injury.2007.02.014","article-title":"Fracture healing in osteoporotic fractures: is it really different? A basic science perspective","volume":"38","author":"Giannoudis","year":"2007","journal-title":"Injury"},{"issue":"Suppl 1","key":"10.1016\/j.cpet.2010.02.007_bib92","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2106\/JBJS.G.01443","article-title":"Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment","volume":"90","author":"Barnes","year":"2008","journal-title":"J Bone Joint Surg Am"},{"issue":"8","key":"10.1016\/j.cpet.2010.02.007_bib93","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00259-006-0280-6","article-title":"The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model","volume":"34","author":"Hsu","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"10.1016\/j.cpet.2010.02.007_bib94","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bone.2006.01.149","article-title":"In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna","volume":"39","author":"Silva","year":"2006","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.cpet.2010.02.007_bib95","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.2967\/jnumed.109.063263","article-title":"Quantitative radionuclide studies of bone","volume":"50","author":"Blake","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.cpet.2010.02.007_bib96","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1359\/jbmr.2002.17.12.2094","article-title":"Pathophysiology and recent advances in the management of renal osteodystrophy","volume":"17","author":"Elder","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cpet.2010.02.007_bib97","series-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","first-page":"347","article-title":"Renal osteodystrophy in adults and children","author":"Goodman","year":"1999"}],"container-title":["PET Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556859810000180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556859810000180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T08:01:06Z","timestamp":1559376066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556859810000180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1556859810000180"],"URL":"https:\/\/doi.org\/10.1016\/j.cpet.2010.02.007","relation":{},"ISSN":["1556-8598"],"issn-type":[{"value":"1556-8598","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}