{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:27:10Z","timestamp":1789090030253,"version":"build-2803163510"},"reference-count":105,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.critrevonc.2014.09.002","type":"journal-article","created":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T16:25:44Z","timestamp":1412526344000},"page":"211-224","source":"Crossref","is-referenced-by-count":75,"title":["Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors"],"prefix":"10.1016","volume":"93","author":[{"given":"Angiolo","family":"Gadducci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Fabrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Lanfredini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sergiampietri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2014.09.002_bib0005","series-title":"Berek and Hacker's gynecologic oncology","first-page":"576","article-title":"Vaginal cancer","author":"Hacker","year":"2009"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"issue":"Suppl. 1","key":"10.1016\/j.critrevonc.2014.09.002_bib0015","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0020-7292(06)60029-5","article-title":"Carcinoma of the vagina. FIGO 26th annual report on the results of treatment in gynecological cancer","volume":"95","author":"Beller","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0020","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ygyno.2007.01.005","article-title":"Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure","volume":"105","author":"Frank","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0025","first-page":"241","article-title":"Primary carcinoma of the vagina","volume":"15","author":"Lilic","year":"2010","journal-title":"J BUON"},{"issue":"Suppl. 2","key":"10.1016\/j.critrevonc.2014.09.002_bib0030","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S0020-7292(12)60022-8","article-title":"Cancer of the vagina","volume":"119","author":"Hacker","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF02524343","article-title":"Primary vaginal melanoma: a critical analysis of therapy","volume":"11","author":"Miner","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0040","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/IGC.0b013e3182a1ced8","article-title":"Treatment approach and outcomes of vaginal melanoma","volume":"23","author":"Kirschner","year":"2013","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0045","doi-asserted-by":"crossref","first-page":"306921","DOI":"10.4061\/2011\/306921","article-title":"Primary small cell neuroendocrine carcinoma of vagina: a rare case report","volume":"2011","author":"Bhalodia","year":"2011","journal-title":"Pathol Res Int"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0050","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/0973-1482.113422","article-title":"Primary neuroendocrine carcinoma of the vagina with coexistent atypical vaginal adenosis: a rare entity","volume":"9","author":"Khurana","year":"2013","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12253-010-9280-8","article-title":"Squamotransitional cell carcinoma of the vagina: diagnosis and clinical management: a literature review starting from a rare case report","volume":"17","author":"Patrelli","year":"2011","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10552-011-9855-z","article-title":"Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States","volume":"23","author":"Smith","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0065","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1701-2163(16)34054-3","article-title":"Primitive clear cell carcinoma of the vagina treated conservatively","volume":"31","author":"Renaud","year":"2009","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/PGP.0b013e3181b6a7d7","article-title":"Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy","volume":"29","author":"Paczos","year":"2010","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0075","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1440-1827.2010.02573.x","article-title":"Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy","volume":"60","author":"Nomoto","year":"2010","journal-title":"Pathol Int"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0080","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0090-8258(03)00266-X","article-title":"M\u00fcllerian adenosarcoma of vagina arising in persistent endometriosis: report of a case and review of the literature","volume":"90","author":"Liu","year":"2003","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/LGT.0b013e318074f968","article-title":"Outcomes after diagnosis of vaginal intraepithelial neoplasia","volume":"12","author":"Massad","year":"2008","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0090","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/1471-0528.12223","article-title":"High-grade vaginal intraepithelial neoplasia: can we be selective about who we treat?","volume":"120","author":"Ratnavelu","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0095","doi-asserted-by":"crossref","first-page":"410.e1","DOI":"10.1016\/j.ajog.2013.01.047","article-title":"A contemporary analysis of epidemiology and management of vaginal intraepithelial neoplasia","volume":"208","author":"Gunderson","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ygyno.2010.09.005","article-title":"Vaginal intraepithelial neoplasia (VAIN) after radiation therapy for gynecologic malignancies: a clinically recalcitrant entity","volume":"120","author":"Liao","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"10 Suppl.","key":"10.1016\/j.critrevonc.2014.09.002_bib0105","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/cncr.23757","article-title":"Descriptive epidemiology of vaginal cancer incidence and survival by race, ethnicity, and age in the United States","volume":"113","author":"Wu","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0110","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ygyno.2013.08.012","article-title":"Primary squamous cell carcinoma of the vagina: prognostic factors, treatment patterns, and outcomes","volume":"131","author":"Hiniker","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00404-007-0415-4","article-title":"A rare case of primary invasive carcinoma of vagina associated with irreducible third degree uterovaginal prolapse","volume":"276","author":"Gupta","year":"2007","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00404-009-1016-1","article-title":"A rare case of invasive vaginal carcinoma associated with vaginal prolapse","volume":"280","author":"Batista","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00404-008-0815-0","article-title":"Primary invasive carcinoma of vagina with third degree uterovaginal prolapse: a case report and review of literature","volume":"279","author":"Ghosh","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/gyno.2001.6417","article-title":"Carcinoma of the neovagina: case report and review of the literature","volume":"84","author":"Steiner","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0135","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1016\/j.jpag.2008.12.009","article-title":"Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovagina","volume":"22","author":"Idrees","year":"2009","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0140","first-page":"588","article-title":"Primary carcinoma of the neovagina: a case report","volume":"32","author":"Kokcu","year":"2011","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0145","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/gyno.2001.6502","article-title":"A population-based study of squamous cell vaginal cancer: HPV and cofactors","volume":"84","author":"Daling","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0150","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ygyno.2008.05.015","article-title":"Smoking increases the risk of high-grade vaginal intraepithelial neoplasia in women with oncogenic human papillomavirus","volume":"110","author":"Sherman","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0155","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/ijc.23446","article-title":"Risk factors for invasive squamous cell carcinoma of the vulva and vagina \u2013 population-based case\u2013control study in Denmark","volume":"122","author":"Madsen","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0160","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/AOG.0b013e31819bd6e0","article-title":"Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors","volume":"113","author":"Smith","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0165","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/ijc.24116","article-title":"Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis","volume":"124","author":"De Vuyst","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0170","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1365-2559.2010.03727.x","article-title":"Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations","volume":"57","author":"Fuste","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0175","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/IGC.0b013e31821bc615","article-title":"The prognostic role of human papillomavirus in patients with vaginal cancer","volume":"21","author":"Brunner","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0180","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ygyno.2011.12.449","article-title":"Human papillomavirus as a favorable prognostic biomarker in squamous cell carcinomas of the vagina","volume":"125","author":"Alonso","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0185","doi-asserted-by":"crossref","first-page":"893275","DOI":"10.1155\/2012\/893275","article-title":"Human papillomavirus genotyping and e6\/e7 mRNA expression in Greek women with intraepithelial neoplasia and squamous cell carcinoma of the vagina and vulva","volume":"2012","author":"Tsimplaki","year":"2012","journal-title":"J Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0190","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0090-8258(91)90319-Z","article-title":"Rapidly progressive squamous cell carcinoma of the cervix coexisting with human immunodeficiency virus infection: clinical opinion","volume":"41","author":"Schwartz","year":"1991","journal-title":"Gynecol Oncol"},{"issue":"23","key":"10.1016\/j.critrevonc.2014.09.002_bib0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/oxfordjournals.jncimonographs.a024172","article-title":"Management of cervical neoplasia in human immunodeficiency virus-infected women","author":"Maiman","year":"1998","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0200","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1006\/gyno.2000.5924","article-title":"Rapid progression of primary vaginal squamous cell carcinoma in a young HIV-infected woman","volume":"78","author":"Lee","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0205","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4103\/0973-1482.103526","article-title":"Acrometastasis to hand in vaginal carcinoma: a rare entity","volume":"8","author":"Khosla","year":"2012","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0210","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ygyno.2007.12.012","article-title":"Laparoscopic radical hysterectomy with vaginectomy and reconstruction of vagina in patients with stage I of primary vaginal carcinoma","volume":"109","author":"Ling","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0215","first-page":"216","article-title":"Vertical rectus abdominis myocutaneous flap for vaginal reconstruction after radical pelvic surgery for Stage II vaginal carcinoma","volume":"32","author":"Tapisiz","year":"2011","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0220","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jmig.2012.05.005","article-title":"Laparoscopic nerve-sparing radical vaginectomy in patients with vaginal carcinoma: surgical technique and operative outcomes","volume":"19","author":"Li","year":"2012","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0225","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.critrevonc.2011.04.004","article-title":"Vaginal cancer","volume":"81","author":"Di Donato","year":"2012","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0230","doi-asserted-by":"crossref","first-page":"76","DOI":"10.5114\/jcb.2013.36177","article-title":"Adjuvant and definitive radiation therapy for primary carcinoma of the vagina using brachytherapy and external beam radiation therapy","volume":"5","author":"Platta","year":"2013","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0235","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijgo.2013.03.012","article-title":"Radical hysterectomy and vaginectomy with sigmoid vaginoplasty for stage I vaginal carcinoma","volume":"122","author":"Yin","year":"2013","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0240","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijrobp.2004.09.032","article-title":"Definitive radiation therapy for squamous cell carcinoma of the vagina","volume":"62","author":"Frank","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0245","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0360-3016(95)02394-1","article-title":"Definitive radiotherapy for carcinoma of the vagina: outcome and prognostic factors","volume":"35","author":"Chyle","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0250","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0090-8258(91)90076-H","article-title":"Radiation management of primary carcinoma of the vagina: clinical and histopathological variables associated with survival","volume":"40","author":"Kucera","year":"1991","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0255","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0360-3016(94)90392-1","article-title":"Radiotherapy alone for carcinoma of the vagina: the importance of overall treatment time","volume":"29","author":"Lee","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0260","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/gyno.1995.1077","article-title":"Carcinoma of the vagina \u2013 experience at the Princess Margaret Hospital (1974\u20131989)","volume":"56","author":"Kirkbride","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0270","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/(SICI)1097-0142(19960501)77:9<1934::AID-CNCR25>3.0.CO;2-#","article-title":"Radiation alone for carcinoma of the vagina: variation in response related to the location of the primary tumor","volume":"77","author":"Ali","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0275","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0360-3016(98)00530-6","article-title":"Factors affecting long-term outcome of irradiation in carcinoma of the vagina","volume":"44","author":"Perez","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"May\u2013June (3)","key":"10.1016\/j.critrevonc.2014.09.002_bib0280","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1525-1438.2006.00520.x","article-title":"Clinical and histopathologic factors related to prognosis in primary squamous cell carcinoma of the vagina","volume":"16","author":"Hellman","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0285","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.radonc.2007.09.015","article-title":"Exclusive radiotherapy for primary squamous cell carcinoma of the vagina","volume":"85","author":"De Crevoisier","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0290","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ygyno.2007.01.033","article-title":"Prognostic factors for outcomes and complications for primary squamous cell carcinoma of the vagina treated with radiation","volume":"105","author":"Tran","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0295","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ygyno.2008.07.007","article-title":"Twenty-year review of radiotherapy for vaginal cancer: an institutional experience","volume":"111","author":"Lian","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0300","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00066-009-1930-y","article-title":"Long-term results of radiotherapy in primary carcinoma of the vagina","volume":"185","author":"Hegemann","year":"2009","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0305","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s10147-012-0379-7","article-title":"Definitive radiation therapy for invasive carcinoma of the vagina: impact of high-dose rate intracavitary brachytherapy","volume":"18","author":"Nonaka","year":"2013","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0310","article-title":"Outcomes of definitive radiation therapy for primary vaginal carcinoma","volume":"October","author":"Greenwalt","year":"2013","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0315","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1048-891x.2004.014066.x","article-title":"Chemoradiation for primary invasive squamous carcinoma of the vagina","volume":"14","author":"Dalrymple","year":"2004","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0320","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ijrobp.2007.04.015","article-title":"Primary vaginal cancer treated with concurrent chemoradiation using cis-platinum","volume":"69","author":"Samant","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10147-007-0758-7","article-title":"Concurrent chemoradiation for locally advanced squamous cell carcinoma of the vagina: case series and literature review","volume":"13","author":"Nashiro","year":"2008","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0330","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/IGC.0b013e3181a12e1d","article-title":"Indiana University experience in the management of vaginal cancer","volume":"19","author":"Sinha","year":"2009","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0335","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0090-8258(85)90216-1","article-title":"Squamous carcinoma of the vagina: treatment, complications, and long-term follow-up","volume":"20","author":"Rubin","year":"1985","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0340","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/gyno.1995.1008","article-title":"A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities","volume":"56","author":"Stock","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0345","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/gyno.2001.6171","article-title":"The role of surgery in invasive squamous carcinoma of the vagina","volume":"81","author":"Tjalma","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0350","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ygyno.2010.11.044","article-title":"Pelvic exenteration in the age of modern chemoradiation","volume":"121","author":"McLean","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0355","first-page":"131","article-title":"Pelvic exenteration in gynecologic oncology: a single institution study over 20 years","volume":"121","author":"Benn","year":"2011","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0360","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ejso.2012.07.002","article-title":"Prognostic factors in pelvic exenteration for gynecological malignancies","volume":"38","author":"Baiocchi","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0365","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ygyno.2011.12.427","article-title":"Modified vertical rectus abdominis myocutaneous flap vaginal reconstruction: an analysis of surgical outcomes","volume":"125","author":"Berger","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0370","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/IGC.0b013e31824eb8cd","article-title":"Pelvic exenterations for gynecological malignancies: a study of 36 cases","volume":"22","author":"Kaur","year":"2012","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0375","first-page":"142","article-title":"Total pelvic exenteration in vaginal cancer \u2013 case report","volume":"84","author":"Olejek","year":"2013","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0380","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1470-2045(06)70903-2","article-title":"Pelvic exenteration for gynaecological tumours: achievements and unanswered questions","volume":"7","author":"H\u00f6ckel","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0385","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ol_00000001","article-title":"Treatment options in recurrent cervical cancer (Review)","volume":"1","author":"Gadducci","year":"2010","journal-title":"Oncol Lett"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0390","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ygyno.2012.03.001","article-title":"Indications and long-term clinical outcomes in 282 patients with pelvic exenteration for advanced or recurrent cervical cancer","volume":"125","author":"Schmidt","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0395","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.suronc.2011.12.008","article-title":"Management of recurrent cervical cancer: a review of the literature","volume":"21","author":"Peiretti","year":"2012","journal-title":"Surg Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0400","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ygyno.2013.01.017","article-title":"The value of 18F-FDG PET\/CT in recurrent gynecologic malignancies prior to pelvic exenteration","volume":"129","author":"Burger","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0405","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1200\/JCO.20.1.179","article-title":"Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study","volume":"20","author":"Benedetti-Panici","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0410","first-page":"CD001774","article-title":"Neoadjuvant chemotherapy for locally advanced cervix cancer","volume":"2","author":"Neoadjuvant Chemotherapy for Cervical Cancer Meta-Analysis Collaboration (NACCCMA)","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0415","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ygyno.2013.09.029","article-title":"Pathological response on surgical samples is an independent prognostic variable for patients with stage Ib2\u2013IIb cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: an Italian multicenter retrospective study (CTF Study)","volume":"131","author":"Gadducci","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0420","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ygyno.2013.12.010","article-title":"Is there a role for postoperative treatment in patients with stage Ib2\u2013IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study","volume":"132","author":"Landoni","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0425","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2008.07.005","article-title":"Neoadjuvant chemotherapy followed by radical surgery in patients affected by vaginal carcinoma","volume":"111","author":"Benedetti-Panici","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0430","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1447-0756.2010.01245.x","article-title":"Neoadjuvant chemotherapy followed by radical surgery and reconstruction of the vagina in a patient with stage II primary vaginal squamous carcinoma","volume":"36","author":"Lv","year":"2010","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0435","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brachy.2011.06.008","article-title":"American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer","volume":"11","author":"Beriwal","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2013.02.014","article-title":"Uncertainties in image guided adaptive cervix cancer brachytherapy: impact on planning and prescription","volume":"107","author":"Tanderup","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0445","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.canrad.2013.02.002","article-title":"Image-guided adaptive brachytherapy in the treatment of patients with cervix cancer","volume":"17","author":"Haie-Meder","year":"2013","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0450","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.radonc.2011.12.024","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy","volume":"103","author":"Dimopoulos","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0455","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/gyno.1995.1042","article-title":"Improved treatment planning for the Syed-Neblett template using endorectal-coil magnetic resonance and intraoperative (laparotomy\/laparoscopy) guidance: a new integrated technique for hysterectomized women with vaginal tumors","volume":"56","author":"Corn","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0460","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/gyno.1999.5354","article-title":"Potential decreased morbidity of interstitial brachytherapy for gynecologic malignancies using laparoscopy: a pilot study","volume":"73","author":"Choi","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0465","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.radonc.2011.08.016","article-title":"Image and laparoscopic guided interstitial brachytherapy for locally advanced primary or recurrent gynaecological cancer using the adaptive GEC ESTRO target concept","volume":"100","author":"Fokdal","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0470","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.ijrobp.2011.03.049","article-title":"Treatment of locally advanced vaginal cancer with radiochemotherapy and magnetic resonance image-guided adaptive brachytherapy: dose-volume parameters and first clinical results","volume":"82","author":"Dimopoulos","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0475","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/AOG.0b013e31819fe844","article-title":"Factors affecting risk of mortality in women with vaginal cancer","volume":"113","author":"Shah","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0480","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1259\/bjr.73.875.11144798","article-title":"Radiotherapy for vaginal carcinoma: a 23-year review","volume":"73","author":"Stryker","year":"2000","journal-title":"Br J Radiol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0485","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00066-012-0291-0","article-title":"Radiotherapy for carcinoma of the vagina. Immunocytochemical and cytofluorometric analysis of prognostic factors","volume":"189","author":"Blecharz","year":"2013","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0490","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/IGC.0b013e31827670c4","article-title":"Prognostic significance of cell cycle- and invasion-related molecular markers and genomic instability in primary carcinoma of the vagina","volume":"23","author":"Hellman","year":"2013","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0495","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ygyno.2004.04.008","article-title":"Association of hemoglobin level with survival in cervical carcinoma patients treated with concurrent cisplatin and radiotherapy: a Gynecologic Oncology Group Study","volume":"94","author":"Winter","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0500","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/02841860600833160","article-title":"Clinical relevance of hemoglobin level in cervical cancer patients administered definitive radiotherapy","volume":"45","author":"Serkies","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0505","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0167-8140(93)90025-4","article-title":"Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix","volume":"26","author":"H\u00f6ckel","year":"1993","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0510","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tracli.2004.11.005","article-title":"Hypoxia and anemia: effects on tumor biology and treatment resistance","volume":"12","author":"Vaupel","year":"2005","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0515","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1200\/JCO.2010.30.4899","article-title":"Randomized phase III trial of sequential adjuvant chemoradiotherapy with or without erythropoietin Alfa in patients with high-risk cervical cancer: results of the NOGGO-AGO intergroup study","volume":"29","author":"Blohmer","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0520","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.critrevonc.2012.09.003","article-title":"Tissue biomarkers as prognostic variables of cervical cancer","volume":"86","author":"Gadducci","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.critrevonc.2014.09.002_bib0525","first-page":"432","article-title":"Human papillomavirus DNA in invasive carcinoma of the vagina","volume":"76","author":"Ikenberg","year":"1990","journal-title":"Obstet Gynecol"},{"issue":"171","key":"10.1016\/j.critrevonc.2014.09.002_bib0535","first-page":"e1","article-title":"Expression of epidermal growth factor receptor and vascular endothelial growth factor in vaginal squamous cell cancer","volume":"204","author":"Brunner","year":"2011","journal-title":"Am J Obstet Gynecol"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842814001504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842814001504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T17:41:15Z","timestamp":1565890875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842814001504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":105,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1040842814001504"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2014.09.002","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}