{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:15:16Z","timestamp":1790032516561,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 311"],"award-info":[{"award-number":["KFO 311"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pet.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["PET Clinics"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.cpet.2023.03.004","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T15:37:28Z","timestamp":1682523448000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiac Applications of Fibroblast Activation Protein Imaging"],"prefix":"10.1016","volume":"18","author":[{"given":"Johanna","family":"Diekmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Bengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpet.2023.03.004_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/ehjci\/jeac242","article-title":"Emerging molecular imaging targets and tools for myocardial fibrosis detection","volume":"24","author":"Barton","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cpet.2023.03.004_bib2","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","article-title":"Myocardial interstitial fibrosis in heart failure: biological and translational perspectives","volume":"71","author":"Gonzalez","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib3","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/S0002-9440(10)63598-5","article-title":"Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair","volume":"163","author":"Virag","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cpet.2023.03.004_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1006\/jmcc.1996.0080","article-title":"Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart","volume":"28","author":"Sun","year":"1996","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib5","doi-asserted-by":"crossref","first-page":"H1117","DOI":"10.1152\/ajpheart.00372.2009","article-title":"Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts","volume":"297","author":"Turner","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/MCB.20.3.1089-1094.2000","article-title":"Targeted disruption of mouse fibroblast activation protein","volume":"20","author":"Niedermeyer","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cpet.2023.03.004_bib7","first-page":"3327","article-title":"Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin","volume":"53","author":"Rettig","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.cpet.2023.03.004_bib8","doi-asserted-by":"crossref","first-page":"36505","DOI":"10.1074\/jbc.274.51.36505","article-title":"Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts","volume":"274","author":"Park","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cpet.2023.03.004_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib10","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2967\/jnumed.119.226993","article-title":"Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labeled fibroblast activation protein inhibitor, FAPI-04","volume":"60","author":"Varasteh","year":"2019","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.cpet.2023.03.004_bib11","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.7150\/thno.51419","article-title":"Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [(68)Ga]MHLL1","volume":"11","author":"Langer","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cpet.2023.03.004_bib12","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.cpet.2023.03.004_bib13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2021.02.019","article-title":"Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction","volume":"77","author":"Diekmann","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/RLU.0000000000003745","article-title":"Visualization of fibroblast activation after myocardial infarction using 68Ga-FAPI PET","volume":"46","author":"Kessler","year":"2021","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.cpet.2023.03.004_bib15","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1007\/s12350-021-02603-z","article-title":"Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using (68)Ga-FAPI-04","volume":"29","author":"Notohamiprodjo","year":"2022","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib16","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2967\/jnumed.121.263555","article-title":"Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with MR tissue characterization and subsequent functional outcome","volume":"63","author":"Diekmann","year":"2022","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.cpet.2023.03.004_bib17","doi-asserted-by":"crossref","first-page":"e010628","DOI":"10.1161\/CIRCIMAGING.120.010628","article-title":"Relationship between cardiac fibroblast activation protein activity by positron emission tomography and cardiovascular disease","volume":"13","author":"Heckmann","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cpet.2023.03.004_bib18","doi-asserted-by":"crossref","first-page":"ytac005","DOI":"10.1093\/ehjcr\/ytac005","article-title":"Cardiac fibroblast activation detected by (68)Gallium-FAPI-46 positron emission tomography-magnetic resonance imaging as a sign of chronic activity in cardiac sarcoidosis","volume":"6","author":"Siebermair","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"10.1016\/j.cpet.2023.03.004_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1148\/radiol.211951","article-title":"68)Ga FAPI PET\/MRI in cardiac amyloidosis","volume":"303","author":"Guo","year":"2022","journal-title":"Radiology"},{"key":"10.1016\/j.cpet.2023.03.004_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00259-022-05994-4","article-title":"68)Ga-FAPI PET visualize heart failure: from mechanism to clinic","volume":"50","author":"Song","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.cpet.2023.03.004_bib21","article-title":"Assessment of myocardial fibrosis in patients with systemic sclerosis using [(68)Ga]Ga-FAPI-04-PET-CT","author":"Treutlein","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.cpet.2023.03.004_bib22","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/eurheartj\/ehz736","article-title":"Cardiac fibroblast activation detected by positron emission tomography\/computed tomography as a possible sign of cardiotoxicity","volume":"41","author":"Totzeck","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cpet.2023.03.004_bib23","doi-asserted-by":"crossref","first-page":"614997","DOI":"10.3389\/fcvm.2021.614997","article-title":"Early detection of checkpoint inhibitor-associated myocarditis using (68)Ga-FAPI PET\/CT","volume":"8","author":"Finke","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cpet.2023.03.004_bib24","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","article-title":"Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies","volume":"43","author":"Frantz","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cpet.2023.03.004_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s42255-022-00537-5","article-title":"CAR-based therapies: opportunities for immuno-medicine beyond cancer","volume":"4","author":"Aghajanian","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.cpet.2023.03.004_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in\u00a0vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cpet.2023.03.004_bib27","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s12350-020-02307-w","article-title":"Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury\/remodeling","volume":"28","author":"Siebermair","year":"2021","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib28","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1007\/s12350-021-02646-2","article-title":"Diffuse uptake of [(68)Ga]Ga-FAPI in the left heart in a patient with hypertensive heart disease by PET\/CT","volume":"29","author":"Lin","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s12350-020-02407-7","article-title":"(68)Ga-FAPI right heart uptake in a patient with idiopathic pulmonary arterial hypertension","volume":"29","author":"Wang","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s12350-020-02315-w","article-title":"Cardiac fibroblast activation in dilated cardiomyopathy detected by positron emission tomography","volume":"29","author":"Shi","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib31","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s12350-020-02517-2","article-title":"Comparison of (68)Ga-FAPI imaging and cardiac magnetic resonance in detection of myocardial fibrosis in a patient with chronic thromboembolic pulmonary hypertension","volume":"29","author":"Xing","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.cpet.2023.03.004_bib32","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00259-021-05577-9","article-title":"Imaging of cardiac fibroblast activation in patients with chronic thromboembolic pulmonary hypertension","volume":"49","author":"Chen","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["PET Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556859823000305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556859823000305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:12:02Z","timestamp":1761563522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556859823000305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1556859823000305"],"URL":"https:\/\/doi.org\/10.1016\/j.cpet.2023.03.004","relation":{},"ISSN":["1556-8598"],"issn-type":[{"value":"1556-8598","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Applications of Fibroblast Activation Protein Imaging","name":"articletitle","label":"Article Title"},{"value":"PET Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpet.2023.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}