{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:06:41Z","timestamp":1780038401696,"version":"3.53.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.critrevonc.2026.105332","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:31:17Z","timestamp":1775896277000},"page":"105332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Salivary phosphate: A promising non-invasive biomarker for oral and systemic disease screening"],"prefix":"10.1016","volume":"223","author":[{"given":"John N.","family":"Cauba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Samaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Salinas","family":"De Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Razzaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushfiq H.","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.critrevonc.2026.105332_bib1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.6026\/973206300181021","article-title":"A review on salivary constituents and their role in diagnostics","volume":"18","author":"Abdul","year":"2022","journal-title":"Bioinformation"},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41581-022-00665-x","article-title":"A review on salivary constituents and their role in diagnostics","volume":"19","author":"Agoro","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.critrevonc.2026.105332_bib3","article-title":"Salivary metabolomics in oral cancer: A systematic review","volume":"11","author":"Antonelli","year":"2024","journal-title":"Oral. Oncol. Rep."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105332_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052634","article-title":"Salivary biomarkers for oral cancer detection: an exploratory systematic review","volume":"25","author":"Bast\u00edas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.critrevonc.2026.105332_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev-physiol-030212-183748","article-title":"Phosphate transporters and their function","volume":"75","author":"Biber","year":"2013","journal-title":"Annu Rev. Physiol."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ccm.2025.04.011","article-title":"Phosphate transporters and their function","volume":"46","author":"Bowerman","year":"2025","journal-title":"Clin. Chest Med."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.oraloncology.2010.10.009","article-title":"Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population","volume":"47","author":"Brinkmann","year":"2011","journal-title":"Oral. Oncol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbcan.2018.04.007","article-title":"Phosphate toxicity and tumorigenesis","volume":"1869","author":"Brown","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews Cancer"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78261-x","article-title":"A sensitive colorimetric probe for detection of the phosphate ion","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105332_bib10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.archoralbio.2004.05.001","article-title":"Validation of ion chromatography for human salivary anionic analysis","volume":"49","author":"Chen","year":"2004","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.critrevonc.2026.105332_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-4347(85)80040-2","article-title":"Determination of inorganic sulfate in human saliva and sweat by controlled-flow anion chromatography: Normal values in adult humans","volume":"337","author":"Cole","year":"1985","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105332_bib12","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1161\/ATVBAHA.113.302249","article-title":"Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2","volume":"33","author":"Crouthamel","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034518816961","article-title":"Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health","volume":"98","author":"Dawes","year":"2019","journal-title":"J. Dent. Res"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jchromb.2008.09.018","article-title":"Application of ion chromatography for the determination of inorganic ions, especially thiocyanates in human saliva samples as biomarkers of environmental tobacco smoke exposure","volume":"875","author":"Demkowska","year":"2008","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41569-023-00903-0","article-title":"FGF23 and klotho at the intersection of kidney and cardiovascular disease","volume":"21","author":"Edmonston","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105332_bib16","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","article-title":"Periodontitis in US Adults: National Health and Nutrition Examination Survey 2009-2014","volume":"149","author":"Eke","year":"2018","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.critrevonc.2026.105332_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4236\/jep.2016.72017","article-title":"Characterization of Crude Oil, Asphaltenes Based on Bismuth (Bi), Thorium (Th) and Uranium (U) Levels: Potential Environmental Impact","volume":"07","author":"Elhameed","year":"2016","journal-title":"J. Environ. Prot."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105332_bib18","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s00198-021-05975-7","article-title":"Diagnosis and management of osteoporosis in chronic kidney disease stages 4\u20135D: a call for a shift from nihilism to pragmatism","volume":"32","author":"Evenepoel","year":"2021","journal-title":"Osteoporos. Int"},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105332_bib19","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J. Clin. Invest"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib20","doi-asserted-by":"crossref","DOI":"10.4103\/0972-124X.118316","article-title":"Association of salivary calcium, phosphate, pH and flow rate on oral health: A study on 90 subjects","volume":"17","author":"Fiyaz","year":"2013","journal-title":"J. Indian Soc. Periodontol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mam.2012.07.007","article-title":"Phosphate transporters of the SLC20 and SLC34 families","volume":"34","author":"Forster","year":"2013","journal-title":"Mol. Asp. Med."},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105332_bib22","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s10067-018-4166-3","article-title":"Basic calcium phosphate and pyrophosphate crystals in early and late osteoarthritis: relationship with clinical indices and inflammation","volume":"37","author":"Frallonardo","year":"2018","journal-title":"Clin. Rheuma"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib23","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1530\/JME-20-0089","article-title":"FGF23-related hypophosphatemic rickets\/osteomalacia: diagnosis and new treatment","volume":"66","author":"Fukumoto","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.critrevonc.2026.105332_bib24","series-title":"Periodontal Disease, StatPearls","author":"Gasner","year":"2025"},{"key":"10.1016\/j.critrevonc.2026.105332_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jsbmb.2019.01.023","article-title":"Dietary phosphorus enhances inflammatory response: A study of human gingivitis","volume":"188","author":"Goodson","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.critrevonc.2026.105332_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.sna.2024.115660","article-title":"Real-time salivary turbidity measurement with a mouthguard-type wearable sensor","volume":"376","author":"Ichikawa","year":"2024","journal-title":"Sens. Actuators A Phys."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00424-018-2242-9","article-title":"Systemic network for dietary inorganic phosphate adaptation among three organs","volume":"471","author":"Ikuta","year":"2019","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4081\/oncol.2020.465","article-title":"Periodontitis and oral cancer - current concepts of the etiopathogenesis","volume":"14","author":"Irani","year":"2020","journal-title":"Oncol. Rev."},{"issue":"23","key":"10.1016\/j.critrevonc.2026.105332_bib30","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.critrevonc.2026.105332_bib31","series-title":"Oral and Oropharyngeal Cancer","first-page":"19","article-title":"Etiology and risk factors","author":"Johnson","year":"2018"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/0971-4065.109421","article-title":"Oral and salivary changes among renal patients undergoing hemodialysis: a cross-sectional study","volume":"23","author":"Kaushik","year":"2013","journal-title":"Indian J. Nephrol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.ackd.2010.12.003","article-title":"Phosphate and cardiovascular disease","volume":"18","author":"Kendrick","year":"2011","journal-title":"Adv. Chronic Kidney Dis."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.otc.2025.08.005","article-title":"KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease\u2013mineral and bone disorder (CKD-MBD)","volume":"59","author":"Kim","year":"2026","journal-title":"Otolaryngol. Clin. North Am."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib36","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12903-021-01998-y","article-title":"Periodontitis as a risk for oral cancer: a case\u2013control study","volume":"21","author":"Koml\u00f3s","year":"2021","journal-title":"BMC Oral. Health"},{"key":"10.1016\/j.critrevonc.2026.105332_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdsr.2024.12.002","article-title":"Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head\/neck squamous cell carcinoma (HNSCC)","volume":"61","author":"Li","year":"2025","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"10.1016\/j.critrevonc.2026.105332_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2019.126822","article-title":"Highly sensitive and specific colorimetric detection of phosphate by using Zr(\u2163) to synergistically suppress the peroxidase-mimicking activity of hydrophilic Fe3O4 nanocubes","volume":"297","author":"Li","year":"2019","journal-title":"Sens. Actuators B Chem."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12882-025-03992-w","article-title":"Association of aberrant mineral metabolic markers with fracture risk in chronic kidney disease: a comprehensive meta-analysis","volume":"26","author":"Liu","year":"2025","journal-title":"BMC Nephrol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cden.2010.08.004","article-title":"Saliva as a diagnostic fluid","volume":"55","author":"Malamud","year":"2011","journal-title":"Dent. Clin. North Am."},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5414\/CNP65235","article-title":"Renal osteodystrophy: what's in a name? Presentation of a clinically useful new model to interpret bone histologic findings","volume":"65","author":"Malluche","year":"2006","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.critrevonc.2026.105332_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.greeac.2022.100006","article-title":"A fully-printed electrochemical platform for assisted colorimetric detection of phosphate in saliva: greenness and whiteness quantification by the AGREE and RGB tools","volume":"1","author":"Mazzaracchio","year":"2022","journal-title":"Green. Anal. Chem."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2144\/btn-2023-0075","article-title":"Comparison of colorimetric, spectroscopic and electrochemical techniques for quantification of hydrogen sulfide","volume":"76","author":"Mhatre","year":"2024","journal-title":"BioTechniques"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib44","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1152\/physrev.00022.2017","article-title":"Phosphate as a signaling molecule and its sensing mechanism","volume":"98","author":"Michigami","year":"2018","journal-title":"Physiol. Rev."},{"issue":"24","key":"10.1016\/j.critrevonc.2026.105332_bib45","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.M109.098616","article-title":"Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1\/2 phosphorylation","volume":"285","author":"Miedlich","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105332_bib46","doi-asserted-by":"crossref","first-page":"580","DOI":"10.5551\/jat.65238","article-title":"Harmonization of Lipoprotein(a) Immunoassays Using A Serum Panel Value Assigned with The IFCC-Endorsed Mass Spectrometry-Based Reference Measurement Procedure as A First Step Towards Apolipoprotein Standardization","volume":"32","author":"Miida","year":"2025","journal-title":"J. Atheroscler. Thromb."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib47","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder","volume":"75","author":"Moe","year":"2009","journal-title":"Kidney Int"},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105332_bib48","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1177\/00220345880670090701","article-title":"Composition of human plaque fluid","volume":"67","author":"Moreno","year":"1988","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00424-022-02764-x","article-title":"Expression of phosphate and calcium transporters and their regulators in parotid glands of mice","volume":"475","author":"Moser","year":"2023","journal-title":"Pflug. Arch."},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib50","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00424-020-02370-9","article-title":"Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease","volume":"472","author":"Motta","year":"2020","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.critrevonc.2026.105332_bib51","article-title":"Secondary Hyperparathyroidism","author":"Muppidi","year":"2023","journal-title":"StatPearls"},{"key":"10.1016\/j.critrevonc.2026.105332_bib52","volume":"1116","author":"Nasution","year":"2018"},{"key":"10.1016\/j.critrevonc.2026.105332_bib53","article-title":"Colorimetric detection of phosphate-based on iron complexing catechol-displacement assay in eutrophicated water bodies","volume":"20","author":"Naveen","year":"2023","journal-title":"Environ. Nanotechnol. Monit. Manag."},{"key":"10.1016\/j.critrevonc.2026.105332_bib54","unstructured":"Nosek, T., 2016. Composition of Saliva. \u3008https:\/\/web.archive.org\/web\/20160117182014\/http:\/\/humanphysiology.tuars.com\/program\/section6\/6ch4\/s6ch4_6.htm\u3009. (Accessed 8\/3\/25 2025)."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2013.10.006","article-title":"Analyses of organic acids and inorganic anions and their relationship in human saliva before and after glucose intake","volume":"59","author":"Park","year":"2014","journal-title":"Arch. Oral. Biol."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105332_bib56","first-page":"58","article-title":"Estimation and comparison of salivary calcium, phosphorous, alkaline phosphatase and ph levels in periodontal health and disease: a cross-sectional biochemical study","volume":"10","author":"Patel","year":"2016","journal-title":"J. Clin. Diagn. Res"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib57","first-page":"139","article-title":"Salivary Markers in Patients with Chronic Kidney Disease","volume":"44","author":"Poposki","year":"2023","journal-title":"Pril. (Make Akad. Nauk. Umet. Odd. Med Nauk."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12116","article-title":"The physiology of salivary secretion","volume":"70","author":"Proctor","year":"2016","journal-title":"Periodontol 2000"},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105332_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/s20102766","article-title":"A paper-based device for ultrasensitive, colorimetric phosphate detection in seawater","volume":"20","author":"Racicot","year":"2020","journal-title":"Sensors"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib60","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0976-237X.169846","article-title":"Assessment of salivary calcium, phosphate, magnesium, pH, and flow rate in healthy subjects, periodontitis, and dental caries","volume":"6","author":"Rajesh","year":"2015","journal-title":"Conte Clin. Dent."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/CS20100377","article-title":"Phosphate toxicity: new insights into an old problem","volume":"120","author":"Razzaque","year":"2011","journal-title":"Clin. Sci."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib62","doi-asserted-by":"crossref","DOI":"10.4103\/AIHB.AIHB_3_20","article-title":"Can excessive dietary phosphate intake influence oral diseases?","volume":"10","author":"Razzaque","year":"2020","journal-title":"Adv. Hum. Biol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib63","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1096\/fba.2021-00104","article-title":"Salivary phosphate as a biomarker for human diseases","volume":"4","author":"Razzaque","year":"2022","journal-title":"FASEB Bioadv"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-07-0095","article-title":"The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis","volume":"194","author":"Razzaque","year":"2007","journal-title":"J. Endocrinol."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105332_bib65","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s40620-022-01274-4","article-title":"Salivary changes in chronic kidney disease and in patients undergoing hemodialysis: a systematic review and meta-analysis","volume":"35","author":"Rodrigues","year":"2022","journal-title":"J. Nephrol."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105332_bib66","first-page":"CC12","article-title":"Correlation of serum and salivary biochemical parameters in end stage renal disease patients undergoing hemodialysis in pre and post-dialysis state","volume":"8","author":"Seethalakshmi","year":"2014","journal-title":"J. Clin. Diagn. Res"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib67","first-page":"305","article-title":"Comparative study on mineralization-related intraoral parameters in periodontitis-affected and periodontitis-free adults","volume":"98","author":"Sew\u00f3n","year":"1990","journal-title":"Scand. J. Dent. Res"},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105332_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23296","article-title":"Ion chromatography as candidate reference method for the determination of chloride in human serum","volume":"34","author":"Shen","year":"2020","journal-title":"J. Clin. Lab Anal."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib69","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Min. Res"},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib70","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1081\/IAS-120022937","article-title":"Improved sensitivity of colorimetric compared to chemiluminescence ELISAs for cytokine assays","volume":"24","author":"Siddiqui","year":"2003","journal-title":"J. Immunoass. Immunochem."},{"issue":"21641","key":"10.1016\/j.critrevonc.2026.105332_bib71","article-title":"The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals","volume":"10","author":"Singh","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105332_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029483","article-title":"High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: dna microarray analysis","volume":"7","author":"Suyama","year":"2012","journal-title":"PLOS ONE"},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105332_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0003-9969(98)00125-3","article-title":"Release of mineral ions in dental plaque following acid production","volume":"44","author":"Tanaka","year":"1999","journal-title":"Arch. Oral. Biol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib74","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.4103\/2230-8210.104041","article-title":"Calcium-sensing receptor: Role in health and disease","volume":"16","author":"Thakker","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.critrevonc.2026.105332_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123312","article-title":"Determination of ions in Caenorhabditis elegans by ion chromatography","volume":"1204","author":"Var\u00e3o Moura","year":"2022","journal-title":"J. Chromatogr. B"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105332_bib76","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00784-024-05540-6","article-title":"Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats","volume":"28","author":"Vaz\u00e3o","year":"2024","journal-title":"Clin. Oral. Investig."},{"key":"10.1016\/j.critrevonc.2026.105332_bib77","doi-asserted-by":"crossref","DOI":"10.1039\/C7AY02558K","article-title":"A high-throughput method for orthophosphate determination of thermostable membrane-bound pyrophosphatase activity","volume":"10","author":"Vidilaseris","year":"2018","journal-title":"Anal. Methods"},{"key":"10.1016\/j.critrevonc.2026.105332_bib78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2015.04.005","article-title":"Salivary biomarkers of oxidative stress: A critical review","volume":"85","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"4-5","key":"10.1016\/j.critrevonc.2026.105332_bib79","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral. Oncol."},{"key":"10.1016\/j.critrevonc.2026.105332_bib80","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2016.11.012","article-title":"Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho","volume":"100","author":"Yamada","year":"2017","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105332_bib81","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/CMR.00021-13","article-title":"Salivary biomarkers: toward future clinical and diagnostic utilities","volume":"26","author":"Yoshizawa","year":"2013","journal-title":"Clin. Microbiol Rev."}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826002192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826002192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:57:03Z","timestamp":1780037823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842826002192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":81,"alternative-id":["S1040842826002192"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105332","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salivary phosphate: A promising non-invasive biomarker for oral and systemic disease screening","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105332"}}