{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:24:54Z","timestamp":1786987494937,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.crad.2022.02.013","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T19:05:14Z","timestamp":1648321514000},"page":"e425-e433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Head and neck squamous cell carcinoma: evaluation of iodine overlay maps and low-energy virtual mono-energetic images acquired with spectral detector CT"],"prefix":"10.1016","volume":"77","author":[{"given":"D.","family":"Zopfs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lennartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gro\u00dfe Hokamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zaeske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.","family":"Laukamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Houbois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Luers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Maintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Puesken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7368","key":"10.1016\/j.crad.2022.02.013_bib1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/bmj.325.7368.822","article-title":"Squamous cell carcinomas of the head and neck","volume":"325","author":"Sanderson","year":"2002","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.crad.2022.02.013_bib2","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.crad.2022.02.013_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0194599816674672","article-title":"Head and neck cancer","volume":"156","author":"Svider","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"8","key":"10.1016\/j.crad.2022.02.013_bib4","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s00330-015-3627-1","article-title":"Assessment of an advanced mono-energetic reconstruction technique in dual-energy computed tomography of head and neck cancer","volume":"25","author":"Albrecht","year":"2015","journal-title":"Eur Radiol"},{"issue":"11","key":"10.1016\/j.crad.2022.02.013_bib5","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1007\/s00330-006-0301-7","article-title":"Staging of laryngeal and hypopharyngeal cancer: value of imaging studies","volume":"16","author":"Hermans","year":"2006","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.oraloncology.2013.12.001","article-title":"Can dual-energy CT improve the assessment of tumour margins in oral cancer?","volume":"50","author":"Toepker","year":"2014","journal-title":"Oral Oncol"},{"issue":"12","key":"10.1016\/j.crad.2022.02.013_bib7","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1586\/14737140.2015.1108193","article-title":"Advanced dual-energy CT for head and neck cancer imaging","volume":"15","author":"Forghani","year":"2015","journal-title":"Expert Rev Anticancer Ther"},{"issue":"7","key":"10.1016\/j.crad.2022.02.013_bib8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/14737140.2019.1626234","article-title":"An update on advanced dual-energy CT for head and neck cancer imaging","volume":"19","author":"Forghani","year":"2019","journal-title":"Expert Rev Anticancer Ther"},{"issue":"9","key":"10.1016\/j.crad.2022.02.013_bib9","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/RLI.0000000000000377","article-title":"Computed tomography of the head and neck region for tumour staging-comparison of dual-source, dual-energy and low-kilovolt, single-energy acquisitions","volume":"52","author":"May","year":"2017","journal-title":"Invest Radiol"},{"issue":"6","key":"10.1016\/j.crad.2022.02.013_bib10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/RCT.0000000000000617","article-title":"Dual-energy CT: balance between iodine attenuation and artefact reduction for the evaluation of head and neck cancer","volume":"41","author":"Nair","year":"2017","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.crad.2022.02.013_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejrad.2018.11.005","article-title":"Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and hypopharynx squamous cell carcinoma","volume":"110","author":"Bahig","year":"2019","journal-title":"Eur J Radiol"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiol.2015142631","article-title":"Dual- and multi-energy CT: principles, technical approaches, and clinical applications","volume":"276","author":"McCollough","year":"2015","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.crad.2022.02.013_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5152\/dir.2019.19136","article-title":"Technical background of a novel detector-based approach to dual-energy computed tomography","volume":"26","author":"Hokamp","year":"2020","journal-title":"Diagn Interv Radiol"},{"issue":"11","key":"10.1016\/j.crad.2022.02.013_bib14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/RLI.0000000000000077","article-title":"Virtual mono-energetic dual-energy computed tomography: optimization of kiloelectron volt settings in head and neck cancer","volume":"49","author":"Wichmann","year":"2014","journal-title":"Invest Radiol"},{"issue":"12","key":"10.1016\/j.crad.2022.02.013_bib15","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1007\/s00330-018-5511-2","article-title":"Improved detection rates and treatment planning of head and neck cancer using dual-layer spectral CT","volume":"28","author":"Loh\u00f6fer","year":"2018","journal-title":"Eur Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s00330-020-06729-5","article-title":"Iodine overlays to improve differentiation between peritoneal carcinomatosis and benign peritoneal lesions","author":"Lennartz","year":"2020","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1148\/radiol.2018181567","article-title":"Dual-energy CT-derived iodine maps: use in assessing pleural carcinomatosis","volume":"290","author":"Lennartz","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2022.02.013_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejrad.2017.02.024","article-title":"Improved detection of melanoma metastases by iodine maps from dual energy CT","volume":"90","author":"Uhrig","year":"2017","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejrad.2019.05.003","article-title":"Low-energy virtual mono-energetic imaging reconstructions of excretory phase spectral dual-energy CT in patients with urothelial carcinoma: a feasibility study","volume":"116","author":"Zopfs","year":"2019","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejrad.2018.11.001","article-title":"Improved visualization of hypodense liver lesions in virtual mono-energetic images from spectral detector CT: proof of concept in a 3D-printed phantom and evaluation in 74 patients","volume":"109","author":"Gro\u00dfe Hokamp","year":"2018","journal-title":"Eur J Radiol"},{"issue":"2","key":"10.1016\/j.crad.2022.02.013_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.crad.2014.10.018","article-title":"Non-linear image blending improves visualization of head and neck primary squamous cell carcinoma compared to linear blending in dual-energy CT","volume":"70","author":"Scholtz","year":"2015","journal-title":"Clin Radiol"},{"issue":"9","key":"10.1016\/j.crad.2022.02.013_bib22","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/RLI.0000000000000272","article-title":"Comprehensive comparison of virtual mono-energetic and linearly blended reconstruction techniques in third-generation dual-source dual-energy computed tomography angiography of the thorax and abdomen","volume":"51","author":"Albrecht","year":"2016","journal-title":"Invest Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib23","series-title":"Proceedings of the 13th fully three-dimensional image reconstruction in radiology and nuclear medicine newport","first-page":"491","article-title":"Impact of spectral separation in dual-energy CT with anti-correlated statistical reconstruction","author":"Brown","year":"2015"},{"issue":"12","key":"10.1016\/j.crad.2022.02.013_bib24","article-title":"Utility of the iodine overlay technique and virtual nonenhanced images for the preoperative T staging of colorectal cancer by dual-energy CT with tin filter technology","volume":"9","author":"Chen","year":"2014","journal-title":"PloS ONE"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2214\/AJR.15.14896","article-title":"Dual-energy CT-based differentiation of benign posttreatment changes from primary or recurrent malignancy of the head and neck: comparison of spectral Hounsfield units at 40 and 70 keV and iodine concentration","volume":"206","author":"Yamauchi","year":"2016","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"10.1016\/j.crad.2022.02.013_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11604-020-01071-8","article-title":"Usefulness of dual-layer spectral CT in follow-up examinations: diagnosing recurrent squamous cell carcinomas in the head and neck","volume":"39","author":"Takumi","year":"2021","journal-title":"Jpn J Radiol"},{"issue":"9","key":"10.1016\/j.crad.2022.02.013_bib27","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1001\/archotol.1997.01900090016003","article-title":"Pretherapeutic staging of hypopharyngeal carcinoma. Clinical findings, computed tomography, and magnetic resonance imaging compared with histopathologic evaluation","volume":"123","author":"Zb\u00e4ren","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.nic.2017.04.001","article-title":"Applications of dual-energy computed tomography for the evaluation of head and neck squamous cell carcinoma","volume":"27","author":"Forghani","year":"2017","journal-title":"Neuroimaging Clin N Am"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0360-3016(94)00535-S","article-title":"Staging and follow-up of nasopharyngeal carcinoma: magnetic resonance imaging versus computerized tomography","volume":"32","author":"Olmi","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.crad.2022.02.013_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ejrad.2018.04.018","article-title":"Artefact reduction from dental implants using virtual mono-energetic reconstructions from novel spectral detector CT","volume":"104","author":"Gro\u00dfe Hokamp","year":"2018","journal-title":"Eur J Radiol"},{"issue":"12","key":"10.1016\/j.crad.2022.02.013_bib31","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1177\/0284185118762611","article-title":"Thoracic-abdominal imaging with a novel dual-layer spectral detector CT: intra-individual comparison of image quality and radiation dose with 128-row single-energy acquisition","volume":"59","author":"Haneder","year":"2018","journal-title":"Acta Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejrad.2019.05.019","article-title":"Virtual mono-energetic images from spectral detector CT as a surrogate for conventional CT images: unaltered attenuation characteristics with reduced image noise","volume":"117","author":"Gro\u00dfe Hokamp","year":"2019","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejrad.2017.11.005","article-title":"Noise characteristics of virtual mono-energetic images from a novel detector-based spectral CT scanner","volume":"98","author":"Kalisz","year":"2018","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.crad.2022.02.013_bib34","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1016\/j.ejrad.2010.11.001","article-title":"Dual energy computed tomography of lung nodules: differentiation of iodine and calcium in artificial pulmonary nodules in\u00a0vitro","volume":"80","author":"Kn\u00f6ss","year":"2011","journal-title":"Eur J Radiol"},{"issue":"4","key":"10.1016\/j.crad.2022.02.013_bib35","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1007\/s00330-020-07298-3","article-title":"Quantitative distribution of iodinated contrast media in body computed tomography: data from a large reference cohort","volume":"31","author":"Zopfs","year":"2021","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.crad.2022.02.013_bib36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/RLI.0000000000000724","article-title":"Intraindividual consistency of iodine concentration in dual-energy computed tomography of the chest and abdomen","volume":"56","author":"Zopfs","year":"2021","journal-title":"Invest Radiol"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926022001210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926022001210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:46:51Z","timestamp":1757868411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926022001210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0009926022001210"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2022.02.013","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Head and neck squamous cell carcinoma: evaluation of iodine overlay maps and low-energy virtual mono-energetic images acquired with spectral detector CT","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2022.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}