{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:12:39Z","timestamp":1784581959850,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFAA069334"],"award-info":[{"award-number":["2025GXNSFAA069334"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.critrevonc.2026.105157","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:52:45Z","timestamp":1769442765000},"page":"105157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer"],"prefix":"10.1016","volume":"220","author":[{"given":"Wenxuan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-994X","authenticated-orcid":false,"given":"Xueni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00401-004-0956-6","article-title":"Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma","volume":"109","author":"Arakawa","year":"2005","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105157_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/gutjnl-2024-332504","article-title":"Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD","volume":"74","author":"Bamias","year":"2025","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00018-016-2355-2","article-title":"Death receptor 3 mediates necroptotic cell death","volume":"74","author":"Bittner","year":"2017","journal-title":"Cell Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/febs.13576","article-title":"Soluble TL1A is sufficient for activation of death receptor 3","volume":"283","author":"Bittner","year":"2016","journal-title":"Febs J."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jcp.20812","article-title":"Death receptor-3 mediates apoptosis in human osteoblasts under narrowly regulated conditions","volume":"209","author":"Borysenko","year":"2006","journal-title":"J. Cell Physiol."},{"issue":"31","key":"10.1016\/j.critrevonc.2026.105157_bib6","doi-asserted-by":"crossref","first-page":"32061","DOI":"10.18632\/oncotarget.5201","article-title":"Expression and function of the TL1A\/DR3 axis in chronic lymphocytic leukemia","volume":"6","author":"Cavallini","year":"2015","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105157_bib7","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.3390\/toxins6082210","article-title":"Cancer cell growth inhibitory effect of bee venom via increase of death receptor 3 expression and inactivation of NF-kappa B in NSCLC cells","volume":"6","author":"Choi","year":"2014","journal-title":"Toxins"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3892\/etm.2011.206","article-title":"Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer","volume":"2","author":"Ge","year":"2011","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105157_bib9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3892\/or.2013.2259","article-title":"Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro","volume":"29","author":"Ge","year":"2013","journal-title":"Oncol. Rep."},{"issue":"18","key":"10.1016\/j.critrevonc.2026.105157_bib10","doi-asserted-by":"crossref","first-page":"9117","DOI":"10.1158\/0008-5472.CAN-05-4605","article-title":"Death receptor-3, a new E-Selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation","volume":"66","author":"Gout","year":"2006","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/geno.1998.5300","article-title":"Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma","volume":"49","author":"Grenet","year":"1998","journal-title":"Genomics"},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105157_bib12","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3349\/ymj.2013.54.5.1186","article-title":"Growth inhibition of hepatocellular carcinoma Huh7 cells by Lactobacillus casei extract","volume":"54","author":"Han","year":"2013","journal-title":"Yonsei Med. J."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12929-017-0347-7","article-title":"Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions","volume":"24","author":"Hsieh","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114491","article-title":"ELAVL1 facilitates gastric cancer progression and metastasis through TL1A mRNA stabilization","volume":"446","author":"Jiang","year":"2025","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41573-022-00615-z","article-title":"Rational combinations of targeted cancer therapies: background, advances and challenges","volume":"22","author":"Jin","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6607","key":"10.1016\/j.critrevonc.2026.105157_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/384372a0","article-title":"A death-domain-containing receptor that mediates apoptosis","volume":"384","author":"Kitson","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib17","first-page":"167","article-title":"Epigenetic modulators hydralazine and sodium valproate act synergistically in VEGI-mediated anti-angiogenesis and VEGF interference in human osteosarcoma and vascular endothelial cells","volume":"55","author":"Kumanishi","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.critrevonc.2026.105157_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.fct.2013.07.068","article-title":"Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29","volume":"60","author":"Lee","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00204-014-1393-5","article-title":"Inhibitory effect of snake venom toxin on NF-\u03baB activity prevents human cervical cancer cell growth via increase of death receptor 3 and 5 expression","volume":"90","author":"Lee","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105157_bib20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1631\/jzus.B0920077","article-title":"DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters","volume":"10","author":"Liang","year":"2009","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.critrevonc.2026.105157_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156540","article-title":"The ever-expanding role of cytokine receptor DR3 in T cells","volume":"176","author":"Liman","year":"2024","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105157_bib22","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/ptr.5430","article-title":"Anti-lung cancer effects of polyphyllin VI and VII potentially correlate with apoptosis in vitro and in vivo","volume":"29","author":"Lin","year":"2015","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00018-023-04726-7","article-title":"The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells","volume":"80","author":"Luo","year":"2023","journal-title":"Cell Mol. Life Sci."},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105157_bib24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1593\/neo.08626","article-title":"Decoy receptor 3 is a prognostic factor in renal cell cancer","volume":"10","author":"Macher-Goeppinger","year":"2008","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-065X.2011.01068.x","article-title":"TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation","volume":"244","author":"Meylan","year":"2011","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105157_bib26","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/ijc.24628","article-title":"Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB","volume":"125","author":"Murtaza","year":"2009","journal-title":"Int J. Cancer"},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105157_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/BJ20051814","article-title":"MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis","volume":"396","author":"Nishito","year":"2006","journal-title":"Biochem J."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24392","article-title":"TL1A promotes metastasis and EMT process of colorectal cancer","volume":"10","author":"Niu","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105157_bib29","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1007\/s10620-018-5126-0","article-title":"Tumor necrosis factor ligand-related molecule 1A regulates the occurrence of colitis-associated colorectal cancer","volume":"63","author":"Niu","year":"2018","journal-title":"Dig. Dis. Sci."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.canlet.2014.07.007","article-title":"Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3","volume":"353","author":"Oh","year":"2014","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2567.2011.03513.x","article-title":"Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3","volume":"135","author":"Park","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.critrevonc.2026.105157_bib32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/1471-2407-11-285","article-title":"Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NF\u03baB survival axis downstream of Death receptor-3","volume":"11","author":"Porquet","year":"2011","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105157_bib33","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41422-018-0018-6","article-title":"Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells","volume":"28","author":"Qi","year":"2018","journal-title":"Cell Res."},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105157_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093347","article-title":"The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens","volume":"21","author":"Rodriguez-Barbosa","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/1568009043481597","article-title":"Death receptors as targets of cancer therapeutics","volume":"4","author":"Sheikh","year":"2004","journal-title":"Curr. Cancer Drug Targets"},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105157_bib36","first-page":"2441","article-title":"Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: important new factors in mucosal homeostasis and inflammation","volume":"21","author":"Siakavellas","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105157_bib37","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/eji.201141477","article-title":"Triggering of TNFRSF25 promotes CD8\u207a T-cell responses and anti-tumor immunity","volume":"41","author":"Slebioda","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105157_bib38","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00432-020-03258-y","article-title":"The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients","volume":"146","author":"Strizova","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105157_bib39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1134\/S0026893313050208","article-title":"DR3\/LARD mRNA spliced variants' frequency at colorectal cancer","volume":"47","author":"Utkin","year":"2013","journal-title":"Mol. Biol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcb.22735","article-title":"Recombinant vascular basement membrane derived multifunctional peptide blocks endothelial cell angiogenesis and neovascularization","volume":"111","author":"Wang","year":"2010","journal-title":"J. Cell Biochem."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib41","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/bbrc.1997.7948","article-title":"A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas","volume":"242","author":"Warzocha","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.critrevonc.2026.105157_bib42","article-title":"Role of TL1A in inflammatory autoimmune diseases: a comprehensive review","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105157_bib43","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3892\/ijo.2015.2924","article-title":"Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells","volume":"46","author":"Yamanegi","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3892\/or.2017.5685","article-title":"DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression","volume":"38","author":"Zhang","year":"2017","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib45","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3892\/mmr.2014.2858","article-title":"The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.critrevonc.2026.105157_bib46","article-title":"TL1A\/DR3 Axis, A Key Target of TNF-a, augments the epithelial-mesenchymal transformation of epithelial cells in OVA-Induced Asthma","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4168\/aair.2022.14.2.233","article-title":"The TL1A-DR3 Axis in Asthma: membrane-bound and secreted TL1A co-determined the development of airway remodeling","volume":"14","author":"Zhang","year":"2022","journal-title":"Allergy Asthma Immunol. Res."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105157_bib48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/07357900802210745","article-title":"Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells","volume":"27","author":"Zhang","year":"2009","journal-title":"Cancer Invest"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105157_bib49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12931-023-02488-1","article-title":"Identification of a novel role for TL1A\/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption","volume":"24","author":"Zhang","year":"2023","journal-title":"Respir. Res."},{"issue":"39","key":"10.1016\/j.critrevonc.2026.105157_bib50","doi-asserted-by":"crossref","first-page":"41929","DOI":"10.18632\/oncotarget.5861","article-title":"E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice","volume":"6","author":"Zheng","year":"2015","journal-title":"Oncotarget"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826000442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826000442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:52:52Z","timestamp":1776973972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842826000442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S1040842826000442"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105157","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105157"}}