{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:18:12Z","timestamp":1787923092615,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172866"],"award-info":[{"award-number":["82172866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012905","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["2021CXGC011102"],"award-info":[{"award-number":["2021CXGC011102"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalradiologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Radiology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.crad.2024.02.016","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:22:45Z","timestamp":1710850965000},"page":"515-525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["MRI radiomics predicts the efficacy of EGFR-TKI in EGFR-mutant non-small-cell lung cancer with brain metastasis"],"prefix":"10.1016","volume":"79","author":[{"given":"H.","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crad.2024.02.016_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejca.2020.03.006","article-title":"Systemic treatment of brain metastases in non-small cell lung cancer","volume":"132","author":"Page","year":"2020","journal-title":"Eur J Cancer"},{"issue":"10","key":"10.1016\/j.crad.2024.02.016_bib2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1200\/JCO.2016.69.7144","article-title":"Management of brain metastases in tyrosine kinase inhibitor\u2013na\u00efve epidermal growth factor receptor\u2013mutant non\u2013small-cell lung cancer: a retrospective multi-institutional analysis","volume":"35","author":"Magnuson","year":"2017","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.crad.2024.02.016_bib3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2214\/AJR.21.25787","article-title":"Development of brain metastases in patients with non\u2013small cell lung cancer and No brain metastases at initial staging evaluation: cumulative incidence and risk factor analysis","volume":"217","author":"Kim","year":"2021","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.crad.2024.02.016_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.lungcan.2018.12.027","article-title":"Incidence of brain metastasis in lung adenocarcinoma at initial diagnosis on the basis of stage and genetic alterations","volume":"129","author":"Yang","year":"2019","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.crad.2024.02.016_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11864-016-0400-x","article-title":"Novel treatment strategies for brain metastases in non-small-cell lung cancer","volume":"17","author":"Bui","year":"2016","journal-title":"Curr Treat Options Oncol"},{"issue":"11","key":"10.1016\/j.crad.2024.02.016_bib6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1470-2045(11)70232-7","article-title":"Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis","volume":"12","author":"Shaw","year":"2011","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.crad.2024.02.016_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/1574887114666181205155211","article-title":"Advanced non-small cell lung cancer with activating epidermal growth factor receptor mutation: first line treatment and beyond","volume":"14","author":"Rocco","year":"2019","journal-title":"Rev Recent Clin Trial."},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-018-2861-1","article-title":"Intracranial control and survival outcome of tyrosine kinase inhibitor (TKI) alone versus TKI plus radiotherapy for brain metastasis of epidermal growth factor receptor-mutant non-small cell lung cancer","volume":"139","author":"Sung","year":"2018","journal-title":"J Neurooncol"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13014-015-0421-9","article-title":"Radiotherapy for asymptomatic brain metastasis in epidermal growth factor receptor mutant non-small cell lung cancer without prior tyrosine kinase inhibitors treatment: a retrospective clinical study","volume":"10","author":"Liu","year":"2015","journal-title":"Radiat Oncol"},{"issue":"8","key":"10.1016\/j.crad.2024.02.016_bib10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ctrv.2013.05.001","article-title":"Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: focus on epidermal growth factor receptor mutation testing and mutation-positive patients","volume":"39","author":"Roengvoraphoj","year":"2013","journal-title":"Cancer Treat Rev"},{"issue":"6","key":"10.1016\/j.crad.2024.02.016_bib11","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/med.21700","article-title":"Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer","volume":"40","author":"Tripathi","year":"2020","journal-title":"Med Res Rev"},{"issue":"33","key":"10.1016\/j.crad.2024.02.016_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016766","article-title":"Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC","volume":"98","author":"Lin","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"10.1016\/j.crad.2024.02.016_bib13","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1007\/s11547-022-01569-3","article-title":"Radiomics for prediction of response to EGFR-TKI based on metastasis\/brain parenchyma (M\/BP)-interface","volume":"127","author":"Fan","year":"2022","journal-title":"Radiol Med (Torino)"},{"issue":"2","key":"10.1016\/j.crad.2024.02.016_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.2015151169","article-title":"Radiomics: images are more than pictures, they are data","volume":"278","author":"Gillies","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.crad.2024.02.016_bib15","first-page":"1","article-title":"CT-based radiomics can predict the efficacy of anlotinib in advanced non-small-cell lung cancer","volume":"2022","author":"Chen","year":"2022","journal-title":"J Oncol"},{"issue":"11","key":"10.1016\/j.crad.2024.02.016_bib16","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1007\/s00259-021-05371-7","article-title":"Radiomics and gene expression profile to characterise the disease and predict outcome in patients with lung cancer","volume":"48","author":"Kirienko","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition lung cancer stage classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.crad.2024.02.016_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109411","article-title":"CT-based radiomics for predicting brain metastases as the first failure in patients with curatively resected locally advanced non-small cell lung cancer","volume":"134","author":"Sun","year":"2021","journal-title":"Eur J Radiol"},{"issue":"18","key":"10.1016\/j.crad.2024.02.016_bib19","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-17-3445","article-title":"Machine learning\u2013based radiomics for molecular subtyping of gliomas","volume":"24","author":"Lu","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.crad.2024.02.016_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1148\/radiol.2020191145","article-title":"The image biomarker standardization initiative: standardized quantitative radiomics for high-throughput image-based phenotyping","volume":"295","author":"Zwanenburg","year":"2020","journal-title":"Radiology"},{"issue":"21","key":"10.1016\/j.crad.2024.02.016_bib21","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1200\/JCO.2015.65.5654","article-title":"Assessing the clinical impact of risk prediction models with decision curves: guidance for correct interpretation and appropriate use","volume":"34","author":"Kerr","year":"2016","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.crad.2024.02.016_bib22","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1148\/radiol.2016152234","article-title":"Radiomics signature: a potential biomarker for the prediction of disease-free survival in early-stage (I or II) non\u2014small cell lung cancer","volume":"281","author":"Huang","year":"2016","journal-title":"Radiology"},{"issue":"18","key":"10.1016\/j.crad.2024.02.016_bib23","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1200\/JCO.2015.65.9128","article-title":"Development and validation of a radiomics nomogram for preoperative prediction of lymph node metastasis in colorectal cancer","volume":"34","author":"Huang","year":"2016","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.crad.2024.02.016_bib24","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1097\/01.CCM.0000275267.64078.B0","article-title":"Assessing the calibration of mortality benchmarks in critical care: the Hosmer-Lemeshow test revisited","volume":"35","author":"Kramer","year":"2007","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.crad.2024.02.016_bib25","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.eururo.2018.08.038","article-title":"Reporting and interpreting decision curve analysis: a guide for investigators","volume":"74","author":"Van Calster","year":"2018","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.crad.2024.02.016_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/tlcr-20-361","article-title":"MRI radiomic signature predicts intracranial progression-free survival in patients with brain metastases of ALK-positive non-small cell lung cancer","volume":"10","author":"Zhao","year":"2021","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.crad.2024.02.016_bib28","article-title":"CT radiomics in predicting EGFR mutation in non-small cell lung cancer: a single institutional study","volume":"10","author":"Wu","year":"2020","journal-title":"Front Oncol"},{"issue":"7818","key":"10.1016\/j.crad.2024.02.016_bib29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-020-2481-8","article-title":"The National Lung Matrix Trial of personalized therapy in lung cancer","volume":"583","author":"Middleton","year":"2020","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.crad.2024.02.016_bib30","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.jtho.2019.06.011","article-title":"Prevention and early detection for NSCLC: advances in thoracic oncology 2018","volume":"14","author":"Balata","year":"2019","journal-title":"J Thorac Oncol"},{"issue":"2","key":"10.1016\/j.crad.2024.02.016_bib31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.radonc.2015.08.023","article-title":"A new nomogram for estimating survival in patients with brain metastases secondary to colorectal cancer","volume":"117","author":"Pietrantonio","year":"2015","journal-title":"Radiother Oncol"},{"issue":"19","key":"10.1016\/j.crad.2024.02.016_bib32","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1002\/cncr.33085","article-title":"Neurological symptom burden impacts survival prognosis in patients with newly diagnosed non\u2013small cell lung cancer brain metastases","volume":"126","author":"Steindl","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.crad.2024.02.016_bib33","article-title":"Gefitinib or chemotherapy for non\u2013small-cell lung cancer with mutated EGFR","author":"Makoto","year":"2010","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.crad.2024.02.016_bib34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.lungcan.2012.05.092","article-title":"Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation","volume":"77","author":"Park","year":"2012","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib35","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/S1470-2045(17)30689-7","article-title":"Leptomeningeal metastases in non-small-cell lung cancer","volume":"19","author":"Cheng","year":"2018","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.crad.2024.02.016_bib36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.lungcan.2007.03.011","article-title":"Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain","volume":"57","author":"Wu","year":"2007","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijrobp.2020.10.034","article-title":"Tumor control probability of radiosurgery and fractionated stereotactic radiosurgery for brain metastases","volume":"110","author":"Redmond","year":"2021","journal-title":"Int J Radiat Oncol"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clineuro.2011.10.013","article-title":"Surgical treatment of brain metastasis: a review","volume":"114","author":"Mut","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"issue":"23","key":"10.1016\/j.crad.2024.02.016_bib39","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1111\/1759-7714.14169","article-title":"Value and significance of brain radiation therapy during first-line EGFR-TKI treatment in lung adenocarcinoma with EGFR sensitive mutation and synchronous brain metastasis: appropriate timing and technique","volume":"12","author":"Gu","year":"2021","journal-title":"Thorac Cancer"},{"issue":"1","key":"10.1016\/j.crad.2024.02.016_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12943-018-0777-1","article-title":"Management of acquired resistance to EGFR TKI\u2013targeted therapy in advanced non-small cell lung cancer","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Cancer"},{"issue":"10","key":"10.1016\/j.crad.2024.02.016_bib41","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.annonc.2020.06.017","article-title":"A phase II, multicenter, two cohort study of 160 mg osimertinib in EGFR T790M-positive non-small-cell lung cancer patients with brain metastases or leptomeningeal disease who progressed on prior EGFR TKI therapy","volume":"31","author":"Park","year":"2020","journal-title":"Ann Oncol"},{"issue":"33","key":"10.1016\/j.crad.2024.02.016_bib42","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1200\/JCO.2018.78.3118","article-title":"CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with untreated EGFR -mutated advanced non\u2013small-cell lung cancer","volume":"36","author":"Reungwetwattana","year":"2018","journal-title":"J Clin Oncol"}],"container-title":["Clinical Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926024001387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009926024001387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:16:18Z","timestamp":1778271378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009926024001387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0009926024001387"],"URL":"https:\/\/doi.org\/10.1016\/j.crad.2024.02.016","relation":{},"ISSN":["0009-9260"],"issn-type":[{"value":"0009-9260","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MRI radiomics predicts the efficacy of EGFR-TKI in EGFR-mutant non-small-cell lung cancer with brain metastasis","name":"articletitle","label":"Article Title"},{"value":"Clinical Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crad.2024.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}