{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:05:40Z","timestamp":1744862740809,"version":"3.40.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.critrevonc.2025.104659","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:12:26Z","timestamp":1739434346000},"page":"104659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Performance of CpG-oligonucleotide DSP30 and interleukin-2 in the cytogenetic study of mature B-cell neoplasms: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"209","author":[{"given":"Eder","family":"Cano-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9nesis","family":"Garc\u00eda-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2025.104659_bib1","article-title":"Contribution of MLPA to routine testing to detect the prognostic chromosomal abnormalities in chronic lymphocytic leukemia","volume":"16","author":"Ayaz","year":"2014","journal-title":"Gene Ther. Mol. Biol."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104659_bib2","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000707","article-title":"Cytogenetics in chronic lymphocytic leukemia: ERIC perspectives and recommendations","volume":"6","author":"Baliakas","year":"2022","journal-title":"HemaSphere"},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104659_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000707","article-title":"Cytogenetics in chronic lymphocytic leukemia: ERIC perspectives and recommendations","volume":"6","author":"Baliakas","year":"2022","journal-title":"Hemasphere"},{"key":"10.1016\/j.critrevonc.2025.104659_bib4","article-title":"Employment of oligodeoxynucleotide plus interleukin-2 improves cytogenetic analysis in splenic marginal zone lymphoma","volume":"2011","author":"Bardi","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104659_bib5","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3109\/10428194.2016.1173212","article-title":"Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets","volume":"57","author":"Bogusz","year":"2016","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104659_bib6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.leukres.2013.10.019","article-title":"Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: a prospective analysis","volume":"38","author":"Brejcha","year":"2014","journal-title":"Leuk. Res."},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104659_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0301-472X(00)00144-2","article-title":"Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype","volume":"28","author":"Decker","year":"2000","journal-title":"Exp. Hematol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104659_bib8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1182\/blood.V95.3.999.003k10_999_1006","article-title":"Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells","volume":"95","author":"Decker","year":"2000","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104659_bib9","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood-2006-02-005322","article-title":"Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: a study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression","volume":"108","author":"Dicker","year":"2006","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104659_bib10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/gcc.22527","article-title":"DSP30 and interleukin-2 as a mitotic stimulant in B-cell disorders including those with a low disease burden","volume":"57","author":"Dun","year":"2018","journal-title":"Genes, Chromosomes Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104659_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/asheducation-2016.1.149","article-title":"Prognostication of chronic lymphocytic leukemia in the era of new agents","volume":"2016","author":"Eichhorst","year":"2016","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104659_bib12","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1038\/sj.leu.2404935","article-title":"Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotyping","volume":"21","author":"Haferlach","year":"2007","journal-title":"Leukemia"},{"issue":"25","key":"10.1016\/j.critrevonc.2025.104659_bib13","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2017-09-806398","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104659_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1189\/jlb.69.1.81","article-title":"CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens","volume":"69","author":"Jahrsd\u00f6rfer","year":"2001","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104659_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000369543","article-title":"Detection of clonal aberrations by cytogenetic analysis after different culture methods and by FISH in 129 patients with chronic lymphocytic leukemia","volume":"144","author":"Jenderny","year":"2014","journal-title":"Cytogenet. Genome Res."},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104659_bib16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1056\/NEJM199009133231105","article-title":"Prognostic subgroups in B-Cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities","volume":"323","author":"Juliusson","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104659_bib17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/10245332.2015.1110948","article-title":"The parallel application of karyotype interphase and metaphase FISH after DSP-30\/IL-2 stimulation is necessary for the investigation of chronic lymphocytic leukemia","volume":"21","author":"Karakosta","year":"2016","journal-title":"Hematology"},{"issue":"32","key":"10.1016\/j.critrevonc.2025.104659_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.14694\/EdBook_AM.2012.32.145","article-title":"Predicting clinical outcome in B-chronic lymphocytic leukemia","author":"Kay","year":"2012","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104659_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.35754\/0234-5730-2019-64-1-21-34","article-title":"Efficacy of oligonucleotide DSP30 in combination with interleukin-2 for the detection of chromosomal aberrations in patients with chronic lymphocytic leukemia","volume":"64","author":"Kislitsyna","year":"2019","journal-title":"Russ. J. Hematol. transfusiology"},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104659_bib20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s12185-014-1681-0","article-title":"CpG Oligonucleotide and Interleukin 2 stimulation enables higher cytogenetic abnormality detection rates than 12-o-tetradecanolyphorbol-13-acetate in Asian patients with B-cell chronic lymphocytic leukemia (B-CLL)","volume":"100","author":"Liaw","year":"2014","journal-title":"Int. J. Hematol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104659_bib21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/09674845.2016.1188970","article-title":"Immunostimulation by cytosine-phosphate-guanine oligodeoxynucleotides in combination with IL-2 can improve the success rate of karyotype analysis in chronic lymphocytic leukaemia","volume":"73","author":"Lin","year":"2016","journal-title":"Br. J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104659_bib22","first-page":"143","article-title":"Chromosomal aberrations detection in chronic lymphocytic leukemia by conventional cytogenetics using DSP30 and IL-2","volume":"41","author":"Liu","year":"2020","journal-title":"Zhonghua xue ye xue za zhi"},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104659_bib23","first-page":"601","article-title":"CpG-oligodeoxynucleotide stimulation improves the success for karyotypic analysis of chronic lymphocytic leukemia cells","volume":"30","author":"Liu","year":"2009","journal-title":"Zhonghua xue ye xue za zhi"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104659_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"10.1016\/j.critrevonc.2025.104659_bib25","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104659_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/gcc.20691","article-title":"Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: a Belgian multicentric study","volume":"48","author":"Put","year":"2009","journal-title":"Genes, Chromosomes Cancer"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104659_bib27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/gcc.22293","article-title":"Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia: clinical and biologic correlations","volume":"54","author":"Rigolin","year":"2015","journal-title":"Genes, Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104659_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.toxlet.2009.05.013","article-title":"ToxRTool\u201d, a new tool to assess the reliability of toxicological data","volume":"189","author":"Schneider","year":"2009","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104659_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/ejh.13329","article-title":"Cytogenetic landscape in 1012 newly diagnosed chronic lymphocytic leukemia","volume":"103","author":"Senouci","year":"2019","journal-title":"Eur. J. Haematol."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104659_bib30","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1182\/blood-2003-07-2281","article-title":"Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL","volume":"103","author":"Shanafelt","year":"2004","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104659_bib31","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1309\/AJCP7G4VMYZJQVFI","article-title":"Improved detection rate of cytogenetic abnormalities in chronic lymphocytic leukemia and other mature B-Cell neoplasms with use of CpG-oligonucleotide DSP30 and interleukin 2 stimulation","volume":"139","author":"Shi","year":"2013","journal-title":"Am. J. Clin. Pathol."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104659_bib32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.14735\/amko2013263","article-title":"Cytogenetick\u00e9 vy\u0161et\u0159en\u00ed lymfocyt\u016f perifern\u00ed krve po stimulaci IL-2 a CpG oligonukleotidem DSP30 u pacient\u016f s chronickou lymfocyt\u00e1rn\u00ed leukemi\u00ed","volume":"26","author":"\u0160t\u011bpanovsk\u00e1","year":"2013","journal-title":"Klin. \u00e1 Onkol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104659_bib33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/leu.2008.252","article-title":"Stimulation of B-cell lymphoproliferations with CpG-oligonucleotide DSP30 plus IL-2 is more effective than with TPA to detect clonal abnormalities","volume":"23","author":"Struski","year":"2009","journal-title":"Leukemia"},{"issue":"20","key":"10.1016\/j.critrevonc.2025.104659_bib34","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"issue":"7414","key":"10.1016\/j.critrevonc.2025.104659_bib35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"DG. Measuring inconsistency in meta-analyses","volume":"327","author":"Thompson","year":"2003","journal-title":"BMJ (Clin. Res. Ed.)"},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104659_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cancergencyto.2009.12.014","article-title":"Cytogenetic investigations of chronic lymphocytic leukemia","volume":"198","author":"Wren","year":"2010","journal-title":"Cancer Genet. Cytogenet."},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104659_bib37","doi-asserted-by":"crossref","DOI":"10.1097\/00043426-200307000-00004","article-title":"Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia","volume":"25","author":"Wu","year":"2003","journal-title":"J. Pediatr. Hematol. \/Oncol."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825000472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825000472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:24:53Z","timestamp":1744784693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842825000472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":37,"alternative-id":["S1040842825000472"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104659","relation":{},"ISSN":["1040-8428"],"issn-type":[{"type":"print","value":"1040-8428"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Performance of CpG-oligonucleotide DSP30 and interleukin-2 in the cytogenetic study of mature B-cell neoplasms: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104659"}}