{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:16:48Z","timestamp":1780661808262,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004152","name":"Macao Polytechnic University","doi-asserted-by":"publisher","award":["RP\/FCA-14\/2023"],"award-info":[{"award-number":["RP\/FCA-14\/2023"]}],"id":[{"id":"10.13039\/501100004152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fund for the Development of Science and Technology","doi-asserted-by":"publisher","award":["0033\/2023\/RIB2"],"award-info":[{"award-number":["0033\/2023\/RIB2"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychoneuroendocrinology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.cpnec.2026.100346","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:32:40Z","timestamp":1774971160000},"page":"100346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Triangulating the link between depression and liver disease: An integrative analysis of genetic, observational, and research trend data"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3854-2939","authenticated-orcid":false,"given":"Zhongwen","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingliu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cpnec.2026.100346_bib1","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.cgh.2023.04.015","article-title":"The global burden of liver disease","volume":"21","author":"Younossi","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100346_bib2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1192\/bjp.2024.266","article-title":"Global, regional and national burden of depressive disorders and attributable risk factors, from 1990 to 2021: results from the 2021 global burden of disease study","volume":"227","author":"Rong","year":"2025","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100346_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","article-title":"The gut microbiome in neurological disorders","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jad.2013.01.014","article-title":"A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise","volume":"148","author":"Lopresti","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.cpnec.2026.100346_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g1151","article-title":"Change in mental health after smoking cessation: systematic review and meta-analysis","volume":"348","author":"Taylor","year":"2014","journal-title":"Br. Med. J."},{"key":"10.1016\/j.cpnec.2026.100346_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fnmol.2017.00134","article-title":"Depression and chronic liver diseases: are there shared underlying mechanisms?","volume":"10","author":"Huang","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100346_bib8","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2012.07.037","article-title":"Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement","volume":"57","author":"Schaefer","year":"2012","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100346_bib9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4088\/JCP.v64n0614","article-title":"Psychiatric symptoms in patients with chronic hepatitis C receiving interferon alfa-2b therapy","volume":"64","author":"Kraus","year":"2003","journal-title":"J. Clin. Psychiatry"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cpnec.2026.100346_bib11","article-title":"A bibliometric analysis of inflammatory bowel disease and COVID-19 researches","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cpnec.2026.100346_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mam.2019.01.002","article-title":"Mendelian randomisation: a powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer","volume":"69","author":"Cornish","year":"2019","journal-title":"Mol. Aspect. Med."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100346_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70296","article-title":"Physical activities and Parkinson's disease progression: a two-sample Mendelian randomization study","volume":"31","author":"Luo","year":"2025","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12911-025-02903-1","article-title":"Prediction of depressive disorder using machine learning approaches: findings from the NHANES","volume":"25","author":"Vu","year":"2025","journal-title":"BMC Med. Inf. Decis. Making"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s13105-023-00991-z","article-title":"Fatty liver index (FLI): more than a marker of hepatic steatosis","volume":"80","author":"Kaneva","year":"2023","journal-title":"J. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100346_bib16","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/s41380-024-02736-w","article-title":"Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation","volume":"30","author":"Sforzini","year":"2025","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.cpnec.2026.100346_bib17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbi.2020.12.020","article-title":"Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: integrating the phenotypic, molecular and neuroanatomical dimensions","volume":"93","author":"Sen","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2022.11.013","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"issue":"17","key":"10.1016\/j.cpnec.2026.100346_bib19","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3748\/wjg.v26.i17.1993","article-title":"Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease","volume":"26","author":"Katsarou","year":"2020","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41392-022-01119-3","article-title":"Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver\/steatohepatitis (NAFL\/NASH)","volume":"7","author":"Xu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100346_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020623","article-title":"Molecular mechanisms of glucocorticoid-induced insulin resistance","volume":"22","author":"Beaupere","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12986-020-00532-1","article-title":"The dysregulation of the hypothalamic-pituitary-adrenal axis in diet-induced prediabetic male sprague dawley rats","volume":"17","author":"Mosili","year":"2020","journal-title":"Nutr. Metab."},{"issue":"15","key":"10.1016\/j.cpnec.2026.100346_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158178","article-title":"New insights into the role of insulin and hypothalamic-pituitary-adrenal (HPA) axis in the metabolic syndrome","volume":"23","author":"Janssen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.cpnec.2026.100346_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155214","article-title":"Gut microbiota metabolites in NAFLD pathogenesis and therapeutic implications","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cpnec.2026.100346_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.997018","article-title":"Gut dysbiosis in nonalcoholic fatty liver disease: pathogenesis, diagnosis, and therapeutic implications","volume":"12","author":"Fang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"22","key":"10.1016\/j.cpnec.2026.100346_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213675","article-title":"Microbiota dysbiosis and gut barrier dysfunction associated with non-alcoholic fatty liver disease are modulated by a specific metabolic cofactors' combination","volume":"23","author":"Quesada-V\u00e1zquez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cpnec.2026.100346_bib27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4254\/wjh.v14.i3.612","article-title":"Interrelationship between physical activity and depression in nonalcoholic fatty liver disease","volume":"14","author":"Weinstein","year":"2022","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.cpnec.2026.100346_bib28","doi-asserted-by":"crossref","DOI":"10.1017\/S204579602000116X","article-title":"Depression and increased risk of non-alcoholic fatty liver disease in individuals with obesity","volume":"30","author":"Cho","year":"2021","journal-title":"Epidemiol. Psychiatr. Sci."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00213-015-4085-9","article-title":"High H1-affinity antidepressants and risk of metabolic syndrome in bipolar disorder","volume":"233","author":"Salvi","year":"2016","journal-title":"Psychopharmacology (Berl)."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100346_bib30","doi-asserted-by":"crossref","DOI":"10.1080\/03602532.2024.2313967","article-title":"Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity","volume":"56","author":"Khalil","year":"2024","journal-title":"Drug Metab. Rev."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s13679-024-00598-5","article-title":"Antidepressants and weight gain: an update on the evidence and clinical implications","volume":"14","author":"Moss","year":"2025","journal-title":"Curr. Obes. Rep."},{"issue":"3","key":"10.1016\/j.cpnec.2026.100346_bib32","doi-asserted-by":"crossref","first-page":"396","DOI":"10.5009\/gnl210081","article-title":"Clinical course of hepatitis B viral infection in patients undergoing anti-tumor necrosis factor \u03b1 therapy for inflammatory bowel disease","volume":"16","author":"Lee","year":"2022","journal-title":"Gut Liver"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-88285-6","article-title":"High FIB4 index is an independent risk factor of diabetic kidney disease in type 2 diabetes","volume":"11","author":"Saito","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100346_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19420-0","article-title":"Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy","volume":"12","author":"Kawai","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Comprehensive Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266649762600010X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266649762600010X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:58:33Z","timestamp":1780660713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266649762600010X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":34,"alternative-id":["S266649762600010X"],"URL":"https:\/\/doi.org\/10.1016\/j.cpnec.2026.100346","relation":{},"ISSN":["2666-4976"],"issn-type":[{"value":"2666-4976","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triangulating the link between depression and liver disease: An integrative analysis of genetic, observational, and research trend data","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpnec.2026.100346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100346"}}