{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T04:07:01Z","timestamp":1785643621389,"version":"3.56.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.critrevonc.2021.103289","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T11:56:39Z","timestamp":1614686199000},"page":"103289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Recent insights into the role of the microbiome in malignant and benign hematologic diseases"],"prefix":"10.1016","volume":"160","author":[{"given":"Bruno","family":"Fattizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-6993","authenticated-orcid":false,"given":"Francesco","family":"Folino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Barcellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2021.103289_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40164-019-0155-8","article-title":"Gut microbiome and CAR-T therapy","volume":"8","author":"Abid","year":"2019","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1871528113666140623113221","article-title":"The gut microbiome","volume":"13","author":"Actis","year":"2014","journal-title":"Inflamm. Allergy - Drug Targets."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0015","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00277-019-03599-w","article-title":"The oral microbiome of patients undergoing treatment for severe aplastic anemia: a pilot study","volume":"98","author":"Ames","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0020","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbmt.2018.02.009","article-title":"The microbiome and hematopoietic cell transplantation: past, present, and future","volume":"7","author":"Andermann","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0025","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/s41598-019-44861-5","article-title":"Conjunctival dysbiosis in mucosa-associated lymphoid tissue lymphoma","volume":"9","author":"Asao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0030","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1099\/jmm.0.000568","article-title":"Changes in the gastrointestinal microbiota of children with acute lymphoblastic leukaemia and its association with antibiotics in the short term","volume":"66","author":"Bai","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0035","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1017\/S0007114510001637","article-title":"Low levels of faecal lactobacilli in women with iron-deficiency anaemia in South India","volume":"104","author":"Balamurugan","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0040","first-page":"1397","article-title":"Epstein-Barr virus and Burkitt lymphoma","volume":"60","author":"Brady","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0045","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0050","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1038\/s41467-018-07305-8","article-title":"Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression","volume":"9","author":"Calcinotto","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0055","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi\u2019s sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature18845","article-title":"A microbial perspective of human developmental biology","volume":"535","author":"Charbonneau","year":"2016","journal-title":"Nature."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0065","doi-asserted-by":"crossref","first-page":"28484","DOI":"10.1038\/srep28484","article-title":"Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40168-017-0250-1","article-title":"Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation","volume":"5","author":"Chua","year":"2017","journal-title":"Microbiome."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0075","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2141.1973.tb01791.x","article-title":"Tuberculosis and blood disorders","volume":"25","author":"Coburn","year":"1973","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0080","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/bjc.2013.60","article-title":"Fecal microbiota diversity in survivors of adolescent\/young adult Hodgkin lymphoma: a study of twins","volume":"108","author":"Cozen","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0085","first-page":"2009026","article-title":"Aplastica anemia and viral hepatitis","volume":"1","author":"Cudillo","year":"2009","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0090","first-page":"1101","article-title":"Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia","volume":"20","author":"de Mendon\u00e7a","year":"2012","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3945\/jn.111.148643","article-title":"Iron depletion and repletion with ferrous sulfate or electrolytic iron modifies the composition and metabolic activity of the gut microbiota in rats","volume":"142","author":"Dostal","year":"2012","journal-title":"J. Nutr."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1574-6941.2012.01461.x","article-title":"Low iron availability in continuous in vitro colonic fermentations induces strong dysbiosis of the child gut microbial consortium and a decrease in main metabolites","volume":"83","author":"Dostal","year":"2013","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0105","doi-asserted-by":"crossref","first-page":"e01453","DOI":"10.1128\/mBio.01453-15","article-title":"Iron modulates butyrate production by a child gut microbiota in vitro","volume":"6","author":"Dostal","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.clim.2016.08.008","article-title":"An altered gut microbiota may trigger autoimmune-mediated acquired bone marrow failure syndromes","volume":"171","author":"Espinoza","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2017.11.009","article-title":"Gastric microbiota: an emerging player in Helicobacter pylori-induced gastric malignancies","volume":"414","author":"Espinoza","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0120","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1017\/ice.2019.93","article-title":"Decrease in vancomycin-resistant Enterococcus colonization associated with a reduction in carbapenem use as empiric therapy for febrile neutropenia in patients with acute leukemia","volume":"40","author":"Ford","year":"2019","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0125","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/hel.12200","article-title":"Helicobacter pylori eradication in patients with immune thrombocytopenic Purpura: a review and the role of biogeography","volume":"20","author":"Frydman","year":"2015","journal-title":"Helicobacter"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0130","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/cncr.30039","article-title":"The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia","volume":"122","author":"Galloway-Pe\u00f1a","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0135","article-title":"Microbiome signatures are predictive of infectious risk following induction therapy for acute myeloid leukemia","author":"Galloway-Pe\u00f1a","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0140","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0145","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1136\/jcp.2007.051953","article-title":"HIV infection and lymphoma","volume":"60","author":"Grogg","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fimmu.2015.00489","article-title":"Intestinal microbiota and the innate immune system - a crosstalk in Crohn\u2019s disease pathogenesis","volume":"6","author":"Haag","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0155","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/cid\/ciy153","article-title":"Gut microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia","volume":"67","author":"Hakim","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0160","first-page":"706","article-title":"Evidence for a relation of Epstein-Barr virus to Burkitt\u2019s lymphoma and nasopharyngeal carcinoma","volume":"36","author":"Henle","year":"1970","journal-title":"Bibl. Haematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0165","doi-asserted-by":"crossref","first-page":"01548","DOI":"10.1128\/mBio.01548-14","article-title":"Intestinal dysbiosis associated with systemic lupus erythematosus","volume":"5","author":"Hevia","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0170","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-020711-074937","article-title":"The microbiome in infectious disease and inflammation","volume":"30","author":"Honda","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0175","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6090878","article-title":"Helicobacter pylori eradication in idiopathic thrombocytopenic Purpura: a meta-analysis of randomized trials","author":"Kim","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41579-018-0029-9","article-title":"Best practices for analysing microbiomes","volume":"16","author":"Knight","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0185","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/1574-6976.12086","article-title":"Nutritional iron turned inside out: intestinal stress from a gut microbial perspective","volume":"38","author":"Kortman","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0190","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chom.2015.01.001","article-title":"The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes","volume":"17","author":"Kostic","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0195","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0950-3536(89)80007-1","article-title":"Viruses and bone marrow failure","volume":"2","author":"Kurtzman","year":"1989","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0200","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/jvh.12892","article-title":"Hepatitis B virus and risk of non-Hodgkin lymphoma: an updated meta-analysis of 58 studies","volume":"25","author":"Li","year":"2018","journal-title":"J. Viral Hepat."},{"issue":"October16","key":"10.1016\/j.critrevonc.2021.103289_bib0205","article-title":"Pediatric Acute Lymphoblastic Leukemia Patients Exhibit Distinctive Alterations in the Gut Microbiota","volume":"10","author":"Liu","year":"2020","journal-title":"Front Cell Infect Microbiol."},{"issue":"June","key":"10.1016\/j.critrevonc.2021.103289_bib0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.thromres.2020.03.012","article-title":"Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia","volume":"190","author":"Liu","year":"2020","journal-title":"Thromb Res."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0215","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/310505a0","article-title":"Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leukaemia","volume":"310","author":"Longo","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0220","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"issue":"Supplement 1","key":"10.1016\/j.critrevonc.2021.103289_bib0225","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1182\/blood-2018-99-117811","article-title":"Next-generation sequencing reveals a t cell receptor signature characteristic of patients with aplastic Anemia","volume":"132","author":"Lundegren","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0230","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3109\/08880018.2015.1034819","article-title":"Oral mucositis in pediatric acute lymphoblastic leukemia patients: evaluation of microbiological and hematological factors","volume":"32","author":"Mendon\u00e7a","year":"2015","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0235","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s00018-019-03044-1","article-title":"Helicobacter pylori infection and gastric cancer biology: tempering a double-edged sword","volume":"76","author":"Mentis","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0240","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/bdrc.21114","article-title":"Development of the infant intestinal microbiome: a bird\u2019s eye view of a complex process","volume":"105","author":"Meropol","year":"2015","journal-title":"Birth Defects Research Part C - Embryo Today: Reviews."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0245","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1556\/030.65.2018.045","article-title":"Iron deficiency anemia-related gut microbiota dysbiosis in infants and young children: a pilot study","volume":"65","author":"Muleviciene","year":"2018","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0250","first-page":"25","article-title":"Multicentric castleman\u2019s disease in HIV infection: a systematic review of the literature","volume":"10","author":"Mylona","year":"2008","journal-title":"AIDS Rev."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fcimb.2019.00028","article-title":"Infectious complications are associated with alterations in the gut microbiome in pediatric patients with acute lymphoblastic leukemia","volume":"9","author":"Nearing","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0260","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ","volume":"7","author":"O\u2019Hara","year":"2006","journal-title":"EMBO Rep."},{"issue":"Suppl 6","key":"10.1016\/j.critrevonc.2021.103289_bib0265","doi-asserted-by":"crossref","first-page":"1688S","DOI":"10.3945\/ajcn.117.156067","article-title":"The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review","volume":"106","author":"Paganini","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0270","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1750-9378-9-34","article-title":"The role of EBV in the pathogenesis of Burkitt\u2019s Lymphoma: an Italian hospital based survey","volume":"9","author":"Pannone","year":"2014","journal-title":"Infect Agent Cancer."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0275","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00277-004-0996-y","article-title":"High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia","volume":"84","author":"Papadaki","year":"2005","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0280","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/archdischild-2016-312049","article-title":"What is broad-range 16S rDNA PCR?","volume":"102","author":"Patel","year":"2017","journal-title":"Arch. Dis. Child. Educ. Pract. Ed."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0285","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3748\/wjg.v20.i3.684","article-title":"Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas","volume":"20","author":"Pereira","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0290","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","article-title":"The NIH human microbiome project","volume":"19","author":"Peterson","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0295","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/bloodadvances.2019032276","article-title":"Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition","volume":"3","author":"Pianko","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0300","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.beha.2017.01.001","article-title":"Bacteria associated with marginal zone lymphomas","volume":"30","author":"Ponzoni","year":"2017","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0310","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12864-016-2965-y","article-title":"Gastrointestinal microbial populations can distinguish pediatric and adolescent Acute Lymphoblastic Leukemia (ALL) at the time of disease diagnosis","volume":"17","author":"Rajagopala","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0315","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1038\/s41598-019-42652-6","article-title":"Dysbiosis patterns during re-induction\/salvage versus induction chemotherapy for acute leukemia","volume":"9","author":"Rashidi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0320","article-title":"Gut dysbiosis during antileukemia chemotherapy versus allogeneic hematopoietic cell transplantation","author":"Rashidi","year":"2019","journal-title":"Cancer"},{"issue":"October 28 (10)","key":"10.1016\/j.critrevonc.2021.103289_bib0325","article-title":"Gut microbiota profiles of treatment-na\u00efve adult acute myeloid leukemia patients with neutropenic fever during intensive chemotherapy","volume":"15","author":"Rattanathammethee","year":"2020","journal-title":"PLoS One."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0330","doi-asserted-by":"crossref","first-page":"2019004","DOI":"10.4084\/mjhid.2019.004","article-title":"Hiv and lymphoma: from epidemiology to clinical management","volume":"11","author":"Re","year":"2019","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0335","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MPH.0000000000001497","article-title":"Probiotic supplementation decreases chemotherapy-induced gastrointestinal side effects in patients with acute leukemia","volume":"41","author":"Reyna-Figueroa","year":"2019","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0340","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2015.01085","article-title":"Regulation of lung immunity and host defense by the intestinal microbiota","volume":"6","author":"Samuelson","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0345","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nmeth1156","article-title":"Next-generation sequencing transforms today\u2019s biology","volume":"5","author":"Schuster","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0350","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1182\/bloodadvances.2019000365","article-title":"Microbiota modification in hematology: still at the bench or ready for the bedside?","volume":"3","author":"Severyn","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0355","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4049\/jimmunol.1400278","article-title":"Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota","volume":"193","author":"Shanmugam","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0360","doi-asserted-by":"crossref","first-page":"30637","DOI":"10.1074\/jbc.M115.689190","article-title":"Commensal bacteria-induced interleukin 1\u03b2 (IL-1\u03b2) secreted by macrophages up-regulates hepcidin expression in hepatocytes by activating the bone morphogenetic protein signaling pathway","volume":"290","author":"Shanmugam","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0365","first-page":"0214526","article-title":"Bacterial translocation in acute lymphocytic leukemia","volume":"14","author":"Song","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0370","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/blood-2016-09-691394","article-title":"The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease","volume":"129","author":"Staffas","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0375","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00043426-199907000-00011","article-title":"Aplastic anemia after Mycoplasma pneumoniae infection: a report of two cases","volume":"21","author":"St\u00e9phan","year":"1999","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"Suppl 3","key":"10.1016\/j.critrevonc.2021.103289_bib0380","article-title":"Helicobacter and gastric MALT lymphoma","volume":"50","author":"Stolte","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0385","first-page":"134","article-title":"Hepatitis C associated B-cell non-hodgkin lymphoma: clinical features and the role of antiviral therapy","volume":"3","author":"Tasleem","year":"2015","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"June 17 (1)","key":"10.1016\/j.critrevonc.2021.103289_bib0390","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1038\/s41598-019-45270-4","article-title":"Depletion of Intestinal Microbiome Partially Rescues Bone Loss in Sickle Cell Disease Male Mice","volume":"9","author":"Tavakoli","year":"2019","journal-title":"Sci Rep."},{"issue":"April(4)","key":"10.1016\/j.critrevonc.2021.103289_bib0395","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1099\/jmm.0.000964","article-title":"Oral microbial dysbiosis in patients with Kostmann syndrome","volume":"68","author":"Topcuoglu","year":"2019","journal-title":"J Med Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0400","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0405","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/adc.59.3.197","article-title":"Human parvovirus, fifth disease, and marrow aplasia","volume":"59","author":"Tyrrell","year":"1984","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0410","doi-asserted-by":"crossref","first-page":"102116","DOI":"10.1371\/journal.pone.0102116","article-title":"Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"issue":"August 25","key":"10.1016\/j.critrevonc.2021.103289_bib0415","article-title":"Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia","author":"Wang","year":"2020","journal-title":"Sci China Life Sci."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0420","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3389\/fmicb.2019.01300","article-title":"Interactions between gut microbiota and acute childhood leukemia","volume":"10","author":"Wen","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0425","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PPO.0000000000000047","article-title":"Intestinal microbiome and lymphoma development","volume":"20","author":"Yamamoto","year":"2014","journal-title":"Cancer J."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0430","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.3390\/ijerph110909038","article-title":"Lymphoma caused by intestinal microbiota","volume":"11","author":"Yamamoto","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0435","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1158\/0008-5472.CAN-13-0022","article-title":"Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity","volume":"14","author":"Yamamoto","year":"2013","journal-title":"Cancer Res."},{"issue":"May (3)","key":"10.1016\/j.critrevonc.2021.103289_bib0440","doi-asserted-by":"crossref","first-page":"e1900058","DOI":"10.1002\/prca.201900058","article-title":"Dysbiosis of the Oral Ecosystem in Severe Congenital Neutropenia Patients","volume":"14","author":"Zaura","year":"2020","journal-title":"Proteomics Clin Appl."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0445","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.12659\/MSM.919988","article-title":"Fecal microbiota taxonomic shifts in chinese multiple myeloma patients analyzed by quantitative polimerase chain reaction (QPCR) and 16S rRNA high-throughput sequencing","volume":"25","author":"Zhang","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"July 8","key":"10.1016\/j.critrevonc.2021.103289_bib0450","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3389\/fmicb.2020.01550","article-title":"Gut Microbiome and Metabolome Were Altered and Strongly Associated With Platelet Count in Adult Patients With Primary Immune Thrombocytopenia","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Microbiol."},{"key":"10.1016\/j.critrevonc.2021.103289_bib0455","doi-asserted-by":"crossref","first-page":"425","DOI":"10.12998\/wjcc.v8.i2.425","article-title":"Excellent response of severe aplastic anemia to treatment of gut inflammation: a case report and review of the literature","volume":"8","author":"Zhao","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.critrevonc.2021.103289_bib0460","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7326\/0003-4819-127-6-199709150-00002","article-title":"Hepatitis C virus infection in patients with B-cell non-hodgkin lymphoma","volume":"127","author":"Zuckerman","year":"1997","journal-title":"Ann. Intern. Med."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842821000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842821000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T19:36:35Z","timestamp":1760902595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842821000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":92,"alternative-id":["S1040842821000779"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2021.103289","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent insights into the role of the microbiome in malignant and benign hematologic diseases","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2021.103289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103289"}}