{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:27:06Z","timestamp":1781497626532,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.crad.2008.03.008","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T05:34:16Z","timestamp":1218864856000},"page":"1112-1120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ultrasound imaging of liver metastases in the delayed parenchymal phase following administration of Sonazoid\u2122 using a destructive mode technique (Agent Detection Imaging\u2122)"],"prefix":"10.1016","volume":"63","author":[{"given":"A.J.","family":"Edey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Beese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crad.2008.03.008_bib1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/bjr.73.867.10817037","article-title":"Imaging liver metastases: current limitations and future prospects","volume":"73","author":"Robinson","year":"2000","journal-title":"Br J Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib2","doi-asserted-by":"crossref","first-page":"N79","DOI":"10.1007\/s00330-003-0012-2","article-title":"Imaging of liver metastases with contrast-specific low-MI real-time ultrasound and SonoVue","volume":"13","author":"Albrecht","year":"2003","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib3","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00330-006-0192-7","article-title":"Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence","volume":"16","author":"Quaia","year":"2006","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib4","doi-asserted-by":"crossref","first-page":"P25","DOI":"10.1007\/s10406-004-0088-z","article-title":"Detection and characterization of liver metastases","volume":"14","author":"Albrecht","year":"2004","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1148\/radiology.210.2.r99fe47409","article-title":"Improved imaging of liver metastases with stimulated acoustic emission in the late phase of enhancement with the US contrast agent SH U 508A: early experience","volume":"210","author":"Blomley","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib6","doi-asserted-by":"crossref","first-page":"P16","DOI":"10.1007\/s10406-004-0077-2","article-title":"Potential impact and utilization of ultrasound contrast media","volume":"14","author":"Leen","year":"2004","journal-title":"Eur Radiol"},{"issue":"4","key":"10.1016\/j.crad.2008.03.008_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-2004-813245","article-title":"Guidelines for the use of contrast agents in ultrasound","volume":"25","author":"Albrecht","year":"2004","journal-title":"Ultraschall Med"},{"key":"10.1016\/j.crad.2008.03.008_bib8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00330-007-0623-0","article-title":"Microbubble ultrasound contrast agents; an update","volume":"17","author":"Quaia","year":"2007","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1148\/radiology.210.1.r99ja11125","article-title":"Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma","volume":"210","author":"Forsberg","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00004424-199702000-00004","article-title":"Delineation of experimental liver tumors in rabbits by a new ultrasound contrast agent and stimulated acoustic emission","volume":"32","author":"Hauff","year":"1997","journal-title":"Invest Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1148\/radiol.2203992044","article-title":"Do different types of liver lesions differ in their uptake of the microbubble contrast agent SH U 508A in the late liver phase? Early experience","volume":"220","author":"Blomley","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1148\/radiol.2323030596","article-title":"Liver phase uptake of a liver specific microbubble improves characterization of liver lesions: a prospective multi-center study","volume":"232","author":"Bryant","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib13","doi-asserted-by":"crossref","first-page":"S343","DOI":"10.1007\/PL00014070","article-title":"Preliminary experience with NC100100, a new ultrasound contrast agent for intravenous injection","volume":"9","author":"Marelli","year":"1999","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib14","doi-asserted-by":"crossref","unstructured":"Sontum PC. Physicochemical characteristics of Sonazoid\u2122, a new contrast agent for ultrasound imaging. Ultrasound Med Biol 2008;34:824\u201333.","DOI":"10.1016\/j.ultrasmedbio.2007.11.006"},{"issue":"Suppl. P","key":"10.1016\/j.crad.2008.03.008_bib15","first-page":"247","article-title":"Multicentre study of Sonazoid enhanced ultrasound of patients with known primary cancer: improved detection of liver metastases","volume":"225","author":"Leen","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1179\/174313406X150131","article-title":"Microbubble contrast enhanced ultrasound features of common focal liver lesions: a guide for the novice","volume":"14","author":"Berry","year":"2006","journal-title":"Ultrasound"},{"key":"10.1016\/j.crad.2008.03.008_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1148\/radiol.2313030544","article-title":"Evidence for spleen-specific uptake of a microbubble contrast agent: a quantitative study in healthy volunteers","volume":"231","author":"Lim","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00004424-199904000-00003","article-title":"Acoustic properties of NC100100 and their relation with the microbubble size distribution","volume":"34","author":"Sontum","year":"1999","journal-title":"Invest Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib19","doi-asserted-by":"crossref","first-page":"iii1","DOI":"10.1136\/gut.2006.098053","article-title":"Guidelines for resection of colorectal cancer liver metastases","volume":"55","author":"Garden","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.crad.2008.03.008_bib20","author":"Americian College of Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib21","first-page":"275","article-title":"Detection of hepatic metastases in colorectal cancer: a prospective study of laboratory and imaging findings","volume":"159","author":"Ohlsson","year":"1993","journal-title":"Eur J Surg"},{"key":"10.1016\/j.crad.2008.03.008_bib22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00330-002-1670-1","article-title":"Detection of liver metastases by pulse inversion harmonic imaging during Levovist late phase: comparison with conventional ultrasound and helical CT in 160 patients","volume":"13","author":"Quaia","year":"2003","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1148\/radiol.2242011322","article-title":"Hepatic metastases in patients with colorectal cancer: relationship between size of metastases, standard of reference, and detection rates","volume":"224","author":"van Erkel","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1148\/radiol.2421051006","article-title":"Focal liver masses: enhancement patterns on contrast-enhanced images\u2014concordance of US scans with CT scans and MR images","volume":"242","author":"Burns","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib25","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.ultrasmedbio.2006.05.031","article-title":"The safety of SonoVue in abdominal applications: retrospective analysis of 23188 investigations","volume":"32","author":"Piscaglia","year":"2006","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.crad.2008.03.008_bib26","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1148\/radiol.2223001786","article-title":"Hepatic tumor detection: MR imaging and conventional US versus pulse-inversion harmonic US of NC100100 during its reticuloendothelial system-specfic phase","volume":"222","author":"Forsberg","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2008.03.008_bib27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s003300100964","article-title":"Ultrasound contrast agents: clinical applications","volume":"11","author":"Jakobsen","year":"2001","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2008.03.008_bib28","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1148\/rg.244035158","article-title":"Blood flow patterns in focal liver lesions at microbubble-enhanced US","volume":"24","author":"Brannigan","year":"2004","journal-title":"Radiographics"},{"key":"10.1016\/j.crad.2008.03.008_bib29","first-page":"491","article-title":"Improved detection of metastatic liver lesions using pulse inversion harmonic imaging with Levovist: a multicentre study","volume":"213","author":"Blomley","year":"1999","journal-title":"Radiology"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926008001761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926008001761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:18:49Z","timestamp":1757866729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926008001761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0009926008001761"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2008.03.008","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound imaging of liver metastases in the delayed parenchymal phase following administration of Sonazoid\u2122 using a destructive mode technique (Agent Detection Imaging\u2122)","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2008.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}