{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:15:01Z","timestamp":1792815301857,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2308085QH245"],"award-info":[{"award-number":["2308085QH245"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017547","name":"Jiangsu Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473372"],"award-info":[{"award-number":["82473372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.critrevonc.2025.104754","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:40:40Z","timestamp":1746186040000},"page":"104754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["CircRNAs in the tumor microenvironment: new frontiers in cancer progression and therapy"],"prefix":"10.1016","volume":"212","author":[{"given":"Yipei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.critrevonc.2025.104754_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.70008","article-title":"The need to establish and recognize the field of clinical laboratory science (CLS) as an essential field in advancing clinical goals","volume":"7","author":"Aghaei","year":"2024","journal-title":"Health Sci. Rep."},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.61186\/ijbc.16.2.84","article-title":"Investigating the dynamic interplay between Cellular Immunity and Tumor cells in the Fight Against Cancer: an updated Comprehensive Review","volume":"16","author":"Aghapour","year":"2024","journal-title":"Iran. J. Blood Cancer"},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0092-8674(80)90505-X","article-title":"Some yeast mitochondrial RNAs are circular","volume":"19","author":"Arnberg","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2025.104754_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.669474","article-title":"Differentiation and Regulation of T(H) Cells: A Balancing Act for Cancer Immunotherapy","volume":"12","author":"Basu","year":"2021","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104754_bib5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","article-title":"CD4(+) T cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104754_bib6","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.cell.2018.01.004","article-title":"NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control","volume":"172","author":"B\u00f6ttcher","year":"2018","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcancer.2013.02.008","article-title":"The dichotomy of neutrophil granulocytes in cancer","volume":"23","author":"Brandau","year":"2013","journal-title":"Semin Cancer Biol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40164-025-00625-8","article-title":"Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer","volume":"14","author":"Cai","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"issue":"14","key":"10.1016\/j.critrevonc.2025.104754_bib9","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/onc.2013.121","article-title":"Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment","volume":"33","author":"Casazza","year":"2014","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib10","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/S1470-2045(24)00522-9","article-title":"Integrating cancer into crisis: a global vision for action from WHO and partners","volume":"26","author":"Casolino","year":"2025","journal-title":"Lancet Oncol."},{"issue":"8","key":"10.1016\/j.critrevonc.2025.104754_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13059-018-1594-y","article-title":"A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1","volume":"19","author":"Chen","year":"2018","journal-title":"Genome Biol."},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104754_bib13","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.18632\/aging.204068","article-title":"CircRNA has_circ_0069313 induced OSCC immunity escape by miR-325-3p-Foxp3 axes in both OSCC cells and Treg cells","volume":"14","author":"Chen","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.molcel.2019.07.016","article-title":"N6-Methyladenosine Modification Controls Circular RNA Immunity","volume":"76","author":"Chen","year":"2019","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40164-023-00378-2","article-title":"Hypoxia-associated circPRDM4 promotes immune escape via HIF-1\u03b1 regulation of PD-L1 in hepatocellular carcinoma","volume":"12","author":"Chen","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41571-022-00689-z","article-title":"Clinical implications of T cell exhaustion for cancer immunotherapy","volume":"19","author":"Chow","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12943-024-02064-1","article-title":"Decoding the spatiotemporal heterogeneity of tumor-associated macrophages","volume":"23","author":"Chu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"2 2","key":"10.1016\/j.critrevonc.2025.104754_bib18","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.jaci.2009.07.008","article-title":"Immunologic messenger molecules: cytokines, interferons, and chemokines","volume":"125","author":"Commins","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104754_bib19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","article-title":"Circular RNA in cancer","volume":"24","author":"Conn","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.smim.2018.02.002","article-title":"The dark side of tumor-associated endothelial cells","volume":"35","author":"De Sanctis","year":"2018","journal-title":"Semin Immunol."},{"issue":"7776","key":"10.1016\/j.critrevonc.2025.104754_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-019-1593-5","article-title":"Harnessing innate immunity in cancer therapy","volume":"574","author":"Demaria","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-024-01966-4","article-title":"Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p\/STAT6 axis to promote gastric cancer progression","volume":"23","author":"Deng","year":"2024","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104754_bib23","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1158\/1078-0432.CCR-22-3836","article-title":"A Tumor-suppressive Molecular Axis EP300\/circRERE\/miR-6837-3p\/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer","volume":"29","author":"Ding","year":"2023","journal-title":"Clin. Cancer Res"},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104754_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18225","article-title":"CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR-769-5p\/IL-10 axis","volume":"28","author":"Dong","year":"2024","journal-title":"J. Cell Mol. Med"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib25","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1038\/s41467-023-38232-y","article-title":"Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy","volume":"14","author":"Dong","year":"2023","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41571-021-00473-5","article-title":"PD-L1 as a biomarker of response to immune-checkpoint inhibitors","volume":"18","author":"Doroshow","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"Pt A","key":"10.1016\/j.critrevonc.2025.104754_bib27","article-title":"Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression","volume":"124","author":"Du","year":"2023","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11658-024-00539-z","article-title":"Regulation of tumor metastasis and CD8(+) T cells infiltration by circRNF216\/miR-576-5p\/ZC3H12C axis in colorectal cancer","volume":"29","author":"Du","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104754_bib29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/17474086.2024.2391102","article-title":"DNA damage repair in megakaryopoiesis: molecular and clinical aspects","volume":"17","author":"Eftekhar","year":"2024","journal-title":"Expert Rev. Hematol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ccell.2023.01.010","article-title":"Spatial profiling technologies illuminate the tumor microenvironment","volume":"41","author":"Elhanani","year":"2023","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib31","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/nar\/gkv1367","article-title":"Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor","volume":"44","author":"Enuka","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib32","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nsmb.2296","article-title":"The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC","volume":"19","author":"Fabian","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104754_bib33","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-11-3687","article-title":"T-regulatory cells: key players in tumor immune escape and angiogenesis","volume":"72","author":"Facciabene","year":"2012","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104754_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41419-023-06119-x","article-title":"Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications","volume":"14","author":"Fang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104754_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.877376","article-title":"Hsa_circ_0046523 Mediates an Immunosuppressive Tumor Microenvironment by Regulating MiR-148a-3p\/PD-L1 Axis in Pancreatic Cancer","volume":"12","author":"Fu","year":"2022","journal-title":"Front Oncol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41418-024-01396-1","article-title":"127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers","volume":"32","author":"Gao","year":"2025","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib37","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.it.2016.09.006","article-title":"Dendritic Cells and Cancer Immunity","volume":"37","author":"Gardner","year":"2016","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib38","doi-asserted-by":"crossref","first-page":"8609","DOI":"10.1038\/s41467-024-52981-4","article-title":"Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma","volume":"15","author":"Ge","year":"2024","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.critrevonc.2025.104754_bib39","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1158\/0008-5472.CAN-20-4321","article-title":"Epstein-Barr Virus-Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1","volume":"81","author":"Ge","year":"2021","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib40","doi-asserted-by":"crossref","first-page":"e01888","DOI":"10.1128\/mBio.01888-15","article-title":"Making the Leap from Research Laboratory to Clinic: Challenges and Opportunities for Next-Generation Sequencing in Infectious Disease Diagnostics","volume":"6","author":"Goldberg","year":"2015","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41392-021-00865-0","article-title":"Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma","volume":"7","author":"Gong","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13045-021-01083-5","article-title":"Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy","volume":"14","author":"Gong","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(17)30953-1","article-title":"PEGPH20 for metastatic pancreatic ductal adenocarcinoma","volume":"19","author":"Gourd","year":"2018","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-023-05647-w","article-title":"Regulation of the tumor immune microenvironment by cancer-derived circular RNAs","volume":"14","author":"Guan","year":"2023","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.critrevonc.2025.104754_bib45","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1097\/CM9.0000000000003231","article-title":"Tumor angiogenesis and anti-angiogenic therapy","volume":"137","author":"Guo","year":"2024","journal-title":"Chin. Med J. (Engl. )"},{"issue":"7441","key":"10.1016\/j.critrevonc.2025.104754_bib46","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41419-025-07431-4","article-title":"Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation","volume":"16","author":"He","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib48","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-023-01824-9","article-title":"Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts","volume":"22","author":"He","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124929","article-title":"The role of circular RNA in tumor microenvironment and immunotherapy","volume":"242","author":"He","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-020-01648-1","article-title":"Circular RNA circ-CPA4\/ let-7 miRNA\/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)","volume":"39","author":"Hong","year":"2020","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"5720","key":"10.1016\/j.critrevonc.2025.104754_bib51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/280339a0","article-title":"Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells","volume":"280","author":"Hsu","year":"1979","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-022-01501-3","article-title":"circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF\/STAT3 axis","volume":"21","author":"Hu","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12943-024-02192-8","article-title":"Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36\u03b3 transcription in colorectal cancer","volume":"23","author":"Hu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12943-023-01759-1","article-title":"Exosome-derived circCCAR1 promotes CD8\u2009+\u2009T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma","volume":"22","author":"Hu","year":"2023","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.critrevonc.2025.104754_bib55","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.7150\/thno.42174","article-title":"Circular RNA-protein interactions: functions, mechanisms, and identification","volume":"10","author":"Huang","year":"2020","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104754_bib56","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","article-title":"Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib58","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41587-023-01900-x","article-title":"Generation of precision preclinical cancer models using regulated in vivo base editing","volume":"42","author":"Katti","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib59","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/nar\/gkab1256","article-title":"Reexamining assumptions about miRNA-guided gene silencing","volume":"50","author":"Kilikevicius","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104754_bib60","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0092-8674(76)90223-3","article-title":"Isolation and characterization of Sendai virus DI-RNAs","volume":"8","author":"Kolakofsky","year":"1976","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104754_bib61","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.critrevonc.2025.104754_bib62","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.canlet.2019.11.009","article-title":"Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy","volume":"470","author":"Lei","year":"2020","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-025-02191-1","article-title":"Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib64","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004029","article-title":"CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype","volume":"10","author":"Li","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"14","key":"10.1016\/j.critrevonc.2025.104754_bib65","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.7150\/thno.77350","article-title":"Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104754_bib66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.trecan.2020.01.012","article-title":"Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance","volume":"6","author":"Li","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib67","article-title":"CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145\/HK2 pathway","author":"Li","year":"2025","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13046-024-03006-x","article-title":"N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib69","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7150\/thno.64096","article-title":"The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70019","article-title":"Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities","volume":"5","author":"Li","year":"2024","journal-title":"MedComm"},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104754_bib71","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.critrevonc.2025.104754_bib72","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1158\/0008-5472.CAN-22-2585","article-title":"circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma","volume":"83","author":"Li","year":"2023","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib73","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1186\/s12967-024-05498-9","article-title":"CircRHBDD1 promotes immune escape via IGF2BP2\/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108467","article-title":"A tumor microenvironment-associated circRNA predictor for tumor relapse and chemotherapy vulnerability in nasopharyngeal carcinoma","volume":"26","author":"Liang","year":"2023","journal-title":"Iscience"},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib75","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41419-021-03545-7","article-title":"Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2\/miR-4756\/IFIT1\/3 axis","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib76","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13045-019-0770-1","article-title":"Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy","volume":"12","author":"Liu","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104754_bib77","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12032-023-02194-4","article-title":"Roles of circRNAs in regulating the tumor microenvironment","volume":"40","author":"Liu","year":"2023","journal-title":"Med. Oncol."},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104754_bib78","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.7150\/thno.58390","article-title":"Turning cold tumors into hot tumors by improving T-cell infiltration","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib79","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-021-01398-4","article-title":"N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer","volume":"20","author":"Liu","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100886","article-title":"N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells","volume":"65","author":"Liu","year":"2022","journal-title":"Drug Resist Updat"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib81","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13045-021-01207-x","article-title":"Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma","volume":"14","author":"Lu","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib82","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41420-022-01037-x","article-title":"circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5","volume":"8","author":"Lu","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.critrevonc.2025.104754_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1453786","article-title":"Immunoregulatory role of exosomal CircRNAs in the tumor microenvironment","volume":"15","author":"Lv","year":"2025","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-023-01723-z","article-title":"CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances","volume":"22","author":"Maalej","year":"2023","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib85","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","article-title":"Metabolic Regulation of Macrophage Polarization in Cancer","volume":"5","author":"Mehla","year":"2019","journal-title":"Trends Cancer"},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib86","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1158\/2326-6066.CIR-13-0102","article-title":"Dendritic cells: master regulators of the immune response","volume":"1","author":"Mellman","year":"2013","journal-title":"Cancer Immunol. Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib87","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12943-023-01883-y","article-title":"Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375\/PRKDC Axis and PD-L1 phosphorylation","volume":"22","author":"Miao","year":"2023","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib88","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib89","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41577-020-0376-4","article-title":"Targeting CD39 in cancer","volume":"20","author":"Moesta","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib90","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41392-023-01561-x","article-title":"Circular RNA vaccine in disease prevention and treatment","volume":"8","author":"Niu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"14","key":"10.1016\/j.critrevonc.2025.104754_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147743","article-title":"Advancements in Personalized CAR-T Therapy: Comprehensive Overview of Biomarkers and Therapeutic Targets in Hematological Malignancies","volume":"25","author":"Olejarz","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104754_bib92","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41423-020-00565-9","article-title":"Tumor-infiltrating lymphocytes in the immunotherapy era","volume":"18","author":"Paijens","year":"2021","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2017.02.021","article-title":"Translation of CircRNAs","volume":"66","author":"Pamudurti","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.critrevonc.2025.104754_bib94","article-title":"A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A-PPAR Axis in Pancreatic Ductal Adenocarcinoma","volume":"7","author":"Pan","year":"2024","journal-title":"Res. (Wash. D. C. )"},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189187","article-title":"Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation","volume":"1879","author":"Qian","year":"2024","journal-title":"Biochim Biophys. Acta Rev. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib96","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11033-024-10200-9","article-title":"Aqueous and ethanolic extracts of Moringa oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53","volume":"52","author":"Rajabi","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib97","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1200\/JCO.21.01497","article-title":"First-Line Immunotherapy for Non-Small-Cell Lung Cancer","volume":"40","author":"Reck","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib98","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/S1470-2045(24)00405-4","article-title":"The changing global landscape of national cancer control plans","volume":"26","author":"Romero","year":"2025","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib99","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s12967-023-04383-1","article-title":"Subject: Motivation can be suppressed, but scientific ability cannot and should not be ignored","volume":"21","author":"Saki","year":"2023","journal-title":"J. Transl. Med"},{"issue":"12","key":"10.1016\/j.critrevonc.2025.104754_bib100","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.arbres.2017.06.016","article-title":"New Immunotherapy and Lung Cancer","volume":"53","author":"S\u00e1nchez de Cos Escu\u00edn","year":"2017","journal-title":"Arch. Bronc-.-."},{"issue":"11","key":"10.1016\/j.critrevonc.2025.104754_bib101","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.critrevonc.2025.104754_bib102","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41568-021-00346-0","article-title":"Therapeutic cancer vaccines","volume":"21","author":"Saxena","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib103","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-020-01235-0","article-title":"Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p\/miR-506-3p- TGF-\u03b21 axis","volume":"19","author":"Shang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib104","article-title":"Exosomal circ_0088300 Derived From Cancer-Associated Fibroblasts Acts as a miR-1305 Sponge and Promotes Gastric Carcinoma Cell Tumorigenesis","volume":"9","author":"Shi","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41419-020-03334-8","article-title":"Hsa_circ_0007456 regulates the natural killer cell-mediated cytotoxicity toward hepatocellular carcinoma via the miR-6852-3p\/ICAM-1 axis","volume":"12","author":"Shi","year":"2021","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104754_bib106","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","article-title":"NK cells for cancer immunotherapy","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"15","key":"10.1016\/j.critrevonc.2025.104754_bib107","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41388-023-02637-2","article-title":"Regulation of CD8(+) T cells infiltration and immunotherapy by circMGA\/HNRNPL complex in bladder cancer","volume":"42","author":"Sun","year":"2023","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib108","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-023-01471-y","article-title":"T cells in health and disease","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib109","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/1120009X.2021.2009990","article-title":"CircRNA_001895 promotes sunitinib resistance of renal cell carcinoma through regulation of apoptosis and DNA damage repair","volume":"35","author":"Tan","year":"2023","journal-title":"J. Chemother."},{"issue":"10197","key":"10.1016\/j.critrevonc.2025.104754_bib110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(19)30764-0","article-title":"Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial","volume":"394","author":"Tap","year":"2019","journal-title":"Lancet"},{"issue":"7483","key":"10.1016\/j.critrevonc.2025.104754_bib111","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib112","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/s12951-024-02826-5","article-title":"Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8(+) T cell exhaustion","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnology"},{"issue":"22","key":"10.1016\/j.critrevonc.2025.104754_bib113","article-title":"Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"8","key":"10.1016\/j.critrevonc.2025.104754_bib114","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/mco2.667","article-title":"Circular RNA-based neoantigen vaccine for hepatocellular carcinoma immunotherapy","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"issue":"2","key":"10.1016\/j.critrevonc.2025.104754_bib115","doi-asserted-by":"crossref","first-page":"562","DOI":"10.7150\/ijbs.48782","article-title":"Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities","volume":"17","author":"Wang","year":"2021","journal-title":"Int J. Biol. Sci."},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104754_bib116","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70060","article-title":"CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma","volume":"14","author":"Wang","year":"2024","journal-title":"Clin. Transl. Med"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib117","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12943-020-01191-9","article-title":"Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p\/CXCL12 axis in melanoma","volume":"19","author":"Wei","year":"2020","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.critrevonc.2025.104754_bib118","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1111\/jcmm.17998","article-title":"Circ-ILF2 in oral squamous cell carcinoma promotes cisplatin resistance and induces M2 polarization of macrophages","volume":"27","author":"Wu","year":"2023","journal-title":"J. Cell Mol. Med"},{"issue":"7446","key":"10.1016\/j.critrevonc.2025.104754_bib119","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104754_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.938672","article-title":"Systematic analysis of circRNA biomarkers for diagnosis, prognosis and therapy in colorectal cancer","volume":"13","author":"Xiao","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.critrevonc.2025.104754_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.critrevonc.2025.104754_bib122","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2147\/OTT.S437536","article-title":"Crosstalk between circRNA and tumor microenvironment of hepatocellular carcinoma: mechanism, function and applications","author":"Xie","year":"2024","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib123","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12943-022-01630-9","article-title":"CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322\/CCL20\/CCR6 signaling","volume":"21","author":"Xie","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110095","article-title":"Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497\/PD-L1 pathway","volume":"86","author":"Xu","year":"2021","journal-title":"Cell Signal"},{"issue":"10","key":"10.1016\/j.critrevonc.2025.104754_bib125","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1016\/j.ymthe.2022.01.046","article-title":"Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment","volume":"30","author":"Xu","year":"2022","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib126","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1186\/s12885-021-08669-9","article-title":"Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214\/PD-L1 axis","volume":"21","author":"Yang","year":"2021","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.critrevonc.2025.104754_bib127","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N(6)-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res"},{"issue":"18","key":"10.1016\/j.critrevonc.2025.104754_bib128","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/15384101.2023.2271341","article-title":"Tumor-derived CircRNA_102191 promotes gastric cancer and facilitates M2 macrophage polarization","volume":"22","author":"Yao","year":"2023","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib129","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13046-023-02916-6","article-title":"Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization","volume":"42","author":"Yao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104754_bib130","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41419-023-05986-8","article-title":"Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication","volume":"14","author":"Ye","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib131","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12943-022-01624-7","article-title":"Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling","volume":"21","author":"Yu","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib132","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12943-024-02124-6","article-title":"Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1","volume":"23","author":"Zang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib133","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13046-021-01987-7","article-title":"Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer","volume":"40","author":"Zhang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib134","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12943-020-01222-5","article-title":"Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-018-0935-5","article-title":"Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1\/mTOR pathway","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib136","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12967-023-04625-2","article-title":"CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p\/PGK1 pathway and inhibiting vimentin phosphorylation","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med"},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104754_bib137","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00262-024-03705-6","article-title":"circATAD2 mitigates CD8(+) T cells antitumor immune surveillance in breast cancer via IGF2BP3\/m(6)A\/PD-L1 manner","volume":"73","author":"Zhang","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"19","key":"10.1016\/j.critrevonc.2025.104754_bib138","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.18632\/aging.102334","article-title":"CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma","volume":"11","author":"Zhao","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.critrevonc.2025.104754_bib139","doi-asserted-by":"crossref","DOI":"10.1002\/cac2.70016","article-title":"Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages","author":"Zhao","year":"2025","journal-title":"Cancer Commun. (Lond. )"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-024-01957-5","article-title":"circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP\/IL-6 axis","volume":"23","author":"Zhao","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib141","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13046-021-02237-6","article-title":"circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-\u03baB signaling pathway","volume":"41","author":"Zheng","year":"2022","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib142","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13046-023-02854-3","article-title":"Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer","volume":"42","author":"Zheng","year":"2023","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib143","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104754_bib144","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8819990","article-title":"circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p","volume":"2021","author":"Zhu","year":"2021","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.critrevonc.2025.104754_bib145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12943-024-02059-y","article-title":"PD1\/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives","volume":"23","author":"Zhu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.critrevonc.2025.104754_bib146","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1763","article-title":"Exosomal circ-0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7\/NRF2 axis","volume":"14","author":"Zhuang","year":"2024","journal-title":"Clin. Transl. Med"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825001428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825001428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:27:36Z","timestamp":1762352856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842825001428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":146,"alternative-id":["S1040842825001428"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104754","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircRNAs in the tumor microenvironment: new frontiers in cancer progression and therapy","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104754"}}