{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:44:01Z","timestamp":1785818641199,"version":"3.56.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071469"],"award-info":[{"award-number":["32071469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Food Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.crfs.2026.101348","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:19:26Z","timestamp":1770970766000},"page":"101348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Production of mannitol from molasses and Jerusalem artichoke tubers at elevated temperatures using engineered Kluyveromyces marxianus through consolidated bioprocessing"],"prefix":"10.1016","volume":"12","author":[{"given":"Feier","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-7083","authenticated-orcid":false,"given":"Jiong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.crfs.2026.101348_bib1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1023\/A:1023512218206","article-title":"Role of glucose in the bioconversion of fructose into mannitol by Candida magnoliae","volume":"25","author":"Baek","year":"2003","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.crfs.2026.101348_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.851768","article-title":"Bioprospecting Kluyveromyces marxianus as a robust host for industrial biotechnology","volume":"10","author":"Bilal","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.crfs.2026.101348_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/bab.1590","article-title":"Microbial production of mannitol by Lactobacillus brevis 3-A5 from concentrated extract of Jerusalem artichoke tubers","volume":"65","author":"Cao","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"16","key":"10.1016\/j.crfs.2026.101348_bib4","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1007\/s00253-020-10757-y","article-title":"Mannitol: physiological functionalities, determination methods, biotechnological production, and applications","volume":"104","author":"Chen","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.crfs.2026.101348_bib5","article-title":"Agricultural waste: review of the evolution, approaches and perspectives on alternative uses","volume":"22","author":"Duque-Acevedo","year":"2020","journal-title":"Glob. Ecol. Conserv."},{"issue":"3","key":"10.1016\/j.crfs.2026.101348_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s13213-013-0733-7","article-title":"Improvement of Lactobacillus brevis NM101-1 grown on sugarcane molasses for mannitol, lactic and acetic acid production","volume":"64","author":"Gomaa","year":"2014","journal-title":"Ann. Microbiol."},{"issue":"2","key":"10.1016\/j.crfs.2026.101348_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00203-002-0507-2","article-title":"A zinc-containing mannitol-2-dehydrogenase from Leuconostoc pseudomesenteroides ATCC 12291: purification of the enzyme and cloning of the gene","volume":"179","author":"Hahn","year":"2003","journal-title":"Arch. Microbiol."},{"issue":"4","key":"10.1016\/j.crfs.2026.101348_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijpam.2018.10.001","article-title":"First case reports of bloodstream infection by Candida magnoliae in two neonates with low birth weight","volume":"5","author":"Hernandez Romero","year":"2018","journal-title":"Int. J. Pediatr. Adolesc. Med."},{"issue":"5","key":"10.1016\/j.crfs.2026.101348_bib9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1389-1723(01)80292-9","article-title":"Cloning of a gene encoding a highly stable endo-beta-1,4-glucanase from Aspergillus niger and its expression in yeast","volume":"92","author":"Hong","year":"2001","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.crfs.2026.101348_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12934-019-1068-2","article-title":"Release of glucose repression on xylose utilization in Kluyveromyces marxianus to enhance glucose-xylose co-utilization and xylitol production from corncob hydrolysate","volume":"18","author":"Hua","year":"2019","journal-title":"Microb. Cell Fact."},{"issue":"1","key":"10.1016\/j.crfs.2026.101348_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/21622515.2021.1892203","article-title":"Composition, valorization and therapeutical potential of molasses: a critical review","volume":"10","author":"Jamir","year":"2021","journal-title":"Environmental Technology Reviews"},{"key":"10.1016\/j.crfs.2026.101348_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1752-0509-2-60","article-title":"Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A","volume":"2","author":"Jouhten","year":"2008","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.crfs.2026.101348_bib13","article-title":"Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.crfs.2026.101348_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/aem.02006-21","article-title":"Distinct metabolic flow in response to temperature in thermotolerant Kluyveromyces marxianus","volume":"88","author":"Kosaka","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.crfs.2026.101348_bib15","series-title":"Roots, Tubers, and Bulb Crop Wastes: Management by Biorefinery Approaches","first-page":"261","article-title":"Valorization of Jerusalem artichoke and its crop residues using green technologies","author":"Kumar","year":"2024"},{"issue":"3","key":"10.1016\/j.crfs.2026.101348_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1021\/bp034025o","article-title":"Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production","volume":"19","author":"Lee","year":"2003","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.crfs.2026.101348_bib17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1385\/ABAB:121:1-3:0391","article-title":"Cloning, expression, purification, and analysis of mannitol dehydrogenase gene mtlK from Lactobacillus brevis","volume":"121","author":"Liu","year":"2005","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"19","key":"10.1016\/j.crfs.2026.101348_bib18","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1111\/febs.16459","article-title":"pH dependencies of glycolytic enzymes of yeast under in vivo--like assay conditions","volume":"289","author":"Luzia","year":"2022","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.crfs.2026.101348_bib19","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1007\/s12010-022-03836-5","article-title":"Mannitol production by heterofermentative lactic acid bacteria: a Review","volume":"194","author":"Mart\u00ednez-Miranda","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"4","key":"10.1016\/j.crfs.2026.101348_bib20","first-page":"992","article-title":"Lactobacillus reuteri CRL 1101 highly produces mannitol from sugarcane molasses as carbon source","volume":"94","author":"Ortiz","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"20","key":"10.1016\/j.crfs.2026.101348_bib21","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1007\/s00253-015-6730-y","article-title":"Efficient mannitol production by wild-type Lactobacillus reuteri CRL 1101 is attained at constant pH using a simplified culture medium","volume":"99","author":"Ortiz","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.crfs.2026.101348_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.126464","article-title":"Consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered cell factories","volume":"345","author":"Panagopoulos","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.crfs.2026.101348_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.128179","article-title":"Improving glycerol utilization during high-temperature xylitol production with Kluyveromyces marxianus using a transient clustered regularly interspaced short palindromic repeats (CRISPR)\/CRISPR-associated protein 9 system","volume":"365","author":"Ren","year":"2022","journal-title":"Bioresour. Technol."},{"issue":"4","key":"10.1016\/j.crfs.2026.101348_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00253-006-0364-z","article-title":"A low-cost medium for mannitol production by Lactobacillus intermedius NRRL B-3693","volume":"72","author":"Saha","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.crfs.2026.101348_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.procbio.2017.03.001","article-title":"Physiological response of Kluyveromyces marxianus during oxidative and osmotic stress","volume":"56","author":"Saini","year":"2017","journal-title":"Process Biochem"},{"issue":"1","key":"10.1016\/j.crfs.2026.101348_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00253-004-1841-x","article-title":"Lactobacillus reuteri ATCC 53608 mdh gene cloning and recombinant mannitol dehydrogenase characterization","volume":"68","author":"Sasaki","year":"2005","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.crfs.2026.101348_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00449-012-0775-4","article-title":"Two-stage fermentation process for enhanced mannitol production using Candida magnoliae mutant R9","volume":"36","author":"Savergave","year":"2013","journal-title":"Bioproc. Biosyst. Eng."},{"issue":"40","key":"10.1016\/j.crfs.2026.101348_bib28","doi-asserted-by":"crossref","first-page":"11148","DOI":"10.1021\/acs.jafc.9b04519","article-title":"Systematic metabolic engineering of Saccharomyces cerevisiae for lycopene overproduction","volume":"67","author":"Shi","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.crfs.2026.101348_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.22159\/ijap.2021v13i5.42068","article-title":"Characteristics and analytical methods of mannitol: an update","volume":"13","author":"Shrivastava","year":"2021","journal-title":"Int. J. Appl. Pharm."},{"issue":"14","key":"10.1016\/j.crfs.2026.101348_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107994119","article-title":"Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation","volume":"119","author":"Tam","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.crfs.2026.101348_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.est.2020.101997","article-title":"Thermal performance of galactitol\/mannitol eutectic mixture\/expanded graphite composite as phase change material for thermal energy harvesting","volume":"34","author":"Wang","year":"2021","journal-title":"J. Energy Storage"},{"issue":"4","key":"10.1016\/j.crfs.2026.101348_bib33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10295-014-1572-7","article-title":"Bioethanol production from the dry powder of Jerusalem artichoke tubers by recombinant Saccharomyces cerevisiae in simultaneous saccharification and fermentation","volume":"42","author":"Wang","year":"2015","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.crfs.2026.101348_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1567-1364.2007.00234.x","article-title":"Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic conditions","volume":"8","author":"Wiebe","year":"2008","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.crfs.2026.101348_bib35","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3389\/fbioe.2020.00844","article-title":"Effect of a novel alpha\/beta hydrolase domain protein on tolerance of K. marxianus to lignocellulosic biomass derived inhibitors","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10","key":"10.1016\/j.crfs.2026.101348_bib36","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s11274-013-1357-6","article-title":"Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations","volume":"29","author":"Yue","year":"2013","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.crfs.2026.101348_bib37","article-title":"Identification of hexose kinase genes in Kluyveromyces marxianus and thermo-tolerant one step producing glucose-free fructose strain construction","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.crfs.2026.101348_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.biortech.2013.10.109","article-title":"Xylitol production at high temperature by engineered Kluyveromyces marxianus","volume":"152C","author":"Zhang","year":"2014","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.crfs.2026.101348_bib39","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biortech.2014.10.150","article-title":"Improving xylitol production at elevated temperature with engineered Kluyveromyces marxianus through over-expressing transporters","volume":"175","author":"Zhang","year":"2015","journal-title":"Bioresour. Technol."},{"issue":"3","key":"10.1016\/j.crfs.2026.101348_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11274-018-2425-8","article-title":"Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies","volume":"34","author":"Zhang","year":"2018","journal-title":"World J. Microbiol. Biotechnol."}],"container-title":["Current Research in Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665927126000481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665927126000481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:47:04Z","timestamp":1785815224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665927126000481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"alternative-id":["S2665927126000481"],"URL":"https:\/\/doi.org\/10.1016\/j.crfs.2026.101348","relation":{},"ISSN":["2665-9271"],"issn-type":[{"value":"2665-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of mannitol from molasses and Jerusalem artichoke tubers at elevated temperatures using engineered Kluyveromyces marxianus through consolidated bioprocessing","name":"articletitle","label":"Article Title"},{"value":"Current Research in Food Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crfs.2026.101348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101348"}}