{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:06:02Z","timestamp":1789473962810,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Psychoneuroendocrinology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cpnec.2026.100370","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:22:23Z","timestamp":1784856143000},"page":"100370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pupil size as a sensitive marker of acute stress dynamics"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-0661","authenticated-orcid":false,"given":"Geoffrey","family":"Millour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-6473","authenticated-orcid":false,"given":"Alexandre","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-2903","authenticated-orcid":false,"given":"Ludovic","family":"Molle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"Lepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hausswirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cpnec.2026.100370_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/cne.920180503","article-title":"The relation of strength of stimulus to rapidity of habit-formation","volume":"18","author":"Yerkes","year":"1908","journal-title":"J. Comp. Neurol. Psychol."},{"issue":"3","key":"10.1016\/j.cpnec.2026.100370_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1037\/0033-2909.130.3.355","article-title":"Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research","volume":"130","author":"Dickerson","year":"2004","journal-title":"Psychol. Bull."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100370_bib3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrn2648","article-title":"Stress signalling pathways that impair prefrontal cortex structure and function","volume":"10","author":"Arnsten","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100370_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11517-018-1879-z","article-title":"Measuring acute stress response through physiological signals: towards a quantitative assessment of stress","volume":"57","author":"Arza","year":"2019","journal-title":"Med. Biol. Eng. Comput."},{"issue":"10","key":"10.1016\/j.cpnec.2026.100370_bib5","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/ACM.0b013e3181b37b8f","article-title":"The effects of acute stress on performance: implications for health professions education","volume":"84","author":"LeBlanc","year":"2009","journal-title":"Acad. Med."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100370_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/24721840.2020.1858714","article-title":"Pilot work related stress (WRS), effects on wellbeing and mental health, and coping methods","volume":"31","author":"Cahill","year":"2021","journal-title":"Int J Aerosp Psychol"},{"issue":"3","key":"10.1016\/j.cpnec.2026.100370_bib7","first-page":"40","article-title":"The requirements for new tools for use by pilots and the aviation industry to manage risks pertaining to work-related stress (WRS) and wellbeing, and the ensuing impact on performance and safety","volume":"8","author":"Cahill","year":"2020","journal-title":"Tech"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100370_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/tbm\/iby019","article-title":"Measurement of physiological responses to acute stress in multiple occupations: a systematic review and implications for front line healthcare providers","volume":"9","author":"Frazier","year":"2019","journal-title":"Transl. Behav. Med."},{"issue":"3","key":"10.1016\/j.cpnec.2026.100370_bib9","first-page":"150","article-title":"Salivary cortisol in psychobiological research: an overview","volume":"22","author":"Kirschbaum","year":"1994","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.cpnec.2026.100370_bib10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neubiorev.2013.11.005","article-title":"Biological and psychological markers of stress in humans: focus on the trier social stress test","volume":"38","author":"Allen","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cpnec.2026.100370_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Special report: heart rate variability standards of measurement, physiological interpretation, and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cpnec.2026.100370_bib12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neubiorev.2011.11.009","article-title":"A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health","volume":"36","author":"Thayer","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100370_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsycho.2005.11.014","article-title":"Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution, and biobehavioral functions","volume":"74","author":"Grossman","year":"2007","journal-title":"Biol. Psychol."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100370_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41583-018-0003-6","article-title":"Breathing matters","volume":"19","author":"Del Negro","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1469-8986.2008.00654.x","article-title":"The pupil as a measure of emotional arousal and autonomic activation","volume":"45","author":"Bradley","year":"2008","journal-title":"Psychophysiology"},{"issue":"8","key":"10.1016\/j.cpnec.2026.100370_bib16","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/ejn.12859","article-title":"Pupil size tracks perceptual content and Surprise","volume":"41","author":"Kloosterman","year":"2015","journal-title":"Eur. J. Neurosci."},{"issue":"11","key":"10.1016\/j.cpnec.2026.100370_bib17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41583-020-0360-9","article-title":"Locus coeruleus: a new look at the blue spot","volume":"21","author":"Poe","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1475-097X.1996.tb00731.x","article-title":"Salivary alpha-amylase as a measure of endogenous adrenergic activity","volume":"16","author":"Chatterton","year":"1996","journal-title":"Clin. Physiol."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib19","first-page":"583","article-title":"Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans","volume":"29","author":"Kudielka","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.psyneuen.2009.01.014","article-title":"Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research","volume":"34","author":"Nater","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.cpnec.2026.100370_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fpsyg.2017.00213","article-title":"Heart rate variability and cardiac vagal tone in psychophysiological research\u2013recommendations for experiment planning, data analysis, and data reporting","volume":"8","author":"Laborde","year":"2017","journal-title":"Front. Psychol."},{"issue":"3","key":"10.1016\/j.cpnec.2026.100370_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/10447318.2013.848320","article-title":"Automatic stress classification with pupil diameter analysis","volume":"30","author":"Pedrotti","year":"2014","journal-title":"Int. J. Hum. Comput. Interact."},{"key":"10.1016\/j.cpnec.2026.100370_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10339-010-0370-z","article-title":"Pupillary stroop effects","volume":"12","author":"Laeng","year":"2011","journal-title":"Cogn. Process."},{"issue":"2","key":"10.1016\/j.cpnec.2026.100370_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212703","article-title":"Supportive hand-holding attenuates pupillary responses to stress in adult couples","volume":"14","author":"Graff","year":"2019","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cpnec.2026.100370_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0256823","article-title":"Spousal emotional support and relationship quality buffers pupillary response to horror movies","volume":"16","author":"Graff","year":"2021","journal-title":"PLoS One"},{"issue":"2\u20133","key":"10.1016\/j.cpnec.2026.100370_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejphar.2007.11.062","article-title":"Convergent regulation of locus coeruleus activity as an adaptive response to stress","volume":"583","author":"Valentino","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100370_bib27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tins.2014.03.006","article-title":"Dynamic adaptation of large-scale brain networks in response to acute stressors","volume":"37","author":"Hermans","year":"2014","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.cpnec.2026.100370_bib28","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J. Exp. Psychol."},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1017\/S1355617799544020","article-title":"Brain activation and pupil response during covert performance of the Stroop Color Word task","volume":"5","author":"Brown","year":"1999","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"1","key":"10.1016\/j.cpnec.2026.100370_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpsycho.2003.12.010","article-title":"Pupillary assessment and computational modeling of the Stroop task in depression","volume":"52","author":"Siegle","year":"2004","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.cpnec.2026.100370_bib31","series-title":"2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)","first-page":"1","article-title":"The stroop competition: a social-evaluative stroop test for acute stress induction","author":"Mueller","year":"2022"},{"issue":"4","key":"10.1016\/j.cpnec.2026.100370_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"issue":"8","key":"10.1016\/j.cpnec.2026.100370_bib33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/occmed\/kqs140","article-title":"Clinical stress assessment using a visual analogue scale","volume":"62","author":"Lesage","year":"2012","journal-title":"Occup. Med."},{"key":"10.1016\/j.cpnec.2026.100370_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2022.105946","article-title":"Evaluation and update of the expert consensus guidelines for the assessment of the cortisol awakening response (CAR)","volume":"146","author":"Stalder","year":"2022","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.cpnec.2026.100370_bib35","article-title":"Luminance effects on pupil dilation in speech-in-noise recognition","volume":"17","author":"Zhang","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.cpnec.2026.100370_bib36","first-page":"1","article-title":"HRVTool\u2013an open-source matlab toolbox for analyzing heart rate variability","volume":"46","author":"Vollmer","year":"2019","journal-title":"Comput. Cardiol."},{"key":"10.1016\/j.cpnec.2026.100370_bib37","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.cpnec.2026.100370_bib38","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"issue":"20","key":"10.1016\/j.cpnec.2026.100370_bib39","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1016\/j.neuron.2024.05.029","article-title":"Neurobehavioral meaning of pupil size","volume":"112","author":"Grujic","year":"2024","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.cpnec.2026.100370_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14637","article-title":"Pupil-linked arousal is driven by decision uncertainty and alters serial choice bias","volume":"8","author":"Urai","year":"2017","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.cpnec.2026.100370_bib41","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.psyneuen.2011.02.018","article-title":"Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress","volume":"36","author":"Engert","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.cpnec.2026.100370_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biopsycho.2006.04.005","article-title":"Cardiovascular response to stroop: effect of verbal response and task difficulty","volume":"73","author":"Boutcher","year":"2006","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.cpnec.2026.100370_bib43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpsychores.2018.01.005","article-title":"Heart rate variability is associated with psychosocial stress in distinct social domains","volume":"106","author":"Lischke","year":"2018","journal-title":"J. Psychosom. Res."},{"issue":"8","key":"10.1016\/j.cpnec.2026.100370_bib44","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.psyneuen.2011.12.010","article-title":"Acute psychosocial stress: does the emotional stress response correspond with physiological responses?","volume":"37","author":"Campbell","year":"2012","journal-title":"Psychoneuroendocrinology"}],"container-title":["Comprehensive Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666497626000342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666497626000342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:39:23Z","timestamp":1789472363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666497626000342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":44,"alternative-id":["S2666497626000342"],"URL":"https:\/\/doi.org\/10.1016\/j.cpnec.2026.100370","relation":{},"ISSN":["2666-4976"],"issn-type":[{"value":"2666-4976","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pupil size as a sensitive marker of acute stress dynamics","name":"articletitle","label":"Article Title"},{"value":"Comprehensive Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cpnec.2026.100370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100370"}}