{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:46:11Z","timestamp":1772059571433,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.crad.2019.09.140","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T17:44:46Z","timestamp":1572630286000},"page":"238.e11-238.e19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Determination of contrast medium dose for hepatic CT enhancement with improved body size dependency using a non-linear analysis based on pharmacokinetic principles"],"prefix":"10.1016","volume":"75","author":[{"given":"T.","family":"Hibino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.T.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.crad.2019.09.140_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1148\/radiology.195.2.7724752","article-title":"Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement","volume":"195","author":"Heiken","year":"1995","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib2","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1148\/radiology.216.3.r00se26718","article-title":"Abdominal helical CT: evaluation of optimal doses of intravenous contrast material-a prospective randomized study","volume":"216","author":"Yamashita","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1148\/radiol.2432060390","article-title":"Determining contrast medium dose and rate on basis of lean body weight: does this strategy improve patient-to-patient uniformity of hepatic enhancement during multi-detector row CT?","volume":"243","author":"Ho","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1148\/radiol.2492080033","article-title":"Abdominal multidetector CT in patients with varying body fat percentages: estimation of optimal contrast material dose","volume":"249","author":"Kondo","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2214\/AJR.07.2765","article-title":"Contrast enhancement in cardiovascular MDCT: effect of body weight, height, body surface area, body mass index, and obesity","volume":"190","author":"Bae","year":"2008","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.crad.2019.09.140_bib6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.2214\/AJR.08.1407","article-title":"Effect of contrast injection protocols with dose adjusted to the estimated lean patient body weight on aortic enhancement at CT angiography","volume":"192","author":"Yanaga","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.crad.2019.09.140_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1148\/radiol.09090369","article-title":"Body size indexes for optimizing iodine dose for aortic and hepatic enhancement at multidetector CT: comparison of total body weight, lean body weight, and blood volume","volume":"254","author":"Kondo","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib8","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1016\/j.ejrad.2010.12.009","article-title":"Aortic and hepatic enhancement at multidetector CT: evaluation of optimal iodine dose determined by lean body weight","volume":"80","author":"Kondo","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2019.09.140_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ejrad.2010.08.037","article-title":"Abdominal multi-detector row CT: effectiveness of determining contrast medium dose on basis of body surface area","volume":"80","author":"Onishi","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2019.09.140_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1258\/ar.2012.120268","article-title":"Hepatic contrast medium enhancement at computed tomography and its correlation with various body size measures","volume":"53","author":"Svensson","year":"2012","journal-title":"Acta Radiol"},{"key":"10.1016\/j.crad.2019.09.140_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/RCT.0b013e31827dbc08","article-title":"Contrast enhancement during hepatic computed tomography: effect of total body weight, height, body mass index, blood volume, lean body weight, and body surface area","volume":"37","author":"Kidoh","year":"2013","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.crad.2019.09.140_bib12","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s00330-013-2808-z","article-title":"Body size indices to determine iodine mass with contrast-enhanced multi-detector computed tomography of the upper abdomen: does body surface area outperform total body weight or lean body weight?","volume":"23","author":"Kondo","year":"2013","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2019.09.140_bib13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1148\/radiol.2015142941","article-title":"The optimal body size index with which to determine iodine dose for hepatic dynamic CT: a prospective multicenter study","volume":"278","author":"Awai","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib14","first-page":"36","article-title":"The relationship among pharmacokinetic parameters: effects of altered kinetics on the drug plasma concentration-time profiles","volume":"68","author":"Mehvar","year":"2004","journal-title":"Am J Pharm Educ"},{"key":"10.1016\/j.crad.2019.09.140_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1148\/radiol.10090908","article-title":"Intravenous contrast medium administration and scan timing at CT: considerations and approaches","volume":"256","author":"Bae","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2019.09.140_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/jcp.19.4.389","article-title":"Prediction of lean body mass from height and weight","volume":"19","author":"Hume","year":"1966","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.crad.2019.09.140_bib17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2125.1981.tb01163.x","article-title":"Should clearance be normalized to body surface or to lean body mass?","volume":"11","author":"Hallynck","year":"1981","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.crad.2019.09.140_bib18","first-page":"833","article-title":"Blood volume studies in healthy Japanese adults","volume":"18","author":"Ogawa","year":"1970","journal-title":"Respir Circ"},{"key":"10.1016\/j.crad.2019.09.140_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jjco\/hyg062","article-title":"Standardization of the body surface area (BSA) formula to calculate the dose of anticancer agents in Japan","volume":"33","author":"Kouno","year":"2003","journal-title":"Jpn J Clin Oncol"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926019305884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926019305884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:40:59Z","timestamp":1757868059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926019305884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0009926019305884"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2019.09.140","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of contrast medium dose for hepatic CT enhancement with improved body size dependency using a non-linear analysis based on pharmacokinetic principles","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2019.09.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}