{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:19:33Z","timestamp":1783066773412,"version":"3.54.6"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403233"],"award-info":[{"award-number":["82403233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472824"],"award-info":[{"award-number":["82472824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173091"],"award-info":[{"award-number":["82173091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017633","name":"Shanghai Anti-Cancer Association","doi-asserted-by":"publisher","award":["ZYJH202312"],"award-info":[{"award-number":["ZYJH202312"]}],"id":[{"id":"10.13039\/100017633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017633","name":"Shanghai Anti-Cancer Association","doi-asserted-by":"publisher","award":["20214Y0396"],"award-info":[{"award-number":["20214Y0396"]}],"id":[{"id":"10.13039\/100017633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21JC1401500"],"award-info":[{"award-number":["21JC1401500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750530"],"award-info":[{"award-number":["2024M750530"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Oncology\/Hematology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.critrevonc.2026.105340","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:09:08Z","timestamp":1777579748000},"page":"105340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MAIT Cells in Tumor Contexts: Functional Diversity and Regulatory Hierarchies"],"prefix":"10.1016","volume":"223","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizhou","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiding","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.critrevonc.2026.105340_bib1","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/nrdp.2017.36","article-title":"Gastric adenocarcinoma","volume":"3","author":"Ajani","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"16","key":"10.1016\/j.critrevonc.2026.105340_bib2","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/j.cell.2024.07.016","article-title":"LAG-3 and PD-1 synergize on CD8(+) T cells to drive T cell exhaustion and hinder autocrine IFN-\u03b3-dependent anti-tumor immunity","volume":"187","author":"Andrews","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.critrevonc.2026.105340_bib3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3389\/fimmu.2020.00949","article-title":"A role for MAIT cells in colorectal cancer","volume":"11","author":"Berzins","year":"2020","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.critrevonc.2026.105340_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2414230122","article-title":"Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu","volume":"122","author":"Boulouis","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.critrevonc.2026.105340_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1594712","article-title":"Control of MAIT cell functions by cytokines in health and disease","volume":"16","author":"Camard","year":"2025","journal-title":"Front Immunol."},{"issue":"38","key":"10.1016\/j.critrevonc.2026.105340_bib6","doi-asserted-by":"crossref","first-page":"61183","DOI":"10.18632\/oncotarget.11282","article-title":"IL-13\/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"issue":"89","key":"10.1016\/j.critrevonc.2026.105340_bib7","doi-asserted-by":"crossref","first-page":"eabn8531","DOI":"10.1126\/sciimmunol.abn8531","article-title":"Transcriptomes and metabolism define mouse and human MAIT cell populations","volume":"8","author":"Chandra","year":"2023","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.critrevonc.2026.105340_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fimmu.2019.00260","article-title":"Circulating mucosal-associated invariant T cells in a large cohort of healthy Chinese individuals from newborn to elderly","volume":"10","author":"Chen","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102324","article-title":"Lactate induces C2C12 myoblasts differentiation by mediating ROS\/p38 MAPK signalling pathway","volume":"87","author":"Cheng","year":"2024","journal-title":"Tissue Cell"},{"issue":"7500","key":"10.1016\/j.critrevonc.2026.105340_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature13160","article-title":"T-cell activation by transitory neo-antigens derived from distinct microbial pathways","volume":"509","author":"Corbett","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.critrevonc.2026.105340_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.omto.2022.02.009","article-title":"A novel fusion protein scaffold 18\/12\/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells","volume":"24","author":"Cubitt","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib13","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/s41467-021-21928-4","article-title":"Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy","volume":"12","author":"De Biasi","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105340_bib14","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.2100856","article-title":"Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy","volume":"209","author":"Dogan","year":"2022","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105340_bib15","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.4049\/jimmunol.1701512","article-title":"Mucosal-associated invariant T cells augment immunopathology and gastritis in chronic helicobacter pylori infection","volume":"200","author":"D'Souza","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.immuni.2022.12.004","article-title":"Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing","volume":"56","author":"du Halgouet","year":"2023","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105340_bib17","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1158\/1078-0432.CCR-18-3040","article-title":"Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma","volume":"25","author":"Duan","year":"2019","journal-title":"Clin. Cancer Res"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105340_bib18","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1182\/blood-2010-08-303339","article-title":"Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells","volume":"117","author":"Dusseaux","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12929-025-01125-x","article-title":"Biological functions and therapeutic applications of human mucosal-associated invariant T cells","volume":"32","author":"Fang","year":"2025","journal-title":"J. Biomed. Sci."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib20","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.3324\/haematol.2017.163758","article-title":"Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition","volume":"102","author":"Favreau","year":"2017","journal-title":"Haematologica"},{"issue":"10127","key":"10.1016\/j.critrevonc.2026.105340_bib21","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105340_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"13","key":"10.1016\/j.critrevonc.2026.105340_bib23","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1177\/15353702221089910","article-title":"Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1\/TGF\u03b2RII agent: current status","volume":"247","author":"Gameiro","year":"2022","journal-title":"Exp. Biol. Med (Maywood)"},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105340_bib24","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/s41590-023-01575-1","article-title":"Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity","volume":"24","author":"Garner","year":"2023","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib25","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1038\/s41598-018-22130-1","article-title":"Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma","volume":"8","author":"Gherardin","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105340_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/imcb.12021","article-title":"Human blood MAIT cell subsets defined using MR1 tetramers","volume":"96","author":"Gherardin","year":"2018","journal-title":"Immunol. Cell Biol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/mi.2016.30","article-title":"MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation","volume":"10","author":"Gibbs","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib28","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1038\/s41467-023-43269-0","article-title":"Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease","volume":"14","author":"Gnirck","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105340_bib29","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib30","doi-asserted-by":"crossref","first-page":"15009","DOI":"10.1038\/nrdp.2015.9","article-title":"Non-small-cell lung cancer","volume":"1","author":"Gridelli","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.critrevonc.2026.105340_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1563303","article-title":"Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives","volume":"16","author":"Gu","year":"2025","journal-title":"Front Immunol."},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105340_bib32","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1097\/JS9.0000000000001479","article-title":"Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: a global-scale, cross-sectional, and large-sample informatics study","volume":"110","author":"Guo","year":"2024","journal-title":"Int J. Surg."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib33","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s00262-018-2132-1","article-title":"Mucosa-associated invariant T cells in malignancies: a faithful friend or formidable foe?","volume":"67","author":"Haeryfar","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"issue":"10074","key":"10.1016\/j.critrevonc.2026.105340_bib34","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","article-title":"Breast cancer","volume":"389","author":"Harbeck","year":"2017","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105340_bib35","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1164\/rccm.201601-0002OC","article-title":"Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection","volume":"194","author":"Hinks","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105340_bib36","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003685","article-title":"Activated but impaired IFN-\u03b3 production of mucosal-associated invariant T cells in patients with hepatocellular carcinoma","volume":"9","author":"Huang","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105340_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.immuni.2024.01.010","article-title":"LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation","volume":"57","author":"Joller","year":"2024","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105340_bib38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/imcb.12281","article-title":"Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers","volume":"97","author":"Kelly","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"7426","key":"10.1016\/j.critrevonc.2026.105340_bib39","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature11605","article-title":"MR1 presents microbial vitamin B metabolites to MAIT cells","volume":"491","author":"Kjer-Nielsen","year":"2012","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.critrevonc.2026.105340_bib40","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ni.3565","article-title":"A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage","volume":"17","author":"Koay","year":"2016","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105340_bib41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/mi.2014.81","article-title":"MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets","volume":"8","author":"Kurioka","year":"2015","journal-title":"Mucosal Immunol."},{"issue":"6","key":"10.1016\/j.critrevonc.2026.105340_bib42","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1182\/blood-2007-10-078022","article-title":"Multiple myeloma","volume":"111","author":"Kyle","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib43","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1038\/s41467-020-18155-8","article-title":"Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.critrevonc.2026.105340_bib44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4143\/crt.2014.46.3.297","article-title":"Interleukin-17 Indirectly Promotes M2 macrophage differentiation through stimulation of COX-2\/PGE2 pathway in the cancer cells","volume":"46","author":"Li","year":"2014","journal-title":"Cancer Res Treat."},{"key":"10.1016\/j.critrevonc.2026.105340_bib45","doi-asserted-by":"crossref","first-page":"20358","DOI":"10.1038\/srep20358","article-title":"Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patients","volume":"6","author":"Ling","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib46","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/JTO.0b013e3182542752","article-title":"Interleukin-17 and prostaglandin E2 are involved in formation of an M2 macrophage-dominant microenvironment in lung cancer","volume":"7","author":"Liu","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib47","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1038\/ncomms14599","article-title":"Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells","volume":"8","author":"Mak","year":"2017","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib48","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1136\/gutjnl-2012-303461","article-title":"Interleukin 13 and its role in gut defence and inflammation","volume":"61","author":"Mannon","year":"2012","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41422-023-00864-6","article-title":"Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation","volume":"34","author":"Mao","year":"2024","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.critrevonc.2026.105340_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13020408","article-title":"Comprehensive analysis of granzymes and perforin family genes in multiple cancers","volume":"13","author":"Mareboina","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.critrevonc.2026.105340_bib51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.coi.2020.05.006","article-title":"MR1: a multi-faceted metabolite sensor for T cell activation","volume":"64","author":"McWilliam","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib52","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3389\/fimmu.2019.01580","article-title":"Mucosal-associated invariant T cells display diminished effector capacity in oesophageal adenocarcinoma","volume":"10","author":"Melo","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.critrevonc.2026.105340_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/sji.12193","article-title":"The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in men and women of reproductive age","volume":"80","author":"Novak","year":"2014","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrgastro.2016.169","article-title":"The intestinal epithelial barrier: a therapeutic target?","volume":"14","author":"Odenwald","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib55","article-title":"Mucosal associated invariant T cells in cancer-friend or foe?","volume":"13","author":"O'Neill","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"Pt B","key":"10.1016\/j.critrevonc.2026.105340_bib56","article-title":"Mucosal-associated invariant T cells reduce and display tissue-resident phenotype with elevated IL-17 producing capacity in non-small cell lung cancer","volume":"113","author":"Ouyang","year":"2022","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib57","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1038\/s41467-021-25009-4","article-title":"MAIT cells regulate NK cell-mediated tumor immunity","volume":"12","author":"Petley","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105340_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11092358","article-title":"The Role of Fusobacterium nucleatum in Oral and Colorectal Carcinogenesis","volume":"11","author":"Pignatelli","year":"2023","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.critrevonc.2026.105340_bib59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4049\/immunohorizons.2100003","article-title":"MR1 tetramer-based artificial APCs Expand MAIT cells from human peripheral blood that effectively Kill Glioblastoma Cells","volume":"5","author":"Priya","year":"2021","journal-title":"Immunohorizons"},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105340_bib60","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3389\/fimmu.2018.00756","article-title":"Unique and Common Features of Innate-Like Human V\u03b42(+) \u03b3\u03b4T Cells and Mucosal-Associated Invariant T Cells","author":"Provine","year":"2018","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib61","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13046-024-03046-3","article-title":"CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy","volume":"43","author":"Qu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res"},{"issue":"9","key":"10.1016\/j.critrevonc.2026.105340_bib62","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1158\/2326-6066.CIR-20-0925","article-title":"Activating mucosal-associated invariant T cells induces a broad antitumor response","volume":"9","author":"Ruf","year":"2021","journal-title":"Cancer Immunol. Res"},{"issue":"17","key":"10.1016\/j.critrevonc.2026.105340_bib63","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1016\/j.cell.2023.07.026","article-title":"Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin","volume":"186","author":"Ruf","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41385-020-0332-4","article-title":"MAIT cell-directed therapy of Mycobacterium tuberculosis infection","volume":"14","author":"Sakai","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coi.2017.07.009","article-title":"MAIT cells in infectious diseases","volume":"48","author":"Salou","year":"2017","journal-title":"Curr. Opin. Immunol."},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105340_bib66","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/eji.201445313","article-title":"IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions","volume":"45","author":"Sattler","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib67","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1038\/nrdp.2015.3","article-title":"Melanoma","volume":"1","author":"Schadendorf","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib68","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00262-017-2050-7","article-title":"Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment","volume":"66","author":"Shaler","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib69","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13578-020-00518-9","article-title":"Decrease of peripheral blood mucosal-associated invariant T cells and impaired serum Granzyme-B production in patients with gastric cancer","volume":"11","author":"Shao","year":"2021","journal-title":"Cell Biosci."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib70","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1016\/j.ymthe.2024.10.021","article-title":"A tumor-conditional IL-15 safely synergizes with immunotherapy to enhance antitumor immune responses","volume":"32","author":"Shi","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.critrevonc.2026.105340_bib71","doi-asserted-by":"crossref","first-page":"17048","DOI":"10.1038\/nrdp.2017.48","article-title":"Oesophageal cancer","volume":"3","author":"Smyth","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10123160","article-title":"Harnessing the power of mucosal-associated invariant T (MAIT) cells in cancer cell therapy","volume":"10","author":"Sugimoto","year":"2022","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib73","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.4049\/jimmunol.1500258","article-title":"Human mucosa-associated invariant T cells accumulate in colon adenocarcinomas but produce reduced amounts of IFN-\u03b3","volume":"195","author":"Sundstr\u00f6m","year":"2015","journal-title":"J. Immunol."},{"issue":"29","key":"10.1016\/j.critrevonc.2026.105340_bib74","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.18632\/oncotarget.26866","article-title":"Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules","volume":"10","author":"Sundstr\u00f6m","year":"2019","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.critrevonc.2026.105340_bib75","doi-asserted-by":"crossref","first-page":"eaaz0374","DOI":"10.1126\/sciadv.aaz0374","article-title":"Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection","volume":"6","author":"Tang","year":"2020","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib76","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.4049\/jimmunol.1203218","article-title":"IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells","volume":"190","author":"Tang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s43018-025-00930-5","article-title":"Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors","author":"Tao","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.critrevonc.2026.105340_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1392535","article-title":"Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials","volume":"15","author":"Thompson","year":"2024","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib79","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1084\/jem.189.12.1907","article-title":"An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha\/beta T cell subpopulation in mammals","volume":"189","author":"Tilloy","year":"1999","journal-title":"J. Exp. Med"},{"issue":"10","key":"10.1016\/j.critrevonc.2026.105340_bib80","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1128\/AEM.00242-14","article-title":"Microbiota of human breast tissue","volume":"80","author":"Urbaniak","year":"2014","journal-title":"Appl. Environ. Microbiol"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib81","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/eji.201343509","article-title":"CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner","volume":"44","author":"Ussher","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib82","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3389\/fimmu.2014.00450","article-title":"Mucosal-associated invariant T-cells: new players in anti-bacterial immunity","volume":"5","author":"Ussher","year":"2014","journal-title":"Front Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib83","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1038\/ncomms11653","article-title":"MAIT cells are activated during human viral infections","volume":"7","author":"van Wilgenburg","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib84","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190456","article-title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","volume":"217","author":"Vitiello","year":"2020","journal-title":"J. Exp. Med"},{"issue":"7","key":"10.1016\/j.critrevonc.2026.105340_bib85","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98487","article-title":"Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions","volume":"3","author":"Voillet","year":"2018","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.critrevonc.2026.105340_bib86","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.stem.2013.03.001","article-title":"Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation","volume":"12","author":"Wakao","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.critrevonc.2026.105340_bib87","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/sji.12237","article-title":"The rise and fall of MAIT cells with age","volume":"80","author":"Walker","year":"2014","journal-title":"Scand. J. Immunol."},{"issue":"46","key":"10.1016\/j.critrevonc.2026.105340_bib88","doi-asserted-by":"crossref","first-page":"76274","DOI":"10.18632\/oncotarget.11187","article-title":"Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer","volume":"7","author":"Won","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib89","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1158\/2159-8290.CD-19-0569","article-title":"MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1","volume":"10","author":"Yan","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.critrevonc.2026.105340_bib90","article-title":"Lactylation and antitumor immunity","volume":"16","author":"Yang","year":"2025","journal-title":"Front Immunol."},{"key":"10.1016\/j.critrevonc.2026.105340_bib91","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3389\/fimmu.2020.01691","article-title":"Leveraging public single-cell and bulk transcriptomic datasets to delineate MAIT cell roles and phenotypic characteristics in human malignancies","volume":"11","author":"Yao","year":"2020","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.critrevonc.2026.105340_bib92","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00262-015-1764-7","article-title":"Increased tumor infiltration by mucosal-associated invariant T cells correlates with poor survival in colorectal cancer patients","volume":"64","author":"Zabijak","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"issue":"7779","key":"10.1016\/j.critrevonc.2026.105340_bib93","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.critrevonc.2026.105340_bib94","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13058-018-1036-5","article-title":"Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells","volume":"20","author":"Zumwalde","year":"2018","journal-title":"Breast Cancer Res"}],"container-title":["Critical Reviews in Oncology\/Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826002271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1040842826002271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:56:07Z","timestamp":1783065367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1040842826002271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":94,"alternative-id":["S1040842826002271"],"URL":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105340","relation":{},"ISSN":["1040-8428"],"issn-type":[{"value":"1040-8428","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MAIT Cells in Tumor Contexts: Functional Diversity and Regulatory Hierarchies","name":"articletitle","label":"Article Title"},{"value":"Critical Reviews in Oncology\/Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.critrevonc.2026.105340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105340"}}