{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:36:35Z","timestamp":1792460195127,"version":"4.5.0"},"reference-count":238,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.critrevonc.2025.104907","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T16:27:23Z","timestamp":1755620843000},"page":"104907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Ferroptosis and immunotherapy: Breaking barriers in cancer treatment resistance"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1356-0540","authenticated-orcid":false,"given":"Mohammad","family":"Ebrahimnezhad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Valizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2025.104907_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13050986","article-title":"Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy","volume":"13","author":"Aboelella","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.critrevonc.2025.104907_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/polym17020136","article-title":"Metal-Coordinated Polymer\u2013Inorganic hybrids: synthesis, properties, and application","volume":"17","author":"Abtahi","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.critrevonc.2025.104907_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116098","article-title":"Lactic acid in macrophage polarization: a factor in carcinogenesis and a promising target for cancer therapy","volume":"222","author":"Ajam-Hosseini","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20240002","article-title":"A ph responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11\/ACSL4\/LPCAT3 pathway","volume":"5","author":"Bai","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.critrevonc.2025.104907_bib5","doi-asserted-by":"crossref","unstructured":"Bajor, M., K\u0142opotowska, M., Baranowska, I., Hajduk, S., Le\u015bniowska, N., Jurga, A., , 2024. GPX4 and FSP1, key ferroptosis regulators, are critical for T cell functions and CAR-T antitumor activity. 2024. https:\/\/doi.org\/10.21203\/rs.3.rs-5280443\/v1..","DOI":"10.21203\/rs.3.rs-5280443\/v1"},{"key":"10.1016\/j.critrevonc.2025.104907_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.159676","article-title":"A novel silkworm excrement-derived nanomedicine integrating ferroptosis and photodynamic therapy, well-suitable for PD-L1-mediated immune checkpoint blockade","volume":"505","author":"Bao","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12967-024-05331-3","article-title":"BIBR1532 combined with radiotherapy induces ferroptosis in NSCLC cells and activates cGAS-STING pathway to promote anti-tumor immunity","volume":"22","author":"Bao","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109422","article-title":"Erastin enhances metastatic potential of ferroptosis-resistant ovarian cancer cells by M2 polarization through STAT3\/IL-8 axis","volume":"113","author":"Cang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.155021","article-title":"Synergetic Sonodynamic-Immunotherapy based on phycocyanin nanoparticles (PCNP) reduces tumor growth and metastasis in mice","volume":"498","author":"Cao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170071","article-title":"CD8+ t cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione\/GPX4","volume":"134","author":"Chen","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.critrevonc.2025.104907_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152397","article-title":"Mutually reinforced cancer treatment based on phototherapy combined with ferroptosis","volume":"493","author":"Chen","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib12","article-title":"Multifunctional liposome boosts glioma ferroptosis and immunotherapy through reinforcement of chemo-dynamic therapy strategy","volume":"31","author":"Chen","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.critrevonc.2025.104907_bib13","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.critrevonc.2025.104907_bib14","article-title":"Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy","volume":"31","author":"Chen","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.critrevonc.2025.104907_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110629","article-title":"ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma","volume":"122","author":"Chen","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41419-023-05803-2","article-title":"CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104907_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00262-024-03628-2","article-title":"Atovaquone enhances antitumor efficacy of TCR-T therapy by augmentation of ROS-induced ferroptosis in hepatocellular carcinoma","volume":"73","author":"Chen","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.critrevonc.2025.104907_bib19","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1021\/acsami.4c21890","article-title":"Lactate-Fueled theranostic nanoplatforms for enhanced MRI-Guided ferroptosis synergistic with immunotherapy of hepatocellular carcinoma","volume":"17","author":"Chen","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.critrevonc.2025.104907_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204514","article-title":"Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer","volume":"10","author":"Chung","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib21","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gutjnl-2022-327909","article-title":"Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade","volume":"72","author":"Conche","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.critrevonc.2025.104907_bib22","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","article-title":"Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein","volume":"16","author":"Dai","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.critrevonc.2025.104907_bib23","first-page":"483","article-title":"Ca & mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening","volume":"33","author":"Deng","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.818453","article-title":"Targeting cancer cell ferroptosis to reverse immune checkpoint inhibitor therapy resistance","volume":"10","author":"Deng","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2023.09.024","article-title":"Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer","volume":"363","author":"Ding","year":"2023","journal-title":"J. Control Release"},{"key":"10.1016\/j.critrevonc.2025.104907_bib26","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-564-5","article-title":"The role of cGAS-STING signaling pathway in ferroptosis","author":"Ding","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib27","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2025.104907_bib28","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1021\/acsnano.2c12217","article-title":"Engineering MMP-2 activated nanoparticles carrying B7-H3 bispecific antibodies for Ferroptosis-Enhanced glioblastoma immunotherapy","volume":"17","author":"Fan","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.critrevonc.2025.104907_bib29","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1158\/0008-5472.CAN-21-1547","article-title":"A dual PI3K\/HDAC inhibitor induces immunogenic ferroptosis to potentiate cancer immune checkpoint therapy","volume":"81","author":"Fan","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib30","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1186\/s12885-024-12820-7","article-title":"APOL6 predicts immunotherapy efficacy of bladder cancer by ferroptosis","volume":"24","author":"Fan","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib31","doi-asserted-by":"crossref","first-page":"12261","DOI":"10.1021\/acsnano.4c00844","article-title":"Light-Triggered nanozymes remodel the tumor hypoxic and immunosuppressive microenvironment for Ferroptosis-Enhanced antitumor immunity","volume":"18","author":"Fan","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.critrevonc.2025.104907_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.actbio.2024.07.034","article-title":"Multifunctional single-component photosensitizers as metal-free ferroptosis inducers for enhanced photodynamic immunotherapy","volume":"186","author":"Fang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202405483","article-title":"Fe\/Al-LDH nanomedicine for antitumor Ferroptosis-Immunotherapy by immunosuppression reversal","volume":"34","author":"Fang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib34","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.7150\/ijbs.83342","article-title":"APOL3-LDHA axis related immunity activation and cancer ferroptosis induction","volume":"19","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114477","article-title":"Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis","volume":"43","author":"Feng","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.critrevonc.2025.104907_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216728","article-title":"Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer","volume":"587","author":"Feng","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1586\/era.09.6","article-title":"Targeting angiogenesis in hepatocellular carcinoma: focus on VEGF and bevacizumab","volume":"9","author":"Finn","year":"2009","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.critrevonc.2025.104907_bib38","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/2326-6066.CIR-24-0130","article-title":"CAR t cells engineered to secrete IFN\u03ba induce tumor ferroptosis via an IFNAR\/STAT1\/ACSL4 axis","volume":"12","author":"Gao","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib39","first-page":"1","article-title":"FOXM1-activated IGF2BP3 promotes cell malignant phenotypes and M2 macrophage polarization in hepatocellular carcinoma by inhibiting ferroptosis via stabilizing RRM2 mRNA in an m6A-dependent manner","author":"Gao","year":"2024","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.critrevonc.2025.104907_bib40","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10495-024-01966-1","article-title":"FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications","volume":"29","author":"Gao","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.critrevonc.2025.104907_bib41","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1186\/s12885-022-10302-2","article-title":"CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma","volume":"22","author":"Gong","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12951-025-03284-3","article-title":"Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation","volume":"23","author":"Gu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233893","article-title":"Tumor cell derived exosomal GOT1 suppresses tumor cell ferroptosis to accelerate pancreatic cancer progression by activating Nrf2\/HO-1 axis via upregulating CCR2 expression","volume":"11","author":"Guo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.critrevonc.2025.104907_bib44","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004381","article-title":"Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis","volume":"10","author":"Guo","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121315","article-title":"Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy","volume":"280","author":"Han","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.critrevonc.2025.104907_bib46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41419-024-06503-1","article-title":"Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ t cells","volume":"15","author":"Han","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104907_bib47","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.molcel.2023.05.011","article-title":"IL-1\u03b2-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance","volume":"83","author":"Han","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.critrevonc.2025.104907_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102463","article-title":"Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing","volume":"56","author":"Hao","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156224","article-title":"Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors","volume":"136","author":"Haoyue","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.critrevonc.2025.104907_bib50","series-title":"Autophagy, Apoptosis Ferroptosis Oncol","first-page":"923","article-title":"Nanoparticles in the stimulation of ferroptosis in cancer therapy","author":"Hashemi","year":"2024"},{"key":"10.1016\/j.critrevonc.2025.104907_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119911","article-title":"Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator","volume":"241","author":"He","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.critrevonc.2025.104907_bib52","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.2147\/JIR.S489191","article-title":"Candida albicans-Derived \u03b2-Glucan as a novel modulator of tumor microenvironment: targeting macrophage polarization and inducing ferroptosis in lung cancer","volume":"17","author":"He","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib53","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41401-024-01299-4","article-title":"Bevacizumab induces ferroptosis and enhances CD8+ t cell immune activity in liver cancer via modulating HAT1 and increasing IL-9","volume":"45","author":"Hou","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.critrevonc.2025.104907_bib54","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.7150\/thno.57803","article-title":"An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment","volume":"11","author":"Hsieh","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.critrevonc.2025.104907_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111004","article-title":"Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer","volume":"395","author":"Hsieh","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.critrevonc.2025.104907_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.727762","article-title":"Ferroptosis driver SOCS1 and suppressor FTH1 independently correlate with M1 and M2 macrophage infiltration in head and neck squamous cell carcinoma","volume":"9","author":"Hu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1148410","article-title":"Phosphatidylethanolamine aggravates angiotensin II-induced atrial fibrosis by triggering ferroptosis in mice","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib58","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13046-023-02865-0","article-title":"TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages","volume":"42","author":"Huang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188848","article-title":"Ferroptosis and its interaction with tumor immune microenvironment in liver cancer","volume":"1878","author":"Huang","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122157","article-title":"Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy","volume":"299","author":"Huang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.critrevonc.2025.104907_bib61","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41417-025-00886-9","article-title":"MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy","volume":"32","author":"Ibrahim","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.critrevonc.2025.104907_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050733","article-title":"Blocking EREG\/GPX4 sensitizes head and neck cancer to cetuximab through ferroptosis induction","volume":"12","author":"Jehl","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.critrevonc.2025.104907_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300881","article-title":"ANO1-Mediated inhibition of cancer ferroptosis confers immunotherapeutic resistance through recruiting Cancer-Associated fibroblasts","volume":"10","author":"Jiang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139434","article-title":"TYRO3 induces anti-PD-1\/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis","volume":"131","author":"Jiang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.critrevonc.2025.104907_bib65","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1039\/C8CS00718G","article-title":"Nanozyme: new horizons for responsive biomedical applications","volume":"48","author":"Jiang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib66","article-title":"Platelet membrane-camouflaged magnetic nanoparticles for ferroptosis-enhanced cancer immunotherapy","volume":"16","author":"Jiang","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.critrevonc.2025.104907_bib67","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/bjc.2013.753","article-title":"Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer","volume":"110","author":"Jonker","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib68","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14506","article-title":"Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma","volume":"10","author":"Ju","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.critrevonc.2025.104907_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202216097","article-title":"Protein-based nanoparticles: from drug delivery to imaging, nanocatalysis and protein therapy","volume":"62","author":"Kaltbeitzel","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.critrevonc.2025.104907_bib70","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","article-title":"Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death","volume":"16","author":"Kapralov","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib71","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.tips.2023.06.005","article-title":"Ferroptosis of immune cells in the tumor microenvironment","volume":"44","author":"Kim","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2020.112912","article-title":"Characterization of a rat monoclonal antibody raised against ferroptotic cells","volume":"489","author":"Kobayashi","year":"2021","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.critrevonc.2025.104907_bib73","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1021\/acs.chemmater.3c00444","article-title":"Membrane fusion Liposome-Mediated ferroptosis explosion for enhanced cancer therapy","volume":"35","author":"Kong","year":"2023","journal-title":"Chem. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib74","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/JLB.3MA1220-815RRR","article-title":"IFN\u03b3-mediated repression of system xc\u2212 drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells","volume":"110","author":"Kong","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib75","doi-asserted-by":"crossref","first-page":"30031","DOI":"10.1021\/acsami.0c03564","article-title":"Tumor Microenvironment-Responsive, multistaged liposome induces apoptosis and ferroptosis by amplifying oxidative stress for enhanced cancer therapy","volume":"12","author":"Kou","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.critrevonc.2025.104907_bib76","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"Kremer","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104907_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215330","article-title":"Distinct features of iron based metal organic frameworks (MOFs) for ferroptosis mediated cancer therapy: a comprehensive review","volume":"494","author":"Kudarha","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib78","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41571-023-00846-y","article-title":"Myeloid-derived suppressor cells in cancer and cancer therapy","volume":"21","author":"Lasser","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib79","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s13577-023-00890-x","article-title":"Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin","volume":"36","author":"Lee","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.critrevonc.2025.104907_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212761","article-title":"Anti-tumor immunity and ferroptosis of hepatocellular carcinoma are enhanced by combined therapy of sorafenib and delivering modified GO-based PD-L1 siRNAs","volume":"136","author":"Li","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.critrevonc.2025.104907_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20230117","article-title":"Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer","volume":"5","author":"Li","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.critrevonc.2025.104907_bib82","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.freeradbiomed.2023.12.034","article-title":"Interventing mitochondrial PD-L1 suppressed IFN-\u03b3-induced cancer stemness in hepatocellular carcinoma by sensitizing sorafenib-induced ferroptosis","volume":"212","author":"Li","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib83","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2021.12.011","article-title":"Interleukin-6 facilitates tumor progression by inducing ferroptosis resistance in head and neck squamous cell carcinoma","volume":"527","author":"Li","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib84","article-title":"Targeting the MCP-GPX4\/HMGB1 axis for effectively triggering immunogenic ferroptosis in pancreatic ductal adenocarcinoma","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib85","article-title":"System Xc\u2212\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib86","article-title":"Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160713","article-title":"Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors","volume":"507","author":"Li","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib88","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12943-023-01926-4","article-title":"Evolving insights into the improvement of adoptive T-cell immunotherapy through PD-1\/PD-L1 blockade in the clinical spectrum of lung cancer","volume":"23","author":"Li","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib89","article-title":"USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy","volume":"121","author":"Li","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.critrevonc.2025.104907_bib90","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1182\/blood-2023-186491","article-title":"Voltage-Dependent anion channel 2 (VDAC2) drives rituximab resistance via inhibiting ferroptosis in diffuse large b cell lymphoma","volume":"142","author":"Li","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.critrevonc.2025.104907_bib91","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/humrep\/deaa363","article-title":"Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis","volume":"36","author":"Li","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.critrevonc.2025.104907_bib92","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6284540","article-title":"A Ferroptosis-Related LncRNA signature associated with prognosis, tumor immune environment, and genome instability in hepatocellular carcinoma","volume":"2022","author":"Lian","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib93","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41420-025-02415-x","article-title":"Ferroptosis: CD8+T cells\u2019 blade to destroy tumor cells or poison for self-destruction","volume":"11","author":"Liang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.critrevonc.2025.104907_bib94","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12951-024-02425-4","article-title":"GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy","volume":"22","author":"Liao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101240","article-title":"Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer","author":"Lin","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.critrevonc.2025.104907_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1255443","article-title":"The crosstalk of CD8+ t cells and ferroptosis in cancer","volume":"14","author":"Lin","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203659","article-title":"Self-Amplifying Iridium(III) photosensitizer for ferroptosis-mediated immunotherapy against transferrin receptor-overexpressing cancer","volume":"18","author":"Ling","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.critrevonc.2025.104907_bib98","article-title":"Asymmetric coordination of iron single-atom nanozymes with efficient self-cascade catalysis for ferroptosis therapy","volume":"34","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib99","article-title":"One-Step symbiosis of bimetallic peroxides nanoparticles to induce Ferroptosis\/Cuproptosis and activate cGAS-STING pathway for enhanced tumor immunotherapy","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib100","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: the new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.critrevonc.2025.104907_bib101","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00018-022-04365-4","article-title":"Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy","volume":"79","author":"Liu","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib102","article-title":"Facile synthesis of Fe-Based Metal-Quinone networks for mutually enhanced mild photothermal therapy and ferroptosis","volume":"64","author":"Liu","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.critrevonc.2025.104907_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102149","article-title":"CAV1 inhibits Xc- system through IFNGR1 to promote ferroptosis to inhibit stemness and improves anti-PD-1 efficacy in breast cancer","volume":"50","author":"Liu","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216006","article-title":"Optical functional nanomaterials for cancer photoimmunotherapy","volume":"517","author":"Liu","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib105","article-title":"Combination RSL3 treatment sensitizes ferroptosis- and EGFR-inhibition-resistant HNSCCs to cetuximab","volume":"23","author":"Liu","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib106","article-title":"Clinical cancer immunotherapy: current progress and prospects","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib107","doi-asserted-by":"crossref","first-page":"12176","DOI":"10.1021\/acs.jmedchem.2c00855","article-title":"PDTAC: targeted photodegradation of GPX4 triggers ferroptosis and potent antitumor immunity","volume":"65","author":"Liu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.critrevonc.2025.104907_bib108","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2025.2473165","article-title":"MERTK inhibition improves therapeutic efficacy of immune checkpoint inhibitors in hepatocellular carcinoma","volume":"14","author":"Llopiz","year":"2025","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.critrevonc.2025.104907_bib109","doi-asserted-by":"crossref","first-page":"288","DOI":"10.5152\/tjg.2023.23300","article-title":"RAS-Selective lethal 3-Induced ferroptosis promotes the antitumor efficiency of anti-programmed cell death protein 1 treatment in colorectal cancer","volume":"35","author":"Lu","year":"2024","journal-title":"Turk. J. Gastroenterol. J. Turk. Soc. Gastroenterol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/1721727X15613911","article-title":"Oxymatrine and cancer therapy","volume":"13","author":"Lu","year":"2015","journal-title":"Eur. J. Inflamm."},{"key":"10.1016\/j.critrevonc.2025.104907_bib111","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/j.apsb.2023.03.025","article-title":"The suppression of cervical cancer ferroptosis by macrophages: the attenuation of ALOX15 in cancer cells by macrophages-derived exosomes","volume":"13","author":"Luo","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.critrevonc.2025.104907_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1053137","article-title":"Exercise-induced IL-15 acted as a positive prognostic implication and tumor-suppressed role in pan-cancer","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112875","article-title":"ALG3 predicts poor prognosis and increases resistance to anti-PD-1 therapy through modulating PD-L1 N-link glycosylation in TNBC","volume":"140","author":"Luo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib114","doi-asserted-by":"crossref","first-page":"13774","DOI":"10.3390\/ijms232213774","article-title":"Fascaplysin induces apoptosis and ferroptosis, and enhances Anti-PD-1 immunotherapy in Non-Small cell lung cancer (NSCLC) by promoting PD-L1 expression","volume":"23","author":"Luo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103303","article-title":"Vitamin e and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis","volume":"75","author":"Luo","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib116","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.7150\/ijbs.74985","article-title":"Apolipoprotein L3 enhances CD8+ t cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis","volume":"19","author":"Lv","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib117","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.it.2022.08.004","article-title":"Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy","volume":"43","author":"Ma","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib118","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41392-024-01772-w","article-title":"Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer","volume":"9","author":"Ma","year":"2024","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.critrevonc.2025.104907_bib119","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1039\/D2BM01126C","article-title":"Boosting cancer immunotherapy by biomineralized nanovaccine with ferroptosis-inducing and photothermal properties","volume":"11","author":"Ma","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib120","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8(+) t cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.critrevonc.2025.104907_bib121","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1182\/blood-2024-203442","article-title":"Translational disruption of NRF2 by zotatifin enhances sensitivity to ferroptosis and CAR-T cells in diffuse large B-Cell lymphoma","volume":"144","author":"Manara","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.critrevonc.2025.104907_bib122","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.7010","article-title":"Integrating natural compounds and nanoparticle-based drug delivery systems: a novel strategy for enhanced efficacy and selectivity in cancer therapy","volume":"13","author":"Manzari-Tavakoli","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib123","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41419-025-07550-y","article-title":"TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy","volume":"16","author":"Mao","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104907_bib124","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/CAD.0000000000001573","article-title":"APOC1 reduced anti-PD-1 immunotherapy of nonsmall cell lung cancer via the transformation of M2 into M1 macrophages by ferroptosis by NRF2\/HO-1","volume":"35","author":"Mei","year":"2024","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.critrevonc.2025.104907_bib125","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300517","article-title":"Ferroptosis-Enhanced immunotherapy with an injectable Dextran-Chitosan hydrogel for the treatment of malignant ascites in hepatocellular carcinoma","volume":"10","author":"Meng","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115083","article-title":"Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer","volume":"202","author":"Mikhail","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/biology13110949","article-title":"Etomoxir sodium salt promotes imidazole ketone Erastin-Induced Myeloid-Derived suppressor cell ferroptosis and enhances cancer therapy","volume":"13","author":"Mohamady Farouk Abdalsalam","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.critrevonc.2025.104907_bib128","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41586-024-08171-9","article-title":"Intravenous and intracranial GD2-CAR t cells for H3K27M+ diffuse midline gliomas","volume":"637","author":"Monje","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104907_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050804","article-title":"Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis","volume":"12","author":"Mortensen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.critrevonc.2025.104907_bib130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12645-023-00234-2","article-title":"Enhanced cancer immunotherapy through synergistic ferroptosis and immune checkpoint blockade using cell membrane-coated nanoparticles","volume":"14","author":"Mu","year":"2023","journal-title":"Cancer Nanotechnol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib131","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/s41417-023-00648-5","article-title":"3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis","volume":"30","author":"Mu","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.critrevonc.2025.104907_bib132","first-page":"51","article-title":"Self-healable and pH-responsive spermidine\/ferrous ion complexed hydrogel Co-loaded with CA inhibitor and glucose oxidase for combined cancer immunotherapy through triple ferroptosis mechanism","volume":"47","author":"Nie","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113244","article-title":"Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer","volume":"142","author":"Ning","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib134","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.2147\/JHC.S492582","article-title":"Oxymatrine inhibits PD-L1 by downregulating IFN-\u03b3 to promote ferroptosis and enhance Anti-PD-L1 efficacy in liver cancer","volume":"11","author":"Nong","year":"2024","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.critrevonc.2025.104907_bib135","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1038\/s41467-024-47198-4","article-title":"Combination of acalabrutinib with lenalidomide and rituximab in relapsed\/refractory aggressive B-cell non-Hodgkin lymphoma: a single-arm phase II trial","volume":"15","author":"Park","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104907_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188365","article-title":"Ferroptosis-mediated immune responses in cancer","volume":"14","author":"Qi","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib138","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1038\/s41467-025-58909-w","article-title":"Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization","volume":"16","author":"Saimoto","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104907_bib139","doi-asserted-by":"crossref","DOI":"10.3390\/ph18030325","article-title":"Therapeutic approaches with iron oxide nanoparticles to induce ferroptosis and overcome radioresistance in cancers","volume":"18","author":"Sant\u2019Angelo","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.critrevonc.2025.104907_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16020412","article-title":"Cetuximab as a key partner in personalized targeted therapy for metastatic colorectal cancer","volume":"16","author":"Saoudi Gonz\u00e1lez","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.critrevonc.2025.104907_bib141","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12951-025-03307-z","article-title":"Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy","volume":"23","author":"Sha","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib142","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib143","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1039\/D0BM01158D","article-title":"Nanomedicine-based tumor photothermal therapy synergized immunotherapy","volume":"8","author":"Shang","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib144","article-title":"Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder cancer","volume":"31","author":"Shi","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.critrevonc.2025.104907_bib145","doi-asserted-by":"crossref","first-page":"14475","DOI":"10.1021\/acsnano.3c00901","article-title":"Ferroptosis and necroptosis produced autologous tumor cell lysates Co-Delivering with combined immnoadjuvants as personalized in situ nanovaccines for antitumor immunity","volume":"17","author":"Shi","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.critrevonc.2025.104907_bib146","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.critrevonc.2025.104907_bib147","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","article-title":"Cancer treatments: past, present, and future","volume":"286\u2013287","author":"Sonkin","year":"2024","journal-title":"Cancer Genet."},{"key":"10.1016\/j.critrevonc.2025.104907_bib148","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01371","article-title":"RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer","volume":"9","author":"Sui","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib149","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.actbio.2024.12.010","article-title":"A metal-organic framework functionalized CaO2-based cascade nanoreactor induces synergistic cuproptosis\/ferroptosis and Ca2+ overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy","volume":"193","author":"Tang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib150","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203973","article-title":"Targeted xCT-mediated ferroptosis and protumoral polarization of macrophages is effective against HCC and enhances the efficacy of the Anti-PD-1\/L1 response","volume":"10","author":"Tang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib151","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008554","article-title":"Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-\u03b3-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors","volume":"12","author":"Tao","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020108","article-title":"Blockade of TIPE2-Mediated ferroptosis of myeloid-derived suppressor cells achieves the full potential of combinatory ferroptosis and Anti-PD-L1 cancer immunotherapy","volume":"14","author":"Tariq","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.critrevonc.2025.104907_bib153","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41375-021-01350-x","article-title":"Catch me if you can: how AML and its niche escape immunotherapy","volume":"36","author":"Tettamanti","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.critrevonc.2025.104907_bib154","first-page":"4","article-title":"Pro-inflammatory cytokines, ferroptosis, and cancer","volume":"17","author":"Vartanian","year":"2025","journal-title":"Acta Nat."},{"key":"10.1016\/j.critrevonc.2025.104907_bib155","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005611","article-title":"Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?","volume":"10","author":"Vos","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib156","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ t cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104907_bib157","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006890","article-title":"PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis","volume":"11","author":"Wang","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104907_bib158","article-title":"Ferroptosis-Enhanced cancer immunity by a ferrocene-appended iridium(III) diphosphine complex","volume":"61","author":"Wang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.critrevonc.2025.104907_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib160","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/tox.23509","article-title":"A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis","volume":"37","author":"Wang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib161","doi-asserted-by":"crossref","DOI":"10.3390\/md21040226","article-title":"Marine-Derived lead fascaplysin: pharmacological activity, total synthesis, and structural modification","volume":"21","author":"Wang","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.critrevonc.2025.104907_bib162","article-title":"Resistance mechanisms and prospects of trastuzumab","volume":"14","author":"Wang","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib163","article-title":"Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer","volume":"36","author":"Wang","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib164","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1038\/s41467-021-25990-w","article-title":"A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104907_bib165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41420-024-02257-z","article-title":"IFN\u03b3 regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.critrevonc.2025.104907_bib166","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jid.2021.05.025","article-title":"CAMKK2 defines ferroptosis sensitivity of melanoma cells by regulating AMPK-NRF2 pathway","volume":"142","author":"Wang","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib167","article-title":"Matrix stiffness-dependent PD-L2 deficiency improves SMYD3\/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223580","article-title":"Targeting Wnt\/\u03b2-Catenin signaling exacerbates ferroptosis and increases the efficacy of melanoma immunotherapy via the regulation of MITF","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.critrevonc.2025.104907_bib169","doi-asserted-by":"crossref","unstructured":"Wang Z., Zhou L., Pang L., Qiu W., Chan A.C.-Y., Man K. IDDF2022-ABS-0176\u2005Tumor-derived iron loaded-exosomes impair CD8+ T anti-tumor ability via ferroptosis in hepatocellular carcinoma. Gut 2022a;71:A21 LP-A23. https:\/\/doi.org\/10.1136\/gutjnl-2022-IDDF.24.","DOI":"10.1136\/gutjnl-2022-IDDF.24"},{"key":"10.1016\/j.critrevonc.2025.104907_bib170","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12951-021-01034-9","article-title":"Atovaquone-HSA nano-drugs enhance the efficacy of PD-1 blockade immunotherapy by alleviating hypoxic tumor microenvironment","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib171","article-title":"Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib172","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.molcel.2020.09.006","article-title":"Amino acids and their transporters in t cell immunity and cancer therapy","volume":"80","author":"Wang","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.critrevonc.2025.104907_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215350","article-title":"Photodynamic therapy combined with immunotherapy: recent advances and future research directions","volume":"495","author":"Warszy\u0144ska","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib174","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2217\/nnm-2023-0270","article-title":"Engineering Iron-Based nanomaterials for breast cancer therapy associated with ferroptosis","volume":"19","author":"Wei","year":"2024","journal-title":"Nanomedicine"},{"key":"10.1016\/j.critrevonc.2025.104907_bib175","unstructured":"Wei Zhenzhen, Jiang Yulang, Sun Mingyu, Yan Huaru, Wang Ziyuan, Suih. Research on the molecular mechanism of Zuo Jin Wan combined with cetuximab inducing ferroptosis in KRAS mutant colorectal cancer cells. Chinese J Clin Pharmacol Ther 2023.;28:130\u2013137."},{"key":"10.1016\/j.critrevonc.2025.104907_bib176","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1035276","article-title":"Current landscape and future directions of bispecific antibodies in cancer immunotherapy","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib177","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1021\/acs.chemrev.3c00409","article-title":"The promise and potential of Metal\u2013Organic frameworks and covalent organic frameworks in vaccine nanotechnology","volume":"124","author":"Wijesundara","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110188","article-title":"Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells","volume":"761","author":"Wu","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.critrevonc.2025.104907_bib179","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303894","article-title":"Taurine inhibits ferroptosis mediated by the crosstalk between tumor cells and tumor-associated macrophages in prostate cancer","volume":"11","author":"Xiao","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib180","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153247","article-title":"IL-9\/STAT3\/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity","volume":"132","author":"Xiao","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.critrevonc.2025.104907_bib181","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1021\/jacs.1c09753","article-title":"Phototheranostic Metal-Phenolic networks with antiexosomal PD-L1 enhanced ferroptosis for synergistic immunotherapy","volume":"144","author":"Xie","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.critrevonc.2025.104907_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216732","article-title":"Acidosis activates breast cancer ferroptosis through ZFAND5\/SLC3A2 signaling axis and elicits M1 macrophage polarization","volume":"587","author":"Xiong","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib183","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.critrevonc.2025.104907_bib184","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molmed.2021.06.014","article-title":"Ferroptosis in the tumor microenvironment: perspectives for immunotherapy","volume":"27","author":"Xu","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib185","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jconrel.2022.09.051","article-title":"Bio-inspired engineered ferritin-albumin nanocomplexes for targeted ferroptosis therapy","volume":"351","author":"Xue","year":"2022","journal-title":"J. Control Release"},{"key":"10.1016\/j.critrevonc.2025.104907_bib186","article-title":"Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment","volume":"32","author":"Yan","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.critrevonc.2025.104907_bib187","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12964-024-01711-w","article-title":"Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance","volume":"22","author":"Yang","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.critrevonc.2025.104907_bib188","article-title":"Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ t cells for triple-negative breast cancer therapy","author":"Yang","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib189","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41419-021-04367-3","article-title":"Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2\/HO-1 signalling pathway in KRAS mutant colorectal cancer","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104907_bib190","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.3390\/cancers14235896","article-title":"ACSL3 and ACSL4, distinct roles in ferroptosis and cancers","volume":"14","author":"Yang","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.critrevonc.2025.104907_bib191","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41590-021-00996-0","article-title":"Selenium\u2013GPX4 axis protects follicular helper t cells from ferroptosis","volume":"22","author":"Yao","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib192","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000042406","article-title":"APOL6 as a potential biomarker of immuno-correlation and therapeutic prediction in cancer immunotherapy","volume":"104","author":"Yao","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.critrevonc.2025.104907_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113756","article-title":"Ginsenosides in cancer: a focus on the regulation of cell metabolism","volume":"156","author":"Yao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.critrevonc.2025.104907_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122803","article-title":"Regulatory mechanisms of amino acids in ferroptosis","volume":"351","author":"Yao","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216935","article-title":"CRISPR\/Cas9 screen reveals that targeting TRIM34 enhances ferroptosis sensitivity and augments immunotherapy efficacy in hepatocellular carcinoma","volume":"593","author":"Yao","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib196","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s12272-024-01516-y","article-title":"Ginsenoside Rg3 activates the immune function of CD8+\u2009T cells via circFOXP1-miR-4477a-PD-L1 axis to induce ferroptosis in gallbladder cancer","volume":"47","author":"Ye","year":"2024","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib197","article-title":"Arginine nanoparticles mediated closed-loop ferroptosis enhancement for t cell activity boosting in cancer immunotherapy","volume":"36","author":"Yin","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.critrevonc.2025.104907_bib198","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163577","article-title":"Copper deposited metal-phenolic networks enabled crosstalk between cuproptosis and ferroptosis for triple-negative breast cancer immunotherapy","volume":"515","author":"Yin","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib199","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS23-PO3-24-05","article-title":"Abstract PO3-24-05: cysteine metabolism related ferroptosis sensitivity in trastuzumab resistant HER2 positive breast cancer","volume":"84","author":"Yin","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/mc.23862","article-title":"M2 macrophage-derived exosomal circ_0088494 inhibits ferroptosis via promoting H3K4me1 modification of STEAP3 in cutaneous squamous cell carcinoma","volume":"64","author":"Yin","year":"2025","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.critrevonc.2025.104907_bib201","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/mc.23796","article-title":"M2 macrophage exosome-derived Apoc1 promotes ferroptosis resistance in osteosarcoma by inhibiting ACSF2 deubiquitination","volume":"63","author":"Yin","year":"2024","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.critrevonc.2025.104907_bib202","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41420-025-02532-7","article-title":"miR-139-5p activates ferroptosis by inhibiting the expression of HMG-CoA reductase to inhibit the progression of glioma","volume":"11","author":"You","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.critrevonc.2025.104907_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216207","article-title":"Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy","volume":"522","author":"Yousefiasl","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.critrevonc.2025.104907_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121724","article-title":"Iron-based nanoscale coordination polymers synergistically induce immunogenic ferroptosis by blocking dihydrofolate reductase for cancer immunotherapy","volume":"288","author":"Yu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.critrevonc.2025.104907_bib205","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13644","article-title":"Targeting novel regulated cell death: ferroptosis, pyroptosis and necroptosis in anti-PD-1\/PD-L1 cancer immunotherapy","volume":"57","author":"Yu","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.critrevonc.2025.104907_bib206","article-title":"An Iron-Polyphenol decorated siRNA-Encapsulated nanomedicine multifacetedly promoted macrophage phagocytosis for synergistic Ferroptosis-Immunotherapy","author":"Yu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib207","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3892\/or.2022.8308","article-title":"IFN\u03b3 enhances ferroptosis by increasing JAK\u2011STAT pathway activation to suppress SLCA711 expression in adrenocortical carcinoma","volume":"47","author":"Yu","year":"2022","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.critrevonc.2025.104907_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101160","article-title":"Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers","volume":"77","author":"Yuan","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.critrevonc.2025.104907_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib210","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13111785","article-title":"Nanoparticles for ferroptosis therapy in cancer","volume":"13","author":"Zaffaroni","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.critrevonc.2025.104907_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2025.114018","article-title":"Organic small molecule for malignant tumor photothermal \/ photodynamic and immunotherapy via apoptosis and ferroptosis","volume":"234","author":"Zeng","year":"2025","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib212","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152675","article-title":"Ferroptosis-induced immunomodulation with biometabolic MOF@COF nanovaccine for self-boosting anti-tumor immunotherapy","volume":"493","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.critrevonc.2025.104907_bib213","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1021\/acsnano.3c01527","article-title":"A Vanadium-Based nanoplatform synergizing Ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.critrevonc.2025.104907_bib214","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2022.10.004","article-title":"Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase","volume":"193","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.critrevonc.2025.104907_bib215","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41419-022-05176-y","article-title":"Ischemia and reperfusion injury combined with cisplatin induces immunogenic cell death in lung cancer cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.critrevonc.2025.104907_bib216","article-title":"Endogenous\/exogenous dual-responsive nanozyme for photothermally enhanced ferroptosis-immune reciprocal synergistic tumor therapy","volume":"11","author":"Zhang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.critrevonc.2025.104907_bib217","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1039\/D4TB02125H","article-title":"Combination of adenosine blockade and ferroptosis for photo-immunotherapy of triple negative breast cancer with aptamer-modified copper sulfide","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.critrevonc.2025.104907_bib218","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1021\/acsami.4c16568","article-title":"Biodegradable Vanadium-Based nanomaterials for Photothermal-Enhanced tumor ferroptosis and pyroptosis","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.critrevonc.2025.104907_bib219","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1038\/s41467-023-41121-z","article-title":"Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104907_bib220","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2147\/JIR.S499403","article-title":"The benefits and safety of monoclonal antibodies: implications for cancer immunotherapy","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.critrevonc.2025.104907_bib221","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20240275","article-title":"Spatial isolation of single Copper(I) sites for cascade enzyme-like catalysis and simultaneous Ferroptosis\/Cuproptosis boosted immunotherapy","author":"Zhang","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.critrevonc.2025.104907_bib222","doi-asserted-by":"crossref","first-page":"21268","DOI":"10.1021\/acsnano.4c05084","article-title":"Biomineralization-tuned nanounits reprogram the signal transducer and activator of transcription 3 signaling for Ferroptosis-Immunotherapy in cancer stem cells","volume":"18","author":"Zhao","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.critrevonc.2025.104907_bib223","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1021\/jacs.4c13241","article-title":"A second near-infrared window-responsive metal\u2013organic-framework-based photosensitizer for tumor immunotherapy via synergistic ferroptosis and STING activation","volume":"147","author":"Zhao","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.critrevonc.2025.104907_bib224","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/s41401-022-00917-3","article-title":"Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1\/NRF2 and CBS-regulated ferroptosis","volume":"43","author":"Zheng","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.critrevonc.2025.104907_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216152","article-title":"Ferroptosis: promising approach for cancer and cancer immunotherapy","volume":"561","author":"Zheng","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.critrevonc.2025.104907_bib226","article-title":"PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation","author":"Zheng","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib227","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202301928","article-title":"PGAM1 inhibition promotes HCC ferroptosis and synergizes with Anti-PD-1 immunotherapy","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib228","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.888570","article-title":"Ferroptosis-related molecular patterns reveal immune escape, inflammatory development and lipid metabolism characteristics of the tumor microenvironment in acute myeloid leukemia","volume":"12","author":"Zhong","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib229","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1080\/16078454.2021.1996055","article-title":"Prognostic significance of ferroptosis-related genes and their methylation in AML","volume":"26","author":"Zhou","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.critrevonc.2025.104907_bib230","article-title":"Photo-enhanced synergistic induction of ferroptosis for Anti-Cancer immunotherapy","volume":"12","author":"Zhou","year":"2023","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.critrevonc.2025.104907_bib231","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s11427-023-2472-4","article-title":"Hemin blocks TIGIT\/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy","volume":"67","author":"Zhou","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.critrevonc.2025.104907_bib232","article-title":"Cisplatin promotes the efficacy of immune checkpoint inhibitor therapy by inducing ferroptosis and activating neutrophils","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib233","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.apsb.2021.07.016","article-title":"Abrogation of HnRNP l enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8(+) t cell-mediated ferroptosis in castration-resistant prostate cancer","volume":"12","author":"Zhou","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.critrevonc.2025.104907_bib234","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.2000500","article-title":"Asah2 represses the p53-Hmox1 axis to protect Myeloid-Derived suppressor cells from ferroptosis","volume":"206","author":"Zhu","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib235","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2174\/1566523218666180214092536","article-title":"CX3CL1\/CX3CR1 axis, as the therapeutic potential in renal diseases: friend or foe?","volume":"17","author":"Zhuang","year":"2017","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.critrevonc.2025.104907_bib236","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23464","article-title":"Analysis of lncRNAs profiles associated with ferroptosis can predict prognosis and immune landscape and drug sensitivity in patients with clear cell renal cell carcinoma","volume":"37","author":"Zong","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.critrevonc.2025.104907_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101126","article-title":"crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer","volume":"77","author":"Zou","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.critrevonc.2025.104907_bib238","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110051","article-title":"Antitumor activity of dictamnine against colorectal cancer through induction of ferroptosis and inhibition of M2 macrophage polarization via the MAPK signaling","volume":"758","author":"Zuo","year":"2024","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825002951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825002951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:20:45Z","timestamp":1758590445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842825002951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":238,"alternative-id":["S1040842825002951"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104907","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis and immunotherapy: Breaking barriers in cancer treatment resistance","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104907"}}