{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:37:05Z","timestamp":1778618225877,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.crad.2021.02.019","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T11:59:17Z","timestamp":1616241557000},"page":"472.e1-472.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Simultaneous assessment of coronary flow reserve and left ventricular function during vasodilator stress evaluated by 13N-ammonia hybrid PET\/MRI"],"prefix":"10.1016","volume":"76","author":[{"given":"T.","family":"Kiko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yokokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Misaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kaneshiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yoshihisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Takeishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.crad.2021.02.019_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0735-1097(95)00218-S","article-title":"Incremental value of prognostic testing in patients with known or suspected ischaemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography","volume":"26","author":"Berman","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/01.CIR.97.6.535","article-title":"Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction","volume":"97","author":"Hachamovitch","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib3","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.crad.2021.02.019_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cpf.12083","article-title":"Comparison of PET rubidium-82 with conventional SPECT myocardial perfusion imaging","volume":"34","author":"Ghotbi","year":"2014","journal-title":"Clin Phys Funct Imag"},{"key":"10.1016\/j.crad.2021.02.019_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0735-1097(87)80228-0","article-title":"Transient ischaemic dilation of the left ventricle on stress thallium-201 scintigraphy: a marker of severe and extensive coronary artery disease","volume":"9","author":"Weiss","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.CIR.100.10.1035","article-title":"Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography","volume":"100","author":"Sharir","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib7","first-page":"831","article-title":"Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischaemia and the poststress ejection fraction","volume":"42","author":"Sharir","year":"2001","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib8","first-page":"349","article-title":"Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: a 82Rb PET\/CT study","volume":"48","author":"Dorbala","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0735-1097(99)00551-3","article-title":"Importance of imaging method over imaging modality in noninvasive determination of left ventricular volumes and ejection fraction: assessment by two- and three-dimensional echocardiography and magnetic resonance imaging","volume":"35","author":"Chuang","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib10","first-page":"806","article-title":"Measurement of ventricular volumes and function: a comparison of gated PET and cardiovascular magnetic resonance","volume":"43","author":"Rajappan","year":"2002","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib11","first-page":"e561","volume":"119","author":"Hendel","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib12","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/01.CIR.86.3.1004","article-title":"Quantification of regional myocardial blood flow using 13N-ammonia and reoriented dynamic positron emission tomographic imaging","volume":"86","author":"Kuhle","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jcin.2016.12.015","article-title":"Diagnostic performance of resting and hyperemic invasive physiological indices to define myocardial ischaemia: validation with 13N-ammonia positron emission tomography","volume":"10","author":"Hwang","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.crad.2021.02.019_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jacc.2009.02.069","article-title":"Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve","volume":"54","author":"Herzog","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib15","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1007\/s00330-017-5008-4","article-title":"Hybrid cardiac imaging using PET\/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)","volume":"28","author":"Nensa","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2021.02.019_bib16","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.2967\/jnumed.111.092726","article-title":"Performance measurements of the Siemens mMR integrated whole-body PET\/MR scanner","volume":"52","author":"Delso","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1053\/j.semnuclmed.2014.12.004","article-title":"PET\/MRI of the heart","volume":"45","author":"Rischpler","year":"2015","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib18","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s12350-018-1237-4","article-title":"Technical aspects of cardiac PET\/MRI","volume":"25","author":"Masuda","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2967\/jnumed.108.054726","article-title":"Tissue classification as a potential approach for attenuation correction in whole-body PET\/MRI: evaluation with PET\/CT data","volume":"50","author":"Martinez-Moller","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1148\/radiology.219.1.r01ap12264","article-title":"MR evaluation of ventricular function: true fast imaging with steady-state precession versus fast low-angle shot cine MR imaging: feasibility study","volume":"219","author":"Barkhausen","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2021.02.019_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1532-429X-15-91","article-title":"Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update","volume":"15","author":"Kramer","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.crad.2021.02.019_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.004768","article-title":"Integrated myocardial perfusion imaging diagnostics improve detection of functionally significant coronary artery stenosis by 13N-ammonia positron emission tomography","volume":"9","author":"Lee","year":"2016","journal-title":"Circ Cardiovasc Imag"},{"key":"10.1016\/j.crad.2021.02.019_bib23","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jacc.2013.07.076","article-title":"Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making","volume":"62","author":"Gould","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib25","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.nuclcard.2006.08.009","article-title":"Positron emission tomography myocardial perfusion and glucose metabolism imaging","volume":"13","author":"Machac","year":"2006","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jacc.2006.06.025","article-title":"What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography?","volume":"48","author":"Yoshinaga","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib27","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s12350-017-1040-7","article-title":"Diagnostic and prognostic significance of transient ischaemic dilation (TID) in myocardial perfusion imaging: a systematic review and meta-analysis","volume":"25","author":"Alama","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1532-429X-15-35","article-title":"Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing","volume":"15","author":"Schulz-Menger","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.crad.2021.02.019_bib29","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0735-1097(97)00388-4","article-title":"Postischaemic stunning can affect left ventricular ejection fraction and regional wall motion on post-stress gated sestamibi tomograms","volume":"30","author":"Johnson","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib30","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/01.mnm.0000126510.81093.02","article-title":"Myocardial stunning demonstrated with rest and post-stress measurements of left ventricular function using dual-isotope gated myocardial perfusion SPECT","volume":"25","author":"Ben-Haim","year":"2004","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.crad.2021.02.019_bib31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2967\/jnumed.111.097600","article-title":"Transient ischaemic dilation ratio in 82Rb PET myocardial perfusion imaging: normal values and significance as a diagnostic and prognostic marker","volume":"53","author":"Rischpler","year":"2012","journal-title":"J Nucl Med"},{"key":"10.1016\/j.crad.2021.02.019_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0002-8703(91)90713-R","article-title":"Dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging: a new marker of triple-vessel disease","volume":"121","author":"Takeishi","year":"1991","journal-title":"Am Heart J"},{"key":"10.1016\/j.crad.2021.02.019_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0002-9149(97)00259-2","article-title":"Myocardial perfusion imaging during adenosine-induced coronary hyperaemia","volume":"79","author":"Iskandrian","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0002-9149(74)90743-7","article-title":"Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperaemia as measures of coronary flow reserve","volume":"33","author":"Gould","year":"1974","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1071-3581(99)90005-3","article-title":"Transient left ventricular dilation at quantitative stress\u2013rest sestamibi tomography: clinical, electrocardiographic, and angiographic correlates","volume":"6","author":"Marcassa","year":"1999","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.crad.2021.02.019_bib36","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/01.CIR.68.6.1328","article-title":"Effects of dipyridamole-induced vasodilation on myocardial uptake and clearance kinetics of thallium-201","volume":"68","author":"Beller","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib37","doi-asserted-by":"crossref","first-page":"190","DOI":"10.7326\/0003-4819-116-3-190","article-title":"Comparison of adenosine, dipyridamole, and dobutamine in stress echocardiography","volume":"116","author":"Martin","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.crad.2021.02.019_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02971251","article-title":"Gated SPECT in assessment of regional and global left ventricular function: major tool of modern nuclear imaging","volume":"13","author":"Abidov","year":"2006","journal-title":"J Nucl Cardiol"},{"issue":"Suppl 6","key":"10.1016\/j.crad.2021.02.019_bib39","first-page":"vi23","article-title":"BSE procedure guidelines for the clinical application of stress echocardiography, recommendations for performance and interpretation of stress echocardiography: a report of the British Society of Echocardiography Policy Committee","volume":"90","author":"Becher","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.crad.2021.02.019_bib40","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/01.CIR.87.4.1211","article-title":"Angiographic and haemodynamic determinants of myocardial ischaemia during adenosine thallium-201 scintigraphy in coronary artery disease","volume":"87","author":"Nishimura","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib41","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/01.CIR.57.6.1103","article-title":"Conditions for vasodilator-induced coronary steal in experimental myocardial ischaemia","volume":"57","author":"Becker","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib42","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/01.CIR.87.4.1415","article-title":"Myocardial ischaemia during pharmacological stress testing","volume":"87","author":"Iskandrian","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.crad.2021.02.019_bib43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF02940016","article-title":"Pharmacologic stress testing: mechanism of action, haemodynamic responses, and results in detection of coronary artery disease","volume":"1","author":"Iskandrian","year":"1994","journal-title":"J Nucl Cardiol"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926021001264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926021001264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:44:37Z","timestamp":1757868277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926021001264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0009926021001264"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2021.02.019","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous assessment of coronary flow reserve and left ventricular function during vasodilator stress evaluated by 13N-ammonia hybrid PET\/MRI","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2021.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}