{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T20:41:35Z","timestamp":1773607295698,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Podiatric Medicine and Surgery"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.cpm.2008.02.002","type":"journal-article","created":{"date-parts":[[2008,5,17]],"date-time":"2008-05-17T04:45:09Z","timestamp":1210999509000},"page":"327-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Pathophysiology of the Chronic Pain Cycle"],"prefix":"10.1016","volume":"25","author":[{"given":"Andrew J.","family":"Meyr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Saffran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpm.2008.02.002_bib1","series-title":"Bonica's management of pain","first-page":"241","article-title":"General considerations of chronic pain","author":"Jacobson","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib2","series-title":"Evaluation and treatment of chronic pain","first-page":"27","article-title":"Transition from acute to chronic pain","author":"Niv","year":"1998"},{"key":"10.1016\/j.cpm.2008.02.002_bib3","series-title":"Bonica's management of pain","first-page":"222","article-title":"General considerations of acute pain","author":"Coda","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib4","series-title":"Practical management of pain","first-page":"69","article-title":"Outcome measures in pain medicine","author":"Wittink","year":"2000"},{"key":"10.1016\/j.cpm.2008.02.002_bib5","series-title":"Handbook of pain assessment","first-page":"3","article-title":"The measurement of pain and the assessment of people experiencing pain","author":"Turk","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib6","series-title":"Handbook of pain assessment","first-page":"15","article-title":"Self-report scales and procedures for assessing pain in adults","author":"Jensen","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib7","series-title":"Manual of pain management","first-page":"6","article-title":"Pathophysiology of pain","author":"Suchdev","year":"2002"},{"key":"10.1016\/j.cpm.2008.02.002_bib8","series-title":"Evaluation and treatment of chronic pain","first-page":"11","article-title":"Neurobiology of normal and pathophysiologic pain","author":"Devor","year":"1998"},{"key":"10.1016\/j.cpm.2008.02.002_bib9","series-title":"Postoperative pain management","first-page":"17","article-title":"Nociception","author":"Katz","year":"1993"},{"key":"10.1016\/j.cpm.2008.02.002_bib10","series-title":"Interventional pain management","first-page":"11","article-title":"Anatomy of the pain-processing system","author":"Yaksh","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib11","series-title":"Principles and practice of pain medicine","first-page":"13","article-title":"Molecular biology of pain","author":"Yaksh","year":"2004"},{"key":"10.1016\/j.cpm.2008.02.002_bib12","series-title":"Bonica's management of pain","first-page":"26","article-title":"Peripheral pain mechanisms and nociceptor plasticity","author":"Byers","year":"2001"},{"key":"10.1016\/j.cpm.2008.02.002_bib13","series-title":"Principles and practice of pain medicine","first-page":"28","article-title":"Anatomy and physiology of pain","author":"Fausett","year":"2004"},{"key":"10.1016\/j.cpm.2008.02.002_bib14","series-title":"Acute pain: mechanisms and management","first-page":"29","article-title":"Neurochemistry and modulation of pain","author":"Aimone","year":"1992"},{"key":"10.1016\/j.cpm.2008.02.002_bib15","first-page":"195","article-title":"Neurophysiologic basis for chemogenic pain and itch","volume":"vol. 3","author":"Handwerker","year":"1994"},{"key":"10.1016\/j.cpm.2008.02.002_bib16","series-title":"Practical management of pain","first-page":"35","article-title":"Pathophysiology of pain","author":"Cohen","year":"2000"},{"key":"10.1016\/j.cpm.2008.02.002_bib17","series-title":"Osteoarthritis: diagnosis and medical\/surgical\u00a0management","first-page":"27","article-title":"Etiopathogenesis of osteoarthritis","author":"Poole","year":"2007"},{"key":"10.1016\/j.cpm.2008.02.002_bib18","series-title":"Osteoarthritis: diagnosis and medical\/surgical management","first-page":"51","article-title":"Pathology of osteoarthritis","author":"Hough","year":"2007"},{"key":"10.1016\/j.cpm.2008.02.002_bib19","series-title":"Bonica's management of pain","first-page":"503","article-title":"Arthritis and periarthritic disorders","author":"Gardner","year":"2001"},{"issue":"S2A","key":"10.1016\/j.cpm.2008.02.002_bib20","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1016\/S0002-9610(98)00182-2","article-title":"The development and complications of diabetic foot ulcers","volume":"176","author":"Laing","year":"1998","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.cpm.2008.02.002_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-8422(23)00741-3","article-title":"The pathophysiology of diabetic foot ulceration","volume":"12","author":"Murray","year":"1995","journal-title":"Clin Podiatr Med Surg"},{"key":"10.1016\/j.cpm.2008.02.002_bib22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1056-8727(99)00065-3","article-title":"Deep foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments and prognosis","volume":"13","author":"Eneroth","year":"1999","journal-title":"J Diabetes Complications"},{"issue":"1","key":"10.1016\/j.cpm.2008.02.002_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0891-5520(20)30644-9","article-title":"Diabetic foot infections: anatomy and surgery","volume":"9","author":"Gibbons","year":"1995","journal-title":"Infect Dis Clin North Am"},{"issue":"7S","key":"10.1016\/j.cpm.2008.02.002_bib24","doi-asserted-by":"crossref","first-page":"193S","DOI":"10.1097\/01.prs.0000225459.93750.29","article-title":"Evidence-based protocol for diabetic foot ulcers","volume":"117","author":"Brem","year":"2006","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"10.1016\/j.cpm.2008.02.002_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1549-8719.2001.tb00181.x","article-title":"Valvular density alone cannot account for sites of chronic venous insufficiency and ulceration in the lower extremity","volume":"8","author":"Aharinejad","year":"2001","journal-title":"Microcirculation"},{"issue":"6 Pt 2","key":"10.1016\/j.cpm.2008.02.002_bib26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1080\/mic.7.S1.S3.S12","article-title":"Microcirculatory dysfunction in chronic venous insufficiency (CVI)","volume":"7","author":"J\u00fcnger","year":"2000","journal-title":"Microcirculation"},{"issue":"Suppl 1A","key":"10.1016\/j.cpm.2008.02.002_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0002-9610(03)00289-7","article-title":"Practical treatment of pain in patients with chronic wounds: pathogenesis-guided management","volume":"188","author":"Freedman","year":"2004","journal-title":"Am J Surg"},{"issue":"Suppl 1","key":"10.1016\/j.cpm.2008.02.002_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1742-481X.2007.00311.x","article-title":"Managing painful chronic wounds: the wound pain management model","volume":"4","author":"Price","year":"2007","journal-title":"Int Wound J"},{"issue":"4","key":"10.1016\/j.cpm.2008.02.002_bib29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/157016106778521652","article-title":"Recent insights into the role of prostanoids in atherosclerotic vascular disease","volume":"4","author":"Reiss","year":"2006","journal-title":"Curr Vasc Pharmacol"},{"issue":"2","key":"10.1016\/j.cpm.2008.02.002_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/187152906777441812","article-title":"The effects of prostaglandin E-1 in patients with intermittent claudication","volume":"6","author":"Milio","year":"2006","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"issue":"8 Pt 2","key":"10.1016\/j.cpm.2008.02.002_bib31","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1177\/000331970005100803","article-title":"PGE(1) treatment of severe intermittent claudication (short-term versus long-term, associated with exercise): efficacy and costs in a 20-week, randomized trial","volume":"51","author":"Belcaro","year":"2000","journal-title":"Angiology"},{"issue":"2","key":"10.1016\/j.cpm.2008.02.002_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/09537105310001645960","article-title":"The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease","volume":"15","author":"Jagroop","year":"2004","journal-title":"Platelets"},{"issue":"15","key":"10.1016\/j.cpm.2008.02.002_bib33","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1001\/jama.292.15.1867","article-title":"Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease","volume":"292","author":"Tran","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.cpm.2008.02.002_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/PL00007853","article-title":"Chemotherapy-induced peripheral neuropathy","volume":"249","author":"Quasthoff","year":"2002","journal-title":"J Neurol"},{"key":"10.1016\/j.cpm.2008.02.002_bib35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1023\/A:1008369315240","article-title":"Acute deterioration of Charcot-Marie-Tooth disease IA (CMT IA) following 2mg of vincristine chemotherapy","volume":"11","author":"Hildebrant","year":"2000","journal-title":"Ann Oncol"},{"issue":"10","key":"10.1016\/j.cpm.2008.02.002_bib36","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1200\/JCO.2005.04.0543","article-title":"Peripheral neuropathy induced by microtubule-stabilizing agents","volume":"24","author":"Lee","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cpm.2008.02.002_bib37","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1200\/JCO.1998.16.10.3353","article-title":"Dose-density therapy with weekly 1-hour paclitaxel infusions in the treatment of metastatic breast cancer","volume":"16","author":"Seidman","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cpm.2008.02.002_bib38","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1200\/JCO.2004.99.298","article-title":"Use of gabapentin in the prevention of taxane induced arthralgias and myalgias","volume":"22","author":"Nguyen","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cpm.2008.02.002_bib39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.amjmed.2004.03.040","article-title":"Adverse effects of thalidomide administration in patients with neoplastic diseases","volume":"117","author":"Dimopoulos","year":"2004","journal-title":"Am J Med"},{"issue":"7","key":"10.1016\/j.cpm.2008.02.002_bib40","first-page":"1364","article-title":"Chemotherapy-related arthropathy","volume":"33","author":"Kim","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cpm.2008.02.002_bib41","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1200\/JCO.1993.11.4.768","article-title":"Postchemotherapy rheumatism","volume":"11","author":"Loprinzi","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cpm.2008.02.002_bib42","series-title":"Manual of pain management","first-page":"181","article-title":"Phantom limb","author":"Houser","year":"2002"},{"key":"10.1016\/j.cpm.2008.02.002_bib43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1037\/h0041681","article-title":"Extended and telescoped phantom limbs","volume":"66","author":"Weiss","year":"1963","journal-title":"J Abnorm Soc Psychol"},{"key":"10.1016\/j.cpm.2008.02.002_bib44","first-page":"273","article-title":"Thermographic correlates of chronic pain","volume":"68","author":"Sherman","year":"1987","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.cpm.2008.02.002_bib45","first-page":"22","article-title":"Phantom pain: a natural history and association with rehabilitation","volume":"76","author":"Houghton","year":"1994","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.cpm.2008.02.002_bib46","series-title":"Classification of chronic pain","author":"Merskey","year":"1986"},{"issue":"3","key":"10.1016\/j.cpm.2008.02.002_bib47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0166-2236(90)90179-E","article-title":"Phantom limbs and the concept of neuromatrix","volume":"13","author":"Melzack","year":"1993","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.cpm.2008.02.002_bib48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/eujp.2000.0194","article-title":"Relationship between mechanical sensitivity and post amputation pain","volume":"4","author":"Nikulajson","year":"2000","journal-title":"Eur J Pain"},{"key":"10.1016\/j.cpm.2008.02.002_bib49","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathy pain: aetiology, symptoms, mechanism and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.cpm.2008.02.002_bib50","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1534734602001002006","article-title":"Phantom limb pain: a complication of lower extremity wound management","volume":"1","author":"Hazelgrove","year":"2002","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.cpm.2008.02.002_bib51","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(02)00074-1","article-title":"Phantom limb pain: characteristics, causes and treatment","volume":"1","author":"Flor","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.cpm.2008.02.002_bib52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.36076\/ppj.2004\/7\/365","article-title":"Managing phantom pain","volume":"7","author":"Manchikanti","year":"2004","journal-title":"Pain Physician"}],"container-title":["Clinics in Podiatric Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891842208000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891842208000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:51:41Z","timestamp":1760208701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891842208000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0891842208000116"],"URL":"https:\/\/doi.org\/10.1016\/j.cpm.2008.02.002","relation":{},"ISSN":["0891-8422"],"issn-type":[{"value":"0891-8422","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Pathophysiology of the Chronic Pain Cycle","name":"articletitle","label":"Article Title"},{"value":"Clinics in Podiatric Medicine and Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpm.2008.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}