{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:48:31Z","timestamp":1792234111476,"version":"4.4.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.critrevonc.2012.08.002","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T07:46:27Z","timestamp":1345880787000},"page":"373-382","source":"Crossref","is-referenced-by-count":27,"title":["Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas"],"prefix":"10.1016","volume":"85","author":[{"given":"Filip Y.","family":"De Vos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Gijtenbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal P.","family":"Bleeker-Rovers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M.","family":"van Herpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2012.08.002_bib0005","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0360-3016(93)90203-8","article-title":"Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials","volume":"26","author":"Simpson","year":"1993","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0015","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1158\/1078-0432.CCR-05-0722","article-title":"Food and Drug Administration approval summary: temozolomide plus radiation therapy for the treatment of newly diagnosed glioblastoma multiforme","volume":"11","author":"Cohen","year":"2005","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/A:1024217527650","article-title":"Pneumocystis carinii pneumonia in HIV negative patients with primary brain tumors","volume":"63","author":"Mahindra","year":"2003","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0025","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1086\/339548","article-title":"Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome","volume":"34","author":"Sepkowitz","year":"2002","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0030","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1056\/NEJMra032588","article-title":"Pneumocystis pneumonia","volume":"350","author":"Thomas","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/653933","article-title":"Quantification and spread of Pneumocystis jirovecii in the surrounding air of patients with Pneumocystis pneumonia","volume":"51","author":"Choukri","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/649868","article-title":"Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population","volume":"50","author":"Ponce","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3062.2009.00447.x","article-title":"Molecular evidence of interhuman transmission in an outbreak of Pneumocystis jirovecii pneumonia among renal transplant recipients","volume":"12","author":"Gianella","year":"2010","journal-title":"Transplant Infectious Disease"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3201\/eid1501.080242","article-title":"Vertical transmission of Pneumocystis jirovecii in humans","volume":"15","author":"Montes-Cano","year":"2009","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0055","first-page":"246","article-title":"Pneumocystis carinii pneumonia in the course of connective disease: report of 34 cases","volume":"21","author":"Godeau","year":"1994","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0060","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3899\/jrheum.091294","article-title":"A cluster of Pneumocystis jirovecii infection among outpatients with rheumatoid arthritis","volume":"37","author":"Mori","year":"2010","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0065","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00296-008-0721-6","article-title":"Risk factors of Pneumocystis jirovecii pneumonia in patients with systemic lupus erythematosus","volume":"29","author":"Lertnawapan","year":"2009","journal-title":"Rheumatology International"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0070","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3748\/wjg.15.1897","article-title":"Pneumocystis jirovecii pneumonia and pneumomediastinum in an anti-TNFalpha naive patient with ulcerative colitis","volume":"15","author":"Lee","year":"2009","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0075","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00054725-200409000-00025","article-title":"Pneumocystis carinii pneumonia during maintenance anti-tumor necrosis factor-alpha therapy with infliximab for Chrohn's disease","volume":"10","author":"Velayos","year":"2004","journal-title":"Inflammatory Bowel Disease"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0080","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/sj.bjc.6602412","article-title":"An analysis of the utilization of chemoprophylaxis against Pneumocystis jirovecii in patients with malignancy receiving corticosteroid therapy at a cancer hospital","volume":"92","author":"Worth","year":"2005","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s10096-006-0149-4","article-title":"Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jirovecii pneumonia in cancer patients","volume":"25","author":"Torres","year":"2006","journal-title":"European Journal of Clinical Microbiology and Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0090","first-page":"651","article-title":"Pneumocystis carinii pneumonia in patients with solid tumors and lymphomas: predisposing factors and outcome","volume":"25","author":"Barbounis","year":"2005","journal-title":"Anticancer Research"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11060-008-9663-9","article-title":"Dose-intensity temozolomide after concurrent chemoradiotherapy in operated high-grade gliomas","volume":"90","author":"Dall\u2019oglio","year":"2008","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0100","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/cncr.2820360912","article-title":"Intensity of immunosuppressive therapy and the incidence of Pneumocystis carinii pneumonitis","volume":"36","author":"Hughes","year":"1975","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1440-1843.2009.01660.x","article-title":"Differences in the clinical characteristics of Pneumocystis jirovecii pneumonia in immunocompromized patients with and without HIV infection","volume":"15","author":"Enomoto","year":"2010","journal-title":"Respiratology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0110","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1378\/chest.118.3.704","article-title":"Management and outcome patterns for adult Pneumocystis carinii pneumonia, 1985 to 1995: comparison of HIV-associated cases to other immunocompromised states","volume":"118","author":"Mansharamani","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0115","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1378\/chest.128.2.573","article-title":"Acute respiratory failure due to Pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features","volume":"128","author":"Festic","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0120","article-title":"HRCT-features of Pneumocystis jirovecii pneumonia and their evolution before and after treatment of non-HIV immunocompromised patients","author":"Vogel","year":"2011","journal-title":"European Journal of Radiology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0125","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/QCO.0b013e32834cac17","article-title":"Pneumocystis jirovecii pneumonia in non-HIV-infected patients: new risks and diagnostic tools","volume":"24","author":"Reid","year":"2011","journal-title":"Current Opinion in Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0130","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.diagmicrobio.2007.02.014","article-title":"Polymerase chain reaction detection of Pneumocystis jirovecii: evaluation of 9 assays","volume":"58","author":"Robberts","year":"2007","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1440-1843.2008.01457.x","article-title":"Real-time PCR is more specific than conventional PCR for induced sputum diagnosis of Pneumocystis pneumonia in immunocompromised patients without HIV infection","volume":"14","author":"Fujisawa","year":"2009","journal-title":"Respirology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00277-009-0888-2","article-title":"Pneumocystis jirovecii pneumonia detected by FDG-PET","volume":"89","author":"Nakazato","year":"2010","journal-title":"Annals of Hematology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2334-9-47","article-title":"Serum markers in interstitial pneumonia with or without Pneumocystis jirovecii colonization: a prospective study","volume":"9","author":"Shimizu","year":"2009","journal-title":"BMC Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0150","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/IAI.60.4.1279-1284.1992","article-title":"Importance of endogenous tumor necrosis factor alpha and gamma interferon in host resistance against Pneumocystis carinii infection","volume":"60","author":"Chen","year":"1992","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0155","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3109\/13693786.2010.484027","article-title":"Cellular and cytokine changes in the alveolar environment among immunocompromised patients during Pneumocystis jirovecii infection","volume":"48","author":"Iriart","year":"2010","journal-title":"Medical Mycology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0160","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0025-7125(16)32150-2","article-title":"Infections associated with immunologic deficiency diseases","volume":"58","author":"Gold","year":"1974","journal-title":"Medical Clinics of North America"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0165","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1128\/IAI.66.1.305-314.1998","article-title":"Activated pulmonary macrophages are insufficient for resistance against Pneumocystis carinii","volume":"66","author":"Hanano","year":"1998","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0170","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1378\/chest.118.3.712","article-title":"Peripheral blood CD4+ T-lymphocyte counts during Pneumocystis carinii pneumonia in immunocompromised patients without HIV infection","volume":"118","author":"Mansharamani","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0175","doi-asserted-by":"crossref","first-page":"813","DOI":"10.7326\/0003-4819-111-10-813","article-title":"Pneumocystis pneumonia: from bench to clinic","volume":"111","author":"Masur","year":"1989","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0180","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1258\/ijsa.2009.009090","article-title":"Pneumocystis jirovecii prophylaxis discontinuation based upon total lymphocyte count in HIV-infected adults treated with antiretroviral therapy","volume":"21","author":"Cheung","year":"2010","journal-title":"International Journal of STD and AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0185","unstructured":"National Cancer Institute. SEER Cancer Statistics Review, 1975\u20132008, Available at http:\/\/seer.cancer.gov\/statfacts\/html\/brain.html#incidence-mortality; 2011 [accessed 18.09.11]."},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0190","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1189\/jlb.0306176","article-title":"T cells traffic from brain to cervical lymph nodes via the cribroid plate and nasal mucosa","volume":"80","author":"Goldmann","year":"2006","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0195","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2004.12.008","article-title":"Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs","volume":"22","author":"Calzascia","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/neuonc\/noq169","article-title":"Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma?","volume":"13","author":"Heimberger","year":"2011","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0205","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1215\/15228517-2006-006","article-title":"An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme","volume":"8","author":"El Andaloussi","year":"2006","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0210","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1541-7786.MCR-07-2180","article-title":"Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas","volume":"6","author":"Brantley","year":"2008","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0215","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1215\/15228517-2008-104","article-title":"Regulatory T cells and the PD-L1\/PD-1 pathway mediate immune suppression in malignant human brain tumors","volume":"11","author":"Jacobs","year":"2009","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0220","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/glia.21136","article-title":"The brain tumor microenvironment","volume":"59","author":"Charles","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0225","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.7326\/0003-4819-119-12-199312150-00007","article-title":"Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates","volume":"119","author":"Boumpas","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0230","first-page":"453","article-title":"Antigen-induced recruitment of circulating lymphocytes to the lungs and hilar lymph nodes of mice challenged intratracheally with alloantigens","volume":"125","author":"Emeson","year":"1982","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0235","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1128\/IAI.27.3.928-937.1980","article-title":"Growth characteristics and pathogenesis of experimental Pneumocystis carinii pneumonia","volume":"27","author":"Walzer","year":"1980","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0240","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4049\/jimmunol.133.5.2502","article-title":"Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia","volume":"133","author":"Walzer","year":"1984","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0245","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/archneur.1991.00530160074017","article-title":"Pneumocystis carinii pneumonia in patients with primary brain tumors","volume":"48","author":"Henson","year":"1991","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0250","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0002-9343(93)90187-T","article-title":"Pneumocystis carinii pneumonia during steroid taper in patients with primary brain tumors","volume":"94","author":"Slivka","year":"1993","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0255","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00165480","article-title":"Pneumocystis pneumonia in brain tumor patients: risk factors and clinical features","volume":"27","author":"Schiff","year":"1996","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0260","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11940-005-0042-y","article-title":"Treatment of medical complications in patients with brain tumors","volume":"7","author":"Pruitt","year":"2005","journal-title":"Current Treatment Options in Neurology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0265","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0360-3016(99)00060-7","article-title":"The effects of sequential versus concurrent chemotherapy and radiotherapy on survival and toxicity in patients with newly diagnosed high-grade astrocytoma","volume":"44","author":"Kleinberg","year":"1999","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0270","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.ijrobp.2004.12.085","article-title":"Primary brain tumors treated with steroids and radiotherapy: low CD4 count and risk of infection","volume":"62","author":"Hughes","year":"2005","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0275","first-page":"547","article-title":"Temozolomide-related infections: review of the literature","volume":"16","author":"Kizilarslanoglu","year":"2011","journal-title":"J BUON"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0280","first-page":"873","article-title":"Complications of chemotherapy in neuro-oncology","volume":"105","author":"Marosi","year":"2012","journal-title":"Journal of Balkan Union of Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0285","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1200\/JCO.20.5.1375","article-title":"Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide","volume":"20","author":"Stupp","year":"2002","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0290","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.4065\/82.9.1052","article-title":"Prophylaxis of Pneumocystis pneumonia in immunocomprimised non-HIV-infected patients: systematic review and meta-analysis of randomized controlled trials","volume":"82","author":"Green","year":"2007","journal-title":"Mayo Clinic Proceedings"},{"issue":"suppl.","key":"10.1016\/j.critrevonc.2012.08.002_bib0295","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1200\/jco.2010.28.15_suppl.2013","article-title":"Iatrogenic immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide: a NABTT CNS consortium study [abstract]","volume":"28","author":"Grossman","year":"2010","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0300","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1158\/1078-0432.CCR-11-0774","article-title":"Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide","volume":"17","author":"Grossman","year":"2011","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0305","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1002\/cncr.25035","article-title":"Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects","volume":"116","author":"Neyns","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0310","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/neuonc\/noq204","article-title":"Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme","volume":"13","author":"Fadul","year":"2011","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0315","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1200\/JCO.2007.10.7722","article-title":"Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma","volume":"25","author":"Wick","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0320","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11060-009-9980-7","article-title":"Extended-schedule dose-dense temozolomide in refractory gliomas","volume":"96","author":"Berrocal","year":"2010","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0325","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11060-010-0423-2","article-title":"Efficacy of protracted dose-dense temozolomide in patients with recurrent high-grade glioma","volume":"103","author":"Abacioglu","year":"2011","journal-title":"Journal of Neuro-Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0330","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/07357900701708393","article-title":"A multicenter cohort study of dose-dense temozolomide (21 of 28 days) for the treatment of recurrent anaplastic astrocytoma or oligoastrocytoma","volume":"26","author":"Neyns","year":"2008","journal-title":"Cancer Investigation"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0335","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/01.wnl.0000196465.83423.ec","article-title":"Is protracted low-dose temozolomide feasible in glioma patients?","volume":"66","author":"Tosoni","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0340","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ncponc0514","article-title":"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide","volume":"3","author":"Gani\u00e8re","year":"2006","journal-title":"Nature Clinical Practice Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0345","doi-asserted-by":"crossref","first-page":"v190","DOI":"10.1093\/annonc\/mdq187","article-title":"High-grade malignant glioma: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"21","author":"Stupp","year":"2010","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0350","unstructured":"Cancer Council Australia. Adult gliomas (astrocytomas and oligodendrogliomas): a guide for patients, their families and carers, Available at http:\/\/www.cancer.org.au\/File\/HealthProfessionals\/Clinical%20Guidelines\/Adult_Glioma_Consumer_Guide_FINAL_bookmarked.pdf; 2011 [accessed 18.05.12]."},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0355","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). Central Nervous System Cancers. Version 1.2012 Available at http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cns.pdf [accessed 18.05.12]."},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0360","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.critrevonc.2006.04.005","article-title":"Should concomitant and adjuvant treatment with temozolomide be used as standard therapy with anaplastic glioma?","volume":"60","author":"Siker","year":"2006","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0365","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1164\/ajrccm.155.1.9001290","article-title":"Predictors of Pneumocystis carinii pneumonia in HIV-infected persons. Pulmonary complications of HIV infection study group","volume":"155","author":"Stansell","year":"1997","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0370","doi-asserted-by":"crossref","first-page":"122","DOI":"10.6004\/jnccn.2008.0013","article-title":"Prevention and treatment of cancer-related infections","volume":"6","author":"Segal","year":"2008","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0375","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/CMR.17.4.770-782.2004","article-title":"Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients","volume":"17","author":"Rodriguez","year":"2004","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0380","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archinte.1996.00440020081010","article-title":"A meta-analysis of the relative efficacy and toxicity of Pneumocystis carinii prophylactic regimens","volume":"156","author":"Ioannidis","year":"1996","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0385","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America","volume":"58","author":"Kaplan","year":"2009","journal-title":"Morbidity and Mortality Weekly Report Recommendations and Reports"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0390","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2125.1997.00590.x","article-title":"Hospitalization for serious blood and skin disorders following co-tromixazol","volume":"43","author":"Meyers","year":"1997","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0395","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/00365540903321606","article-title":"Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency","volume":"42","author":"Douzinas","year":"2010","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0400","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00042560-199706010-00002","article-title":"Meta-analysis of prophylactic treatments against Pneumocytis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients","volume":"15","author":"Bucher","year":"1997","journal-title":"Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0405","first-page":"CD005646","article-title":"Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV\/AIDS in patients with previous history of hypersensitivity to cotrimoxazole","volume":"2","author":"Lin","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0410","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0163-4453(96)91312-2","article-title":"Risks and benefits of aerosolized pentamidine and cotrimoxazole in primary prophylaxis of Pneumocystis carinii pneumonia in HIV-1-infected patients: a two-year Italian multicentre randomized controlled trial","volume":"32","author":"Rizzardi","year":"1996","journal-title":"Journal of Infection"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0415","first-page":"457","article-title":"Trimethorpim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial","volume":"7","author":"May","year":"1994","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0420","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1056\/NEJM199212243272603","article-title":"A controlled trial of aerosolized pentamidine or trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodificiency virus infection","volume":"327","author":"Schneider","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0425","doi-asserted-by":"crossref","first-page":"755","DOI":"10.7326\/0003-4819-122-10-199505150-00004","article-title":"Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of Pneumocystis pneumonia and toxoplasmosis in patients infected with HIV","volume":"122","author":"Podzamczer","year":"1995","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0430","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00002030-199304000-00008","article-title":"Thrice-weekly cotrimoxazole is better than weekly dapsone-pyrimethamine for the primary prevention of Pneumocystis carinii pneumonia in HIV-infected patients","volume":"7","author":"Podzamczer","year":"1993","journal-title":"AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0435","first-page":"341","article-title":"Comparative trial dapsone versus trimethoprim\/sulfamethoxazole for primary prophylaxis of Pneumocystis carinii pneumonia","volume":"5","author":"Blum","year":"1992","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0440","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199503163321101","article-title":"A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection","volume":"332","author":"Bozzette","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0445","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/00002030-199210000-00017","article-title":"Oral dapsone versus nebulized pentamidine for Pneumocystis carinii pneumonia prophylaxis: an open randomized prospective trial to assess efficacy and haematological toxicity","volume":"6","author":"Slavin","year":"1992","journal-title":"AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0450","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1056\/NEJM199305273282102","article-title":"Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection","volume":"328","author":"Girard","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0455","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0002-9343(93)90352-P","article-title":"Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis","volume":"95","author":"Torres","year":"1993","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0460","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/clinids\/20.3.531","article-title":"Once-weekly administration of dapsone\/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients","volume":"20","author":"Opravil","year":"1995","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0465","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/AAC.46.5.1163-1173.2002","article-title":"Antiparasitic agent atovaquone","volume":"46","author":"Baggish","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0470","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1086\/314893","article-title":"Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides","volume":"180","author":"Chan","year":"1999","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0475","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJM199812243392604","article-title":"Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both","volume":"339","author":"El-Sadr","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0480","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/sj.bmt.1702004","article-title":"A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim\/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation","volume":"24","author":"Colby","year":"1999","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0485","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00002030-199512000-00007","article-title":"Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis","volume":"9","author":"Antinori","year":"1995","journal-title":"AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0490","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00002030-199301000-00009","article-title":"Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine","volume":"7","author":"Mallolas","year":"1993","journal-title":"AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0495","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00002030-199402000-00021","article-title":"Four different regimens for prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients","volume":"8","author":"Toccheti","year":"1994","journal-title":"AIDS"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0500","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/j.1875-9114.1995.tb04378.x","article-title":"A large population-based follow-up study of trimethoprim-sulfamethoxazole, trimethoprim, and cephalexin for uncommon serious drug toxicity","volume":"15","author":"Jick","year":"1995","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0505","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2125.1997.00590.x","article-title":"Hospitalization for serious blood and skin disorders following co-trimoxazole","volume":"43","author":"Myers","year":"1997","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0510","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/archinte.163.4.402","article-title":"Trimethoprim-sulfamethoxazole revisited","volume":"163","author":"Masters","year":"2003","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0515","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/cid\/cir067","article-title":"Does trimethoprim-sulfamethoxazole prophylaxis for HIV induce bacterial resistance to other antibiotic classes? Results of a systematic review","volume":"52","author":"Sibanda","year":"2011","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0520","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/cncr.11882","article-title":"Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management","volume":"100","author":"Crawford","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0525","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1200\/JCO.2006.06.4451","article-title":"2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline","volume":"24","author":"Smith","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0530","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.critrevonc.2006.06.014","article-title":"Glioblastoma in the elderly: current and future trends","volume":"60","author":"Brandes","year":"2006","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"10.1016\/j.critrevonc.2012.08.002_bib0535","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11864-011-0158-0","article-title":"Treatment of glioblastoma in \u201celderly\u201d patients","volume":"12","author":"Yovino","year":"2011","journal-title":"Current Treatment Options in Oncology"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842812001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842812001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T18:26:00Z","timestamp":1714328760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842812001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1040842812001680"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2012.08.002","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}