{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:41:22Z","timestamp":1788270082284,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.critrevonc.2011.02.001","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T04:33:06Z","timestamp":1299558786000},"page":"21-28","source":"Crossref","is-referenced-by-count":53,"title":["Can we increase the chance of sphincter saving surgery in rectal cancer with neoadjuvant treatments: Lessons from a systematic review of recent randomized trials"],"prefix":"10.1016","volume":"81","author":[{"given":"Jean-Pierre","family":"Gerard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousri","family":"Rostom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Benchimol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Ortholan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Aschele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel Hannoun","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2011.02.001_bib0005","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0140-6736(86)91510-2","article-title":"Recurrence and survival after total mesorectal excision for rectal cancer","volume":"1","author":"Heald","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0010","first-page":"335","article-title":"Total mesorectal excision in the operative treatment of rectal cancer","volume":"181","author":"Enker","year":"1995","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0015","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1200\/JCO.2008.20.9502","article-title":"Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex","volume":"27","author":"Krouse","year":"2009","journal-title":"J Clin Oncol"},{"issue":"January\u2013February (1)","key":"10.1016\/j.critrevonc.2011.02.001_bib0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1245\/ASO.2003.04.010","article-title":"Adequacy of 1-cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy","volume":"10","author":"Moore","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jnci\/93.8.583","article-title":"Guidelines 2000 for colon and rectal cancer surgery","volume":"93","author":"Nelson","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0030","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa010580","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer","volume":"345","author":"Kapiteijn","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0035","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0040","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa060829","article-title":"Chemotherapy with preoperative radiotherapy in rectal cancer","volume":"355","author":"Bosset","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0045","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1200\/JCO.2006.06.7629","article-title":"Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203","volume":"24","author":"G\u00e9rard","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0360-3016(03)00532-7","article-title":"The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumour response, leading to increased sphincter preservation in locally advanced rectal cancer","volume":"57","author":"Crane","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0360-3016(97)00918-8","article-title":"Preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation","volume":"40","author":"Valentini","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2006.04.012","article-title":"Does rectal cancer shrinkage induced by preoperative radio(chemo)therapy increase the likelihood of anterior resection? A systematic review of randomised trials","volume":"80","author":"Bujko","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0065","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0140-6736(09)60484-0","article-title":"Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial","volume":"373","author":"Sebag-Montefiore","year":"2009","journal-title":"Lancet"},{"issue":"Suppl. 18","key":"10.1016\/j.critrevonc.2011.02.001_bib0070","article-title":"Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: pathologic response analysis of the Studio Terapia Adjuvante Retto (STAR)-01 randomized phase III trial","volume":"27","author":"Aschele","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0075","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1200\/JCO.2009.25.8376","article-title":"Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer. Results of the phase III trial ACCORD 12\/0405-Prodige 2","volume":"28","author":"G\u00e9rard","year":"2010","journal-title":"J Clin Oncol"},{"issue":"Suppl. 7","key":"10.1016\/j.critrevonc.2011.02.001_bib0080","article-title":"A randomized trial comparing local recurrence rates between short-course and long-course preoperative radiotherapy for clinical T3 rectal cancer: an intergroup trial (TROG,AGITG,CSSANZ RACS)","volume":"28","author":"Ngan","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0085","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/00000658-198811000-00011","article-title":"Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC)","volume":"208","author":"G\u00e9rard","year":"1988","journal-title":"Ann Surg"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0090","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/BF02049892","article-title":"Prognostic factors in colorectal carcinoma treated by preoperative radiotherapy and immediate surgery","volume":"34","author":"James","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0095","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1200\/JCO.1999.17.8.2396","article-title":"Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial","volume":"17","author":"Fran\u00e7ois","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2003.12.006","article-title":"Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy","volume":"72","author":"Bujko","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0105","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bjs.5506","article-title":"Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer","volume":"93","author":"Bujko","year":"2006","journal-title":"Br J Surg"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0110","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1200\/JCO.2004.08.170","article-title":"Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the lyon R96-02 randomized trial","volume":"22","author":"Gerard","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0115","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1200\/JCO.2007.15.3858","article-title":"Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer","volume":"26","author":"Braendengen","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00000658-199002000-00011","article-title":"Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial","volume":"211","author":"P\u00e5hlman","year":"1990","journal-title":"Ann Surg"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0125","doi-asserted-by":"crossref","unstructured":"Swedish rectal cancer trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. NEJM 1997;336:980\u2013987.","DOI":"10.1056\/NEJM199704033361402"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0130","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1200\/JCO.2005.08.144","article-title":"Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate","volume":"23","author":"Folkesson","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0135","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1200\/JCO.2009.22.0467","article-title":"Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03","volume":"27","author":"Roh","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0140","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1200\/JCO.2005.03.6095","article-title":"Randomized phase II study of neoadjuvant combined modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012","volume":"24","author":"Mohiuddin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0145","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0150","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/DCR.0b013e3181ba14ed","article-title":"Increasing the rates of complete response to neoadjuvant chemoradiotherapy for distal rectal cancer: results of a prospective study using additional chemotherapy during the resting period","volume":"52","author":"Habr-Gama","year":"2009","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0167-8140(90)90001-D","article-title":"Present status of radiation therapy in the conservative management of rectal cancer","volume":"17","author":"Papillon","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0160","first-page":"142","article-title":"Long-term control of T2-T3 rectal adenocarcinoma with radiotherapy alone","volume":"54","author":"G\u00e9rard","year":"2002","journal-title":"IJROBP"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0167-8140(90)90113-B","article-title":"The Dijon clinical staging system for early rectal carcinomas amenable to intracavitary treatment techniques","volume":"18","author":"Horiot","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0170","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.clon.2007.07.003","article-title":"Conservative alternatives to extirpative surgery for rectal cancer","volume":"19","author":"Myerson","year":"2007","journal-title":"Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0175","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.clon.2007.07.007","article-title":"Is there a limit to dose escalation for rectal cancer?","volume":"19","author":"Cummings","year":"2007","journal-title":"Clin Oncol"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0180","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s10350-005-0263-x","article-title":"Role of radiotherapy with surgery for T3 and resectable T4 rectal cancer: evidence from randomized trials","volume":"49","author":"Ortholan","year":"2006","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.critrevonc.2011.02.001_bib0185","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00464-007-9596-y","article-title":"A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy","volume":"22","author":"Lezoche","year":"2008","journal-title":"Surg Endosc"},{"issue":"Suppl. 7","key":"10.1016\/j.critrevonc.2011.02.001_bib0190","article-title":"Pathologic complete response to neoadjuvant chemoradiation of uT2 N0 rectal cancer treated by local excision: results of the ACOSOG Z6041 trial","volume":"28","author":"Garcia Aguilar","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842811000473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842811000473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T02:57:29Z","timestamp":1637377049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842811000473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1040842811000473"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2011.02.001","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}