{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:03:58Z","timestamp":1790636638998,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","croh-online.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.critrevonc.2015.11.006","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T05:26:51Z","timestamp":1448170011000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Vismodegib, itraconazole and sonidegib as hedgehog pathway inhibitors and their relative competencies in the treatment of basal cell carcinomas"],"prefix":"10.1016","volume":"98","author":[{"given":"Mohd","family":"Wahid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Jawed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju K.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad A.","family":"Dar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafiul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2015.11.006_bib0005","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.3389","article-title":"Unraveling the therapeutic potential of the hedgehog pathway in cancer","volume":"19","author":"Amakye","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1600-0625.2006.00473.x","article-title":"Hedgehog signaling in skin development and cancer","volume":"15","author":"Athar","year":"2006","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.critrevonc.2015.11.006_bib0015","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a013581","article-title":"Advanced treatment for basal cell carcinomas","volume":"4","author":"Atwood","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0020","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001599","article-title":"Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma","volume":"2","author":"Buonamici","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0025","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1158\/0008-5472.CAN-10-2876","article-title":"Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance","volume":"71","author":"Dijkgraaf","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0030","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1158\/1078-0432.CCR-06-1736","article-title":"The hedgehog signaling pathway in cancer","volume":"20","author":"Evangelista","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0035","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","article-title":"Mechanisms of cancer drug resistance","volume":"53","author":"Gottesman","year":"2002","journal-title":"Annu. Rev. Med."},{"issue":"6","key":"10.1016\/j.critrevonc.2015.11.006_bib0040","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81268-4","article-title":"Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome","volume":"85","author":"Hahn","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0045","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s001099900018","article-title":"The patched signaling pathway in tumorigenesis and development: lessons from animal models","volume":"77","author":"Hahn","year":"1999","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.02169","article-title":"Signaling from SMO to Ci\/Gli: conservation and divergence of hedgehog pathways from Drosophila to vertebrates","volume":"133","author":"Huangfu","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0055","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nrg1969","article-title":"Orchestrating ontogenesis: variations on a theme by sonic hedgehog","volume":"7","author":"Ingham","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0060","unstructured":"Jacob L., Lun L., 2007. Hedgehog signaling pathway. Sci.STKE, cm6. doi: 10.1126\/STKE. 4072007cm6."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0065","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.272.5268.1668","article-title":"Human homolog of patched, a candidate gene for the basal cell nevus syndrome","volume":"272","author":"Johnson","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0070","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2174\/156652409789105570","article-title":"Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation","volume":"9","author":"Katoh","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0075","doi-asserted-by":"crossref","first-page":"13432","DOI":"10.1073\/pnas.1006822107","article-title":"Arsenic antagonizes the hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0080","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ccr.2010.02.027","article-title":"Itraconazole, a commonly used antifungal that inhibits hedgehog pathway activity and cancer growth","volume":"17","author":"Kim","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2012.11.017","article-title":"Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists","volume":"23","author":"Kim","year":"2013","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.critrevonc.2015.11.006_bib0090","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1200\/JCO.2013.49.9525","article-title":"Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma","volume":"32","author":"Kim","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13555-013-0019-9","article-title":"Targeted therapy for advanced basal-cell carcinoma: vismodegib and beyond","volume":"3","author":"Lance Cowey","year":"2013","journal-title":"Dermatol. Ther. (Heidelb)"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0100","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1158\/0008-5472.CAN-06-0505","article-title":"Patched 2 modulates tumorigenesis in patched I heterozygous mice","volume":"66","author":"Lee","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0105","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1200\/JCO.2010.27.9943","article-title":"Clinical experience with hedgehog pathway inhibitors","volume":"28","author":"Low","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0110","series-title":"Presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO)","article-title":"Randomized, double-blind study of sonidegib (LDE225) in patients (pts) with locally advanced (La) or metastatic (m) basal-cell carcinoma (BCC)","author":"Migden","year":"2014"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0115","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","article-title":"Mutations affecting segment number and polarity in Drosophila","volume":"287","author":"Nusslein-Volhard","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0120","unstructured":"Pivotal data for Novartis' investigational compound LDE225 (sonidegib) show marked tumor responses in advanced basal cell carcinoma. http:\/\/www.oncotrends.de\/pivotal-data-for-novartis-investigational-compound-lde225-sonidegib-show-marked-tumor-responses-in-advanced-basal-cell-carcinoma-422202 (accessed 08.11.14.)."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0125","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.critrevonc.2015.11.006_bib0130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molonc.2014.09.003","article-title":"Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma","volume":"9","author":"Pricl","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0135","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1056\/NEJMra044151","article-title":"Basal-cell carcinoma","volume":"353","author":"Rubin","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2009.03.007","article-title":"Mechanisms of hedgehog pathway activation in cancer and implications for therapy","volume":"30","author":"Scales","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0145","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1056\/NEJMoa1113713","article-title":"Efficacy and safety of vismodegib in advanced basal-cell carcinoma","volume":"366","author":"Sekulic","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0150","unstructured":"Stevens DAe., 2001. Managing Fungal Infections in the 21st Century: Focus on Itraconazole. Drugs. 61, 1\u201356."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0155","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMoa1113538","article-title":"Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome","volume":"366","author":"Tang","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.03309","article-title":"Hedgehog signaling","volume":"120","author":"Varjosalo","year":"2007","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0165","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1056\/NEJMoa0905360","article-title":"Inhibition of the hedgehog pathway in advanced basal-cell carcinoma","volume":"361","author":"Von Hoff","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D313V4J8VJ","article-title":"Metastatic basal cell carcinoma: a case report and literature review. How accurate is our incidence data?","volume":"12","author":"Wadhera","year":"2006","journal-title":"Dermatol. Online J."},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0175","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1038\/sj.onc.1203282","article-title":"The hedgehog signalling pathway in tumorigenesis and development","volume":"18","author":"Wicking","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.critrevonc.2015.11.006_bib0180","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1179386","article-title":"Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma","volume":"326","author":"Yauch","year":"2009","journal-title":"Science"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842815300767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842815300767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T20:08:07Z","timestamp":1653595687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842815300767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":36,"alternative-id":["S1040842815300767"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2015.11.006","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vismodegib, itraconazole and sonidegib as hedgehog pathway inhibitors and their relative competencies in the treatment of basal cell carcinomas","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2015.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}