{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:01:10Z","timestamp":1784761270652,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.crad.2023.09.020","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:35:46Z","timestamp":1697816146000},"page":"e156-e163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of smoking and aging on emphysema and small airways disease in asymptomatic healthy men by CT-based parametric response mapping analysis"],"prefix":"10.1016","volume":"79","author":[{"given":"X.Q.","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.Y.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10131","key":"10.1016\/j.crad.2023.09.020_bib1","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(18)30841-9","article-title":"Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study","volume":"391","author":"Wang","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.crad.2023.09.020_bib2","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00671-2017","article-title":"Global initiative for chronic obstructive lung disease (GOLD) 20th anniversary: a brief history of time","volume":"50","author":"Rodriguez-Roisin","year":"2017","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.crad.2023.09.020_bib3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S2213-2600(20)30155-7","article-title":"Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study","volume":"8","author":"Xiao","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"2","key":"10.1016\/j.crad.2023.09.020_bib4","first-page":"198","article-title":"Progression of emphysema and small airways disease in cigarette smokers","volume":"8","author":"Pompe","year":"2021","journal-title":"Chronic Obstr Pulm Dis"},{"key":"10.1016\/j.crad.2023.09.020_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-physiol-021119-034610","article-title":"Aging and lung disease","volume":"82","author":"Cho","year":"2020","journal-title":"Annu Rev Physiol"},{"issue":"8","key":"10.1016\/j.crad.2023.09.020_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.cell.2021.03.005","article-title":"The aging lung: physiology, disease, and immunity","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.crad.2023.09.020_bib7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiology.214.3.r00mr05831","article-title":"Correlation of aging and smoking with air trapping at thin-section CT of the lung in asymptomatic subjects","volume":"214","author":"Lee","year":"2000","journal-title":"Radiology"},{"issue":"11","key":"10.1016\/j.crad.2023.09.020_bib8","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/nm.2971","article-title":"Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression","volume":"18","author":"Galb\u00e1n","year":"2012","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.crad.2023.09.020_bib9","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1183\/09031936.00009415","article-title":"Effects of ageing and smoking on pulmonary computed tomography scans using parametric response mapping","volume":"46","author":"Boudewijn","year":"2015","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1016\/j.crad.2023.09.020_bib10","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update. An official American thoracic society and European respiratory society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.crad.2023.09.020_bib12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.compmedimag.2014.01.002","article-title":"Bidirectional elastic image registration using B-spline affine transformation","volume":"38","author":"Gu","year":"2014","journal-title":"Comput Med Imaging Graph"},{"issue":"9","key":"10.1016\/j.crad.2023.09.020_bib13","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jamainternmed.2015.2735","article-title":"Clinical and radiologic disease in smokers with normal spirometry","volume":"175","author":"Regan","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"8","key":"10.1016\/j.crad.2023.09.020_bib14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1513\/AnnalsATS.201810-669OC","article-title":"Using novel computed tomography analysis to describe the contribution and distribution of emphysema and small airways disease in chronic obstructive pulmonary disease","volume":"16","author":"Ostridge","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"8","key":"10.1016\/j.crad.2023.09.020_bib15","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1164\/rccm.202012-4528OC","article-title":"Radiographic graft surveillance in lung transplantation: prognostic role of parametric response mapping","volume":"204","author":"Belloli","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.crad.2023.09.020_bib16","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/S2214-109X(22)00456-9","article-title":"Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study","volume":"11","author":"Knox-Brown","year":"2023","journal-title":"Lancet Glob Health"},{"issue":"9","key":"10.1016\/j.crad.2023.09.020_bib17","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1513\/AnnalsATS.201405-224OC","article-title":"Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease","volume":"11","author":"Hobbs","year":"2014","journal-title":"Ann Am Thorac Soc"},{"issue":"4","key":"10.1016\/j.crad.2023.09.020_bib18","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1164\/rccm.201604-0871OC","article-title":"Age and small airway imaging abnormalities in subjects with and without airflow obstruction in SPIROMICS","volume":"195","author":"Martinez","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.crad.2023.09.020_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1183\/09031936.99.14614549","article-title":"Physiological changes in respiratory function associated with ageing","volume":"13","author":"Janssens","year":"1999","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.crad.2023.09.020_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4103\/lungindia.lungindia_266_17","article-title":"Chronic obstructive pulmonary disease and the hallmarks of aging","volume":"35","author":"Kukrety","year":"2018","journal-title":"Lung India"},{"issue":"1","key":"10.1016\/j.crad.2023.09.020_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/1479972311433766","article-title":"The interaction of ageing and lung disease","volume":"9","author":"Dyer","year":"2012","journal-title":"Chron Respir Dis"},{"issue":"5","key":"10.1016\/j.crad.2023.09.020_bib22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/ijerph15051033","article-title":"Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review","volume":"15","author":"Strzelak","year":"2018","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"10.1016\/j.crad.2023.09.020_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1165\/rcmb.2017-0200TR","article-title":"Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure","volume":"58","author":"Aghapour","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.crad.2023.09.020_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12931-022-02113-7","article-title":"Subtyping preserved ratio impaired spirometry (PRISm) by using quantitative HRCT imaging characteristics","volume":"23","author":"Lu","year":"2022","journal-title":"Respir Res"},{"issue":"10","key":"10.1016\/j.crad.2023.09.020_bib25","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1164\/rccm.200307-1006OC","article-title":"Cigarette smoke produces airway wall remodeling in rat tracheal explants","volume":"168","author":"Wang","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.crad.2023.09.020_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.genom.2.1.435","article-title":"The genetics of aging","volume":"2","author":"Finch","year":"2001","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.crad.2023.09.020_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev-physiol-030212-183715","article-title":"Genome instability and aging","volume":"75","author":"Vijg","year":"2013","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"10.1016\/j.crad.2023.09.020_bib28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.crad.2023.09.020_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1165\/rcmb.2003-0290OC","article-title":"Cigarette smoke induces senescence in alveolar epithelial cells","volume":"31","author":"Tsuji","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"10.1016\/j.crad.2023.09.020_bib30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1164\/rccm.200509-1374OC","article-title":"Alveolar cell senescence in patients with pulmonary emphysema","volume":"174","author":"Tsuji","year":"2006","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926023004373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926023004373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:13:44Z","timestamp":1762114424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926023004373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0009926023004373"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2023.09.020","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of smoking and aging on emphysema and small airways disease in asymptomatic healthy men by CT-based parametric response mapping analysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2023.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}