{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:36:19Z","timestamp":1790750179004,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.crad.2016.05.017","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T16:14:56Z","timestamp":1467044096000},"page":"1018-1029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Value of pretherapeutic DWI in evaluating prognosis and therapeutic effect in immunocompetent patients with primary central nervous system lymphoma given high-dose methotrexate-based chemotherapy: ADC-based assessment"],"prefix":"10.1016","volume":"71","author":[{"given":"Y.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-x.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-f.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-z.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crad.2016.05.017_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jocn.2012.05.021","article-title":"Central nervous system lymphoma in immunocompetent patients: the North Shore-Long Island Jewish Health System experience","volume":"20","author":"Zhang","year":"2013","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.crad.2016.05.017_bib2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejrad.2012.11.002","article-title":"Differentiation of glioblastoma and primary CNS lymphomas using susceptibility weighted imaging","volume":"82","author":"Radbruch","year":"2013","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1634\/theoncologist.2008-0236","article-title":"Primary CNS lymphoma in immunocompetent patients","volume":"14","author":"Sierra del Rio","year":"2009","journal-title":"Oncologist"},{"key":"10.1016\/j.crad.2016.05.017_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ncpneuro0395","article-title":"Primary CNS lymphoma","volume":"3","author":"Hochberg","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.crad.2016.05.017_bib5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1586\/14737140.2013.829634","article-title":"Recurrent or refractory primary central nervous lymphoma: therapeutic considerations","volume":"13","author":"Dahiya","year":"2013","journal-title":"Expert Rev Anticancer Ther"},{"issue":"Suppl. 2","key":"10.1016\/j.crad.2016.05.017_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1634\/theoncologist.13-S2-19","article-title":"Endpoints for assessing drug activity in clinical trials","volume":"13","author":"Pazdur","year":"2008","journal-title":"Oncologist"},{"key":"10.1016\/j.crad.2016.05.017_bib7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3760\/cma.j.issn.0366-6999.20120844","article-title":"Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma","volume":"126","author":"Chen","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.crad.2016.05.017_bib8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ijrobp.2009.10.011","article-title":"Current management of primary central nervous system lymphoma","volume":"76","author":"Schultz","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.crad.2016.05.017_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s11604-012-0124-1","article-title":"Prognosis of primary central nervous system lymphoma treated with radiotherapy alone","volume":"30","author":"Taguchi","year":"2012","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4137\/CMO.S7752","article-title":"Current and emerging pharmacotherapies for primary CNS lymphoma","volume":"6","author":"Prodduturi","year":"2012","journal-title":"Clin Med Insights Oncol"},{"key":"10.1016\/j.crad.2016.05.017_bib11","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1200\/JCO.2003.03.036","article-title":"Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: a report of NABTT 96-07","volume":"21","author":"Batchelor","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.crad.2016.05.017_bib12","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1200\/JCO.2003.99.053","article-title":"International Collaborative Group against Primary CNS Lymphomas","volume":"21","author":"Ferreri","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.crad.2016.05.017_bib13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ijrobp.2003.11.001","article-title":"Primary non-Hodgkin's lymphoma of the CNS treated with CHOD\/BVAM or BVAM chemotherapy before radiotherapy: long-term survival and prognostic factors","volume":"59","author":"Bessell","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.crad.2016.05.017_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11060-010-0182-0","article-title":"Prognostic value of pretreatment 18F-FDG PET in patients with primary central nervous system lymphoma: SUV-based assessment","volume":"100","author":"Kawai","year":"2010","journal-title":"J Neurooncol"},{"key":"10.1016\/j.crad.2016.05.017_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/neuonc\/nor203","article-title":"Cerebrospinal fluid interleukin-10 is a potentially useful biomarker in immunocompetent primary central nervous system lymphoma (PCNSL)","volume":"14","author":"Sasayama","year":"2012","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.crad.2016.05.017_bib16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s11547-011-0650-4","article-title":"Diffusion-weighted MR imaging in assessing cervical tumour response to nonsurgical therapy","volume":"116","author":"Rizzo","year":"2011","journal-title":"Radiol Med"},{"key":"10.1016\/j.crad.2016.05.017_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejrad.2010.12.081","article-title":"Relationship of apparent diffusion coefficient to survival for patients with unresectable primary hepatocellular carcinoma after chemoembolization","volume":"81","author":"Dong","year":"2012","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1148\/radiol.2343031721","article-title":"Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats","volume":"234","author":"Thoeny","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2016.05.017_bib19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00004728-200605000-00024","article-title":"Diffusion changes in a tumor and peritumoral tissue after stereotactic irradiation for brain tumors: possible prediction of treatment response","volume":"30","author":"Tomura","year":"2006","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.crad.2016.05.017_bib20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1593\/neo.81328","article-title":"Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations","volume":"11","author":"Padhani","year":"2009","journal-title":"Neoplasia"},{"key":"10.1016\/j.crad.2016.05.017_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejrad.2009.06.031","article-title":"Imaging parameter effects in apparent diffusion coefficient determination of magnetic resonance imaging","volume":"77","author":"Ogura","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2463\/mrms.2012-0098","article-title":"Interimager variability in ADC measurement of the human brain","volume":"13","author":"Tsujita","year":"2014","journal-title":"Magn Reson Med Sci"},{"key":"10.1016\/j.crad.2016.05.017_bib23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1148\/radiol.2492071681","article-title":"Variability in absolute apparent diffusion coefficient values across different platforms may be substantial: a multivendor, multi-institutional comparison study","volume":"249","author":"Sasaki","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2016.05.017_bib24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1148\/radiol.2212001823","article-title":"Diffusion-tensor MR imaging at 1.5 and 3.0 T: initial observations","volume":"221","author":"Hunsche","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2016.05.017_bib25","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3109\/02841851.2010.495351","article-title":"Diffusion tensor imaging of the brain in a healthy adult population: normative values and measurement reproducibility at 3 T and 1.5 T","volume":"51","author":"Brander","year":"2010","journal-title":"Acta Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib26","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00330-006-0175-8","article-title":"Quantitative diffusion tensor MR imaging of the brain: field strength related variance of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) scalars","volume":"16","author":"Huisman","year":"2006","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2016.05.017_bib27","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/RCT.0000000000000266","article-title":"Apparent diffusion coefficient value is not dependent on magnetic resonance systems and field strength under fixed imaging parameters in brain","volume":"39","author":"Ogura","year":"2015","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.crad.2016.05.017_bib28","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1158\/1078-0432.CCR-11-0625","article-title":"Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI","volume":"18","author":"Wieduwilt","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.crad.2016.05.017_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3174\/ajnr.A1750","article-title":"Diffusion-weighted MR imaging derived apparent diffusion coefficient is predictive of clinical outcome in primary central nervous system lymphoma","volume":"31","author":"Barajas","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.crad.2016.05.017_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.7314\/APJCP.2015.16.2.411","article-title":"Ki-67 is a valuable prognostic factor in gliomas: evidence from a systematic review and meta-analysis","volume":"16","author":"Chen","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.crad.2016.05.017_bib31","first-page":"1068","article-title":"Primary central nervous system lymphoma in immunocompetent individuals: a single center experience","volume":"6","author":"Aki","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.crad.2016.05.017_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11060-009-0078-z","article-title":"Prognostic value of immunohistochemical profile and response to high-dose methotrexate therapy in primary CNS lymphoma","volume":"98","author":"Momota","year":"2010","journal-title":"J Neurooncol"},{"key":"10.1016\/j.crad.2016.05.017_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiol.2413051276","article-title":"Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis","volume":"241","author":"Higano","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2016.05.017_bib34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11060-004-3342-2","article-title":"Characterization of brain tumors by MRS, DWI and Ki-67 labeling index","volume":"72","author":"Calvar","year":"2005","journal-title":"J Neurooncol"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926016302173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926016302173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:33:56Z","timestamp":1757867636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926016302173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0009926016302173"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2016.05.017","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Value of pretherapeutic DWI in evaluating prognosis and therapeutic effect in immunocompetent patients with primary central nervous system lymphoma given high-dose methotrexate-based chemotherapy: ADC-based assessment","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2016.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}