{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:08:26Z","timestamp":1791302906588,"version":"4.1.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["494"],"award-info":[{"award-number":["494"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["448"],"award-info":[{"award-number":["448"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["463"],"award-info":[{"award-number":["463"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.critrevonc.2025.104977","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:28Z","timestamp":1760145148000},"page":"104977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review"],"prefix":"10.1016","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-0593","authenticated-orcid":false,"given":"Melissa","family":"Bolier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie J.M.","family":"van Leerdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Broer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lotte F.","family":"van der Kooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Masroor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel W.","family":"van Gijzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"Streefkerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S.P.","family":"Wens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demi T.C.","family":"de Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Zolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.H.","family":"Coenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen L.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J.C.M.M.","family":"Neggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-879X","authenticated-orcid":false,"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2025.104977_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2217\/pgs-2018-0169","article-title":"Identification of a single-nucleotide polymorphism within CDH2 gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors","volume":"20","author":"Aaron","year":"2019","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.critrevonc.2025.104977_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109324","article-title":"Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4","volume":"183","author":"Arab","year":"2024","journal-title":"Comput. Biol. Med"},{"key":"10.1016\/j.critrevonc.2025.104977_bib3","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1200\/JCO.2013.49.3205","article-title":"Modifiable risk factors and major cardiac events among adult survivors of childhood cancer","volume":"31","author":"Armstrong","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib4","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051280","article-title":"Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity","volume":"22","author":"Babolmorad","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.critrevonc.2025.104977_bib5","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0140-6736(17)31610-0","article-title":"The cumulative burden of surviving childhood cancer: an initial report from the st jude lifetime cohort study (SJLIFE)","volume":"390","author":"Bhakta","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175711","article-title":"Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines","volume":"12","author":"Bhavsar","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.critrevonc.2025.104977_bib7","article-title":"Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors: a replication study of variants associated with dyslipidemia","author":"Bolier","year":"2025","journal-title":"Manuscr. Submitt. Publ. BMC Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.30248","article-title":"Sodium thiosulfate as cisplatin otoprotectant in children: the challenge of when to use it","volume":"70","author":"Brock","year":"2023","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jnci\/djx281","article-title":"A High-risk haplotype for premature menopause in childhood cancer survivors exposed to gonadotoxic therapy","volume":"110","author":"Brooke","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.critrevonc.2025.104977_bib10","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/cam4.516","article-title":"SOD2 genetic variant associated with treatment-related ototoxicity in cisplatin-treated pediatric medulloblastoma","volume":"4","author":"Brown","year":"2015","journal-title":"Cancer Med."},{"key":"10.1016\/j.critrevonc.2025.104977_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/447655a","article-title":"Replicating genotype-phenotype associations","volume":"447","author":"Chanock","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104977_bib12","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1097\/MPH.0b013e3182707fc5","article-title":"Cisplatin-induced ototoxicity in pediatric solid tumors: the role of glutathione S-transferases and megalin genetic polymorphisms","volume":"35","author":"Choeyprasert","year":"2013","journal-title":"J. Pedia Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib13","doi-asserted-by":"crossref","first-page":"10688","DOI":"10.1038\/s41598-021-89176-6","article-title":"GWAS of allometric body-shape indices in UK biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer","volume":"11","author":"Christakoudi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.critrevonc.2025.104977_bib14","first-page":"294","article-title":"Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: the international PanCareLIFE study","volume":"20","author":"Clemens","year":"2020","journal-title":"Pharm. J."},{"key":"10.1016\/j.critrevonc.2025.104977_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.critrevonc.2018.04.001","article-title":"The influence of genetic variation on late toxicities in childhood cancer survivors: a review","volume":"126","author":"Clemens","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.critrevonc.2018.04.001","article-title":"The influence of genetic variation on late toxicities in childhood cancer survivors: a review","volume":"126","author":"Clemens","year":"2018","journal-title":"Crit. Rev. Oncol. \/Hematol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrg2751","article-title":"Genome-wide association studies in pharmacogenomics","volume":"11","author":"Daly","year":"2010","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.3412","article-title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","volume":"47","author":"Day","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib19","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1002\/pbc.26198","article-title":"Genetic variation and bone mineral density in long-term adult survivors of childhood cancer","volume":"63","author":"den Hoed","year":"2016","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Conte Clin. Trials"},{"key":"10.1016\/j.critrevonc.2025.104977_bib21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s40272-022-00532-z","article-title":"Phentermine\/Topiramate: pediatric first approval","volume":"24","author":"Dhillon","year":"2022","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.critrevonc.2025.104977_bib22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(22)02471-0","article-title":"Specific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the childhood cancer survivor study cohort","volume":"401","author":"Dixon","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib23","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1073\/pnas.0807219105","article-title":"A catechol-O-methyltransferase that is essential for auditory function in mice and humans","volume":"105","author":"Du","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.critrevonc.2025.104977_bib24","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41467-019-11112-0","article-title":"Analysis of polygenic risk score usage and performance in diverse human populations","volume":"10","author":"Duncan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.critrevonc.2025.104977_bib25","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1186\/s12885-017-3722-6","article-title":"Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors","volume":"17","author":"England","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2020.101733","article-title":"Childhood cancer: survival, treatment modalities, late effects and improvements over time","volume":"71","author":"Erdmann","year":"2021","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat. Genet"},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104977_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003152","article-title":"Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study","volume":"17","author":"Forgetta","year":"2020","journal-title":"PLos Med"},{"key":"10.1016\/j.critrevonc.2025.104977_bib29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.critrevonc.2025.104977_bib30","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1113\/jphysiol.2013.267914","article-title":"A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells","volume":"592","author":"Fuchs","year":"2014","journal-title":"J Physiol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib31","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.fertnstert.2005.03.070","article-title":"Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in Male infertility and the polygenic nature of the pathology","volume":"84","author":"Galan","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.critrevonc.2025.104977_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5--a population-based study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jbmr\/zjad013","article-title":"Genetic susceptibility and late bone outcomes in childhood acute lymphoblastic leukemia survivors","volume":"39","author":"Genevi\u00e8ve","year":"2024","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.critrevonc.2025.104977_bib34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1517\/17425255.2010.487861","article-title":"Oxazaphosphorines: new therapeutic strategies for an old class of drugs","volume":"6","author":"Giraud","year":"2010","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-med-041916-124328","article-title":"Evidence for genetic risk contributing to Long-Term adverse treatment effects in childhood cancer survivors","volume":"69","author":"Gramatges","year":"2018","journal-title":"Annu Rev. Med."},{"key":"10.1016\/j.critrevonc.2025.104977_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1096-203","article-title":"Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene","volume":"14","author":"Grant","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib37","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/humrep\/dei439","article-title":"Estrogen receptor \u03b1 promoter polymorphism: stronger estrogen action is coupled with lower sperm count","volume":"21","author":"Guarducci","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.critrevonc.2025.104977_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115869","article-title":"Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts","volume":"9","author":"Hagleitner","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.critrevonc.2025.104977_bib39","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng.385","article-title":"Genome-wide association studies identify loci associated with age at menarche and age at natural menopause","volume":"41","author":"He","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib40","article-title":"Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: results of GO-CAT and United Kingdom MAGIC consortia","volume":"13","author":"Hurkmans","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.critrevonc.2025.104977_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jbmr.4234","article-title":"Genome-wide association studies reveal novel locus with Sex-\/Therapy-Specific fracture risk effects in childhood cancer survivors","volume":"36","author":"Im","year":"2021","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.critrevonc.2025.104977_bib42","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S1470-2045(23)00510-7","article-title":"Development and validation of age-specific risk prediction models for primary ovarian insufficiency in long-term survivors of childhood cancer: a report from the childhood cancer survivor study and st jude lifetime cohort","volume":"24","author":"Im","year":"2023","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41431-017-0050-x","article-title":"Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors","volume":"26","author":"Im","year":"2018","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib44","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1200\/JCO.23.02281","article-title":"Trans-Ancestral genetic risk factors for Treatment-Related type 2 diabetes mellitus in survivors of childhood cancer","volume":"42","author":"Im","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib45","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajhg.2020.08.014","article-title":"Generalizability of \"GWAS hits\" in clinical populations: lessons from childhood cancer survivors","volume":"107","author":"Im","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0020124","article-title":"Why most published research findings are false","volume":"2","author":"Ioannidis","year":"2005","journal-title":"PLoS Med"},{"key":"10.1016\/j.critrevonc.2025.104977_bib47","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib48","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1200\/JCO.2007.14.6399","article-title":"CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia","volume":"26","author":"Jones","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104977_bib49","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2019.03.028","article-title":"Polygenic prediction of weight and obesity trajectories from birth to adulthood","volume":"177","author":"Khera","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2025.104977_bib50","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","article-title":"Genetics of blood lipids among \u223c300,000 multi-ethnic participants of the million veteran program","volume":"50","author":"Klarin","year":"2018","journal-title":"Nat. Genet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib51","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1200\/JCO.2016.69.2319","article-title":"Group-Wide, prospective study of ototoxicity assessment in children receiving cisplatin chemotherapy (ACCL05C1): a report from the children's oncology group","volume":"35","author":"Knight","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib52","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/EDE.0b013e318181b865","article-title":"Curses--winner's and otherwise--in genetic epidemiology","volume":"19","author":"Kraft","year":"2008","journal-title":"Epidemiology"},{"key":"10.1016\/j.critrevonc.2025.104977_bib53","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/s41436-020-0884-4","article-title":"Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort","volume":"22","author":"Lakeman","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.critrevonc.2025.104977_bib54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1200\/JCO.2013.51.2038","article-title":"Ototoxicity in children with high-risk neuroblastoma: prevalence, risk factors, and concordance of grading scales--a report from the children's oncology group","volume":"32","author":"Landier","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib55","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejca.2020.07.019","article-title":"Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: results of the european PanCareLIFE cohort study","volume":"138","author":"Langer","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib56","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2217\/pgs.14.182","article-title":"Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity","volume":"16","author":"Lanvers-Kaminsky","year":"2015","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.critrevonc.2025.104977_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpet.2024.100057","article-title":"TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer","volume":"392","author":"Lee","year":"2025","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.critrevonc.2025.104977_bib58","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/FTD.0000000000000298","article-title":"Clinical practice recommendations for the management and prevention of Cisplatin-Induced hearing loss using pharmacogenetic markers","volume":"38","author":"Lee","year":"2016","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.critrevonc.2025.104977_bib59","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s12094-018-1964-7","article-title":"Contribution of the GSTP1c.313A>G variant to hearing loss risk in patients exposed to platin chemotherapy during childhood","volume":"21","author":"Liberman","year":"2019","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib60","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/gepi.20410","article-title":"STrengthening the REporting of genetic association studies (STREGA)--an extension of the STROBE statement","volume":"33","author":"Little","year":"2009","journal-title":"Genet Epidemiol."},{"issue":"7538","key":"10.1016\/j.critrevonc.2025.104977_bib61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104977_bib62","doi-asserted-by":"crossref","first-page":"19952","DOI":"10.1074\/jbc.R117.819060","article-title":"Asparagine synthetase: function, structure, and role in disease","volume":"292","author":"Lomelino","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.critrevonc.2025.104977_bib63","first-page":"S642","article-title":"Association between genetic polymorphisms and Platinum-Induced ototoxicity in children","volume":"65","author":"Lui","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib64","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1200\/JCO.23.02353","article-title":"Use of sodium thiosulfate as an otoprotectant in patients with cancer treated with platinum compounds: a review of the literature","volume":"42","author":"Meijer","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41698-021-00178-z","article-title":"TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study","volume":"5","author":"Meijer","year":"2021","journal-title":"NPJ Precis Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib66","doi-asserted-by":"crossref","first-page":"1336714","DOI":"10.3389\/fonc.2024.1336714","article-title":"Prevention of cisplatin-induced hearing loss in children: achievements and challenges for evidence-based implementation of sodium thiosulfate","volume":"14","author":"Meijer","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040028","article-title":"Most published research findings are false-but a little replication goes a long way","volume":"4","author":"Moonesinghe","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.critrevonc.2025.104977_bib68","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJMoa012752","article-title":"Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism","volume":"347","author":"Moreno","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.critrevonc.2025.104977_bib69","first-page":"33","article-title":"Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors","volume":"12","author":"Nadeau","year":"2019","journal-title":"Pharmgenomics Pers. Med"},{"key":"10.1016\/j.critrevonc.2025.104977_bib70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijporl.2016.09.001","article-title":"Analysis of genetic and non genetic risk factors for cisplatin ototoxicity in pediatric patients","volume":"90","author":"Olgun","year":"2016","journal-title":"Int J. Pedia Otorhinolaryngol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s43042-020-00083-3","article-title":"Polymorphism and neurological complications in pediatric acute lymphoblastic leukemia patients and their associations with altered bone mineral density","volume":"21","author":"Omran","year":"2020","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib72","first-page":"180","article-title":"A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment","volume":"17","author":"Park","year":"2017","journal-title":"Pharm. J."},{"key":"10.1016\/j.critrevonc.2025.104977_bib73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/clpt.2013.80","article-title":"Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children","volume":"94","author":"Pussegoda","year":"2013","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.critrevonc.2025.104977_bib74","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/pbc.24366","article-title":"Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma","volume":"60","author":"Rednam","year":"2013","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib75","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/cpt.1304","article-title":"Clinical pharmacogenetics implementation consortium guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update","volume":"105","author":"Relling","year":"2019","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.critrevonc.2025.104977_bib76","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/cncr.33258","article-title":"Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study and the st. Jude lifetime cohort","volume":"127","author":"Richard","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib77","article-title":"Germline genetic and Treatment-Related risk factors for diabetes mellitus in survivors of childhood cancer: a report from the childhood cancer survivor study and st jude lifetime cohorts","volume":"6","author":"Richard","year":"2022","journal-title":"JCO Precis Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib78","first-page":"23","article-title":"Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin","volume":"8","author":"Riedemann","year":"2008","journal-title":"Pharm. J."},{"key":"10.1016\/j.critrevonc.2025.104977_bib79","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/FPC.0b013e328343a132","article-title":"Estrogen receptor alpha single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors","volume":"21","author":"Romerius","year":"2011","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.critrevonc.2025.104977_bib80","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ng.478","article-title":"Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy","volume":"41","author":"Ross","year":"2009","journal-title":"Nat. Genet"},{"key":"10.1016\/j.critrevonc.2025.104977_bib81","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1200\/JCO.2004.11.152","article-title":"Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study","volume":"22","author":"Ross","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib82","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaccao.2021.01.007","article-title":"Contribution of polygenic risk to hypertension among Long-Term survivors of childhood cancer","volume":"3","author":"Sapkota","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.critrevonc.2025.104977_bib83","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/s41591-022-01902-3","article-title":"Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer","volume":"28","author":"Sapkota","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.critrevonc.2025.104977_bib84","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1158\/0008-5472.CAN-20-0093","article-title":"A novel locus predicts spermatogenic recovery among childhood cancer survivors exposed to alkylating agents","volume":"80","author":"Sapkota","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.critrevonc.2025.104977_bib85","doi-asserted-by":"crossref","first-page":"7495234","DOI":"10.1155\/2018\/7495234","article-title":"Cardiovascular risk factors after childhood cancer treatment are independent of the FTO gene polymorphism?","volume":"2018","author":"Sawicka-Zukowska","year":"2018","journal-title":"Int J. Endocrinol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/805312","article-title":"Does Q223R polymorphism of leptin receptor influence on anthropometric parameters and bone density in childhood cancer survivors?","volume":"2013","author":"Sawicka-Zukowska","year":"2013","journal-title":"Int J. Endocrinol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib87","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/ijc.30080","article-title":"Cause-specific long-term mortality in survivors of childhood cancer in Switzerland: a population-based study","volume":"139","author":"Schindler","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib88","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/FTD.0000000000001113","article-title":"Systematic critical review of genetic factors associated with Cisplatin-induced ototoxicity: Canadian pharmacogenomics network for drug safety 2022 update","volume":"45","author":"Scott","year":"2023","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.critrevonc.2025.104977_bib89","first-page":"19","article-title":"Genetic factors contributing to late adverse musculoskeletal effects in childhood acute lymphoblastic leukemia survivors","volume":"22","author":"Shalmiev","year":"2022","journal-title":"Pharm. J."},{"key":"10.1016\/j.critrevonc.2025.104977_bib90","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031627","article-title":"Platinum-induced ototoxicity in pediatric cancer survivors: GSTP1c.313A>G variant association","volume":"101","author":"Sherief","year":"2022","journal-title":"Medicine"},{"key":"10.1016\/j.critrevonc.2025.104977_bib91","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/FTD.0000000000001085","article-title":"Role of cisplatin dose intensity and TPMT variation in the development of hearing loss in children","volume":"45","author":"Siemens","year":"2023","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.critrevonc.2025.104977_bib92","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12041-011-0089-3","article-title":"Homozygosity for the rs9939609T allele of the FTO gene May have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia","volume":"90","author":"Skoczen","year":"2011","journal-title":"J. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib93","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1756-9966-30-64","article-title":"Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > a and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia","volume":"30","author":"Skoczen","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.critrevonc.2025.104977_bib94","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature13138","article-title":"Obesity-associated variants within FTO form long-range functional connections with IRX3","volume":"507","author":"Smemo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104977_bib95","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26931","article-title":"Clinical and genetic associations for carboplatin-related ototoxicity in children treated for retinoblastoma: a retrospective noncomparative single-institute experience","volume":"65","author":"Soliman","year":"2018","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib96","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.fertnstert.2009.03.034","article-title":"Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors","volume":"94","author":"Su","year":"2010","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.critrevonc.2025.104977_bib97","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1470-2045(19)30800-9","article-title":"Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study","volume":"21","author":"Suh","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib98","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MPH.0b013e3181dccc0b","article-title":"Impaired glucose tolerance and insulin resistance in survivors of childhood acute lymphoblastic leukemia: prevalence and risk factors","volume":"32","author":"Surapolchai","year":"2010","journal-title":"J. Pedia Hematol. Oncol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib99","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-024-07019-6","article-title":"Genetic drivers of heterogeneity in type 2 diabetes pathophysiology","volume":"627","author":"Suzuki","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104977_bib100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bone.2010.10.163","article-title":"Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study","volume":"48","author":"te Winkel","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.critrevonc.2025.104977_bib101","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3324\/haematol.2009.016303","article-title":"Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia","volume":"95","author":"te Winkel","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.critrevonc.2025.104977_bib102","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/FPC.0000000000000281","article-title":"TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity","volume":"27","author":"Thiesen","year":"2017","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.critrevonc.2025.104977_bib103","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1002\/cncr.33775","article-title":"Clinical and genetic risk factors for radiation-associated ototoxicity: a report from the childhood cancer survivor study and the st. Jude lifetime cohort","volume":"127","author":"Trendowski","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib104","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00280-019-03968-2","article-title":"Cisplatin ototoxicity in children: risk factors and its relationship with polymorphisms of DNA repair genes ERCC1, ERCC2, and XRCC1","volume":"84","author":"Turan","year":"2019","journal-title":"Cancer Chemother. Pharm."},{"issue":"7","key":"10.1016\/j.critrevonc.2025.104977_bib105","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41588-019-0447-2","article-title":"Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity","volume":"51","author":"Turcot","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib106","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S2213-8587(22)00286-8","article-title":"Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study","volume":"11","author":"van Atteveld","year":"2023","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.critrevonc.2025.104977_bib107","unstructured":"Van den Heuvel-Eibrink, M. (2025). Figure 1. Created in Biorender: https:\/\/ BioRender.com\/zujaxdf."},{"key":"10.1016\/j.critrevonc.2025.104977_bib108","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/humrep\/deaa342","article-title":"Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function","volume":"36","author":"van der Kooi","year":"2021","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.critrevonc.2025.104977_bib109","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/humrep\/deaa342","article-title":"Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function","volume":"36","author":"van der Kooi","year":"2021","journal-title":"Hum Reprod."},{"key":"10.1016\/j.critrevonc.2025.104977_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184598","article-title":"Effect of genetic variation in CYP450 on gonadal impairment in a european cohort of female childhood cancer survivors, based on a candidate gene approach: results from the PanCareLIFE study","volume":"13","author":"van der Perk","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.critrevonc.2025.104977_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2024.05.002","article-title":"Inter-individual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE","author":"van der Perk","year":"2024","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.critrevonc.2025.104977_bib112","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/humrep\/des472","article-title":"Genetic variation May modify ovarian reserve in female childhood cancer survivors","volume":"28","author":"van Dorp","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.critrevonc.2025.104977_bib113","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ejca.2012.09.007","article-title":"Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors","volume":"49","author":"van Waas","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib114","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/FPC.0000000000000212","article-title":"Replication of a genetic variant in ACYP2 associated with cisplatin-induced hearing loss in patients with osteosarcoma","volume":"26","author":"Vos","year":"2016","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.critrevonc.2025.104977_bib115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03243-6","article-title":"Improving reporting standards for polygenic scores in risk prediction studies","volume":"591","author":"Wand","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2025.104977_bib116","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cpt.2350","article-title":"An Evidence-Based framework for evaluating pharmacogenomics knowledge for personalized Medicine","volume":"110","author":"Whirl-Carrillo","year":"2021","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.critrevonc.2025.104977_bib117","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/cncr.29153","article-title":"Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: a report from the st. Jude lifetime cohort","volume":"121","author":"Wilson","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.critrevonc.2025.104977_bib118","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng.3217","article-title":"Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss","volume":"47","author":"Xu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.critrevonc.2025.104977_bib119","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/clpt.2013.121","article-title":"The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer","volume":"94","author":"Yang","year":"2013","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.critrevonc.2025.104977_bib120","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in \u223c700000 individuals of european ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum. Mol. Genet"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825003658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842825003658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:24:46Z","timestamp":1773296686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842825003658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":120,"alternative-id":["S1040842825003658"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104977","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104977"}}