{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:08:19Z","timestamp":1791259699344,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","croh-online.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.critrevonc.2016.05.008","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T02:16:53Z","timestamp":1464056213000},"page":"30-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas"],"prefix":"10.1016","volume":"104","author":[{"given":"Jelte","family":"Helfferich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Nijmeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oebele F.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Fock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco W.","family":"Hoving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisethe","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred F.A.","family":"den Dunnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline S.J.M.","family":"de Bont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2016.05.008_bib0005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/COC.0b013e31826b9903","article-title":"Histologically proven, low-grade brainstem gliomas in children: 30-Year experience with long-term follow-up at mayo clinic","volume":"37","author":"Ahmed","year":"2014","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/MCB.13.1.487","article-title":"A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity","volume":"13","author":"Andersen","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0015","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ydbio.2005.09.023","article-title":"Lhx2 mediates the activity of Six3 in zebrafish forebrain growth","volume":"287","author":"Ando","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/neuonc\/noq178","article-title":"Survival and long-term health and cognitive outcomes after low-grade glioma","volume":"13","author":"Armstrong","year":"2011","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0025","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1200\/JCO.2011.36.6054","article-title":"Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children\u2019s Oncology Group","volume":"30","author":"Ater","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0030","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1128\/MCB.22.14.5100-5113.2002","article-title":"Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation","volume":"22","author":"Bajenaru","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0035","first-page":"8573","article-title":"Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity","volume":"63","author":"Bajenaru","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ana.20337","article-title":"Natural history of neurofibromatosis 1-associated optic nerve glioma in mice","volume":"57","author":"Bajenaru","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0045","doi-asserted-by":"crossref","first-page":"15996","DOI":"10.1073\/pnas.1019012108","article-title":"Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC\/Rheb-independent manner","volume":"108","author":"Banerjee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1158\/1535-7163.MCT-10-0654","article-title":"Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes","volume":"10","author":"Banerjee","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0055","first-page":"314","article-title":"Vascularity and angiogenesis as predictors of growth in optic pathway\/hypothalamic gliomas","volume":"104","author":"Bartels","year":"2006","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0060","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/356713a0","article-title":"Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients","volume":"356","author":"Basu","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00381-011-1676-6","article-title":"Biologic tumor behavior in pilocytic astrocytomas","volume":"28","author":"Belirgen","year":"2012","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0070","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1200\/JCO.2011.34.5843","article-title":"Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma","volume":"30","author":"Bouffet","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrneurol.2010.159","article-title":"Update on molecular findings, management and outcome in low-grade gliomas","volume":"6","author":"Bourne","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(09)70033-6","article-title":"Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1","volume":"10","author":"Brems","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0085","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/08830738030180070401","article-title":"Optic pathway gliomas in children with and without neurofibromatosis 1","volume":"18","author":"Czyzyk","year":"2003","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0090","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/hmg\/ddm059","article-title":"Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth","volume":"16","author":"Daginakatte","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0095","doi-asserted-by":"crossref","first-page":"10358","DOI":"10.1158\/0008-5472.CAN-08-2506","article-title":"Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation","volume":"68","author":"Daginakatte","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fonc.2013.00110","article-title":"The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas","volume":"3","author":"Dasgupta","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0105","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1158\/0008-5472.CAN-04-4058","article-title":"Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors","volume":"65","author":"Dasgupta","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0110","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1158\/0008-5472.236.65.1","article-title":"Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes","volume":"65","author":"Dasgupta","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0115","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1086\/374821","article-title":"Elevated risk for MPNST in NF1 microdeletion patients","volume":"72","author":"De Raedt","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24093","article-title":"Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1","volume":"75","author":"Diggs-Andrews","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0125","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archneurpsyc.1958.02340060003001","article-title":"Gliomas of the optic nerves","volume":"79","author":"Dodge","year":"1958","journal-title":"AMA Arch. Neurol. Psychiatry"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0130","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1002\/cncr.29649","article-title":"Long-term visual outcome after chemotherapy for optic pathway glioma in children: site and age are strongly predictive","volume":"121","author":"Dodgshun","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0135","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.187922.112","article-title":"Emerging insights into the molecular and cellular basis of glioblastoma","volume":"26","author":"Dunn","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0140","article-title":"A proteomic approach of pediatric astrocytomas: MiRNAs and network insight","author":"Esparza-Garrido","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/neuonc\/nos076","article-title":"Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis","volume":"14","author":"Fisher","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0155","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1212\/01.wnl.0000435745.95155.b8","article-title":"Functional outcome measures for NF1-associated optic pathway glioma clinical trials","volume":"81","author":"Fisher","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0160","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ana.24157","article-title":"Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma","volume":"75","author":"Fisher","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0165","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/path.2558","article-title":"Activation of the ERK\/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas","volume":"218","author":"Forshew","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-2004-832355","volume":"216","author":"Gnekow","year":"2004","journal-title":"Klin. Padiatr."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0175","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/neuonc\/nos202","article-title":"Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and Hematology","volume":"14","author":"Gnekow","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/1531-8249(199903)45:3<393::AID-ANA17>3.0.CO;2-B","article-title":"Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma","volume":"45","author":"Grill","year":"1999","journal-title":"Ann. Neurol."},{"issue":"346","key":"10.1016\/j.critrevonc.2016.05.008_bib0185","article-title":"Brainstem glioma: a review","volume":"13","author":"Grimm","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/brain\/awg016","article-title":"Prognostic factors of CNS tumours in neurofibromatosis 1 (NF1): a retrospective study of 104 patients","volume":"126","author":"Guillamo","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0195","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/35002593","article-title":"A neurofibromatosis-1-regulated pathway is required for learning in Drosophila","volume":"403","author":"Guo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1215\/15228517-2006-030","article-title":"Temozolomide in children with progressive low-grade glioma","volume":"9","author":"Gururangan","year":"2007","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0205","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/neuonc\/not154","article-title":"Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas\u2014a pediatric brain tumor consortium study","volume":"16","author":"Gururangan","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0210","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1073\/pnas.88.21.9658","article-title":"Identification of the neurofibromatosis type 1 gene product","volume":"88","author":"Gutmann","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0215","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1038\/sj.onc.1202829","article-title":"Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation","volume":"18","author":"Gutmann","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0220","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2990.2000.00258.x","article-title":"Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas","volume":"26","author":"Gutmann","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0225","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1212\/WNL.59.5.759","article-title":"Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)","volume":"59","author":"Gutmann","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0230","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.61.10.1397","article-title":"Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1","volume":"61","author":"Gutmann","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0235","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1101\/gr.142604.112","article-title":"Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma","volume":"23","author":"Gutmann","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0240","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/088307380201700809","article-title":"Review article: neurofibromin in the brain","volume":"17","author":"Gutmann","year":"2002","journal-title":"J. Child Neurol."},{"issue":"189","key":"10.1016\/j.critrevonc.2016.05.008_bib0245","article-title":"First experiences in treatment of low-grade glioma grade I and II with proton therapy","volume":"7","author":"Hauswald","year":"2012","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1750-3639.1999.tb00535.x","article-title":"High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors","volume":"9","author":"Hayes","year":"1999","journal-title":"Brain Pathol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0255","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/1097-0142(19930801)72:3<856::AID-CNCR2820720335>3.0.CO;2-K","article-title":"Astrocytomas of the cerebellum: a comparative clinicopathologic study of pilocytic and diffuse astrocytomas","volume":"72","author":"Hayostek","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0260","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1158\/0008-5472.CAN-07-5916","article-title":"Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma","volume":"68","author":"Hegedus","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0265","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11060-010-0159-z","article-title":"Natural history and management of low-grade glioma in NF-1 children","volume":"100","author":"Hernaiz Driever","year":"2010","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0270","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00066-002-0874-2","article-title":"Conformal proton radiation therapy for pediatric low-grade astrocytomas","volume":"178","author":"Hug","year":"2002","journal-title":"Strahlenther. Onkol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0275","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1172\/JCI60578","article-title":"MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors","volume":"123","author":"Jessen","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0280","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1073\/pnas.0503224102","article-title":"The NF1 tumor suppressor critically regulates TSC2 and mTOR","volume":"102","author":"Johannessen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0285","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1097\/PAS.0b013e3181fd66c3","article-title":"Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors","volume":"34","author":"Johnson","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0290","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1158\/0008-5472.CAN-08-2097","article-title":"Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas","volume":"68","author":"Jones","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0295","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/onc.2009.73","article-title":"Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma","volume":"28","author":"Jones","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0300","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ng.2682","article-title":"Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma","volume":"45","author":"Jones","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0305","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1097\/MPH.0000000000000371","article-title":"Confirmation of bevacizumab activity, and maintenance of efficacy in retreatment after subsequent relapse, in pediatric low-grade glioma","volume":"37","author":"Kalra","year":"2015","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0310","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/neuonc\/nou059","article-title":"Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas","volume":"16","author":"Karajannis","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0315","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1101\/gad.200907.112","article-title":"Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner","volume":"26","author":"Kaul","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0320","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.22415","article-title":"Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects","author":"Kaul","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0325","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/exd.12115","article-title":"NF1 gene silencing induces upregulation of vascular endothelial growth factor expression in both Schwann and non-Schwann cells","volume":"22","author":"Kawachi","year":"2013","journal-title":"Exp. Dermatol."},{"issue":"441","key":"10.1016\/j.critrevonc.2016.05.008_bib0330","article-title":"Targeted therapy in pediatric low-grade glioma","volume":"14","author":"Kilday","year":"2014","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0335","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2010.06.017","article-title":"Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma","volume":"170","author":"Kim","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0340","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/jnen\/60.9.917","article-title":"Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas","volume":"60","author":"Kluwe","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"72","key":"10.1016\/j.critrevonc.2016.05.008_bib0345","first-page":"79","article-title":"Pilocytic and pilomyxoid hypothalamic\/chiasmatic astrocytomas","volume":"54","author":"Komotar","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0350","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1200\/JCO.2003.03.043","article-title":"Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy\u2013results of the first French prospective study for the French Society of Pediatric Oncology","volume":"21","author":"Laithier","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0355","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/59.9.759","article-title":"Loss of neurofibromin is associated with activation of RAS\/MAPK and PI3-K\/AKT signaling in a neurofibromatosis 1 astrocytoma","volume":"59","author":"Lau","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0360","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gad.1957110","article-title":"Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner","volume":"24","author":"Lee da","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0365","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ccr.2012.05.036","article-title":"Innate neural stem cell heterogeneity determines the patterning of glioma formation in children","volume":"22","author":"Lee da","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0370","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/gcc.2870100405","article-title":"TP53 mutations are frequent in malignant NF1 tumors","volume":"10","author":"Legius","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0375","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<362::AID-CNCR20>3.0.CO;2-Z","article-title":"Microvessel density is a prognostic indicator for patients with astroglial brain tumors","volume":"77","author":"Leon","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0380","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0092-8674(92)90408-5","article-title":"Somatic mutations in the neurofibromatosis 1 gene in human tumors","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0385","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1073\/pnas.091100298","article-title":"Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation","volume":"98","author":"Lin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0390","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-3476(95)70159-1","article-title":"Optic pathway tumors in children: the effect of neurofibromatosis type 1 on clinical manifestations and natural history","volume":"127","author":"Listernick","year":"1995","journal-title":"J. Pediatr."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0395","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations","volume":"61","author":"Listernick","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0400","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/jamaophthalmol.2013.1652","article-title":"Optic pathway gliomas: neoplasms, not hamartomas","volume":"131","author":"Liu","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0405","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0410","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2407-13-387","article-title":"Molecular fingerprinting reflects different histotypes and brain region in low grade gliomas","volume":"13","author":"Mascelli","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0415","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1200\/JCO.2002.08.087","article-title":"High response rate to cisplatin\/etoposide regimen in childhood low-grade glioma","volume":"20","author":"Massimino","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0420","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1200\/JCO.2008.20.9494","article-title":"Phase II trial of conformal radiation therapy for pediatric low-grade glioma","volume":"27","author":"Merchant","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0425","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N","article-title":"Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects","volume":"15","author":"Messiaen","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0430","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.ejca.2010.03.028","article-title":"Does chemotherapy affect the visual outcome in children with optic pathway glioma? A systematic review of the evidence","volume":"46","author":"Moreno","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0435","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00066-013-0357-7","article-title":"Radiotherapy in pediatric pilocytic astrocytomas: a subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH)","volume":"189","author":"Muller","year":"2013","journal-title":"Strahlenther. Onkol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0440","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0002-9440(10)65507-1","article-title":"Rosenberg AE, Louis DN. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A\/p16 inactivation","volume":"155","author":"Nielsen","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0445","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ejca.2006.02.022","article-title":"Prognostic factors for progression of childhood optic pathway glioma: a systematic review","volume":"42","author":"Opocher","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0450","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ajmg.a.10167","article-title":"Homozygous inactivation of NF1 gene in a patient with familial NF1 and disseminated neuroblastoma","volume":"118A","author":"Origone","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0455","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10456-004-6643-3","article-title":"Targeting neovascular pericytes in neurofibromatosis type 1","volume":"7","author":"Ozerdem","year":"2004","journal-title":"Angiogenesis"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0460","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3171\/jns.1997.86.5.0747","article-title":"Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas","volume":"86","author":"Packer","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0465","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00381-010-1163-5","article-title":"Posterior fossa tumors in children with neurofibromatosis type 1 (NF1)","volume":"26","author":"Pascual-Castroviejo","year":"2010","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0470","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/jmedgenet-2012-100978","article-title":"Neurofibromatosis type 1: from genotype to phenotype","volume":"49","author":"Pasmant","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0475","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00250204","article-title":"Special issues in the management of gliomas in children with neurofibromatosis 1","volume":"28","author":"Pollack","year":"1996","journal-title":"J. Neurooncol."},{"issue":"June","key":"10.1016\/j.critrevonc.2016.05.008_bib0480","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1212\/WNL.46.6.1652","article-title":"The management of brainstem gliomas in patients with neurofibromatosis 1","volume":"46","author":"Pollack","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0485","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.23813","article-title":"Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation","volume":"73","author":"Pong","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0490","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/79075","article-title":"Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects","volume":"26","author":"Reilly","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0495","doi-asserted-by":"crossref","first-page":"13008","DOI":"10.1073\/pnas.0401236101","article-title":"Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects","volume":"101","author":"Reilly","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0500","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1200\/JCO.2008.17.1371","article-title":"Cognitive and adaptive outcome in extracerebellar low-grade brain tumors in children: a report from the Children\u2019s Oncology Group","volume":"26","author":"Ris","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"18","key":"10.1016\/j.critrevonc.2016.05.008_bib0505","article-title":"Non-invasive endothelial function assessment in patients with neurofibromatosis type 1: a cross-sectional study","volume":"13","author":"Rodrigues","year":"2013","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0510","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/NEN.0b013e318165eb75","article-title":"Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients","volume":"67","author":"Rodriguez","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0515","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1212\/01.WNL.0000150544.00016.69","article-title":"Cerebrovascular abnormalities in a population of children with neurofibromatosis type 1","volume":"64","author":"Rosser","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0520","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1523\/JNEUROSCI.4216-12.2013","article-title":"LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis","volume":"33","author":"Roy","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0525","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1158\/0008-5472.CAN-06-4470","article-title":"Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes","volume":"67","author":"Sandsmark","year":"2007","journal-title":"Cancer Res."},{"issue":"23","key":"10.1016\/j.critrevonc.2016.05.008_bib0530","article-title":"An emerging role for microRNAs in NF1 tumorigenesis","volume":"6","author":"Sedani","year":"2012","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0535","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/FOC-07\/11\/E3","article-title":"Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications","volume":"23","author":"Shamji","year":"2007","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0540","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1200\/JCO.2005.03.8349","article-title":"Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy","volume":"24","author":"Sharif","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0545","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/jmg.2010.081760","article-title":"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype-phenotype correlations","volume":"48","author":"Sharif","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0550","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1212\/01.wnl.0000180409.78098.d7","article-title":"RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma","volume":"65","author":"Sharma","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0555","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/0008-5472.CAN-06-0973","article-title":"Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin","volume":"67","author":"Sharma","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0560","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1365-2990.2010.01113.x","article-title":"Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma","volume":"36","author":"Sie","year":"2010","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0565","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/0883073809342005","article-title":"Pediatric low-grade gliomas","volume":"24","author":"Sievert","year":"2009","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0570","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1073\/pnas.1219232110","article-title":"Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas","volume":"110","author":"Sievert","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0575","first-page":"1257","article-title":"A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702)","volume":"12","author":"Stokland","year":"2010","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0580","doi-asserted-by":"crossref","first-page":"E265","DOI":"10.1073\/pnas.1101109108","article-title":"Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus","volume":"108","author":"Subramanian","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0585","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/1098-2272(200012)19:4<429::AID-GEPI13>3.0.CO;2-N","article-title":"Associations of clinical features in neurofibromatosis 1 (NF1)","volume":"19","author":"Szudek","year":"2000","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0590","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1259\/bjr\/65246351","article-title":"Radiological classification of optic pathway gliomas: experience of a modified functional classification system","volume":"81","author":"Taylor","year":"2008","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0595","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/brain\/awp048","article-title":"Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature","volume":"132","author":"Tchoghandjian","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0600","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1002\/cncr.28110","article-title":"Long-term outcome of centrally located low-grade glioma in children","volume":"119","author":"Terashima","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0605","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nn792","article-title":"Neurofibromin regulates G protein-stimulated adenylyl cyclase activity","volume":"5","author":"Tong","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0610","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ng2004","article-title":"Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster","volume":"39","author":"Tong","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0615","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/humu.20601","article-title":"Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs)","volume":"29","author":"Upadhyaya","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0620","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0092-8674(90)90252-A","article-title":"Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus","volume":"62","author":"Viskochil","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0625","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/neuonc\/nos330","article-title":"A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method","volume":"15","author":"Walker","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0630","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.2134734","article-title":"Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients","volume":"249","author":"Wallace","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0635","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00439-002-0858-4","article-title":"Neurofibromatosis type 1 gene as a mutational target in a mismatch repair-deficient cell type","volume":"112","author":"Wang","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0640","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2012.06.034","article-title":"ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities","volume":"150","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0645","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1158\/0008-5472.CAN-06-2220","article-title":"Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1","volume":"67","author":"Warrington","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0650","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1158\/0008-5472.CAN-09-3769","article-title":"Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1","volume":"70","author":"Warrington","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0655","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1200\/JCO.2005.03.8638","article-title":"Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas","volume":"24","author":"Widemann","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0660","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.2007-3204","article-title":"Neurofibromatosis type 1 revisited","volume":"123","author":"Williams","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0665","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/jnen\/61.10.896","article-title":"Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas","volume":"61","author":"Wimmer","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0670","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1096-8628(19970303)69:1<98::AID-AJMG19>3.0.CO;2-J","article-title":"Deletion of the entire NF1 gene causing distinct manifestations in a family","volume":"69","author":"Wu","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0675","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/glia.20845","article-title":"Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation","volume":"57","author":"Yeh","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0680","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ng.2611","article-title":"Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas","volume":"45","author":"Zhang","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0685","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0690","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccr.2005.07.004","article-title":"Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma","volume":"8","author":"Zhu","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0695","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1242\/dev.02162","article-title":"Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation","volume":"132","author":"Zhu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.critrevonc.2016.05.008_bib0700","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842816301159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842816301159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T04:23:54Z","timestamp":1656563034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842816301159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":140,"alternative-id":["S1040842816301159"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2016.05.008","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2016.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s). Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}