{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:03:39Z","timestamp":1777503819754,"version":"3.51.4"},"reference-count":157,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"grants from the S\u00e3o Paulo Research Foundation-FAPESP","award":["2017\/02338-0"],"award-info":[{"award-number":["2017\/02338-0"]}]},{"name":"grants from the S\u00e3o Paulo Research Foundation-FAPESP","award":["2017\/11329-4"],"award-info":[{"award-number":["2017\/11329-4"]}]},{"name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico -FONDECYT-Chile","award":["3160567"],"award-info":[{"award-number":["3160567"]}]},{"name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico -FONDECYT-Chile","award":["1171765"],"award-info":[{"award-number":["1171765"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.critrevonc.2019.03.004","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T11:20:13Z","timestamp":1553080813000},"page":"131-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Role of epigenetic mechanisms in cisplatin-induced toxicity"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-4474","authenticated-orcid":false,"given":"J\u00falia Coelho Fran\u00e7a","family":"Quintanilha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen Francinette","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Berlofa","family":"Visacri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-7022","authenticated-orcid":false,"given":"Patricia","family":"Moriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40360-016-0110-9","article-title":"Synthetic and natural antioxidants attenuate cisplatin-induced vomiting","volume":"18","author":"Alam","year":"2017","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.110.170084","article-title":"Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity","volume":"335","author":"Aleksunes","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"12","key":"10.1016\/j.critrevonc.2019.03.004_bib0015","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.critrevonc.2019.03.004_bib0020","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S2221-1691(12)60112-9","article-title":"Science behind cisplatin-induced nephrotoxicity in humans: a clinical study","volume":"2","author":"Arunkumar","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"7209","key":"10.1016\/j.critrevonc.2019.03.004_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12943-015-0354-9","article-title":"p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis","volume":"14","author":"Bhat","year":"2015","journal-title":"Mol. Cancer"},{"issue":"9-10","key":"10.1016\/j.critrevonc.2019.03.004_bib0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2119\/molmed.2010.00002","article-title":"MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival","volume":"16","author":"Bhatt","year":"2010","journal-title":"Mol. Med."},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0045","first-page":"679","article-title":"Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer","volume":"1","author":"Booton","year":"2006","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0050","first-page":"1663","article-title":"Cisplatin and platinum drugs at the molecular level","volume":"10","author":"Boulikas","year":"2003","journal-title":"Review) Oncol. Rep."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0055","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/nox076","article-title":"DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors","author":"Brown","year":"2017","journal-title":"Neuro Oncol."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0060","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/tpj.2009.19","article-title":"Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients","volume":"9","author":"Caronia","year":"2009","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0065","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.12842","article-title":"GSTP1 c.313A&G, XPD c.934G&A, XPF c.2505T&C and CASP9 c.-1339A&G polymorphisms and severity of vomiting in head and neck Cancer patients treated with cisplatin chemoradiation","author":"Carron","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0070","first-page":"547","article-title":"Membrane transporters as mediators of cisplatin side-effects","volume":"34","author":"Ciarimboli","year":"2014","journal-title":"Anticancer Res."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0075","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1517\/14712590902932889","article-title":"MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases","volume":"9","author":"Cortez","year":"2009","journal-title":"Expert Opin. Biol. Ther."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0305-7372(98)90061-5","article-title":"Cumulative toxicities from cisplatin therapy and current cytoprotective measures","volume":"24","author":"Cvitkovic","year":"1998","journal-title":"Cancer Treat. Rev."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0085","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0009-2797(82)90155-7","article-title":"The inhibition of renal ATPase by cisplatin and some biotransformation products","volume":"40","author":"Daley-Yates","year":"1982","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0090","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2001.9171","article-title":"Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals","volume":"174","author":"Dehne","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0100","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/1097-0142(197804)41:4<1274::AID-CNCR2820410410>3.0.CO;2-F","article-title":"Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man","volume":"41","author":"Dentino","year":"1978","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0105","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00280-016-2976-z","article-title":"Platinum-based drugs: past, present and future","volume":"77","author":"Dilruba","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1526-0968.2003.00127.x","article-title":"Drug-induced thrombotic thrombocytopenic purpura\/hemolytic uremic syndrome: a concise review","volume":"8","author":"Dlott","year":"2004","journal-title":"Ther. Apheresis Dialysis"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0115","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0120","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1039\/C4MT00238E","article-title":"Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin","volume":"6","author":"Eljack","year":"2014","journal-title":"Metallomics"},{"issue":"12","key":"10.1016\/j.critrevonc.2019.03.004_bib0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"issue":"6B","key":"10.1016\/j.critrevonc.2019.03.004_bib0130","first-page":"4123","article-title":"Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin","volume":"25","author":"Fenoglio","year":"2005","journal-title":"Anticancer Res."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/clpt.2009.139","article-title":"Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity","volume":"86","author":"Filipski","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0140","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/cpt.343","article-title":"DNA methylation of ADME genes","volume":"99","author":"Fisel","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0145","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/annonc\/mdt370","article-title":"Association of somatic DNA methylation variability with progression-free survival and toxicity in ovarian cancer patients","volume":"24","author":"Flanagan","year":"2013","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0150","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0155","first-page":"819","article-title":"[Effect of antioxidant supplementation over oxidative stress and quality of life in cervical cancer]","volume":"26","author":"Fuchs-Tarlovsky","year":"2011","journal-title":"Nutr. Hosp."},{"issue":"9","key":"10.1016\/j.critrevonc.2019.03.004_bib0160","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/15376510600751962","article-title":"Changes of serum erythropoietin during Cisplatin- or 5-Fluorouracil-induced anemia in rats","volume":"16","author":"Gao","year":"2006","journal-title":"Toxicol. Mech. Methods"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/15376516.2013.769656","article-title":"The effects of vitamin C on DDP-induced anemia in rats","volume":"23","author":"Gao","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0170","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/bjc.1993.221","article-title":"Cellular accumulation of the anticancer agent cisplatin: a review","volume":"67","author":"Gately","year":"1993","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0175","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0192623310379139","article-title":"Evaluation of novel biomarkers of nephrotoxicity in two strains of rat treated with Cisplatin","volume":"38","author":"Gautier","year":"2010","journal-title":"Toxicol. Pathol."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0185","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1017\/S0022215113000947","article-title":"Mechanisms of cisplatin ototoxicity: theoretical review","volume":"127","author":"Goncalves","year":"2013","journal-title":"J. Laryngol. Otol."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/1382-6689(96)00008-7","article-title":"Antiemetic activity of antioxidants against cisplatin-induced emesis in dogs","volume":"1","author":"Gupta","year":"1996","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0195","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1074\/jbc.M116.754929","article-title":"MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-beta","volume":"292","author":"Hao","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0200","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1002\/lary.24948","article-title":"A low-dose regimen of cisplatin before high-dose cisplatin potentiates ototoxicity","volume":"125","author":"Harrison","year":"2015","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0205","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/1389202917666160202220555","article-title":"A comprehensive review on the genetic regulation of cisplatin-induced nephrotoxicity","volume":"17","author":"Herrera-Perez","year":"2016","journal-title":"Curr. Genomics"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0210","first-page":"731","article-title":"Temporal bone histopathology of cisplatin ototoxicity","volume":"16","author":"Hinojosa","year":"1995","journal-title":"Am. J. Otol."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(93)80066-N","article-title":"Bcl-2 functions in an antioxidant pathway to prevent apoptosis","volume":"75","author":"Hockenbery","year":"1993","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0220","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4161\/epi.1.2.2762","article-title":"Epigenetics: a historical overview","volume":"1","author":"Holliday","year":"2006","journal-title":"Epigenetics"},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0225","first-page":"2600","article-title":"Genetic variants of miRNA sequences and non-small cell lung cancer survival","volume":"118","author":"Hu","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0230","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bcp.2012.02.015","article-title":"Covalent binding of cisplatin impairs the function of Na(+)\/K(+)-ATPase by binding to its cytoplasmic part","volume":"83","author":"Huliciak","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0235","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1111\/j.1523-1755.2005.00625.x","article-title":"Roles of HNF-1beta in kidney development and congenital cystic diseases","volume":"68","author":"Igarashi","year":"2005","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0240","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cbf.1232","article-title":"Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat","volume":"24","author":"Iraz","year":"2006","journal-title":"Cell Biochem. Funct."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0245","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10157-012-0638-y","article-title":"Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events","volume":"16","author":"Iwata","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0250","doi-asserted-by":"crossref","first-page":"e899","DOI":"10.1038\/cddis.2013.427","article-title":"miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury","volume":"4","author":"Joo","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tox.2014.05.004","article-title":"Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats","volume":"324","author":"Kanki","year":"2014","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/0253-7613.201022","article-title":"Effect of daidzein on cisplatin-induced hematotoxicity and hepatotoxicity in experimental rats","volume":"49","author":"Karale","year":"2017","journal-title":"Indian J. Pharmacol."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0265","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2015.06.012","article-title":"An integrated view of cisplatin-induced nephrotoxicity and ototoxicity","volume":"237","author":"Karasawa","year":"2015","journal-title":"Toxicol. Lett."},{"issue":"7092","key":"10.1016\/j.critrevonc.2019.03.004_bib0270","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.critrevonc.2019.03.004_bib0275","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0280","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/tpj.2009.45","article-title":"Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients","volume":"10","author":"Khrunin","year":"2010","journal-title":"Pharmacogenomics J."},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101902","article-title":"Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection","volume":"9","author":"Kidera","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0290","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1523\/JNEUROSCI.6054-09.2010","article-title":"Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity","volume":"30","author":"Kim","year":"2010","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.critrevonc.2019.03.004_bib0295","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/j.1349-7006.2010.01650.x","article-title":"Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis","volume":"101","author":"Kosaka","year":"2010","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0300","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5507\/bp.2014.018","article-title":"Na(+)\/K(+)-ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity","volume":"158","author":"Kubala","year":"2014","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech."},{"issue":"5543","key":"10.1016\/j.critrevonc.2019.03.004_bib0305","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Lagos-Quintana","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0310","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bcp.2010.04.030","article-title":"The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin","volume":"80","author":"Larson","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0315","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2215\/CJN.08070715","article-title":"Long-term renal outcomes after cisplatin treatment","volume":"11","author":"Latcha","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"5543","key":"10.1016\/j.critrevonc.2019.03.004_bib0320","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","article-title":"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans","volume":"294","author":"Lau","year":"2001","journal-title":"Science"},{"issue":"5543","key":"10.1016\/j.critrevonc.2019.03.004_bib0325","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.1065329","article-title":"An extensive class of small RNAs in Caenorhabditis elegans","volume":"294","author":"Lee","year":"2001","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0330","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0335","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cub.2012.03.068","article-title":"PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium","volume":"22","author":"Lee","year":"2012","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0340","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ki.2014.117","article-title":"Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury","volume":"86","author":"Lee","year":"2014","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.critrevonc.2019.03.004_bib0345","doi-asserted-by":"crossref","first-page":"e2362","DOI":"10.1038\/cddis.2016.246","article-title":"MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis."},{"issue":"24","key":"10.1016\/j.critrevonc.2019.03.004_bib0350","doi-asserted-by":"crossref","first-page":"39859","DOI":"10.18632\/oncotarget.16339","article-title":"Roles of long noncoding RNAs in colorectal cancer metastasis","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0355","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s10620-012-2424-9","article-title":"Long-term cisplatin exposure promotes methylation of the OCT1 gene in human esophageal cancer cells","volume":"58","author":"Lin","year":"2013","journal-title":"Dig. Dis. Sci."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0360","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1046\/j.1523-1755.2003.00908.x","article-title":"Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis","volume":"63","author":"Liu","year":"2003","journal-title":"Kidney Int."},{"issue":"2A","key":"10.1016\/j.critrevonc.2019.03.004_bib0365","first-page":"863","article-title":"Effect of cytochrome P450 2E1 inhibitors on cisplatin-induced cytotoxicity to renal proximal tubular epithelial cells","volume":"22","author":"Liu","year":"2002","journal-title":"Anticancer Res."},{"issue":"16","key":"10.1016\/j.critrevonc.2019.03.004_bib0370","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1097\/MD.0000000000000578","article-title":"Do genetic polymorphisms modulate response rate and toxicity of Cisplatin associated with radiotherapy in laryngeal squamous cell carcinoma? A case report","volume":"94","author":"Lopes-Aguiar","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"10.1016\/j.critrevonc.2019.03.004_bib0375","doi-asserted-by":"crossref","first-page":"16190","DOI":"10.18632\/oncotarget.7668","article-title":"XPD c.934G&A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation","volume":"8","author":"Lopes-Aguiar","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0380","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1124\/pr.110.003533","article-title":"Pharmacogenetics, pharmacogenomics, and individualized medicine","volume":"63","author":"Ma","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0385","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cbi.2016.01.007","article-title":"miR214-regulated p53-NOX4\/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells","volume":"245","author":"Ma","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0390","first-page":"656","article-title":"Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats","volume":"39","author":"Mansour","year":"2006","journal-title":"J. Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0395","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s12011-010-8788-9","article-title":"Effects of acute in vivo cisplatin and selenium treatment on hematological and oxidative stress parameters in red blood cells of rats","volume":"142","author":"Markovic","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0400","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jat.1284","article-title":"Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver","volume":"28","author":"Martins","year":"2008","journal-title":"J. Appl. Toxicol."},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"Marullo","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0410","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00204-006-0079-z","article-title":"Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats","volume":"80","author":"Masubuchi","year":"2006","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0415","first-page":"329","article-title":"Effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals","volume":"248","author":"Matsuki","year":"1993","journal-title":"Eur. J. Pharmacol."},{"issue":"Spec No 1","key":"10.1016\/j.critrevonc.2019.03.004_bib0420","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","article-title":"Non-coding RNA","volume":"15","author":"Mattick","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0425","first-page":"413","article-title":"Elevated levels of serum creatinine: recommendations for management and referral","volume":"161","author":"Mendelssohn","year":"1999","journal-title":"CMAJ"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0430","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0435","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2217\/14622416.10.3.399","article-title":"MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine","volume":"10","author":"Mishra","year":"2009","journal-title":"Pharmacogenomics"},{"issue":"33","key":"10.1016\/j.critrevonc.2019.03.004_bib0440","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1073\/pnas.0706217104","article-title":"A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance","volume":"104","author":"Mishra","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0445","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4161\/cc.7.7.5666","article-title":"MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: introducing microRNA pharmacogenomics","volume":"7","author":"Mishra","year":"2008","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0450","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/j.seminoncol.2005.12.001","article-title":"Gastrointestinal toxicity of chemotherapeutic agents","volume":"33","author":"Mitchell","year":"2006","journal-title":"Semin. Oncol."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0455","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1056\/NEJM199001113220210","article-title":"Cisplatin neurotoxicity","volume":"322","author":"Mollman","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0460","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1208\/s12248-013-9465-7","article-title":"Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney","volume":"15","author":"Motohashi","year":"2013","journal-title":"AAPS J."},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0465","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2217\/pgs.11.48","article-title":"Pharmacogenomics of cisplatin-induced ototoxicity","volume":"12","author":"Mukherjea","year":"2011","journal-title":"Pharmacogenomics"},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0470","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1203\/00006450-199710000-00003","article-title":"Mutation analysis and expression of the mottled gene in the macular mouse model of Menkes disease","volume":"42","author":"Murata","year":"1997","journal-title":"Pediatr. Res."},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0475","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.bcp.2010.08.019","article-title":"Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity","volume":"80","author":"Nakamura","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0480","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s00125-015-3563-2","article-title":"The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells","volume":"58","author":"Natalicchio","year":"2015","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0485","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00467-013-2662-x","article-title":"Hnf1beta and nephron segmentation","volume":"29","author":"Naylor","year":"2014","journal-title":"Pediatr. Nephrol."},{"issue":"21","key":"10.1016\/j.critrevonc.2019.03.004_bib0490","first-page":"5829","article-title":"Drug-induced DNA hypermethylation and drug resistance in human tumors","volume":"49","author":"Nyce","year":"1989","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0495","first-page":"467","article-title":"The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds","volume":"55","author":"Olas","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0500","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1200\/JCO.2006.08.9599","article-title":"Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors","volume":"25","author":"Oldenburg","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"50","key":"10.1016\/j.critrevonc.2019.03.004_bib0505","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.1073\/pnas.0506483102","article-title":"A human transporter protein that mediates the final excretion step for toxic organic cations","volume":"102","author":"Otsuka","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.critrevonc.2019.03.004_bib0510","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"issue":"6808","key":"10.1016\/j.critrevonc.2019.03.004_bib0515","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0520","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2014.05.005","article-title":"Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury","volume":"324","author":"Pavkovic","year":"2014","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0525","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/toxsci\/kfw077","article-title":"Detection of drug-induced acute kidney injury in humans using urinary KIM-1, miR-21, -200c, and -423","volume":"152","author":"Pavkovic","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0530","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/toxsci\/kfu143","article-title":"MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin","volume":"141","author":"Pellegrini","year":"2014","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0535","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5935\/0101-2800.20130052","article-title":"Acute nephrotoxicity of cisplatin: molecular mechanisms","volume":"35","author":"Peres","year":"2013","journal-title":"J. Bras. Nefrol."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0540","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.phrs.2016.08.002","article-title":"Pharmacogenetic predictors of toxicity to platinum based chemotherapy in non-small cell lung cancer patients","volume":"111","author":"Perez-Ramirez","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0545","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"116","key":"10.1016\/j.critrevonc.2019.03.004_bib0550","article-title":"The role of methylation in gene expression","volume":"1","author":"Phillips","year":"2008","journal-title":"Nature Education"},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0555","first-page":"167","article-title":"Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA","volume":"780","author":"Pinto","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.critrevonc.2019.03.004_bib0560","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/nbt.1685","article-title":"Epigenetic modifications and human disease","volume":"28","author":"Portela","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0565","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.7314\/APJCP.2015.16.3.1117","article-title":"Incidence of cisplatin-induced nephrotoxicity and associated factors among cancer patients in Indonesia","volume":"16","author":"Prasaja","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0570","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejphar.2006.01.007","article-title":"Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats","volume":"532","author":"Pratibha","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0575","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0305-7372(79)80057-2","article-title":"Cisplatin (cis-diamminedichloroplatinum II)","volume":"6","author":"Prestayko","year":"1979","journal-title":"Cancer Treat. Rev."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0580","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/clpt.2013.80","article-title":"Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children","volume":"94","author":"Pussegoda","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0585","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40880-016-0145-8","volume":"35","author":"Qian","year":"2016","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0590","doi-asserted-by":"crossref","first-page":"818","DOI":"10.12659\/MSM.897187","article-title":"Inhibiting microRNA-449 attenuates cisplatin-induced injury in NRK-52E cells possibly via regulating the SIRT1\/P53\/BAX pathway","volume":"22","author":"Qin","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0595","first-page":"2","article-title":"New promising approaches to treatment of chemotherapy-induced toxicities","author":"Quintanilha","year":"2017","journal-title":"AvidScience (Ed.) Chemotherapy."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0600","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00280-017-3358-x","article-title":"Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity","volume":"80","author":"Quintanilha","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0605","article-title":"Cisplatin-induced human peripheral blood mononuclear cells\u2019 oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide","author":"Quintanilha","year":"2017","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0610","first-page":"F179","article-title":"Heparin-binding EGF-like growth factor","volume":"1333","author":"Raab","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0615","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0272-6386(86)80112-3","article-title":"Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity","volume":"8","author":"Ries","year":"1986","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0620","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/annonc\/mdj078","article-title":"Antiemetic Subcomittee of the Multinational Association of Supportive Care in Cancer. Prevention of chemotherapy and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference","volume":"17","author":"Rolla","year":"2006","journal-title":"Ann Oncol."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0625","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/205698a0","article-title":"Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode","volume":"205","author":"Rosenberg","year":"1965","journal-title":"Nature"},{"issue":"5191","key":"10.1016\/j.critrevonc.2019.03.004_bib0630","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum compounds: a new class of potent antitumour agents","volume":"222","author":"Rosenberg","year":"1969","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0635","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00204-006-0173-2","article-title":"Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria","volume":"81","author":"Santos","year":"2007","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0640","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/08880010590964381","article-title":"Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine","volume":"22","author":"Sastry","year":"2005","journal-title":"Pediatr. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0645","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1200\/JCO.1989.7.6.754","article-title":"Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation","volume":"7","author":"Schell","year":"1989","journal-title":"J. Clin. Oncol."},{"issue":"7209","key":"10.1016\/j.critrevonc.2019.03.004_bib0650","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0655","series-title":"SHIELD: An Integrative Gene Expression Database for Inner Ear Research. Database (Oxford) 2015, bav071","author":"Shen","year":"2015"},{"issue":"47","key":"10.1016\/j.critrevonc.2019.03.004_bib0660","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0665","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fct.2015.04.018","article-title":"Vetiver oil (Java) attenuates cisplatin-induced oxidative stress, nephrotoxicity and myelosuppression in Swiss albino mice","volume":"81","author":"Sinha","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"16","key":"10.1016\/j.critrevonc.2019.03.004_bib0670","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1242\/dev.065961","article-title":"Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms","volume":"138","author":"Sipe","year":"2011","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.critrevonc.2019.03.004_bib0675","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1177\/0960327110377521","article-title":"Chemotherapy-induced myelotoxicity and incidence of lung metastasis in an animal model","volume":"30","author":"Son","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0680","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/clpt.2008.61","article-title":"Genetic variants of the organic cation transporter 2 influence the disposition of metformin","volume":"84","author":"Song","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0685","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfm177","article-title":"The dynamic epigenome and its implications in toxicology","volume":"100","author":"Szyf","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0690","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ng1293-344","article-title":"The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene","volume":"5","author":"Tanzi","year":"1993","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0695","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1476-5381.1994.tb14753.x","article-title":"Induction of emesis in Suncus murinus by pyrogallol, a generator of free radicals","volume":"111","author":"Torii","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.critrevonc.2019.03.004_bib0700","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2165\/11316640-000000000-00000","article-title":"Cisplatin overdose: toxicities and management","volume":"32","author":"Tsang","year":"2009","journal-title":"Drug Saf."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0705","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/bcpt.12443","article-title":"Effects of high-dose cisplatin chemotherapy and conventional radiotherapy on urinary oxidative and nitrosative stress biomarkers in patients with head and neck Cancer","volume":"118","author":"Tuan","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0710","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jphs.2017.03.001","article-title":"Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew)","volume":"133","author":"Ullah","year":"2017","journal-title":"J. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0715","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccc.2006.02.002","article-title":"Drug-associated disease: hematologic dysfunction","volume":"22","author":"Vandendries","year":"2006","journal-title":"Crit. Care Clin."},{"issue":"4","key":"10.1016\/j.critrevonc.2019.03.004_bib0720","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","article-title":"MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins","volume":"13","author":"Vickers","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.critrevonc.2019.03.004_bib0725","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40199-017-0178-9","article-title":"Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study","volume":"25","author":"Visacri","year":"2017","journal-title":"Daru"},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0730","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.heares.2013.02.002","article-title":"Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity","volume":"299","author":"Waissbluth","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.critrevonc.2019.03.004_bib0735","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13148-015-0150-9","article-title":"Real-time monitoring efficiency and toxicity of chemotherapy in patients with advanced lung cancer","volume":"7","author":"Wang","year":"2015","journal-title":"Clin. Epigenetics"},{"issue":"11","key":"10.1016\/j.critrevonc.2019.03.004_bib0740","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.critrevonc.2019.03.004_bib0745","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. Elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0750","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jat.3358","article-title":"Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage","volume":"37","author":"Wolenski","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"5532","key":"10.1016\/j.critrevonc.2019.03.004_bib0755","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.293.5532.1103","article-title":"Genes, genetics, and epigenetics: a correspondence","volume":"293","author":"Wu","year":"2001","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0760","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.lungcan.2012.03.023","article-title":"Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients","volume":"77","author":"Xu","year":"2012","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.critrevonc.2019.03.004_bib0765","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2125.2012.04379.x","article-title":"Association between eIF3alpha polymorphism and severe toxicity caused by platinum-based chemotherapy in non-small cell lung cancer patients","volume":"75","author":"Xu","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.critrevonc.2019.03.004_bib0770","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jcla.21544","article-title":"Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population","volume":"26","author":"Zhan","year":"2012","journal-title":"J. Clin. Lab. Anal."},{"issue":"3","key":"10.1016\/j.critrevonc.2019.03.004_bib0775","first-page":"523","article-title":"Role of microRNA-181a in the apoptosis of tubular epithelial cell induced by cisplatin","volume":"125","author":"Zhu","year":"2012","journal-title":"Chin. Med. J (Engl)"},{"issue":"12","key":"10.1016\/j.critrevonc.2019.03.004_bib0780","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00204-015-1633-3","article-title":"DNA damage response in cisplatin-induced nephrotoxicity","volume":"89","author":"Zhu","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.critrevonc.2019.03.004_bib0785","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.5966\/sctm.2015-0355","article-title":"MicroRNA-146b, a sensitive Indicator of mesenchymal stem cell repair of acute renal injury","volume":"5","author":"Zhu","year":"2016","journal-title":"Stem Cells Transl. Med."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842818303913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842818303913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T19:30:15Z","timestamp":1760902215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842818303913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":157,"alternative-id":["S1040842818303913"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2019.03.004","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of epigenetic mechanisms in cisplatin-induced toxicity","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2019.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}